Energy Yield from Lipid Oxidation Process

Understanding the energy generation process from lipid oxidation involves the conversion of fatty acids into Acetyl-CoA through multiple rounds of oxidation, which then enter the Krebs cycle to produce ATP. Each round of oxidation results in the production of Acetyl-CoA, NADH, FADH2, and net gains of FADH2, NADH, and Acetyl-CoA molecules. The energy load considerations and conversion rates of FADH2 and NADH to ATP are crucial for determining the total ATP yield from complete oxidation of fatty acids.

• Lipid oxidation
• Energy yield
• Acetyl-CoA
• Fatty acids
• ATP production

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Uploaded on Jul 25, 2024 | 0 Views

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1. Lipids Calculating Energy Yield

2. Summary of One Round of -Oxidation Fatty Acyl-CoA + CoASH + NAD+ + FAD Fatty Acyl-CoA (-2 Carbons) + Acetyl-CoA + NADH + H+ + FADH2 Net Gains: 1 molecule FADH2 1 molecule NADH + H+ 1 molecule of Acetyl-CoA

3. Total Acetyl-CoA Total # of Acetyl-CoA molecules from a fatty acid # Acetyl-CoA = # Carbons/2 7 8 1 3 5 6 2 4 16

4. Total Rounds of -Oxidation Total # of Rounds of -Oxidation from a fatty acid # Rounds = (# Carbons/2) - 1 16 5 6 4 7 2 3 1

5. ATP Conversion Rate In Oxidative Phosphorylation (ETC and ATP Synthase) 1 FADH2 = 1.5 ATP 1 NADH = 2.5 ATP

6. Energy Load to Consider Activation of the Fatty Acid (Cost = 2 ATP) Converts ATP AMP (equivalent of 2 ATP) Each Round of -Oxidation (Gain = 4 ATP) 1 FADH2 = 1.5 ATP 1 NADH = 2.5 ATP 1 Acetyl-CoA Each Round of Kreb Cycle or 1 Acetyl-CoA (Gain = 10 ATP) 1 FADH2 = 1.5 ATP 3 NADH2 = 3 (2.5 ATP) = 7.5 1 GTP = 1 ATP equivalent 1 Round = 4 ATP 1 Acetyl-CoA = 10 ATP

7. Total ATP with Complete Oxidation 4 7 8 1 3 5 6 2 16 5 6 4 7 2 3 1 8 Acetyl-CoA X 10 ATP/Acetyl-CoA 7 Rounds X 4 ATP/Round Activation Fee = 80 ATP = 28 ATP = - 2 ATP Sum = 106 ATP