The OCTIVUS Randomized Clinical Trial compared the clinical efficacy and safety of Optical Coherence Tomography (OCT)-guided and Intravascular Ultrasound (IVUS)-guided strategies in patients undergoing PCI for significant CAD. The study aimed to determine if OCT-guided PCI is noninferior to IVUS-gui

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This prospective, multicentre, randomised clinical trial led by Dr. Tiffany Patterson aims to determine whether direct delivery to a cardiac arrest centre following non-ST elevation out-of-hospital cardiac arrest reduces deaths compared to delivery to the nearest emergency department. Funded by the

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The KDIGO 2024 guideline emphasizes the importance of evaluating and managing Chronic Kidney Disease (CKD) effectively. It highlights defining CKD, distinguishing between AKD and CKD, personalized care across the lifespan, diagnosing CKD in older adults, and improving the accuracy of GFR assessment.

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Genetic testing plays a crucial role in identifying inherited kidney diseases, with around 15% of CKD cases having monogenic causes. Despite a high percentage of patients reporting a family history of CKD, Mendelian causes only account for about 10% of adult ESRD cases. Understanding the genetic bas

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This informative presentation by Dr. Karthik Ramani emphasizes the crucial role of primary care providers in managing chronic kidney disease (CKD). It covers timely testing, intervention, and referral practices, along with case studies highlighting key considerations for patients with diabetes, hype

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Prof. Goce Spasovski, a distinguished nephrologist from North Macedonia, has made significant contributions to the field of nephrology. With an extensive international career, he has been involved in numerous clinical trials and research projects, focusing on CKD, anemia, CKD-MBD, and kidney transpl

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This case study discusses the management of Chronic Kidney Disease in pregnancy, focusing on a patient with severe anemia and the need for medical termination of pregnancy. The patient underwent blood transfusion and medical termination, followed by post-evacuation monitoring and counseling on steri

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This UK-wide clinical trial aims to assess the effectiveness of early peripheral norepinephrine infusion in adult patients with septic shock. The study will compare the impact on mortality and other outcomes of targeting a mean arterial pressure (MAP) above 65mmHg within the first 48 hours of admiss

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This presentation discusses the work-up and management of chronic kidney disease (CKD) before nephrology referral. It covers the definition of CKD, work-up steps including history and investigations, and management strategies such as treating underlying causes, controlling risk factors, and lifestyl

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Explore the essentials of Chronic Kidney Disease (CKD): its significance, the functioning of kidneys, causes, diagnosis methods, and considerations based on age. Gain insights into CKD stages and learn how to maintain kidney health for a better quality of life.

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This primary report funded by the National Heart, Lung, and Blood Institute presents the International Study of Comparative Health Effectiveness with Medical and Invasive Approaches. The research evaluates whether an invasive strategy improves health status in stable patients with moderate ischemia,

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Empagliflozin's impact on cardiovascular and renal events in heart failure with reduced ejection fraction was assessed in the EMPEROR-Reduced trial led by Milton Packer, MD, and Faiez Zannad, MD. The trial, enriched for patients with severe left ventricular dysfunction, randomized participants to em

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Explore the process of simulating clinical trial designs, including traditional and adaptive approaches. Learn how to generate data, conduct analysis, make within-trial decisions, and summarize results using fixed-sample two-arm parallel group trials and group-sequential designs. Dive into methods l

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The UK Mini Mitral Trial compares the outcomes of minimally invasive thoracoscopic-guided right minithoracotomy versus conventional sternotomy for mitral valve repair. The trial aims to determine if physical function improvement post-surgery at 12 weeks is superior in the minimally invasive approach

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Explore the various types of hearings available in the Court Management System, such as Motion Calendar, Special Sets, Calendar Call/Trial, Pre-Trial Conference, and Case Management. Learn how to set up new hearings/events and understand the process of generating trial orders and pre-trial conferenc

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The STRESS-L Trial focuses on reversing septic shock using Landiolol, a beta-blockade treatment. It provides training for non-GCP trained clinicians involved in eligibility review, medical care, and prescribing in the trial. The slides cover key GCP principles, trial agenda, study information, backg

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This presentation outlines the aims and focus areas of the National Chronic Kidney Disease Audit (NCKDA) in primary care settings. It covers the identification, management, and outcomes of CKD patients, with a particular emphasis on performance against NICE quality standards. The report is divided i

