Cellular Membrane Transport in Biology/Chemistry Interface 2
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Carmen Domingo
Christian Hansel
Jennifer Breckler
Kimberly Tanner
Melina Hale
Tom McKnight
Wayne Versaw
Coaches - Stacy Hagemeier and Mark Hens
O
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:
Students will understand how cells exchange
substances with their environment.
T
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:
Introductory Biology class for majors
~150 students
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:
1)
Be able to explain the basis of selective membrane permeability
and distinguish between passive and active mechanisms of
membrane transport.
2)
Be able to distinguish structural characteristics and functional
roles of the various membrane transport proteins (i.e. carriers,
channels, pumps)
3)
Describe the physiological importance of membrane transport (i.e.
energy considerations)
4)
Predict the outcomes of disruption of various membrane transport
systems
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exchange substances with their environment.
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Be able to distinguish structural characteristics and functional
roles of the various membrane transport proteins (i.e. carriers,
channels, pumps)
3)
Describe the physiological importance of membrane transport
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Rationale for a teachable tidbit
Bio 101
Today….
Congratulations!
Exam review
E
x
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2
,
Q
u
e
s
t
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#
4
What happens to glucose when the Na/K pump is blocked?
A.
No effect on glucose transport
B.
Glucose transport into the cell stops immediately
C.
Glucose flows out of the cell
D.
Glucose transport into the cell stops but not immediately
E
x
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2
,
Q
u
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s
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#
4
What happens to glucose when the Na/K pump is blocked?
A.
No effect on glucose transport
B.
Glucose transport into the cell stops immediately
C.
Glucose flows out of the cell
D.
Glucose transport into the cell stops but not immediately
Percent
Review: active transport of glucose into the cell
http://www.stolaf.edu/people/giannini/flashanimat/transport/secondary%20active%20transport.swf
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What happens to glucose when the Na/K pump is blocked?
BACK (outside cell)
FRONT (inside cell)
Aisle
(Na
+
/K
+
Pump)
Aisle
(Glucose
Trans)
Tables
(membrane)
Na
+
G
G
G
G
G
G
G
G
G
G
G
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
G
G
G
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
G
G
G
PROLOGUE
Na
+
(HUGE amounts of
Glucose)
Na
+
G
BACK (outside cell)
FRONT (inside cell)
Aisle
(Na
+
/K
+
Pump)
Aisle
(Glucose
Trans)
Tables
(membrane)
ADP
ATP
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
ACT 1
Build gradient
G
G
G
G
G
G
G
G
G
G
G
G
G
G
G
G
G
Na
+
G
(HUGE amounts of
Glucose)
Na
+
G
BACK (outside cell)
FRONT (inside cell)
Aisle
(Na
+
/K
+
Pump)
Aisle
(Glucose
Trans)
Tables
(membrane)
ADP
ATP
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
END ACT 1
Gradient
established
G
G
G
G
G
G
G
G
G
G
G
G
G
G
G
G
G
Na
+
Na
+
G
(HUGE amounts of
Glucose)
Na
+
G
BACK (outside cell)
FRONT (inside cell)
Aisle
(Na
+
/K
+
Pump)
Aisle
(Glucose
Trans)
Tables
(membrane)
ADP
ATP
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
ACT 2
glucose
transport
G
G
G
G
G
G
G
G
G
G
G
Na
+
G
Na
+
Na
+
Na
+
Na
+
G
G
G
G
G
G
Na
+
(HUGE amounts of
Glucose)
Na
+
G
BACK (outside cell)
FRONT (inside cell)
Aisle
(Na
+
/K
+
Pump)
Aisle
(Glucose
Trans)
Tables
(membrane)
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
ACT 3 tragic
inhibition
G
G
G
G
G
G
G
G
G
G
Na
+
G
(HUGE amounts of
Glucose)
Na
+
Na
+
Na
+
Na
+
G
G
Na
+
Na
+
Na
+
Na
+
G
G
G
G
G
Na
+
Na
+
G
BACK (outside cell)
FRONT (inside cell)
Aisle
(Na
+
/K
+
Pump)
Aisle
(Glucose
Trans)
Tables
(membrane)
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
Na
+
End of
ACT 3
G
G
G
G
G
Na
+
G
(HUGE amounts of
Glucose)
Na
+
Na
+
Na
+
Na
+
G
G
Na
+
Na
+
Na
+
Na
+
G
G
G
G
G
Na
+
G
G
G
G
G
Na
+
Na
+
G
http://www.stolaf.edu/people/giannini/flashanimat/transport/secondary%20active%20transport.swf
Questions to discuss in groups:
1.
