Explore Zilebesiran, an investigational RNA interference therapeutic targeting hepatic AGT synthesis for hypertension. Primary findings from Phase 2 trial KARDIA-1 reveal sustained blood pressure reduction. Addressing the unmet need for innovative antihypertensive treatments.

0 views • 12 slides

Epigenetics Market by Offering (Kits, Reagents, Instruments, Software) Method (DNA Methylation, PCR, Chromatin Analysis, Histone, RNA Modification), Application (Oncology, Non-oncology) End User (Pharma, Academics, Hospitals) \u2013 Global Forecast to 2030\n

0 views • 4 slides

Explore various physical and chemical methods used for gene transfer, including electroporation, particle bombardment, microinjection, ultrasound, and bacterial transformation. Learn how DNA enters the nucleus and the role of retroviruses in gene transfer efficiency. Understand the process of RNA co

0 views • 17 slides

Delve into the intricate world of nucleic acids with a focus on DNA and RNA structures, DNA replication, RNA transcription, protein biosynthesis, cancer/chemotherapy, genetic engineering, and more. Explore the structures of bases, sugars, nucleosides, nucleotides, and parts of nucleotides, along wit

8 views • 58 slides

Viruses interact with host cells in various ways, encoding genes that manipulate cell functions for their benefit. These interactions can range from benign to lethal outcomes. Factors influencing these interactions include viral factors, cellular responses, and the presence of virulence factors. Dif

0 views • 37 slides

Gene expression is a crucial process that leads to the production of functional gene products like RNA and proteins. This article explores the regulation of gene expression in both prokaryotes and eukaryotes, covering the importance of regulating gene expression, types of regulation elements, specif

5 views • 22 slides

Microarray Kits Market by Product Type (DNA [cDNA, Oligo, BAC, SNP], RNA, Protein, Tissue), Application (Drug Discovery & Development, Research, Diagnostic), End User (CRO, Pharma & Biotech, Academic, Hospital & Diagnostic Lab) \u2013 Global Forecast to 2031\n

10 views • 4 slides

Exploring the biosynthesis of purines and pyrimidines, essential components for DNA and RNA structures. Delve into the world of pyrimidines, purines, nucleosides, nucleotides, and adenosine derivatives like AMP, ADP, ATP, and cAMP, crucial for various biological processes. Unravel the significance o

5 views • 44 slides

Gene translation from RNA to protein involves the specific binding of transfer RNA molecules to messenger RNA codons, enabling the translation of nucleotide sequences into amino acids. Each amino acid is attached to a specific tRNA through activating enzymes, and the anticodon on tRNA pairs with the

0 views • 4 slides

Transcription factors play a crucial role in gene expression by controlling the recruitment of RNA polymerase. Promoter regions contain sequences like CAAT box and TATA box that regulate transcription by binding proteins. Consensus sequences are conserved patterns in the genome with various biologic

1 views • 10 slides

Explore the detailed procedure of Sanger sequencing, from sample collection to DNA extraction, gene amplification, and sequencing preparation. Learn about the components involved, such as polymerase, nucleotides, and dideoxynucleotides, to achieve accurate DNA sequencing results. Follow the chain-te

3 views • 11 slides

DNA replication is a crucial biological process where identical copies of DNA molecules are produced for cell division. Initiated by specific proteins, it involves stages like initiation, elongation, and termination. Enzymes like helicases and DNA polymerase play key roles in forming replication for

0 views • 33 slides

This content provides insights into important enzymes used in modern biotechnology, focusing on DNA ligases and polymerases. It delves into the structures, mechanisms, and characteristics of these enzymes, such as Taq polymerase and bacteriophage T4 DNA ligase. Through detailed descriptions and imag

0 views • 15 slides

Polymerase Chain Reaction (PCR) is a crucial technique for amplifying specific DNA segments rapidly and accurately. Developed in 1983, PCR is widely used in various fields such as molecular biology, forensics, evolution, and medical diagnostics. On the other hand, the Blot technique transfers DNA, R

0 views • 10 slides

This content delves into the intricacies of analyzing 10X single-cell RNA-Seq data, covering topics such as how 10X RNA-Seq works, evaluating CellRanger QC reports, dimensionality reduction techniques like PCA, tSNE, and UMAP, using the Loupe cell browser, and frameworks for scRNA analysis in R. It

0 views • 39 slides

Explore the intricacies of analyzing 10X Single-Cell RNA-Seq data, from how the technology works to using tools like CellRanger, Loupe Cell Browser, and Seurat in R. Learn about the process of generating barcode counts, mapping, filtering, quality control, and quantitation of libraries. Dive into di

0 views • 34 slides

Delve into the world of nucleic acids with a focus on DNA and RNA molecules. Discover the fundamental building blocks, such as nucleotides, and the role they play in genetic information storage and cell function. Learn about the unique characteristics of DNA like its double-helix structure and the s

0 views • 26 slides

A primary transcript is the initial RNA copy of a transcription unit, subject to posttranscriptional modifications like cleavage and further alterations to form functional tRNAs, rRNAs, and mRNAs. In eukaryotic cells, pre-rRNAs and pre-tRNAs undergo processing by ribonucleases to yield mature RNA sp

0 views • 12 slides

Recombinant DNA technology is crucial for developing new vaccines and pharmaceuticals by combining genetic material from various sources to create unique sequences. Techniques like transformation, non-bacterial transformation, and phage introduction are used to make recombinant DNA. Tools like enzym

