Understanding Liver Function Tests in Cholestatic Injury
Cholestatic liver disease affects Alkaline Phosphatase (ALP) and bilirubin levels, indicating bile duct damage. GGT and 5'-Nucleotidase help differentiate hepatobiliary vs. bone origin of ALP elevation. ALP is produced by bile duct epithelium and can be normal in acute biliary obstruction. GGT and N
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Understanding Steatotic Liver Disease: Importance, Epidemiology, and Pathology
Steatotic liver disease, including metabolic dysfunction associated steatohepatitis (MASLD) and metabolic associated alcoholic liver disease (MALD), is a common cause of liver test abnormalities in the United States. Risk factors such as obesity and metabolic syndrome can lead to advanced fibrosis a
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Proton Beam Therapy Outcomes for Hepatocellular Carcinoma: Multi-Institutional Study
This study by the Proton Collaborative Group evaluates the outcomes of proton beam therapy for hepatocellular carcinoma across multiple institutions. Factors such as liver tolerance, baseline function, and prior therapies were considered in the treatment of liver cancer. The study emphasizes the imp
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Liver Transplant in India for treatment
Liver is the largest gland in our body, and an important metabolic organ which carries out many essential biological functions. The liver is a wedge-shaped, reddish-brown in color with two lobes of different size and shape. The approximate weight of a human liver is 1.5 kilograms. It is in the upper
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Understanding Liver Complications in Cystic Fibrosis: Latest Insights for 2024
Liver complications in cystic fibrosis (CF) have gained importance due to CFTR modulators impacting liver health. This presentation by Dr. Zachary M. Sellers delves into new definitions for CF liver disease, CFF recommendations for screening, management, and treatment of hepatobiliary issues in CF.
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Clinical Characteristics of Liver Disease in Patients with Common Variable Immunodeficiency (CVID)
This study examines the clinical features of liver disease in patients with CVID, revealing insights into the relative frequency, age at onset, duration of follow-up, immunosuppressive treatments, examinations performed, and histological features observed. The data sheds light on the association bet
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Liver Diseases Treatment in Chennai - Dr S. Srivatsan Gurumurthy
Liver disorders can profoundly impact your well-being, resulting in fatigue, weight loss, and jaundice. In severe cases, they may even prove fatal. If you suspect any symptoms, it\u2019s crucial to promptly consult Dr S. Srivatsan Gurumurthy for Liver Disease Treatment in Chennai. Timely medical att
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Best Liver transplant hospitals in India
Best Liver Transplant Hospitals in India\nThe liver is a vital organ that performs important functions in the human body, including detoxification, metabolism, and the production of essential proteins. However, certain conditions such as liver failure, cirrhosis, or liver cancer may necessitate a li
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Understanding the Differences Between Fibrolamellar Carcinoma (FLC) and Hepatocellular Carcinoma (HCC)
Fibrolamellar Carcinoma (FLC) and Hepatocellular Carcinoma (HCC) are distinct liver cancers with important differences in age of onset, underlying causes, diagnostic markers, metastatic patterns, symptoms, treatment options, and outcomes. FLC primarily affects young and healthy individuals with no k
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Understanding COX Enzymes and Their Impact on Pain and Inflammation
COX enzymes, including COX1, COX2, and COX3, play a crucial role in synthesizing prostanoids like prostaglandins in the body, affecting pain and inflammation. By inhibiting these enzymes, relief from pain and inflammation can be achieved. However, non-selective COX inhibitors may lead to various sid
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Understanding the Link Between Diet, Inflammation, and Chronic Diseases
Inflammation is the body's natural response to injury, infection, or attack, but chronic low-grade inflammation can lead to various diseases. The immune system plays a crucial role in protecting the body against harmful substances. Chronic diseases like obesity, diabetes, and cancer often have under
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Histological Structure of Liver and Spleen: Key Features and Functions
In this informative content, the histological structures of the liver and spleen are explored in detail. Key components such as hepatocytes, sinusoids, bile canaliculi, and the spaces of Disse in the liver, and the white pulp and red pulp in the spleen are highlighted. The classic liver lobule, cent
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Translational Liver Cancer Research Initiatives
Translational Liver Consortia (TLC) and the Translational Hepatocellular Carcinoma Consortium (THCCC) led by Dr. Hashem B. El-Serag are focused on advancing research for early detection of liver cancer. The main objectives include patient stratification for liver cancer risk, surveillance in cirrhos
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Urea Biosynthesis and the Krebs-Henseleit Cycle in the Liver
