Stage-and-Gate Approach in Research Projects

Developed by Prof. Alexei Lapkin, University of Cambridge, Dr.
Martyn Jones, The University of Manchester, Dr. Dana Kralisch,
University of Jena. January 2016.
Stage-and-Gate in
Research Projects
Content and learning objectives:
This module introduces stage-and-gate as a decision support framework for academic
and academic-industrial collaborative research projects. The concept is largely based
on industrial framework of stage-and-gate processes, but has been adapted by the
authors and trialed in a number of collaborative R&D projects.
About this module
What is stage-and-gate
Stage-and-gate is an approach to guide projects through a
series of evaluations, cutting out less-promising options along
the way, and focusing resources onto the more promising (in
terms of the pre-determined criteria) solutions.
This process is useful in guiding research projects through the
innovation funnel (right): from the early stage R&D when
multiple solutions to the same problem seem feasible (high
degree of freedom) to the final result, when very few, or a
single solution is viable (few, or no degrees of freedom).
Today’s
solution
space
What is stage-gating
Stage-gate approach is common practice in industrial innovation / product development
»
Innovation process is
broken into multiple
defined 
stages
»
Decision/review 
gates 
sit
between stages
»
Number and location of stages and gate success criteria are defined at project start
»
Quality assessments at each gate – continue to next stage or kill unsuccessful projects
Stage has been completed to acceptable level
Continues to meet initial targets
Resources available to continue within timeframe
What is stage-gating
Stage-and-gate
 applied to research projects:
Highly effective 
project planning/monitoring 
tool
Help ensure 
successful delivery 
of key objectives
Used pragmatically to 
stop research activities
 less likely to
meet goals
Not economically viable / competitive or achievable
within timeframe
Prioritise projects most likely to contribute to success
criteria
Re-evaluation of research activities throughout project
Make decisions based on 
up-to-date information
Defining the gates
For the stage-and-gate process to work effectively the gates and the corresponding
success criteria should be pre-determined at the start of the project and then adjusted as
the project progresses. The gates should help to realize which of the initial research
directions have no chance of delivering the main project objectives.
The gates are not linked to any specific functional barriers, such as disciplines or expertise.
It is best if the entire project team, including different expertise (e.g., synthetic chemists,
process chemists, process engineers, operators, business manager, etc..) are involved in
specifying the gates and pass criteria.
The key elements of the process are the gates: review of criteria met by the project and
decisions to kill or continue specific activities.
Defining the gates
Figure from: R. G. Cooper, E. J. Kleinschmidt, 
New products - the key factors in success
,
American Marketing Association, Chicago, 1990.
The image is for so-called 2
nd
 generation stage-gating process (see reference). This stage-
gating scheme is clearly designed for an industrial development from idea to
commercialisation. A simplified version of this approach is suggested for academic
projects.
Defining the gates
In-depth
development
or optimisation
at small-scale
Demonstration
at pilot-scale
Lab scale
investigation
Screening
Suggested gates for collaborative R&D projects
1
st
 gate: using simplified LCA
 
Potential for significant savings of fossil fuels and non-renewable primary resources
 
Potential to meet the required technology readiness level within project timescale
 
Potential for innovation and industrial uptake
2
nd
 gate: using experimental or simulation data with wider impact assessments
 
Potential to meet the required environmental sustainability targets
3
rd
 gate: using full ISO 14040/44 LCA using results from demonstration activities
 
Meets the required environmental sustainability targets at production scale
 
Meets the technical feasibility criteria for the case study
 
Potential to have significant economic benefit (production cost savings,
 
including product value)
 
Potential to have positive social impact (employment)
Defining the gates
Suggested gates for collaborative R&D projects
Coupling life cycle thinking to stage-and-gate
First gate - 
simple screening methods
Later gates – 
Full ISO14040/44 LCA
Integrate LC(Social)A results into gate decisions
Significant challenges 
to operating stage-gates
Inflexibility of personnel
Inflexibility of funding within consortia
Larger consortia more able to accommodate the process (flexibility of funding and
personnel)
Agreement on projects to kill or continue – stage and gate buy in
Larger consortia less able to agree, more competing interests
Defining the gates
Case Studies: stage-and-gate in
collaborative R&D projects
A frequently encountered situation within a collaborative research project:
 
a 4-year programme starts from speculative ideas formulated within a proposal
 
the project target is a demonstration at an agreed scale
 
what is the best approach to guide the development from initial speculative ideas
 
to the demonstration?
Here is an example of criteria for stage-gating process, which could be evaluated at
each project review meeting, say at 6-monthly intervals:
 
