Zongertinib (BI.1810631) Phase I Study in Advanced Solid Tumors with HER2 Aberrations focusing on NSCLC. The trial involves dose escalation and expansion, testing different doses in cohorts with varied HER2 mutations. Primary endpoints include MTD, OR, and DLTs.

2 views • 14 slides

This information delves into the procedural safeguards for students with disabilities receiving special education services, covering topics such as laws governing procedural safeguards, parents' rights and responsibilities, abbreviation glossary, and the required Notice of Procedural Safeguards unde

1 views • 37 slides

This collection features various experiments in chemistry involving titration and solutions. It includes procedures such as standardizing hydrochloric acid using sodium carbonate, titrating hydrochloric acid with sodium hydroxide to produce sodium chloride, determining the concentration of ethanoic

0 views • 10 slides

The OCTIVUS Randomized Clinical Trial compared the clinical efficacy and safety of Optical Coherence Tomography (OCT)-guided and Intravascular Ultrasound (IVUS)-guided strategies in patients undergoing PCI for significant CAD. The study aimed to determine if OCT-guided PCI is noninferior to IVUS-gui

8 views • 27 slides

This prospective, multicentre, randomised clinical trial led by Dr. Tiffany Patterson aims to determine whether direct delivery to a cardiac arrest centre following non-ST elevation out-of-hospital cardiac arrest reduces deaths compared to delivery to the nearest emergency department. Funded by the

0 views • 17 slides

Explore a detailed guide on bug hunting tools, techniques, and resources by expert bug hunter Orwa Atyat from Jordan. Learn valuable tips on finding high/critical bugs, conducting basic recon, subdomain enumerations, collecting URLs/endpoints, and searching for backup files. Enhance your cybersecuri

2 views • 14 slides

Iron deficiency is prevalent in heart failure patients with reduced ejection fraction and is linked to poor outcomes. The HEART-FID trial investigates the impact of intravenous ferric carboxymaltose (FCM) on all-cause mortality, heart failure hospitalizations, and exercise capacity in chronic HFrEF

1 views • 17 slides

Point-of-care ultrasound (POCUS) is emerging as a potential tool for confirming endotracheal tube (ETT) positioning in neonates, providing a viable alternative to X-ray examination. The study aims to assess the accuracy of POCUS in determining ETT placement, particularly by using the superior aspect

2 views • 25 slides

SISTER Study led by Eva Mistry aims to identify a safe and effective dose of TS23 for treating ischemic stroke patients with core-penumbra mismatch. The Phase-2 trial involves 300 adults and spans 54 months, with primary endpoints focusing on treatment efficacy and safety. The study is randomized, p

0 views • 22 slides

This study explores the use of extracorporeal life support (ECLS) in patients with acute myocardial infarction complicated by cardiogenic shock. The researchers investigate the impact of ECLS on mortality and various secondary endpoints such as renal failure, recurrent infarction, and need for revas

0 views • 20 slides

Discussing the efficacy and safety of Nivolumab and Relatlimab as a superior first-line therapy option for newly diagnosed metastatic melanoma patients, with comparisons to other treatments based on key endpoints and tolerability data presented at ASCO Annual Meeting.

0 views • 8 slides

Cohort studies are a type of observational study where a group of healthy subjects is followed over time to investigate relationships between exposures and outcomes. They provide valuable insights into disease development and risk factors, offering advantages like assessing multiple exposures and en

0 views • 21 slides

This session discusses the landscape of DHT-derived novel endpoints in clinical research, focusing on considerations for regulatory decision-making. It explains the use of digital health technology in clinical outcome assessments and highlights the potential benefits of digitally collected COAs, suc

0 views • 42 slides

Empagliflozin's impact on cardiovascular and renal events in heart failure with reduced ejection fraction was assessed in the EMPEROR-Reduced trial led by Milton Packer, MD, and Faiez Zannad, MD. The trial, enriched for patients with severe left ventricular dysfunction, randomized participants to em

2 views • 22 slides

A soliloquy is a form of monologue where a character speaks to themselves, the audience, or a surrogate, revealing inner thoughts. This presentation explores different types of soliloquies and their significance in literary works, including examples from Shakespeare's Hamlet. Additionally, it delves

0 views • 9 slides

This educational slide module delves into fundamental statistics for analyzing clinical endpoints in diabetes research. It covers the choice of statistical methods, the distinction between statistical and clinical significance, and the importance of different endpoints in evaluating clinical benefit

1 views • 37 slides

In patients with acute myocardial infarction (AMI) and multivessel coronary artery disease, this study aims to compare fractional flow reserve (FFR)-guided PCI with angiography-guided PCI for non-infarct-related artery lesions. The hypothesis is that selective PCI guided by FFR is superior to routin

2 views • 23 slides

The Fundamental Theorem of Calculus states that if a function is continuous on an interval and has an antiderivative on that interval, then the integral of the function over the interval is equal to the difference of the antiderivative evaluated at the endpoints. This concept is further explored thr

0 views • 14 slides

Back titration is a technique used in analytical chemistry to determine the concentration of an analyte by reacting it with an excess of another reagent first, followed by titration of the excess reactant. This method is especially useful in cases where direct titration endpoints are difficult to di

2 views • 14 slides

In computer graphics, the Digital Differential Analyzer (DDA) Algorithm is utilized as the basic line drawing algorithm. This method involves interpolation of variables between two endpoints to rasterize lines, triangles, and polygons efficiently. The algorithm requires inputting coordinates of two

