Zongertinib (BI.1810631) Phase I Study in Advanced Solid Tumors with HER2 Aberrations focusing on NSCLC. The trial involves dose escalation and expansion, testing different doses in cohorts with varied HER2 mutations. Primary endpoints include MTD, OR, and DLTs.

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This collection features various experiments in chemistry involving titration and solutions. It includes procedures such as standardizing hydrochloric acid using sodium carbonate, titrating hydrochloric acid with sodium hydroxide to produce sodium chloride, determining the concentration of ethanoic

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The OCTIVUS Randomized Clinical Trial compared the clinical efficacy and safety of Optical Coherence Tomography (OCT)-guided and Intravascular Ultrasound (IVUS)-guided strategies in patients undergoing PCI for significant CAD. The study aimed to determine if OCT-guided PCI is noninferior to IVUS-gui

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This prospective, multicentre, randomised clinical trial led by Dr. Tiffany Patterson aims to determine whether direct delivery to a cardiac arrest centre following non-ST elevation out-of-hospital cardiac arrest reduces deaths compared to delivery to the nearest emergency department. Funded by the

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Explore a detailed guide on bug hunting tools, techniques, and resources by expert bug hunter Orwa Atyat from Jordan. Learn valuable tips on finding high/critical bugs, conducting basic recon, subdomain enumerations, collecting URLs/endpoints, and searching for backup files. Enhance your cybersecuri

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Apache MINA is a robust framework for building high-performance network applications. With features like non-blocking I/O, event-driven architecture, and enhanced scalability, MINA provides a reliable platform for developing multipurpose infrastructure and networked applications. Its strengths lie i

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Iron deficiency is prevalent in heart failure patients with reduced ejection fraction and is linked to poor outcomes. The HEART-FID trial investigates the impact of intravenous ferric carboxymaltose (FCM) on all-cause mortality, heart failure hospitalizations, and exercise capacity in chronic HFrEF

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The GHOST project focuses on the challenges of modeling, analyzing, and generating patterns of network activity. By utilizing Non-Negative Matrix Factorization (NMF), realistic network activity patterns can be created and injected into live wireless networks. Understanding and predicting user behavi

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Anomaly Detection Tool (ADT) aims to automate the detection of network degradation in a mobile communications network, reducing the time and effort required significantly. By utilizing statistical and machine learning models, ADT can generate anomaly reports efficiently across a large circle network

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SISTER Study led by Eva Mistry aims to identify a safe and effective dose of TS23 for treating ischemic stroke patients with core-penumbra mismatch. The Phase-2 trial involves 300 adults and spans 54 months, with primary endpoints focusing on treatment efficacy and safety. The study is randomized, p

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This study explores the use of extracorporeal life support (ECLS) in patients with acute myocardial infarction complicated by cardiogenic shock. The researchers investigate the impact of ECLS on mortality and various secondary endpoints such as renal failure, recurrent infarction, and need for revas

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Discussing the efficacy and safety of Nivolumab and Relatlimab as a superior first-line therapy option for newly diagnosed metastatic melanoma patients, with comparisons to other treatments based on key endpoints and tolerability data presented at ASCO Annual Meeting.

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Explore the concept and benefits of Intent-Based Networking (IBN) in simplifying network configuration and enhancing efficiency. Learn how IBN automates network operations, aligns with business objectives, improves security, and ensures scalability and reliability. Discover the potential of IBN tool

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Cohort studies are a type of observational study where a group of healthy subjects is followed over time to investigate relationships between exposures and outcomes. They provide valuable insights into disease development and risk factors, offering advantages like assessing multiple exposures and en

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This session discusses the landscape of DHT-derived novel endpoints in clinical research, focusing on considerations for regulatory decision-making. It explains the use of digital health technology in clinical outcome assessments and highlights the potential benefits of digitally collected COAs, suc

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This educational slide module delves into fundamental statistics for analyzing clinical endpoints in diabetes research. It covers the choice of statistical methods, the distinction between statistical and clinical significance, and the importance of different endpoints in evaluating clinical benefit

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In patients with acute myocardial infarction (AMI) and multivessel coronary artery disease, this study aims to compare fractional flow reserve (FFR)-guided PCI with angiography-guided PCI for non-infarct-related artery lesions. The hypothesis is that selective PCI guided by FFR is superior to routin

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Various network compression techniques such as network pruning, knowledge distillation, and parameter quantization are discussed in this content. The importance of pruning redundant weights and neurons in over-parameterized networks is highlighted. Practical issues like weight pruning and neuron pru

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Overview of Network Slicing with OAI 5G CN workshop focusing on the crucial role of network slicing in realizing the service-oriented 5G vision. This workshop covers topics like multiple logical networks creation on shared infrastructure, different types of network slices, preparation and instantiat