1.
Does a particular approach have a chance of hitting the technical success criteria
for the case study?
2.
Could the specific approach potentially reach the required sustainability targets?
3.
Is it feasible to develop each specific approach to the required technical level of
performance, such that it could be built as a demonstrator 
within the lifetime of a
project
.
Assessment of technical level of an approach against set criteria:
 
this requires clear definition of performance criteria and understanding
 
of fundamental limitations of specific approaches; this is not always feasible
 
to evaluate. An example when this is possible, is when a thermodynamic limit of
 
performance could be established.
Case Studies: stage-and-gate in
collaborative R&D projects
Could the specific approach potentially reach the required sustainability targets?
 
at the early stages of a project there is little data available; as project evolves,
 
there is more data and more indicators of sustainability could be evaluated.
 
However, it is highly desirable to have an indication about the likely
 
sustainability metrics even at the very early stages. So, some data-lean methods
 
are highly desirable.
Case Studies: stage-and-gate in
collaborative R&D projects
Could the specific approach potentially reach the required sustainability targets?
 
here is a possible design of criteria for three gates in the case of a chemical
process
 
development, starting from selection of appropriate chemical route, then
 
decisions on process options and final optimisation of the demonstration
 
system.
Case Studies: stage-and-gate in
collaborative R&D projects
Is it feasible to develop each specific approach to the required technical level of
performance, such that it could be built as a demonstrator 
within the lifetime of a
project
.
 
this is largely a ‘business’ decision based on experience of the investigators:
 
some really interesting ideas and leads may be identified at the start of
 
the project, but if they are too far from demonstration, is there enough time
 
to get these ideas developed sufficiently?
 
For this analysis it is important to work backwards from the end of the project:
 
how long is the demonstration campaign and what should be done with
 
the generated data? 
 
by when demonstration plant should be ready? 
 
when all parts for the demo plant must be ordered by 
 designed by? 
 
so when is the decision about demonstrator case study must be made? 
 