What is the direct energy source in a cell used
to transport glucose across the membrane against
its concentration gradient?
2. What happens to glucose when the Na/K pump
is blocked?
Question #4 from exam 2
What happens to glucose when the Na/K pump is blocked?
A.
No effect on glucose transport
B.
Glucose transport into the cell stops immediately
C.
Glucose flows out of the cell
D.
Glucose transport into the cell stops but not immediately
S
p
e
c
i
f
i
c
s
t
u
d
e
n
t
l
e
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r
n
i
n
g
o
u
t
c
o
m
e
s
f
o
r
t
h
e
u
n
i
t
:
1)
Be able to explain the basis of selective membrane permeability
and distinguish between passive and active mechanisms of
membrane transport.
2)
Be able to distinguish structural characteristics and functional
roles of the various membrane transport proteins (i.e. carriers,
channels, pumps)
3)
Describe the physiological importance of membrane transport (i.e.
energy considerations)
4)
Predict the outcomes of disruption of various membrane transport
systems
O
v
e
r
a
l
l
g
o
a
l
:
S
t
u
d
e
n
t
s
w
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l
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s
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l
s
exchange substances with their environment.
Explore the teachable unit on membrane transport in an introductory biology class for majors to understand how cells exchange substances with their environment. The unit covers selective membrane permeability, membrane transport mechanisms, proteins involved, physiological importance, and outcomes of disruption. A focus on secondary active transport helps clarify the energy source for moving molecules against concentration gradients.
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Presentation Transcript
Biology/Chemistry Interface 2 Pump House Gang Carmen Domingo Christian Hansel Jennifer Breckler Kimberly Tanner Melina Hale Tom McKnight Wayne Versaw Coaches - Stacy Hagemeier and Mark Hens
Teachable Unit: Membrane Transport Overall goal: Students will understand how cells exchange substances with their environment. Setting: Introductory Biology class for majors ~150 students
Overall goal: Students will understand how cells exchange substances with their environment. Specific student learning outcomes for the unit: 1) Be able to explain the basis of selective membrane permeability and distinguish between passive and active mechanisms of membrane transport. 2) Be able to distinguish structural characteristics and functional roles of the various membrane transport proteins (i.e. carriers, channels, pumps) 3) Describe the physiological importance of membrane transport (i.e. energy considerations) 4) Predict the outcomes of disruption of various membrane transport systems
Relationship of our Tidbit to Learning Outcomes: 1) Be able to explain the basis of selective membrane permeability and distinguish between passive and active mechanisms of membrane transport. 2) Be able to distinguish structural characteristics and functional roles of the various membrane transport proteins (i.e. carriers, channels, pumps) 3) Describe the physiological importance of membrane transport 4) Predict the outcomes of disruption of various membrane transport systems
Rationale for a teachable tidbit When it comes to secondary active transport, many students have difficulty understanding the source of energy needed to move molecules against their concentration gradient
Bio 101 Today . Congratulations! Exam review
Exam 2, Question #4 What happens to glucose when the Na/K pump is blocked? A. No effect on glucose transport B. Glucose transport into the cell stops immediately C. Glucose flows out of the cell D. Glucose transport into the cell stops but not immediately
