Exploring the mechanisms of gene delivery via viral vectors, this content delves into the basics of viral structure, infection, and replication. It discusses common viral vector systems like Adenoviral and Lentiviral vectors, highlighting safety considerations and the production processes involved.

1 views • 19 slides

Viral pathogenesis explores the intricate relationship between viruses and their hosts, encompassing factors like viral effects on cells, entry mechanisms, tissue tropism, immune responses, and the outcomes of infection. This process involves a series of interactions leading to either virus clearanc

1 views • 29 slides

Barney S. Graham, MD, PhD, outlines a scientific framework for epidemic and pandemic research preparedness to achieve fast and equitable access to high-quality vaccines for future pandemics. The discussion covers new human viral pathogens, 21st-century viral threats, viral taxonomy, and a prototype

0 views • 16 slides

Viral diseases like Newcastle Disease (ND) and Avian Influenza (AI) pose significant threats to poultry farming, impacting bird health and production. ND, caused by Avian paramyxovirus type 1, is highly contagious and manifests in various forms affecting birds' respiratory and nervous systems. On th

7 views • 24 slides

This study investigates the uptake of viral load testing and frequency of viraemic episodes during pregnancy among HIV-positive mothers in Johannesburg, South Africa. Data from a cohort of mothers and infants born at a local hospital were linked to laboratory data for analysis. The results show the

2 views • 12 slides

Explore the distinction between reactive arthritis and viral arthritis in the context of COVID-19, discussing symptoms, triggers, and potential long-term consequences on joint health. Learn how viral infections can lead to acute arthralgia and arthritis, including common pathogens such as Hepatitis

0 views • 30 slides

HIV, a member of the lentivirus subfamily of retroviruses, causes Acquired Immunodeficiency Syndrome (AIDS). HIV-1 and HIV-2 have distinct characteristics, with HIV-1 being global and HIV-2 primarily in West Africa. The virus encodes reverse transcriptase and has an envelope containing glycoproteins

1 views • 31 slides

Plant viruses are transmitted through various means such as cell-to-cell movement via plasmodesmata and systemic spread through vascular tissues. The viral proteins and mechanisms facilitating these movements are crucial for viral infection and spread within plant hosts. Understanding the different

0 views • 47 slides

Exploring the diverse ways viruses enter the body through various routes such as respiratory tract, oropharynx, skin, genitourinary tract, and eyes, shedding light on the steps of the virus life cycle shaping pathogenesis. Viral diseases result from the intricate interaction between viral and host f

4 views • 20 slides

SARS-CoV-2, the virus responsible for COVID-19, follows a complex life cycle involving viral attachment and entry, replication and synthesis, as well as viral assembly and release. The virus interacts with host cell proteins to enter, produce essential proteins and RNA for reproduction, and then ass

1 views • 5 slides

Viruses utilize different replication strategies to ensure the replication of viral genomes, packaging into virions, and potentially altering the host cell's structure or function. These strategies are vital for the virus to operate effectively within the host cell's constraints. The replication pro

0 views • 15 slides

Understanding the distinction between viral and bacterial upper respiratory tract infections is crucial for effective management and treatment. This article discusses key differences in symptoms, diagnostic methods, and treatment approaches to aid in accurate differentiation between the two types of

2 views • 87 slides

Family sculpting is a unique form of family therapy where trained therapists use psychodrama techniques to explore and address deep family dynamics. Through verbal and nonverbal expressions, family members are placed in scenes that reflect their roles and attitudes within the group. The sculptor, ty

0 views • 14 slides

Viral gastroenteritis is an inflammation of the gastrointestinal tract primarily affecting the stomach and small intestine, leading to symptoms like acute diarrhea and vomiting. It can be caused by various infectious agents such as Rotavirus, Adenovirus, Caliciviruses, Astrovirus, Coronavirus, Torov

1 views • 7 slides

Viral infections exhibit diverse cellular tropism based on receptor interactions, impacting cell function through modulation and potential host defense responses. Infections can lead to various outcomes, from cell death to persistent or latent states, with nuanced effects on cellular behavior. Diffe

0 views • 8 slides

Canine Viral Infection, caused by canine parvovirus-2, is a highly contagious disease affecting dogs, especially puppies. The infection spreads through fecal-oral route and can lead to severe clinical signs like vomiting, diarrhea, and dehydration. The virus replicates in lymphoid tissues, affecting

0 views • 11 slides

Real-Time PCR, also known as quantitative PCR, is a specialized technique used in molecular biology for gene expression analysis, medical research, disease diagnosis, viral quantification, and more. It enables the real-time visualization and measurement of DNA sequences in a sample, playing a crucia

4 views • 8 slides

This content discusses the Capability Maturity Model stages, focusing on process improvement and the stages of viral load testing demand creation. It outlines the evolution from initial to optimized stages and the development towards standardized processes in organizations. Additionally, it touches

3 views • 8 slides

Specimen selection for viral testing depends on the suspected viral etiologies and disease syndrome. Throat and nasopharyngeal swabs are used for different viruses, while rectal swabs, urine, blood, and tissue samples are also collected for specific viral detection. Proper specimen transport and sto

0 views • 7 slides

Antiviral chemotherapy plays a crucial role in preventing and treating viral infections, especially when public health measures and vaccines are not sufficient. This form of treatment has been successful in combating diseases like HIV by inhibiting viral replication and targeting specific functions

