Understand the correlation between lipoprotein metabolism imbalance and the development of atherosclerosis. Learn about LDL and HDL cholesterol metabolism, receptor-mediated endocytosis, and the role of lipoprotein(a).

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Pharmacokinetics, as explained in a lecture by Oula Mohammed Sami, M.B.Ch.B/MSc in clinical pharmacology, delves into how the body processes drugs, contrasting with pharmacodynamics which focuses on drug actions. Key topics covered include properties influencing treatment outcomes, the significance

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Exploring the genetic control of metabolism in microbes, focusing on wild type organisms and the process of strain improvement through mutagenesis, selective breeding, and recombinant DNA techniques. The potential benefits and challenges of altering microbial genomes for biotechnological application

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Cellular respiration is a vital process in all living cells, producing energy through chemical reactions. Metabolism, consisting of anabolism and catabolism, maintains growth and function. ATP plays a central role as energy currency in cells. Through stages like glycolysis and the Krebs cycle, cellu

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Digestion and metabolism of protein in both ruminants and non-ruminants involve enzymatic breakdown of proteins into polypeptides and amino acids in the stomach and intestines. Key enzymes such as pepsin, trypsin, and chymotrypsin play important roles in protein digestion. Gastric digestion in the s

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Calcium metabolism plays a critical role in various bodily functions like nerve conduction, coagulation, and bone mineralization. It involves processes such as calcium absorption, distribution, and homeostasis, regulated by hormones like PTH and calcitriol. The balance of calcium in the body is cruc

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Paracetamol, a widely used non-opioid analgesic, is effective for treating musculoskeletal pains and headaches. This synthetic medication primarily acts in the Central Nervous System and is available in various forms. However, caution is advised due to potential side effects such as rare skin reacti

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Explore the detailed information about bilirubin metabolism and various types of jaundice, including their clinical presentations, etiologies, and management strategies. Learn to differentiate between different types of jaundice based on case scenarios and understand the functional anatomy and physi

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Nitrogen metabolism is crucial in the biosynthesis of amino acids such as glutamate and glutamine, incorporating ammonia for various physiological processes. Ammonia is efficiently transported and stored using compounds like alanine and glutamate, playing a key role in the urea cycle. Glutamate, a v

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Metabolism of xenobiotics, foreign chemicals like drugs, food additives, and pollutants, is crucial for pharmacology, toxicology, and disease management. Knowledge allows for beneficial applications such as antioxidant research, pollutant conversion, and drug biosynthesis using transgenic organisms.

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Exploring the metabolic processes in seeds, this study aims to compare carbon dioxide production before and during germination. Students will hypothesize and verify using a carbon dioxide SensorLab sensor. Theoretical aspects of plant metabolism, including photosynthesis and cellular respiration, wi

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The integration of metabolism involving carbohydrates, lipids, and proteins can be divided into three stages: hydrolysis to simpler units, preparatory stage, and oxidative stage. In the hydrolysis stage, complex polysaccharides, lipids, and proteins are broken down to simpler forms. The preparatory

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Corticosteroids, including glucocorticoids and mineralocorticoids, play vital roles in intermediary metabolism, immune responses, and inflammation regulation. They bind to specific receptors in the cell, entering the nucleus to influence gene transcription and protein production. These hormones have

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The process of protein digestion involves proteolytic enzymes produced by the stomach, pancreas, and small intestine. Pepsinogen is activated to pepsin in the stomach, breaking down proteins into oligopeptides and amino acids. After absorption, amino acids are utilized for protein synthesis and as d

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Glycine, the simplest amino acid, plays a crucial role in various metabolic pathways in the body. It can be converted to important compounds like pyruvic acid, lactic acid, and creates the one-carbon pool. Glycine is essential for heme synthesis, glutathione formation, purine synthesis, and more. In

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Explore the intricate pathways of purine and pyrimidine catabolism, salvage, and degradation. Uncover the causes and symptoms of genetic disorders like Lesch-Nyhan Syndrome and Gout. Discover the importance of ribonucleotides conversion to deoxyribonucleotides in DNA synthesis. Dive into the mechani

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Inborn Errors of Metabolism (IEM) are genetic disorders that disrupt metabolic pathways, leading to substrate accumulation or product deficiency. These disorders can be classified based on toxic accumulation, protein metabolism, carbohydrate intolerance, lysosomal storage issues, energy production d

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Amino acid metabolism involves pathways such as transamination, deamination, and the clinical significance of serum transaminases like ALT and AST. Transamination involves the transfer of amino groups, while deamination involves the removal of the amino group. Transaminases are important intracellul

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Decarboxylation is a crucial reaction in amino acid metabolism where CO2 is removed to form biogenic amines, catalyzed by decarboxylase enzymes. Important biogenic amines include tyramine, tryptamine, and histamine, each impacting physiological functions like blood pressure regulation. Aromatic amin

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Thyroid hormones, including triiodothyronine (T3) and thyroxine (T4), are essential for regulating metabolism, growth, development, body temperature, and heart rate. They are tyrosine-based hormones produced by the thyroid gland, requiring iodine for synthesis. T3 affects various physiological proce