the remainder from the project start is what’s available for R&D – this is
 
almost always less than one thinks!
Case Studies: stage-and-gate in
collaborative R&D projects
This is an example of a design of stage-gating
approach for a collaborative academic R&D
project, aimed at identifying new chemical
transformations and processes.
Data required for gate 1:
-
Several alternative chemical routes
-
Suggestions of likely processes for each route
-
Evaluated supply chain analysis for each route
(availability, desired scale of production, etc.)
-
Evaluated simplified LCA impact scores for
each route.
Decision at gate 1 based on numerical data and
using multi-criteria decision analysis.
Case Studies: stage-and-gate in
collaborative R&D projects
Data required for gate 2:
-
Scalability of processes within the selected
route
This decision is primarily technical.
In this 2-gate design  of the stage-gating process,
a significant burden is placed on generating a lot
of data for gate 1. The two-stage approach may
work well for more academic projects, when the
initial period (of ca. 50-60 % duration of the
project) is left for exploration of new leads and
generation of data for the gate criteria
evaluation, close to the date of the review
meeting.
Case Studies: stage-and-gate in
collaborative R&D projects
LCA and stage-and-gate
Generation of LCA (and costing data) at the very early stage of R&D project using
literature data or best guesses is potentially most useful in identifying the critical
parameters of the processes that must be addressed in the R&D programme. Shown is
the approach of simplified LCA – to obtain the insight from using a life-cycle thinking
approach, but without performing a full rigorous LCA.
Case Studies: stage-and-gate in
collaborative R&D projects
LCA and stage-and-gate
Case Studies: stage-and-gate in
collaborative R&D projects
Stage-and-gate is a very useful methodology to streamline projects towards a set of
specific objectives. In the case of the innovation-driven projects, this approach should
result in a large % of successful (in terms of reaching the demonstration stage) projects.
For this it is recommended that:
Milestones in work-programmes are replaced with stage-gates.
Milestones are already envisaged to be decision points. However, in practice
milestones are seldom used for the purpose of narrowing down options and tracking
the progress towards objectives. Stage-and-gate assessments are evaluations against
targets that are progressively closer to the objectives, and remain to be decision
points.
Work-programmes should develop an initial set of criteria for stage-gates at the
proposal stage and should put in place a mechanism for updating those during the
projects.
Flexible fund within the projects would allow for change of direction, bringing in new
expertise and moving personnel between beneficiaries, which may require additional
resources for relocation, salary differences, 
etc
.
Conclusions
J. C. Mankins, Advanced Concepts Office, Office of Space and Technology, NASA, 1995.
D. Mann, 
Hands-on systematic innovation: for technical systems
, CREAX Press, Ieper, Belgium, 2002.
a) R. G. Cooper, E. J. Kleinschmidt, 
New products - the key factors in success
, American Marketing
Association, Chicago, 1990; b) R. G. Cooper, E. J. Kleinschmidt, 
Ind. 
Marketing Management 
1991,
20
, 137-147.
D. Kralisch, D. Ott, S. Kressirer, C. Staffel, I. Sell, U. Krtschil, P. Loeb, 
gps 
2013, 
2
, 465-478.
V. Hessel, 
Chem. Eng. Technol. 
2009, 
32
, 1655-1681.
D. Kralisch, C. Staffel, D. Ott, S. Bensaid, G. Saracco, P. Bellantoni, P. Loeb, 
Green Chem. 
2013, 
15
,
463-477.
a) D. Kralisch, D. Ott, S. Kressirer, C. Staffel, I. Sell, U. Krtschil, P. Loeb, 
Green Processing and Synthesis
2013, 
2
, 465–478; b) I. Sell, D. Ott, D. Kralisch, 
ChemBioEng Reviews 
2014, 
1
, 50-56.
a) D. Ott, D. Kralisch, I. Denčic, V. Hessel, Y. Laribi, P. D. Perrichon, C. Berguerand, L. Kiwi-Minsker, P.
Loeb, 
ChemSusChem 
2014, 
7
, 3521–3533; b) I. Dencic, D. Ott, D. Kralisch, T. Noel, J. Meuldijk, M. De
Croon, V. Hessel, Y. Laribi, P. Perrichon, 
Organic Process Research & Development 
2014, 
18
, 1326–
1338.
Literature and further reading
Slide Note
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Stage-and-Gate is a decision support framework for academic and academic-industrial collaborative research projects. It guides projects through evaluations, focusing on promising solutions while cutting out less feasible options. This approach helps in navigating the innovation funnel from the early R&D phase to the final viable solution. It involves breaking the innovation process into defined stages with decision gates in between, ensuring resources are allocated effectively and projects meet predetermined success criteria. The process aids in project planning, monitoring, and decision-making based on up-to-date information throughout the project duration.

  • Research Projects
  • Decision Support Framework
  • Innovation Process
  • Evaluation
  • Academic Collaboration

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  1. Stage-and-Gate in Research Projects Developed by Prof. Alexei Lapkin, University of Cambridge, Dr. Martyn Jones, The University of Manchester, Dr. Dana Kralisch, University of Jena. January 2016.

  2. About this module Content and learning objectives: This module introduces stage-and-gate as a decision support framework for academic and academic-industrial collaborative research projects. The concept is largely based on industrial framework of stage-and-gate processes, but has been adapted by the authors and trialed in a number of collaborative R&D projects.

  3. What is stage-and-gate Stage-and-gate is an approach to guide projects through a series of evaluations, cutting out less-promising options along the way, and focusing resources onto the more promising (in terms of the pre-determined criteria) solutions. Today s solution space This process is useful in guiding research projects through the innovation funnel (right): from the early stage R&D when multiple solutions to the same problem seem feasible (high degree of freedom) to the final result, when very few, or a single solution is viable (few, or no degrees of freedom).

