Exploring the mechanisms of gene delivery via viral vectors, this content delves into the basics of viral structure, infection, and replication. It discusses common viral vector systems like Adenoviral and Lentiviral vectors, highlighting safety considerations and the production processes involved.

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Viral pathogenesis explores the intricate relationship between viruses and their hosts, encompassing factors like viral effects on cells, entry mechanisms, tissue tropism, immune responses, and the outcomes of infection. This process involves a series of interactions leading to either virus clearanc

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Barney S. Graham, MD, PhD, outlines a scientific framework for epidemic and pandemic research preparedness to achieve fast and equitable access to high-quality vaccines for future pandemics. The discussion covers new human viral pathogens, 21st-century viral threats, viral taxonomy, and a prototype

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Bacterial pathogenesis involves the ability of certain bacteria to cause disease by attributes such as transmissibility, adherence, motility, invasion, and toxigenicity. Pathogens can exploit host defenses, while virulence determines the severity of infection. Learn about opportunistic pathogens, no

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Viral diseases like Newcastle Disease (ND) and Avian Influenza (AI) pose significant threats to poultry farming, impacting bird health and production. ND, caused by Avian paramyxovirus type 1, is highly contagious and manifests in various forms affecting birds' respiratory and nervous systems. On th

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This study investigates the uptake of viral load testing and frequency of viraemic episodes during pregnancy among HIV-positive mothers in Johannesburg, South Africa. Data from a cohort of mothers and infants born at a local hospital were linked to laboratory data for analysis. The results show the

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Explore the distinction between reactive arthritis and viral arthritis in the context of COVID-19, discussing symptoms, triggers, and potential long-term consequences on joint health. Learn how viral infections can lead to acute arthralgia and arthritis, including common pathogens such as Hepatitis

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Plant viruses are transmitted through various means such as cell-to-cell movement via plasmodesmata and systemic spread through vascular tissues. The viral proteins and mechanisms facilitating these movements are crucial for viral infection and spread within plant hosts. Understanding the different

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Exploring the diverse ways viruses enter the body through various routes such as respiratory tract, oropharynx, skin, genitourinary tract, and eyes, shedding light on the steps of the virus life cycle shaping pathogenesis. Viral diseases result from the intricate interaction between viral and host f

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The article discusses the physiological basis, types, pathogenesis, and genetic predisposition of hypertension. It explains the revision of terminology related to blood pressure and the calculation of mean arterial pressure. Secondary hypertension, causes, and mean arterial pressure determination ar

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Viruses utilize different replication strategies to ensure the replication of viral genomes, packaging into virions, and potentially altering the host cell's structure or function. These strategies are vital for the virus to operate effectively within the host cell's constraints. The replication pro

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Viral gastroenteritis is an inflammation of the gastrointestinal tract primarily affecting the stomach and small intestine, leading to symptoms like acute diarrhea and vomiting. It can be caused by various infectious agents such as Rotavirus, Adenovirus, Caliciviruses, Astrovirus, Coronavirus, Torov

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Myocarditis is an inflammatory heart condition with various causes, including viral infections and autoimmune responses. This article discusses the epidemiology, risk factors, pathogenesis, diagnosis, and management of myocarditis, highlighting the importance of differentiating it from pericarditis

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Explore the algorithms for identifying Salmonella and Shigella, their antigenic structures, virulence factors, pathogenesis, clinical features, and management concepts. Understand the characteristics, transmission, and prevention strategies for these gastrointestinal pathogens.

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This educational material delves into the pathology, pathogenesis, and clinical features of acute pancreatitis, detailing the causes, morphological changes, and diagnostic challenges associated with this medical condition. Detailed explanations and images help enhance understanding for medical profe

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This content discusses the Capability Maturity Model stages, focusing on process improvement and the stages of viral load testing demand creation. It outlines the evolution from initial to optimized stages and the development towards standardized processes in organizations. Additionally, it touches

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Specimen selection for viral testing depends on the suspected viral etiologies and disease syndrome. Throat and nasopharyngeal swabs are used for different viruses, while rectal swabs, urine, blood, and tissue samples are also collected for specific viral detection. Proper specimen transport and sto

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Herpes viruses are common human pathogens causing both asymptomatic infection and active disease. Ocular herpes, typically caused by HSV-1, presents with symptoms like pain, photophobia, and blurred vision. Factors like UV rays, trauma, and stress can trigger reactivation. Recurrent infections often

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Peptic ulcer disease and dyspepsia are common gastrointestinal conditions. Dyspepsia presents with upper abdominal pain and may or may not be associated with peptic ulcers. The most prevalent causes of dyspepsia include non-ulcer dyspepsia, GERD, and peptic ulcers. Peptic ulcers account for a signif

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Viral gastroenteritis, commonly known as viral diarrhea, is a prevalent infection affecting mainly infants and young children. The disease is self-limiting, with symptoms like diarrhea, vomiting, and abdominal pain. Key viral etiologies include Rota viruses, Astroviruses, Norovirus, and Enteric aden

