Understanding Mitosis Through a Hands-On Modeling Activity

 
Modeling Mitosis
 
How living things create new cells
  
Cell Division Video Clip
 
Learning Goal:  SWBAT describe and model the
steps of mitosis
 
Scale of Understanding
 
Rate yourself on your level of understanding of mitosis-
mark this on your sheet:
 
4
-I can describe each phase of mitosis and create a
model of each phase
3
-I can describe each phase of mitosis
2
-I can generally describe 
some of the changes
 the cell
undergoes in mitosis
1
-I can describe 
one change 
that occurs in the cell during
mitosis
0
-I cannot describe any changes in the cell during mitosis
 
Review
 
1.
Mitosis is the process that ______ use to divide
2.
It contains a series of _________ or steps
3.
Cells created through mitosis are ________ to the
parent cell
4.
New cells are called ________cells
5.
This process creates new _______ cells
6.
The cell makes a copy of its genetic information
during_________________ (which phase)?
 
 
Review
 
1.
Mitosis is the process that 
cells
 use to divide
2.
It contains a series of 
phases
 or steps
3.
Cells created through mitosis are 
identical
 to
the parent cell
4.
New cells are called 
daughter
 cells
5.
This process creates new 
body
 cells
6.
The cell makes a copy of its genetic
information during 
Interphase
 (which phase)?
 
Materials
 
You will need:
-gummy worms (6)
-toothpicks (3)
-twizzlers
-cell templates
-colored pencils
 
Safety:
   Do not eat your chromosomes (gummy worms)
until the end of lab.  Keep your materials on your templates
 
Materials used in model
 
Gummy worms will represent the
chromosomes
toothpicks will represent the
centromeres
Pull apart twizzlers will represent
the 
spindle fibers
Interphase
 
Description:
DNA is copied, cell prepares for division
 
DO:  Lay your cell handouts on your table. Start off in the Parent
Cell with one gummy worm of each color.  Draw a 
c
o
l
o
r
e
d
picture in the first cell circle.
Replicate each chromosome by laying the other chromosomes
(gummy worms) next to the original chromosomes. Draw a
c
o
l
o
r
e
d
 picture in the 
second cell circle
 
*Once the DNA is duplicated, the cell can go through a process
called mitosis. This is the way a cell sorts and divides its genetic
information in the nucleus.
 
Interphase
 
Before DNA replication
 
Interphase
 
After DNA replication
 
Prophase
 
Description:
membrane around the nucleus dissolves 
and the
chromatin condenses into chromosomes.
Chromosomes are held together by a centromere
, a
section of DNA
The two copies of DNA are called 
sister
 chromatids
 
 
With your group, discuss a way to model this
phase using your materials
 
 
 
Prophase
 
 
DO: Attach each sister chromatid to its copy
using a bead and place them in the parent
cell.  Draw a picture on your lab sheet.
 
Prophase
 
metaphase
 
Description:
Sister chromatids line up in center of
cell, spindle fibers form to help
separate the sister chromatids
 
How could you model this phase?
 
metaphase
 
DO:  Take two strands of yarn and lay them down on
opposite sides of the cell. Next, line up the sister
chromatids end to end in the middle of the cell.
Then, have one spindle fiber connect to each sister
chromatid.
 
Metaphase
 
Anaphase
 
Description:
spindle fibers pull the sister
chromatids apart and towards the
side of the cell
 
How could you model this phase?
 
Anaphase
 
 
DO: Remove the centromere (beads) from your
chromosomes and separate the sister chromatids
so that one goes to the left side of the cell and the
other goes to the right side. Repeat this for your
other chromosomes and draw a picture
 
Anaphase
 
Telophase
 
Description:
Chromosomes are pulled to each side, cell
begins to divide, new nuclei forms
 
 
How could you model this?  Hint: use the daughter cell side of
your template
 
Telophase
 
Description:
The chromosomes reach the sides of the cell
cell begins to divide
membrane of a nucleus forms around each set of chromosomes-new
nucleus for each daughter cell
DO: Move the chromosomes onto the Daughter Cells handout to
form two new cells called 
daughter cells
.  Draw a picture on your lab
sheet
 
Telophase
 
Wrap up
 
Are the daughter cells identical to each other?
Are the daughter cells identical to the parent cell?
If your parent cell started off with 8 chromosomes,
how many sister chromatids would be present during
interphase (after replication)?
How would I rate my level of understanding of
mitosis after the lab?   (circle one) 0, 1, 2, 3, 4
Which part of this activity helped you learn the most
about mitosis?
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Explore the process of mitosis by engaging in a hands-on activity using gummy worms, toothpicks, and twizzlers to represent chromosomes, centromeres, and spindle fibers. Through a series of steps starting from Interphase, participants will replicate the stages of cell division, gaining a deeper understanding of how living things create new cells. Embrace the learning journey and scale your understanding as you describe and model the steps of mitosis.