0 views • 9 slides

European Patients Academy on Therapeutic Innovation explains how biomarkers are measurable indicators providing insights into health conditions. Biomarkers like glucose levels in diabetes management and MRI imaging for Multiple Sclerosis play crucial roles. The Academy aims to enhance the medicine d

0 views • 24 slides

Explore the procedural safeguards, state complaint procedures, mediation, and due process in special education as outlined by the U.S. Department of Education. Learn about filing complaints, required content, and who can file a complaint. Get insights into the resolution process, surrogate parents,

2 views • 33 slides

This study by CTTI explores barriers and solutions for adopting digitally derived endpoints in clinical trials. Through in-depth interviews with industry sponsors, the research identifies gaps, barriers, and recommendations for using DHT-derived novel endpoints as key endpoints in pivotal clinical t

0 views • 16 slides

This study explores the formulation of petroleum and alternative jet fuel surrogates, coupling chemical kinetics with computational fluid mechanics for engine design, and the variability of aviation fuels. It delves into the concept of surrogate fuel models, previous research on jet fuel surrogates,

0 views • 20 slides

The presentation discusses various endpoints in aortic valve development and Transcatheter Aortic Valve Replacement (TAVR) trials, including comparisons, study stages, and newer devices. It covers different trial populations, primary and secondary endpoints, and the evaluation of non-inferiority. Su

0 views • 18 slides

In the SOLVE-TAVI trial, patients undergoing transcatheter aortic valve implantation were randomized to receive either self-expandable or balloon-expandable valves under general or local anesthesia. The study aims to compare the effectiveness and safety of different valve types and anesthesia approa

0 views • 27 slides

The Texas Risk Reduction Program (TRRP) provides guidelines for managing Total Petroleum Hydrocarbons (TPH) in environmental assessments. Different regulations and programs govern TPH analysis depending on the source, with specific methods like TCEQ Method 1005 and 1006 used for TPH analysis and det

0 views • 21 slides

This analysis delves into the challenges, strengths, weaknesses, and missing data in a clinical trial study focusing on rare diseases. It critiques aspects such as recruitment, study design, surrogate markers, and statistical analysis, offering valuable insights for interpreting clinical trial resul

0 views • 12 slides

Embryo transfer (ET) in cattle allows for the production of genetically superior offspring, increasing milk production and weaning weights. While offering advantages like rapid genetic improvement and flexibility in genetics transfer, ET also presents challenges such as increased costs and disease r

0 views • 20 slides

This presentation discusses the exploration of endpoints in pivotal clinical trials to treat Alcohol Use Disorder (AUD), focusing on Primary Alcohol Drinking Endpoints like PSNHDD. Evidence supporting PSNHDD as a primary endpoint includes clinical benefit data from alcohol clinical trials and epidem

0 views • 54 slides

Utilizing Bayesian optimization in ocean modeling, this research explores optimizing mixed layer parameterizations and turbulent kinetic energy closure schemes. It addresses challenges like expensive evaluations of objective functions and the uncertainty of vertical mixing, presenting a solution thr

0 views • 35 slides

Explore the concepts of pain, distress, and humane endpoints in animals through a training program aimed at researchers developing protocols for the welfare of laboratory animals. The program includes pre- and post-assessments to gauge knowledge and learning outcomes, covers scenarios illustrating c

0 views • 19 slides

This research focuses on developing a systematic optimization model that incorporates a ReLU activation function-based neural network as input. The model generates a linear output that can be modeled as MILP and solved using a Mixed-Integer Programming approach. By producing scalable surrogate model

0 views • 7 slides

This project discusses the API endpoints and data structures from the PaNOSC Workshop, focusing on reviewing use cases, required search results/data, actors involved, and the design of endpoints reflecting proposal/experiment processes. It covers detailed discussions on data models, instrument setup

0 views • 19 slides

This article discusses an algorithm proposed by L.R. Rabiner and M.R. Sambur in 1975 for determining endpoints in isolated utterances. The algorithm focuses on detecting word boundaries in speech through the recognition of silence, which can lead to reduced processing load and increased convenience,

0 views • 22 slides

IGEL Universal Management Suite (UMS) is a comprehensive system that empowers IT professionals with easy control over all endpoints. Included features like centralized installation, configuration, and update management make UMS a versatile tool for managing IGEL Zero Clients and third-party endpoint

0 views • 25 slides

Eugene J. Sullivan, MD, explains the importance of establishing efficacy in clinical trials based on substantial evidence from well-controlled trials. The discussion includes primary endpoints for Phase 3 trials, legal and regulatory requirements, and the significance of clinically meaningful effect

0 views • 21 slides

These guidelines outline the identification of scientific endpoints, humane intervention points, and cumulative endpoints in animal research. They emphasize the need for protocols approved by animal care committees, consideration of welfare-appropriate endpoints, and adaptation of endpoints during t

0 views • 17 slides

The Animal Rule addresses the approval of new drugs when human efficacy studies are not possible. It serves as a surrogate for human studies, requiring well-controlled animal testing to predict clinical benefits in humans. Safety must still be demonstrated in human trials, and the rule can be bypass

0 views • 27 slides

This content explores the importance of reviewing research protocols to minimize pain and distress in animal experiments. It covers defining pain, distress, experimental and humane endpoints, evaluating management strategies, and ensuring ethical practices. It also includes a quick exercise to asses

0 views • 11 slides