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Explore the fascinating world of pharmaceutical organic chemistry in Unit IV, focusing on the chemistry, synthesis, reactions, and medicinal applications of Pyrimidine and Purine compounds. Dive deep into the structures, properties, and pharmacological significance of these essential molecules throu

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The adrenal gland consists of the cortex and the medulla, each responsible for secreting different hormones. The cortex produces glucocorticoids, mineralocorticoids, and adrenal androgens, while the medulla secretes catecholamines. Corticosteroids play a crucial role in regulating metabolism, stress

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Purine alkaloids are a class of compounds with a unique structure, different from typical alkaloids. They include caffeine, theophylline, and theobromine, each with distinct effects on the body. These compounds are found in plants like coffee, tea, and cola, and have various pharmacological activiti

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Explore the intricate processes of oxidative decarboxylation and the Krebs Cycle, essential pathways in cellular energy metabolism. Learn about the conversion of pyruvate to acetyl-CoA, regulatory mechanisms, clinical implications, and more. Discover the fates of pyruvate, allosteric regulation, and

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This article highlights the digestion and metabolism of fat in both ruminant and non-ruminant species. It explains the differences in lipid digestion in the stomach and small intestine of animals, focusing on the role of lipase, bile, and colipase in the breakdown of triglycerides. The process of mi

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Carbohydrates play a vital role in energy production through processes like glycolysis and gluconeogenesis. Glucose metabolism involves pathways like aerobic glycolysis and anaerobic lactate production. In diabetes mellitus, there is a disruption in carbohydrate metabolism leading to elevated blood

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Purine alkaloids are a group of compounds with unique characteristics, such as a heterocyclic nucleus and specific methylated forms like caffeine, theophylline, and theobromine. While they have diverse pharmacological activities like CNS stimulation and diuretic effects, their identification often i

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Purine degradation pathway involves the breakdown of dietary nucleic acids, mainly from meat, into uric acid through specific enzymatic steps. Excessive uric acid production can lead to conditions like gout and hyperuricemia. Humans excrete uric acid in the urine as the final product, while other an

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This lecture discusses the various amino acidopathies, including phenylketonuria, albinism, alkaptonuria, maple syrup urine disease, and homocystinuria. It covers the metabolic defects in amino acid metabolism, symptoms, causes, and treatment methods for these disorders. Emphasizing the importance o

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This content discusses the difference between background/endogenous and exogenous methanol, how metabolism of endogenous methanol affects exogenous metabolism, and the impact of exposure to different levels of methanol on blood concentrations. It highlights EPA PBPK models and assumptions regarding

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Bilirubin, a key pigment in bile, is derived from heme breakdown and plays a crucial role in the liver's detoxification process. This article explores the metabolism of bilirubin, its relationship with heme and globin, as well as its excretion steps involving enzymatic reactions and conjugation in h

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Drug metabolism is a crucial process in the body that transforms drugs into forms easily excreted, affecting their efficacy and toxicity. This involves different sites such as the liver, kidney, and plasma, with enzymes in cellular organelles like cytoplasm and mitochondria playing key roles. First-

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Drug metabolism involves the biotransformation of pharmaceutical substances in the body, primarily in the liver, to facilitate their elimination. This process helps convert drugs into less active forms for enhanced elimination through various reactions in Phase I and Phase II metabolism. Factors suc

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This presentation covers the functions of calcium, calcium metabolism, bone physiology, and hormonal regulation of calcium metabolism focusing on parathyroid hormone, calcitonin, and Vitamin D. It discusses hypo and hyperparathyroidism in detail, including clinical manifestations and treatment optio

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Chronic angina is a condition marked by impaired quality of life and decreased life expectancy, primarily due to myocardial ischemia. It is characterized by symptoms like tightness, heaviness, and pressure sensation, often located retrosternally. The pathophysiology involves a mismatch between oxyge

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The process of Purine Nucleotide Synthesis involves the formation of purine ribonucleotides, breakdown into uric acid, and the detailed steps of purine nucleotide synthesis. Key components like IMP, SAICAR, PRPP, and ATP play crucial roles in this complex metabolic pathway, offering insights into th

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Discover the fascinating realm of nucleotides and nucleic acids through characteristic bases, pentoses, tautomeric forms of common pyrimidine and purine bases, electron-rich nature, UV absorption spectra, furanose structures, major and minor bases, nucleosides, and phosphodiester bonds linking succe

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Serum uric acid is a crucial marker of purine metabolism, with elevated levels indicating hyperuricemia which can lead to conditions like Gout. The measurement of serum uric acid helps in diagnosing hyperuricemia, with serum being the preferred specimen for testing. Various factors such as diet, gen

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DNA and RNA are composed of nucleotides that form long chains called polynucleotides. Nucleotides consist of nitrogenous bases, pentoses (sugar molecules), and phosphate groups. The nitrogenous bases are derivatives of pyrimidine and purine compounds, with DNA containing adenine (A), guanine (G), cy

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The GNRA tetraloop in DNA consists of a sheared base pair (Hoogsteen) and hydrogen bonding interactions, essential for its structural stability. This loop sequence exhibits specific structural characteristics, such as the interaction between the 2'-OH of G and the Hoogsteen edge of a base. Chemical

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