  4. What is stage-gating Stage-gate approach is common practice in industrial innovation / product development Innovation process is broken into multiple defined stages Decision/review gates sit between stages Number and location of stages and gate success criteria are defined at project start Quality assessments at each gate continue to next stage or kill unsuccessful projects Stage has been completed to acceptable level Continues to meet initial targets Resources available to continue within timeframe

  5. What is stage-gating Stage-and-gate applied to research projects: Highly effective project planning/monitoring tool Help ensure successful delivery of key objectives Used pragmatically to stop research activities less likely to meet goals Not economically viable / competitive or achievable within timeframe Prioritise projects most likely to contribute to success criteria Re-evaluation of research activities throughout project Make decisions based on up-to-date information

  6. Defining the gates For the stage-and-gate process to work effectively the gates and the corresponding success criteria should be pre-determined at the start of the project and then adjusted as the project progresses. The gates should help to realize which of the initial research directions have no chance of delivering the main project objectives. The gates are not linked to any specific functional barriers, such as disciplines or expertise. It is best if the entire project team, including different expertise (e.g., synthetic chemists, process chemists, process engineers, operators, business manager, etc..) are involved in specifying the gates and pass criteria. The key elements of the process are the gates: review of criteria met by the project and decisions to kill or continue specific activities.

  7. Defining the gates The image is for so-called 2nd generation stage-gating process (see reference). This stage- gating scheme is clearly designed for an industrial development from idea to commercialisation. A simplified version of this approach is suggested for academic projects. Figure from: R. G. Cooper, E. J. Kleinschmidt, New products - the key factors in success, American Marketing Association, Chicago, 1990.

  8. Defining the gates Suggested gates for collaborative R&D projects In-depth development or optimisation at small-scale Lab scale investigation Demonstration at pilot-scale Screening

  9. Defining the gates Suggested gates for collaborative R&D projects 1st gate: using simplified LCA Potential for significant savings of fossil fuels and non-renewable primary resources Potential to meet the required technology readiness level within project timescale Potential for innovation and industrial uptake 2nd gate: using experimental or simulation data with wider impact assessments Potential to meet the required environmental sustainability targets 3rd gate: using full ISO 14040/44 LCA using results from demonstration activities Meets the required environmental sustainability targets at production scale Meets the technical feasibility criteria for the case study Potential to have significant economic benefit (production cost savings, including product value) Potential to have positive social impact (employment)

  10. Defining the gates Coupling life cycle thinking to stage-and-gate First gate - simple screening methods Later gates Full ISO14040/44 LCA Integrate LC(Social)A results into gate decisions Significant challenges to operating stage-gates Inflexibility of personnel Inflexibility of funding within consortia Larger consortia more able to accommodate the process (flexibility of funding and personnel) Agreement on projects to kill or continue stage and gate buy in Larger consortia less able to agree, more competing interests

  11. Case Studies: stage-and-gate in collaborative R&D projects A frequently encountered situation within a collaborative research project: a 4-year programme starts from speculative ideas formulated within a proposal the project target is a demonstration at an agreed scale what is the best approach to guide the development from initial speculative ideas to the demonstration? Here is an example of criteria for stage-gating process, which could be evaluated at each project review meeting, say at 6-monthly intervals: 1. Does a particular approach have a chance of hitting the technical success criteria for the case study? 2. Could the specific approach potentially reach the required sustainability targets? 3. Is it feasible to develop each specific approach to the required technical level of performance, such that it could be built as a demonstrator within the lifetime of a project.

  12. Case Studies: stage-and-gate in collaborative R&D projects Assessment of technical level of an approach against set criteria: this requires clear definition of performance criteria and understanding of fundamental limitations of specific approaches; this is not always feasible to evaluate. An example when this is possible, is when a thermodynamic limit of performance could be established.

  13. Case Studies: stage-and-gate in collaborative R&D projects Could the specific approach potentially reach the required sustainability targets? at the early stages of a project there is little data available; as project evolves, there is more data and more indicators of sustainability could be evaluated. However, it is highly desirable to have an indication about the likely sustainability metrics even at the very early stages. So, some data-lean methods are highly desirable.

  14. Case Studies: stage-and-gate in collaborative R&D projects Could the specific approach potentially reach the required sustainability targets? here is a possible design of criteria for three gates in the case of a chemical process development, starting from selection of appropriate chemical route, then decisions on process options and final optimisation of the demonstration system. NoStage Early route selection Tools/Indicators Material intensity pentagon; Toxicity; Hazard & risk; Availability of supply Simplified gate-to-gate flow sheet analysis; Critical issues, including business case viability; Social indicators Life Cycle Assessment; Economic and Social indicators; Multiobjective optimisation 1 Early process selection 2 Process optimisation 3

  15. Case Studies: stage-and-gate in collaborative R&D projects Is it feasible to develop each specific approach to the required technical level of performance, such that it could be built as a demonstrator within the lifetime of a project. this is largely a business decision based on experience of the investigators: some really interesting ideas and leads may be identified at the start of the project, but if they are too far from demonstration, is there enough time to get these ideas developed sufficiently? For this analysis it is important to work backwards from the end of the project: how long is the demonstration campaign and what should be done with the generated data? by when demonstration plant should be ready? when all parts for the demo plant must be ordered by designed by? so when is the decision about demonstrator case study must be made? the remainder from the project start is what s available for R&D this is almost always less than one thinks!