Urea is synthesized in the liver through a series of enzymatic steps known as the urea cycle or Krebs-Henseleit cycle. This process involves converting toxic ammonia into urea, a less toxic and water-soluble compound that can be easily excreted in urine. The liver plays a crucial role in urea biosyn
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Liver Transplantation Report 2021/22 Statistics & Research Findings
The Annual Report on Liver Transplantation 2021/22 presents detailed statistics and clinical research findings from the NHS Blood and Transplant BLTG Transplant Meeting in September 2022. The report covers an overview, transplant list, donor and organ supply, transplant activity, and outcomes. It hi
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Understanding Inflammation and Its Characteristics
Inflammation is the response of tissues to harmful agents, categorized as acute or chronic. Acute inflammation is rapid and short-lived, while chronic inflammation is insidious and prolonged. Chemical mediators play a crucial role in both forms, leading to tissue necrosis. The five cardinal signs of
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Nutritional Considerations for Chronic Liver Disease in Critical Care
Malnutrition is common in chronic liver disease, leading to complications such as ascites and infections. Sarcopenia and weight loss are prevalent regardless of BMI. Critical care patients with liver disease face challenges due to limited physiological reserve, with main causes for ICU admission bei
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Understanding Cellular Events in Inflammation and Repair
Explore the lecture on Cellular Events in Inflammation by Dr. Maha Arafah, focusing on the sequence of vascular changes in acute inflammation, phases of changes in vascular caliber and flow, and objectives covering leukocyte extravasation, chemotaxis, phagocytosis, and microbial killing. Reference m
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Understanding Inflammation and Repair in Tissue Response
Inflammation is a crucial process in response to tissue injury, aiming to eliminate harmful agents and promote healing. It involves vascular changes, increased permeability, and the formation of edema. Repair follows inflammation, involving regeneration and fibroblastic tissue formation. While infla
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Strategies for Maintaining Liver Health in the New Year
The article discusses five effective strategies to improve liver health, focusing on caloric restriction, intermittent fasting, exercise, and caution in weight loss efforts. It emphasizes the importance of adopting healthy lifestyle interventions to prevent liver diseases such as NAFLD and provides
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Clinical Practice Guidelines on Nutrition in Chronic Liver Disease
Comprehensive overview of the EASL clinical practice guidelines on nutrition in chronic liver disease, first presented at the International Liver Congress 2018. These guidelines, published in the Journal of Hepatology, offer key recommendations and address unresolved issues in patient management. Ab
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Liver Services at Imperial College Healthcare NHS Trust
The liver services at Imperial College Healthcare NHS Trust, led by Dr. Ameet Dhar, provide a comprehensive range of services for patients with liver conditions. With over 2000 new patients seen annually, services include inpatient care, specialist clinics, outreach programs, and referral pathways.
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Chemical Mediators of Inflammation: Understanding Sources and Effects
Chemical mediators of inflammation play a pivotal role in inducing specific events during acute inflammation. These mediators are produced in response to various triggers, including microbial products and host proteins, leading to a cascade of inflammatory responses. Understanding the sources and ef
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Understanding Abnormal Liver Function Tests: Insights from Dr. Heather Lewis, Consultant Hepatologist
Abnormal liver function tests can be a perplexing issue with various underlying causes. Dr. Heather Lewis, a renowned Consultant Hepatologist at Imperial College Healthcare NHS Trust, sheds light on the significance of liver function tests, liver enzymes, and blood markers in diagnosing liver condit
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Clinical Practice Guidelines: Nutrition in Chronic Liver Disease Overview
These slides provide a comprehensive overview of the EASL clinical practice guidelines on nutrition in chronic liver disease. The guidelines were first presented at the International Liver Congress 2018 and will soon be published in the Journal of Hepatology. The content covers methods of grading ev
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Managing Alcohol Use in Alcohol-Related Liver Disease
Alcohol-related liver disease (ALD) presents challenges due to advanced liver damage from heavy alcohol use. Patients often have severe alcohol use disorder (AUD), requiring multidisciplinary care. Treatment focuses on managing alcohol consumption and addressing comorbid substance use disorders. Tea
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Evaluation and Management of Incidental Liver Lesions
Understanding the natural history, evaluation, and management of benign liver lesions is crucial for diagnosing incidental liver findings. Common benign liver lesions include hepatic hemangioma, focal nodular hyperplasia, hepatic adenoma, and hepatic cyst. Differential diagnosis plays a key role in