Exam 2, Question #4 What happens to glucose when the Na/K pump is blocked? A. No effect on glucose transport B. Glucose transport into the cell stops immediately C. Glucose flows out of the cell D. Glucose transport into the cell stops but not immediately 40 35 30 25 Percent 20 Q #4 15 10 5 0 A B C D
http://www.stolaf.edu/people/giannini/flashanimat/transport/secondary%20active%20transport.swfhttp://www.stolaf.edu/people/giannini/flashanimat/transport/secondary%20active%20transport.swf
What happens to glucose when the Na/K pump is blocked? Role Play A tragedy in three acts
G G BACK (outside cell) G G G G G G G PROLOGUE G G G G G G G G Tables (membrane) Aisle (Na+/K+ Pump) Aisle (Glucose Trans) Na+ Na+ Na+ Na+ Na+ G Na+ Na+ Na+ Na+ Na+ Na+ (HUGE amounts of Glucose) Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+ FRONT (inside cell) Na+ Na+ Na+ Na+
G G BACK (outside cell) G G G G G G Na+ G Na+ G G Na+ Na+ G Na+ G Na+ G G Na+ G G Tables (membrane) Aisle (Na+/K+ Pump) Aisle (Glucose Trans) ACT 1 Build gradient QuickTime and a decompressor are needed to see this picture. ATP ADP Na+ G G Na+ (HUGE amounts of Glucose) Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+ Na+ FRONT (inside cell) Na+ Na+ Na+ Na+ Na+
Na+ G G BACK (outside cell) G G Na+ Na+ G G Na+ Na+ G G Na+ G Na+ Na+ Na+ Na+ G G Na+ Na+ G Na+ G Na+ G Na+ G Na+ G G Na+ Na+ Tables (membrane) Aisle (Na+/K+ Pump) Aisle (Glucose Trans) END ACT 1 Gradient established Na+ Na+ QuickTime and a decompressor are needed to see this picture. ATP ADP G G (HUGE amounts of Glucose) FRONT (inside cell)
BACK (outside cell) Na+ Na+ Na+ G G Na+ Na+ G Na+ Na+ G Na+ Na+ Na+ Na+ G G Na+ G Na+ G Na+ G G Na+ Tables (membrane) Aisle (Na+/K+ Pump) Aisle (Glucose Trans) ACT 2 glucose transport G G Na+ Na+ QuickTime and a decompressor are needed to see this picture. ATP G ADP G G G G Na+ Na+ Na+ Na+ G (HUGE amounts of Glucose) Na+ Na+ G FRONT (inside cell) Na+
BACK (outside cell) Na+ Na+ Na+ G G Na+ Na+ G Na+ Na+ G Na+ Na+ Na+ Na+ G G Na+ G Na+ G Na+ G G Na+ Tables (membrane) Aisle (Na+/K+ Pump) Aisle (Glucose Trans) ACT 3 tragic inhibition G G Na+ Na+ G G G G G Na+ Na+ Na+ Na+ G (HUGE amounts of Glucose) Na+ Na+ G FRONT (inside cell) Na+
BACK (outside cell) Na+ Na+ G Na+ Na+ G Na+ G Na+ Na+ Na+ G G Na+ Na+ G G Na+ Tables (membrane) Aisle (Na+/K+ Pump) Aisle (Glucose Trans) End of ACT 3 QuickTime and a decompressor are needed to see this picture. G G G Na+ Na+ Na+ Na+ G Na+ G G G G Na+ Na+ Na+ G (HUGE amounts of Glucose) Na+ Na+ Na+ G G G FRONT (inside cell) Na+
http://www.stolaf.edu/people/giannini/flashanimat/transport/secondary%20active%20transport.swfhttp://www.stolaf.edu/people/giannini/flashanimat/transport/secondary%20active%20transport.swf
Questions to discuss in groups: 1. What is the direct energy source in a cell used to transport glucose across the membrane against its concentration gradient? 2. What happens to glucose when the Na/K pump is blocked?
Question #4 from exam 2 What happens to glucose when the Na/K pump is blocked? A. No effect on glucose transport B. Glucose transport into the cell stops immediately C. Glucose flows out of the cell D. Glucose transport into the cell stops but not immediately 40 35 30 25 20 Q #4 15 10 5 0 A B C D
Overall goal: Students will understand how cells exchange substances with their environment. Specific student learning outcomes for the unit: 1) Be able to explain the basis of selective membrane permeability and distinguish between passive and active mechanisms of membrane transport. 2) Be able to distinguish structural characteristics and functional roles of the various membrane transport proteins (i.e. carriers, channels, pumps) 3) Describe the physiological importance of membrane transport (i.e. energy considerations) 4) Predict the outcomes of disruption of various membrane transport systems
