The evidence-based science and clinical management of Cardiovascular-Kidney-Metabolic Syndrome (CKM) in this comprehensive slide set. Learn about the pathophysiological interactions, multi-organ dysfunction, and adverse cardiovascular outcomes associated with CKM.

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This study explores how inflammation and cholesterol levels predict cardiovascular events among 13,970 statin-intolerant patients in the CLEAR Outcomes trial. Findings suggest residual inflammatory risk may be a stronger predictor than residual cholesterol risk for future events. The research analyz

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The study compares the efficacy of ticagrelor monotherapy after less than 1 month of dual anti-platelet therapy (DAPT) to 12-month ticagrelor-based DAPT in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) with drug-eluting stent implantation. The aim is

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Cardiovascular disease is a growing concern in individuals living with HIV, despite advancements in treatment. The REPRIEVE Trial sheds light on the importance of assessing cardiovascular risk and implementing primary prevention measures in this population. Dr. Grinspoon's financial disclosures and

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The REPRIEVE trial focuses on developing a cardiovascular disease prevention strategy for individuals living with HIV. It addresses the increased risk of CVD in this population, even with good viral suppression. The study evaluates the use of pitavastatin, a statin with anti-inflammatory properties,

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This training package focuses on the safety monitoring and management of active tuberculosis drugs, specifically emphasizing causality assessment in determining adverse reactions. Participants will learn about assessing the likelihood of TB medicines causing adverse events, attributing relationships

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This data compilation covers the reporting trends, breakdown of reports, components issued, and specific types of adverse transfusion reactions experienced within the National Healthcare Organization (NHO) from 2019 to 2022. The information includes statistics on Serious Adverse Events (SAE), Seriou

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Explore the differences between pediatric and adult cardiovascular exams, highlighting key differences in disease patterns, examination approaches, and objectives. Learn about the importance of distinguishing between routine well-baby exams and evaluations of ill children, along with step-by-step gu

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Adverse Events Following Immunization (AEFI) are medical incidents that occur after immunization, potentially caused by the vaccine, leading to unfavorable symptoms. Pharmacovigilance plays a crucial role in detecting, assessing, and preventing these events. AEFI can impact immunization programs at

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The CLEAR Outcomes Trial investigated the effects of bempedoic acid, an ATP citrate lyase inhibitor, on cardiovascular outcomes in primary prevention patients. Results showed a reduction in cardiovascular events with bempedoic acid, particularly in patients intolerant to statins. Baseline characteri

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This presentation covers the identification, recording, and reporting of adverse events in clinical trials conducted by University of Edinburgh and/or NHS Lothian. It includes definitions, examples of adverse event recording, SAE form completion, and common mistakes. AEs can range from minor issues

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Study investigates the association between renal and cerebral near-infrared spectroscopy (NIRS) values and low cardiac output syndrome in single ventricle patients post Stage I palliation. Data from infants who underwent surgery between 2010-2019 is analyzed to determine correlations with adverse ou

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Exploring the immediate and long-term effects of exercise on the cardiovascular system reveals the remarkable adaptations and responses the body undergoes. From short-term increases in heart rate and blood pressure to long-lasting changes in cardiac output, exercise plays a crucial role in enhancing

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The impact of diet on the cardiovascular system is significant, with a high intake of LDL leading to clogged arteries and increased risk of Coronary Heart Disease. Regular exercise brings about positive changes in the cardiovascular system, enhancing heart function and oxygen delivery. Immediate ben

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Adverse drug reactions resulting from medication errors are a significant concern faced by pharmacovigilance centers. This content discusses the importance of this problem, contributing factors, the relevance to pharmacovigilance centers, and strategies for managing medication errors. It highlights

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The New Jersey Patient Safety Act, enacted in April 2004, aims to enhance patient safety, minimize adverse events, and improve system/facility performance. It emphasizes confidentiality, promotes a blame-free culture, and encourages evidence-based practices. Healthcare facilities, including ASCs, ar

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The CLEAR Trial is a 2x2 factorial randomized trial evaluating the effectiveness of hypertonic saline and carbocisteine for airway clearance in bronchiectasis over 52 weeks. Led by Professor Stuart Elborn and Professor Judy Bradley from Queen's University Belfast, the trial focuses on clinical and c

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This report discusses the morphologic and physiologic connections in continuous blood pressure waveforms and their association with incident cardiovascular events. The study aims to assess if changes in arterial elasticity contribute to predicting CVD events and explores additional measures derived

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This detailed content covers the importance of reporting adverse information regarding cleared employees in national security settings. It outlines the impact of adverse information on security clearances, the 13 adjudicative guidelines used in determining eligibility for sensitive duties, NISPOM re

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Cardiovascular disease remains a significant contributor to maternal mortality in the UK, with maternal deaths from cardiac issues outnumbering those from other direct causes, except thrombosis. The prevalence of cardiovascular risk factors in pregnant women, combined with a lack of consideration fo

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Exploring the essential elements of disclosing adverse clinical events to patients and families in healthcare settings. It covers why disclosure is crucial, barriers to disclosure, triggers for disclosure, policies and procedures, and the other important aspects related to the disclosure process.