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The National Viral Hepatitis Control Program in India is working towards combating viral hepatitis and achieving SDG goal 3.3 through a comprehensive approach that includes awareness generation, prevention, management, and financing under the NHM. The aim is to eliminate hepatitis C by 2030, reduce

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Helicobacter pylori is a spiral-shaped Gram-negative bacterium associated with various gastrointestinal conditions like gastritis, duodenal ulcers, gastric ulcers, and gastric carcinoma. It exhibits unique characteristics in common with Campylobacters and has specific culture and growth requirements

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Zimbabwe hosted a vital learning session on viral load clinic laboratory interfaces and the epidemiology of HIV in the country. The session aimed to sensitize participants on the VL CLI, introduce the LARC team, and identify gaps in managing clients on ART with high viral loads. The country context

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YouTube, a giant in user-generated video content, offers immense potential for videos to go viral. Understanding the dynamics of viralization on YouTube is crucial for content creators. This chapter delves into the phenomena of viral videos on YouTube, explores key factors that contribute to a video

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Oedema is an abnormal accumulation of fluid in body tissues that can lead to various health conditions. This article explores the definition of oedema, its different types (localized and generalized), and the pathogenesis behind it, such as decreased plasma oncotic pressure and increased capillary h

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Viral infection involves a replicative cycle within the host, leading to a range of cellular responses from no apparent effect to disease. Factors such as virulence genes, host characteristics, and viral genome influence the pathogenicity and virulence of a virus. The process includes entry into the

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This content provides valuable information on the pathogenesis of infectious diseases, including definitions, phases of disease progression, types of infections, acute vs. chronic diseases, signs vs. symptoms, steps in pathogenesis, and ways pathogens can enter the body. It discusses the importance

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The pathogenesis of infectious diseases involves the development of a disease caused by a pathogen, with phases like incubation, prodromal, illness, and convalescent periods. Infections can be localized or systemic, acute, subacute, or chronic. Differentiating signs and symptoms, recognizing latent

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A comprehensive guide discussing the definition, pathogenesis, causes, risk factors, clinical features, diagnosis, and management of patients with confusion, as outlined by Consultant Neurologist Dr. Hana Albulaihe. The content covers various aspects including disturbances in attention, cognition, p

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Zimbabwe's plan to scale up HIV viral load testing from 2018 to 2020 is outlined, with targets set for each year. The country has made significant progress in expanding its viral load testing capacity, going from targeted testing to near-universal coverage by 2018. Various testing laboratories in Zi

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Understanding viral load dynamics in HIV infection is crucial for managing treatment and transmission risks. Viral load monitoring helps assess response to antiretroviral therapy and identify treatment failure. Regular viral load testing is recommended for both adults and children on ART, allowing f

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Explore the dynamics of viral load in HIV infection, its impact on transmission and disease progression, response to antiretroviral therapy, identification of treatment failure, and monitoring schedules. Understand the significance of viral load testing in managing HIV patients effectively.

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Viral hepatitis is caused by various hepatotropic viruses, including Hepatitis A, B, C, D, and E. This type of liver inflammation can manifest acutely or chronically, leading to symptoms such as jaundice, abdominal pain, nausea, and fatigue. Hepatitis A virus, in particular, is primarily transmitted

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Explore the prevalence and impact of viral social media challenges, reflect on why they become popular, and discuss the importance of making conscious decisions to participate or abstain. Delve into examples like the Paqui Challenge and the concept of trends going viral, highlighting the influence o

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Cell, organ, and tissue tropism are crucial in viral pathogenesis, influenced by factors such as routes of entry and spread within the host, cell permissiveness, and immune responses. Viruses penetrate epithelial barriers through various mechanisms to establish infection, navigating specialized cell

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Infectious diseases play a significant role in public health, with a focus on antibiotic stewardship, community-acquired and healthcare-associated infections, as well as various bacterial, viral, fungal, and parasitic agents. Specific topics include the prevention of infectious diseases, with a deta

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The LARC Capability Maturity Model (CMM) focuses on enhancing the viral load cascade, aiming to achieve better patient outcomes and improve institutional capabilities for viral load scale-up. Developed by Carnegie-Mellon University Software Engineering Institute in 1987, the CMM provides a structure

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Study focuses on Canine Meningoencephalitis of unknown etiology using Pan-Viral PCR to detect infectious agents in cerebrospinal fluid samples. The research aims to identify aberrant immune responses in dogs with MUE. Consensus degenerate primers are used to target viral families like Herpesviridae,

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Guide providing insights into viral transmission and exponential growth through a mathematical model programmed in Google Sheets. Students explore the impact of reproduction numbers (R0) on viral spread and strategies for reducing transmission. The resource includes instructional strategies, discuss

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The study investigates the impact of incident tuberculosis on viral non-suppression among patients transitioning to Dolutegravir-based therapy in Zambia. It aims to identify factors associated with viral non-suppression and describe clinical outcomes in the context of tuberculosis occurrence. The re

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