1 views • 34 slides

This study led by Dr. Geoffrey Chipungu, an HIV/AIDS Specialist at UNICEF ESARO, explores the rates, trends, and factors associated with HIV viral load suppression (VLS) in children. The research reveals sub-optimal VLS rates in children compared to adults, highlighting the need for improved policie

5 views • 12 slides

Viral gastroenteritis, commonly known as viral diarrhea, is a prevalent infection affecting mainly infants and young children. The disease is self-limiting, with symptoms like diarrhea, vomiting, and abdominal pain. Key viral etiologies include Rota viruses, Astroviruses, Norovirus, and Enteric aden

0 views • 19 slides

The National Viral Hepatitis Control Program in India is working towards combating viral hepatitis and achieving SDG goal 3.3 through a comprehensive approach that includes awareness generation, prevention, management, and financing under the NHM. The aim is to eliminate hepatitis C by 2030, reduce

0 views • 19 slides

Vinavirales is a group of viruses that were previously part of the PM2-like group. The content discusses various species and bacterium within Vinavirales, as well as related groups such as Nucleocytoviricota and Virophages. It explores their presence in marine metagenomes, sediment environments, and

0 views • 7 slides

The DRIVE-SHIFT study evaluated switching to DOR/3TC/TDF in HIV patients with suppressed viral loads. The study aimed to assess the efficacy of DOR/3TC/TDF compared to continuation of current antiretroviral therapy (cART) at both 24 and 48 weeks. Results showed non-inferiority of DOR/3TC/TDF in main

1 views • 7 slides

Zimbabwe hosted a vital learning session on viral load clinic laboratory interfaces and the epidemiology of HIV in the country. The session aimed to sensitize participants on the VL CLI, introduce the LARC team, and identify gaps in managing clients on ART with high viral loads. The country context

0 views • 18 slides

YouTube, a giant in user-generated video content, offers immense potential for videos to go viral. Understanding the dynamics of viralization on YouTube is crucial for content creators. This chapter delves into the phenomena of viral videos on YouTube, explores key factors that contribute to a video

0 views • 42 slides

Viral infection involves a replicative cycle within the host, leading to a range of cellular responses from no apparent effect to disease. Factors such as virulence genes, host characteristics, and viral genome influence the pathogenicity and virulence of a virus. The process includes entry into the

0 views • 16 slides

Zimbabwe's plan to scale up HIV viral load testing from 2018 to 2020 is outlined, with targets set for each year. The country has made significant progress in expanding its viral load testing capacity, going from targeted testing to near-universal coverage by 2018. Various testing laboratories in Zi

0 views • 9 slides

Understanding viral load dynamics in HIV infection is crucial for managing treatment and transmission risks. Viral load monitoring helps assess response to antiretroviral therapy and identify treatment failure. Regular viral load testing is recommended for both adults and children on ART, allowing f

0 views • 40 slides

Explore the dynamics of viral load in HIV infection, its impact on transmission and disease progression, response to antiretroviral therapy, identification of treatment failure, and monitoring schedules. Understand the significance of viral load testing in managing HIV patients effectively.

0 views • 47 slides

Explore the prevalence and impact of viral social media challenges, reflect on why they become popular, and discuss the importance of making conscious decisions to participate or abstain. Delve into examples like the Paqui Challenge and the concept of trends going viral, highlighting the influence o

0 views • 16 slides

Bovine Viral Diarrhea Virus (BVDV) is an RNA virus belonging to the Pestivirus genus in the Flaviviridae family. It is classified into BVDV-1 and BVDV-2 genotypes with distinct biotypes. BVDV is a significant infectious disease in the livestock industry worldwide, with high prevalence and clinical c

0 views • 14 slides

Cell, organ, and tissue tropism are crucial in viral pathogenesis, influenced by factors such as routes of entry and spread within the host, cell permissiveness, and immune responses. Viruses penetrate epithelial barriers through various mechanisms to establish infection, navigating specialized cell

0 views • 29 slides

Infectious diseases play a significant role in public health, with a focus on antibiotic stewardship, community-acquired and healthcare-associated infections, as well as various bacterial, viral, fungal, and parasitic agents. Specific topics include the prevention of infectious diseases, with a deta

0 views • 18 slides

The LARC Capability Maturity Model (CMM) focuses on enhancing the viral load cascade, aiming to achieve better patient outcomes and improve institutional capabilities for viral load scale-up. Developed by Carnegie-Mellon University Software Engineering Institute in 1987, the CMM provides a structure

0 views • 14 slides

Chicken pox, caused by the Varicella-zoster virus, is a contagious infection primarily affecting children. This seminar presentation delves into the classification, route of infection, symptoms, and treatment of this viral disease common in Africa. The Varicella-zoster virus, a member of the herpes

0 views • 17 slides

Study focuses on Canine Meningoencephalitis of unknown etiology using Pan-Viral PCR to detect infectious agents in cerebrospinal fluid samples. The research aims to identify aberrant immune responses in dogs with MUE. Consensus degenerate primers are used to target viral families like Herpesviridae,

0 views • 13 slides

Guide providing insights into viral transmission and exponential growth through a mathematical model programmed in Google Sheets. Students explore the impact of reproduction numbers (R0) on viral spread and strategies for reducing transmission. The resource includes instructional strategies, discuss

0 views • 8 slides

The study investigates the impact of incident tuberculosis on viral non-suppression among patients transitioning to Dolutegravir-based therapy in Zambia. It aims to identify factors associated with viral non-suppression and describe clinical outcomes in the context of tuberculosis occurrence. The re

0 views • 13 slides