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The data report examines the prevalence of cardiovascular diseases in adult End-Stage Renal Disease (ESRD) patients in 2016 by treatment modality and age. It includes information on various cardiovascular conditions such as atrial fibrillation, acute myocardial infarction, coronary artery disease, a

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The comparison between Etravirine (ETR) and Efavirenz (EFV) in the SENSE Study showed differences in neuropsychiatric adverse events, treatment response, and patient characteristics. ETR with 2 NRTIs resulted in fewer drug-related adverse events than EFV with 2 NRTIs. ETR also showed better response

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This informative content discusses the normal physiological changes of the cardiovascular system in pregnancy, symptoms and signs of cardiovascular disease, the impact of pregnancy on cardiovascular health, and the management of cardiovascular issues during pregnancy, labor, and the postpartum perio

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Guidelines for reporting adverse reactions in Stress Ulcer Prophylaxis in the Intensive Care Unit (SUP-ICU), including definitions of Adverse Reactions (AR), Serious Adverse Reactions (SAR), Adverse Events (AE), Serious Adverse Events (SAE), SARs in SUP-ICU, and SUSARs. Specific conditions considere

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Explore the world of cardiovascular drugs, including antihypertensive, antianginal, heart failure, antiarrhythmic, diuretic, antithrombotic, and antihyperlipidemic medications. Dive into the mechanisms of action, clinical indications, and adverse effects of these drugs, gaining valuable insights int

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Yellow fever vaccination can lead to severe adverse reactions like anaphylaxis, neurotropic disease, and viscerotropic disease. These reactions can range from immediate hypersensitivity to rare but serious outcomes such as meningitis and multiple system organ failure. The mortality rate associated w

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Collaborative meta-analysis explores the efficacy of long-term dual antiplatelet therapy in preventing cardiovascular events in patients with previous myocardial infarction. Trials show heterogeneous results on the benefits and safety of prolonged therapy, with varying recommendations based on patie

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The study conducted by the PURE investigators examined the relationship between fruit, vegetable, and legume consumption and cardiovascular disease (CVD) and mortality in a cohort of 135,335 individuals from 18 countries. Dietary guidelines recommend at least 5 daily servings of these foods, which h

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Cardiovascular effects of older glucose-lowering therapies and the history of cardiovascular outcome trials are discussed in this educational slide module. It outlines the timeline of treatment options from the discovery of insulin to the introduction of various medications. Evidence regarding the c

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Individuals with type 2 diabetes have an increased risk of cardiovascular events compared to those without the condition. Research indicates that certain GLP-1 receptor agonists have shown promising results in reducing cardiovascular events in diabetic patients with specific HbA1c levels. However, t

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The ATLAS-ACS 2 study investigated the efficacy and safety of rivaroxaban in ACS patients post-index event. The primary endpoints included cardiovascular death, MI, and stroke, with significant reductions seen with rivaroxaban compared to placebo. Stent thrombosis was also reduced with rivaroxaban t

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This study examines the association between ECG abnormalities and incident CVD events in patients with type 1 diabetes, focusing on the prognostic significance in a population where CVD develops earlier. Major and minor ECG abnormalities were classified, with cardiovascular events such as myocardial

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GripTrack is a portable grip strength monitoring device designed to track cardiovascular and musculoskeletal health in the elderly population. It aims to provide an accurate early warning system by assessing grip strength, which can indicate cognitive decline, cardiovascular health, and frailty synd

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This presentation discusses the significant cardiovascular effects of air pollution, particularly on vulnerable populations such as older adults, women, and Latinos. It highlights the environmental factors contributing to cardiovascular health disparities and emphasizes the nursing implications for

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The Adverse Outcome Pathway (AOP) for Skin Sensitisation provides a mechanistic framework linking Molecular Initiating Events (MIE) to Adverse Outcomes (AO) through Key Events (KE) and Key Event Relationships (KER). AOPs offer a transparent justification for toxicological predictions and play a vita

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Explore the significance of adverse event reporting in clinical research, including definitions of adverse events (AEs) and serious adverse events (SAEs), as well as unanticipated problems (UAPs). Learn about the responsibilities of Investigators, Clinical Research Coordinators (CRCs), and Sponsors

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Explore the intricate workings of the cardiovascular system, encompassing the heart, blood vessels, and blood circulation. Learn the anatomy, physiology, and function of this vital system, including the roles of arteries, veins, capillaries, and red and blue blood. Understand how the cardiovascular

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Understanding the prevalence and causes of cardiovascular diseases in patients with End-Stage Renal Disease (ESRD) is crucial for effective management. This report analyzes data from 2011-2013, focusing on the causes of death in ESRD patients, prevalence of cardiovascular diseases by treatment modal

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This study led by Dr. Robert Silbergleit focuses on adverse events in brain oxygen optimization for severe Traumatic Brain Injury (TBI) patients. It outlines key points for reporting adverse events, discusses relatedness algorithms, and presents scenarios to analyze adverse events occurrence post-en

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