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  1. Modeling Mitosis How living things create new cells Cell Division Video Clip Learning Goal: SWBAT describe and model the steps of mitosis

  2. Scale of Understanding Rate yourself on your level of understanding of mitosis- mark this on your sheet: 4-I can describe each phase of mitosis and create a model of each phase 3-I can describe each phase of mitosis 2-I can generally describe some of the changes the cell undergoes in mitosis 1-I can describe one change that occurs in the cell during mitosis 0-I cannot describe any changes in the cell during mitosis

  3. Review 1. 2. 3. Mitosis is the process that ______ use to divide It contains a series of _________ or steps Cells created through mitosis are ________ to the parent cell New cells are called ________cells This process creates new _______ cells The cell makes a copy of its genetic information during_________________ (which phase)? 4. 5. 6.

  4. Review 1. Mitosis is the process that cells use to divide 2. It contains a series of phases or steps 3. Cells created through mitosis are identical to the parent cell 4. New cells are called daughter cells 5. This process creates new body cells 6. The cell makes a copy of its genetic information during Interphase (which phase)?

  5. Materials You will need: -gummy worms (6) -toothpicks (3) -twizzlers -cell templates -colored pencils Safety: Do not eat your chromosomes (gummy worms) until the end of lab. Keep your materials on your templates

  6. Materials used in model Gummy worms will represent the chromosomes toothpicks will represent the centromeres Pull apart twizzlers will represent the spindle fibers

  7. Interphase Description: DNA is copied, cell prepares for division DO: Lay your cell handouts on your table. Start off in the Parent Cell with one gummy worm of each color. Draw a colored picture in the first cell circle. Replicate each chromosome by laying the other chromosomes (gummy worms) next to the original chromosomes. Draw a colored picture in the second cell circle *Once the DNA is duplicated, the cell can go through a process called mitosis. This is the way a cell sorts and divides its genetic information in the nucleus.

  8. Interphase Before DNA replication

  9. Interphase After DNA replication

  10. Prophase Description: membrane around the nucleus dissolves and the chromatin condenses into chromosomes. Chromosomes are held together by a centromere, a section of DNA The two copies of DNA are called sister chromatids With your group, discuss a way to model this phase using your materials

  11. Prophase DO: Attach each sister chromatid to its copy using a bead and place them in the parent cell. Draw a picture on your lab sheet.

  12. Prophase

  13. metaphase Description: Sister chromatids line up in center of cell, spindle fibers form to help separate the sister chromatids How could you model this phase?

  14. metaphase DO: Take two strands of yarn and lay them down on opposite sides of the cell. Next, line up the sister chromatids end to end in the middle of the cell. Then, have one spindle fiber connect to each sister chromatid.

  15. Metaphase

  16. Anaphase Description: spindle fibers pull the sister chromatids apart and towards the side of the cell How could you model this phase?

  17. Anaphase DO: Remove the centromere (beads) from your chromosomes and separate the sister chromatids so that one goes to the left side of the cell and the other goes to the right side. Repeat this for your other chromosomes and draw a picture

  18. Anaphase

  19. Telophase Description: Chromosomes are pulled to each side, cell begins to divide, new nuclei forms How could you model this? Hint: use the daughter cell side of your template

  20. Telophase Description: The chromosomes reach the sides of the cell cell begins to divide membrane of a nucleus forms around each set of chromosomes-new nucleus for each daughter cell DO: Move the chromosomes onto the Daughter Cells handout to form two new cells called daughter cells. Draw a picture on your lab sheet

  21. Telophase

  22. Wrap up Are the daughter cells identical to each other? Are the daughter cells identical to the parent cell? If your parent cell started off with 8 chromosomes, how many sister chromatids would be present during interphase (after replication)? How would I rate my level of understanding of mitosis after the lab? (circle one) 0, 1, 2, 3, 4 Which part of this activity helped you learn the most about mitosis?

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