3 views • 15 slides

Craig L. Zirbel at Bowling Green State University offers services through the BGSU RNA group for analyzing and annotating RNA 3D structures. They focus on Watson-Crick and non-Watson-Crick base pairs, base stacking, interactions, and motif searches. The group's ultimate goal is to predict 3D motifs

0 views • 31 slides

A research project at Bowling Green State University aims to identify 3D motifs in RNA hairpin and internal loops using sequence and secondary structure information. The study focuses on finding likely sequence variants of known motifs, leveraging geometric considerations and basepair isostericity f

0 views • 28 slides

This educational material covers Biology Power Standards related to DNA structure, protein synthesis, genetic variations, meiosis, mutations, and natural selection. Essential questions are provided for each standard, focused on topics like mRNA, DNA duplication, enzyme polymerase, and the relationsh

0 views • 13 slides

Genetic material plays a crucial role in the transmission of traits from one generation to the next. This article explores the significance of DNA and RNA as genetic material, highlighting key experiments and discoveries that demonstrate DNA's role in carrying hereditary information. From Mendel's h

0 views • 32 slides

STAR Study compared the efficacy and safety of RPV/FTC/TDF and EFV/FTC/TDF in treatment-naive HIV patients. The study included 394 participants in each group, assessing HIV RNA suppression rates, CD4 count improvements, treatment responses, and resistance analyses up to 48 weeks. Results showed RPV/

0 views • 15 slides

Tophat2 is a versatile pipeline aimed at aligning RNA reads to a genome, addressing gaps in alignments through innovative strategies. It involves the use of Bowtie for mapping and is written in C++, with a Python wrapper for seamless execution. The pipeline deals with large datasets and requires var

0 views • 13 slides

Dive into the world of RNA-Seq expression analysis through topics such as read mapping, quantitation, and the challenges faced in short-read mapping. Discover the typical parameters, design pressures, and basic ideas behind suffix tree index construction for efficient handling of large reads and dat

0 views • 19 slides

Transition bias and substitution models, explored by Xuhua Xia, delve into the concepts of transitions and transversions in genetic mutations, the causes of transition bias, the ubiquitous nature of transition bias in invertebrate and vertebrate genes, the mitochondrial genetic code, and RNA seconda

0 views • 25 slides

This data set presents key findings from RNA sequencing analysis, including distribution of mapped reads, junction identification, TPM correlation, principal component analysis, and gene expression effects. Visual representations illustrate differences in gene expression profiles across samples, emp

0 views • 6 slides

The recombinant vector with a kanamycin resistance gene can be used to clone other genes by inserting human DNA fragments and selecting transformed E. coli cells. This technique has enabled the production of various human proteins for therapeutic purposes, such as insulin, growth hormones, and clot-

0 views • 6 slides

Protein structure is composed of amino acids arranged in specific orders to form polypeptides. This process involves transcription of DNA into RNA followed by translation of RNA into proteins. Replication plays a crucial role in preparing DNA for cell division. The central dogma of molecular biology

0 views • 24 slides

Explore the intricate process of transcription in biology, where mRNA is synthesized from DNA to carry the genetic code for protein production. Learn about the connection between genotype and phenotype, the role of genes in protein synthesis, and the significance of terms such as RNA Polymerase, int

0 views • 16 slides

Transcription initiation in eukaryotes involves RNA Polymerase II, general transcription factors, and Mediator complex to communicate with activators. Chromatin remodeling complexes and histone-modifying enzymes play pivotal roles in transcription regulation. Elongation requires different factors an

0 views • 18 slides

DNA transcription is the process where DNA is used as a template to create mRNA in the nucleus. This mRNA is complementary to the DNA and goes through initiation, elongation, and termination stages. RNA polymerases are essential for this process in eukaryotes. Various RNA polymerases have specific f

0 views • 47 slides

This content discusses the general variances between DNA replication and RNA transcription, highlighting their purposes, processes, enzymes involved, timing, and more. It delves into the initiation, template, and involved areas of replication and transcription, as well as key DNA regions like promot

0 views • 24 slides

Gene expression involves two crucial phases - transcription and translation. Transcription, the first step, is the process where RNA is synthesized from DNA with the help of RNA polymerase. It begins with initiation, where the enzyme recognizes the promoter region and forms a complex with the DNA, m

0 views • 33 slides

Transcription is a crucial process where RNA is synthesized from DNA, involving complex steps of initiation, elongation, and termination. This process is regulated by specific DNA regions, proteins, and enzymes like DNA-dependent RNA polymerase. The differences between DNA and RNA synthesis lie in t

0 views • 15 slides

The process of RNA transcription involves three main stages: initiation, elongation, and termination. Initiation starts with RNA polymerase binding to a promoter, followed by the formation of a transcription initiation complex. Elongation involves RNA polymerase untwisting the DNA helix and adding n

0 views • 17 slides

Explore the intricate processes of transcription and RNA processing in molecular biology, delving into the types of RNA molecules, the differences between DNA and RNA, RNA polymerase enzymes, transcription factors, and the preinitiation complex. Visual aids and detailed descriptions help elucidate t

0 views • 55 slides

RNA polymerases play a crucial role in synthesizing cellular RNA through transcription, where RNA is created from a DNA template. This process involves specific requirements such as a DNA template, ribonucleoside triphosphates, and divalent metal ions. RNA polymerase catalyzes the initiation and elo

0 views • 15 slides

Investigating gene function and expression is crucial in molecular genetics. Key discoveries by pioneers like Archibald Garrod, George Beadle, Edward Tatum, Linus Pauling, and Vernon Ingram have shed light on how genes are responsible for enzyme synthesis, polypeptide specification, and protein synt

0 views • 29 slides