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Issues in designing a Local Area Network (LAN) include needs analysis, technological design, and cost assessment. The traditional approach involves structured systems analysis, but faces challenges due to rapidly changing technology and increasing network traffic. The Building Blocks Approach recomm

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In computer graphics, the Digital Differential Analyzer (DDA) Algorithm is utilized as the basic line drawing algorithm. This method involves interpolation of variables between two endpoints to rasterize lines, triangles, and polygons efficiently. The algorithm requires inputting coordinates of two

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Explore the intricate world of 5G Radio Access Network (RAN) and Network Slicing, delving into concepts such as SO Service Orchestrator, SDN-C Service Design, and Core Network Elements. Discover the significance of managing and designing mobile slice services, including eMBB, Massive IoT, and Missio

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Snort is an open-source Network Intrusion Detection System (NIDS) developed by Cisco, capable of analyzing network packets to identify suspicious activities. It can function as a packet sniffer, packet logger, or a full-fledged intrusion prevention system. By monitoring and matching network activity

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Learn about IP addresses, ports, network sockets, and socket functions in network programming using Python. Explore the concepts of communication endpoints, socket creation, and essential functions for network communication.

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This overview delves into the data flows and network challenges faced in particle physics infrastructure, focusing on the JUNO project. It discusses the process of data reception, storage, and replication across various data centers, highlighting the bidirectional nature of data flows. Additionally,

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In the Network Architecture Group led by Namseok Ko, significant progress has been made in defining the IMT-2020 architecture. The work has involved gap analysis, draft recommendations, and setting framework and requirements. Phase 1 focused on identifying 19 architectural gaps, such as demands for

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Exploring the topology of interconnection networks helps determine the arrangement of channels and nodes, impacting network cost, performance, latency, energy consumption, and complexity of implementation. Abstract metrics such as degree, hop count, and network diameter play crucial roles in evaluat

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This content outlines the features and functionalities of the C.Coupled SE Platform (CSET Platform) developed by the Connetics Transportation Group. It covers aspects such as interface design, inputs merging, purposes, platform development using Cube, TAZs merging, and network attributes. The platfo

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The Human Disease Symptom Network (HSDN) is constructed using a large-scale medical bibliographic records database to form a network of human diseases based on symptom similarities. By integrating disease-gene associations and protein-protein interaction data, correlations between symptom similarity

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This study by CTTI explores barriers and solutions for adopting digitally derived endpoints in clinical trials. Through in-depth interviews with industry sponsors, the research identifies gaps, barriers, and recommendations for using DHT-derived novel endpoints as key endpoints in pivotal clinical t

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This presentation introduces the concept of network analysis using .NET in the humanities classroom. It provides a template for teaching and adapting network analysis tools for educational purposes. The guide explains the relevance of networks in processing and visualizing data, emphasizing the coll

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The presentation discusses various endpoints in aortic valve development and Transcatheter Aortic Valve Replacement (TAVR) trials, including comparisons, study stages, and newer devices. It covers different trial populations, primary and secondary endpoints, and the evaluation of non-inferiority. Su

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In the SOLVE-TAVI trial, patients undergoing transcatheter aortic valve implantation were randomized to receive either self-expandable or balloon-expandable valves under general or local anesthesia. The study aims to compare the effectiveness and safety of different valve types and anesthesia approa

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Meridian is an SDN platform developed by Mohammad Banikazemi, David Olshefski, Anees Shaikh, John Tracey, and GuohuiWang at IBM T. J. Watson Research Center. The platform focuses on providing cloud network services efficiently. It encompasses an architecture that enables faster and more convenient n

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Explore the implementation of Snort, Barnyard, and PulledPork within a Software-Defined Network framework using OpenFlow technology. Learn how these tools enhance network security through intrusion detection engines, rule management, and network traffic control mechanisms. Dive into the architecture

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This presentation introduces network metrics as tools to describe network characteristics and answer important questions. Using centrality metrics as an example, participants learn how to identify the most important nodes in a network based on different criteria such as degree centrality and closene

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This presentation discusses the exploration of endpoints in pivotal clinical trials to treat Alcohol Use Disorder (AUD), focusing on Primary Alcohol Drinking Endpoints like PSNHDD. Evidence supporting PSNHDD as a primary endpoint includes clinical benefit data from alcohol clinical trials and epidem

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This content delves into the fundamental concepts of network layer functions in router design, including data forwarding, control plane operations, and route processing. It explains the analogy of the postal system to address and locate network endpoints, and emphasizes the importance of route looku

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Explore the concepts of pain, distress, and humane endpoints in animals through a training program aimed at researchers developing protocols for the welfare of laboratory animals. The program includes pre- and post-assessments to gauge knowledge and learning outcomes, covers scenarios illustrating c

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This content showcases various aspects of 5G system architecture, including system handover, non-roaming architecture, service-based architecture, and user plane functionality. It delves into the control plane functions, user plane functions, and core network endpoints of the 5G network. The images

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