  16. Case Studies: stage-and-gate in collaborative R&D projects This is an example of a design of stage-gating approach for a collaborative academic R&D project, aimed at identifying new chemical transformations and processes. Data required for gate 1: - Several alternative chemical routes - Suggestions of likely processes for each route - Evaluated supply chain analysis for each route (availability, desired scale of production, etc.) - Evaluated simplified LCA impact scores for each route. Decision at gate 1 based on numerical data and using multi-criteria decision analysis.

  17. Case Studies: stage-and-gate in collaborative R&D projects Data required for gate 2: - Scalability of processes within the selected route This decision is primarily technical. In this 2-gate design of the stage-gating process, a significant burden is placed on generating a lot of data for gate 1. The two-stage approach may work well for more academic projects, when the initial period (of ca. 50-60 % duration of the project) is left for exploration of new leads and generation of data for the gate criteria evaluation, close to the date of the review meeting.

  18. Case Studies: stage-and-gate in collaborative R&D projects LCA and stage-and-gate Generation of LCA (and costing data) at the very early stage of R&D project using literature data or best guesses is potentially most useful in identifying the critical parameters of the processes that must be addressed in the R&D programme. Shown is the approach of simplified LCA to obtain the insight from using a life-cycle thinking approach, but without performing a full rigorous LCA.

  19. Case Studies: stage-and-gate in collaborative R&D projects LCA and stage-and-gate

  20. Conclusions Stage-and-gate is a very useful methodology to streamline projects towards a set of specific objectives. In the case of the innovation-driven projects, this approach should result in a large % of successful (in terms of reaching the demonstration stage) projects. For this it is recommended that: Milestones in work-programmes are replaced with stage-gates. Milestones are already envisaged to be decision points. However, in practice milestones are seldom used for the purpose of narrowing down options and tracking the progress towards objectives. Stage-and-gate assessments are evaluations against targets that are progressively closer to the objectives, and remain to be decision points. Work-programmes should develop an initial set of criteria for stage-gates at the proposal stage and should put in place a mechanism for updating those during the projects. Flexible fund within the projects would allow for change of direction, bringing in new expertise and moving personnel between beneficiaries, which may require additional resources for relocation, salary differences, etc.

  21. Literature and further reading J. C. Mankins, Advanced Concepts Office, Office of Space and Technology, NASA, 1995. D. Mann, Hands-on systematic innovation: for technical systems, CREAX Press, Ieper, Belgium, 2002. a) R. G. Cooper, E. J. Kleinschmidt, New products - the key factors in success, American Marketing Association, Chicago, 1990; b) R. G. Cooper, E. J. Kleinschmidt, Ind. Marketing Management 1991, 20, 137-147. D. Kralisch, D. Ott, S. Kressirer, C. Staffel, I. Sell, U. Krtschil, P. Loeb, gps 2013, 2, 465-478. V. Hessel, Chem. Eng. Technol. 2009, 32, 1655-1681. D. Kralisch, C. Staffel, D. Ott, S. Bensaid, G. Saracco, P. Bellantoni, P. Loeb, Green Chem. 2013, 15, 463-477. a) D. Kralisch, D. Ott, S. Kressirer, C. Staffel, I. Sell, U. Krtschil, P. Loeb, Green Processing and Synthesis 2013, 2, 465 478; b) I. Sell, D. Ott, D. Kralisch, ChemBioEng Reviews 2014, 1, 50-56. a) D. Ott, D. Kralisch, I. Den ic, V. Hessel, Y. Laribi, P. D. Perrichon, C. Berguerand, L. Kiwi-Minsker, P. Loeb, ChemSusChem 2014, 7, 3521 3533; b) I. Dencic, D. Ott, D. Kralisch, T. Noel, J. Meuldijk, M. De Croon, V. Hessel, Y. Laribi, P. Perrichon, Organic Process Research & Development 2014, 18, 1326 1338.

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