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Insights into Liver Anatomy, Function, and Imaging Studies
Delve into a comprehensive overview of the liver's anatomy, including ligaments, blood supply, and structure in the hilum. Explore the vital functions performed by the liver, such as maintaining body temperature, synthesizing clotting factors, and drug metabolism. Discover liver function tests and t
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Evolution of Liver Biopsy in Children: ESPGHAN Position Paper
Liver biopsy plays a crucial role in diagnosing, staging, and prognostic evaluation of liver diseases in children. Indications for liver biopsy include diagnostic, prognostic, and monitoring purposes. Specific scenarios like neonatal cholestasis and progressive familial intrahepatic cholestasis requ
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Understanding Liver Detoxification and Harmony in Traditional Chinese Medicine
The liver plays a crucial role in detoxification and maintaining harmony in the body according to Traditional Chinese Medicine (TCM). Issues like liver disharmony can lead to various symptoms and health conditions. TCM emphasizes the importance of supporting liver function for overall well-being by
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NGM282 in NASH: Phase 2 Study on Liver Fat Reduction and Histology Changes
A phase 2 study on NGM282 in NASH patients showed a significant decrease in liver fat content, meeting the primary endpoint. Exploratory findings also indicated potential improvements in liver histology. The treatment involved NGM282 at 3 mg QD, with additional rosuvastatin if needed. Promising resu
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Medical Nutrition Therapy in Non-alcoholic Fatty Liver Disease
Medical Nutrition Therapy (MNT) plays a crucial role in managing Non-alcoholic Fatty Liver Disease (NAFLD), focusing on insulin resistance, metabolic syndrome, oxidative stress, dyslipidemia, and cardiovascular risk. Lifestyle recommendations include weight management and increasing physical activit
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Optimising Liver Cancer Care: Addressing Unmet Patient Needs in Europe
Liver cancer patient representatives emphasize the importance of incorporating patient perspectives, improving communication of scientific developments, enhancing healthcare literacy, implementing screening programs, and reducing disparities in diagnosis and treatment across Europe. Addressing socia
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Understanding Abnormal Liver Function Tests: Acute vs. Chronic Approach
Comprehensive discussion on assessing patients with abnormal liver test results, focusing on distinguishing between acute and chronic liver conditions. Covers diagnostic workup, patient cases, and differential diagnosis, emphasizing the importance of patient history, physical examination, and key di
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Role of REG3 and I-FABP in HIV-Related Gut Permeability and Inflammation
This presentation highlights the significance of Regenerating Islet-Derived Protein-3 (REG3) and Intestinal Fatty Acid Binding Protein (I-FABP) in microbial translocation, inflammation, and reservoir size in individuals living with HIV. REG3 and I-FABP serve as markers of gut epithelial damage and p
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Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: An Updated Review by Anita Eftekharzadeh
This comprehensive review discusses the pharmacotherapy options for Non-Alcoholic Fatty Liver Disease (NAFLD), covering topics such as sub-classification of NAFLD, proposed risk stratification, non-invasive measures for assessing liver fibrosis, and the NAFLD Activity Score (NAS). Anita Eftekharzade
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National Liver Review Board: Solving Inconsistencies in Transplant Approvals
The National Liver Review Board, led by Dr. Ryutaro Hirose at the University of California, San Francisco, aims to address inconsistencies in liver transplant applications and approvals across UNOS regions. The board focuses on eliminating disparities in acceptance rates, refining approval practices
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CYNOBIL Liver Capsules – Boost Liver Health & Detox | LYF Healthcare
CYNOBIL liver capsules offer comprehensive liver support with a natural blend of silymarin, artichoke extract, and NAC. Improve liver function, detox, and digestion with CYNOBIL by LYF Healthcare.\n
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Understanding Phagocytosis, Inflammation, and Granulomas in Tuberculosis
Phagocytosis is a crucial process where cells engulf and digest pathogens. Inflammation responses involve various immune cells like neutrophils, plasma cells, lymphocytes, and macrophages. Granulomas, typical in diseases like tuberculosis, are mass accumulations in chronic inflammation. Tuberculosis
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Understanding Viral Hepatitis: Causes, Types, and Clinical Symptoms
Viral hepatitis is caused by various hepatotropic viruses, including Hepatitis A, B, C, D, and E. This type of liver inflammation can manifest acutely or chronically, leading to symptoms such as jaundice, abdominal pain, nausea, and fatigue. Hepatitis A virus, in particular, is primarily transmitted
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