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The CLEAR Trial is a 2x2 factorial randomized trial evaluating the effectiveness of hypertonic saline and carbocisteine for airway clearance in bronchiectasis over 52 weeks. Led by Professor Stuart Elborn and Professor Judy Bradley from Queen's University Belfast, the trial focuses on clinical and c

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ACST-2 is a randomized trial comparing carotid artery stenting (CAS) versus carotid artery surgery (CEA) in asymptomatic patients with severe carotid stenosis. The trial, published in The Lancet in August 2021, involved 3625 patients. While surgery has been shown to reduce stroke rates, modern medic

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The Sixth Amendment guarantees various rights during criminal trials, such as a speedy and public trial, trial by jury, notice of accusations, the right to confront witnesses, and the assistance of counsel. Defendants can opt for a bench trial where the judge decides innocence or guilt. Juries, typi

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The CLEAR Trial is a 2x2 factorial randomized trial examining the effectiveness of hypertonic saline and carbocisteine for airway clearance in bronchiectasis over 52 weeks. Led by Professor Stuart Elborn and Professor Judy Bradley from Queen's University Belfast, the study focuses on exacerbation ma

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Study focuses on the benefits of adding cardiac catheterization and revascularization to medical therapy in stable CKD patients with moderate ischemia. The ISCHEMIA-CKD trial compared invasive versus conservative treatment strategies, enrolling high-risk patients with various comorbidities. Results

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NCI-MATCH is a groundbreaking clinical trial aiming to match tumor gene alterations with targeted therapies. The interim analysis results revealed impressive patient enrollment and site participation exceeding expectations. Despite challenges with pausing new patient registrations for the analysis,

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This informative content details the histo-anatomy of blood vessels, pathophysiology of atherosclerosis, peripheral ischemia, and carotid artery disease. It covers the definition, risk factors, and processes involved in atherosclerosis, including endothelial cell function, blood flow dynamics, and f

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Understanding the key components of a clinical trial research protocol is essential for conducting successful studies. This includes identifying session objectives, discussing trial protocol contents, exploring observational study elements, and learning about reporting guidelines. Study objectives f

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This resource delves into the psychiatric care aspects of patients with chronic kidney disease (CKD), detailing symptoms, staging, common psychiatric disorders, pharmacokinetic changes, and renal adverse effects of psychotropic medications. It also presents facts about CKD prevalence in the US, stag

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Enhance your trial skills in family law with a focus on evidence collection, trial strategies, and client examination. Learn best practices for preserving evidence, drafting persuasive statements, and navigating trials confidently. This workshop covers important aspects of evidence collection, such

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A 73-year-old patient with COPD, hypertension, and hyperlipidemia presents with severe lower extremity ischemia, leading to a plan for urgent aorto-bifemoral bypass. The clinical examination and test results revealed critical limb ischemia and extensive vascular disease requiring intervention from c

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Difficulty accessing traditional clinics, especially in deprived areas, has led to the proposal of virtual CKD clinics as a more accessible and efficient alternative. By providing holistic care, reducing waiting times, and improving patient satisfaction, virtual clinics aim to bridge gaps in healthc

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Explore the innovative tool nQuery Predict for accurate clinical trial milestone predictions, demonstrated in a webinar hosted by industry experts. Learn about key milestones, adaptive design considerations, enrollment predictions, and the significance of statistical approaches in optimizing trial d

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This report delves into the sources and parameters of prescription drug coverage in Medicare enrollees with chronic kidney disease (CKD) for the years 2010 to 2015. It explores the trends in Medicare Part D enrollment, out-of-pocket costs, and catastrophic coverage benefits. The data presented sheds

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Exploring the detailed process of civil rights litigation, covering steps from fact gathering to trial preparation and post-trial activities. The visual presentation showcases key elements such as client retention, complaint filing, discovery phases, trial preparation, and post-trial procedures like

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Simulation competition where students portray attorneys and witnesses in a civil jury trial based on the case of professional writer Riley Winter suing an online magazine for wrongful termination due to age discrimination. Judges preside over the trial, score performances, and provide feedback, focu

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In this competition, students simulate a criminal jury trial where they take on roles as attorneys and witnesses in a fictitious jurisdiction called Midlands. This year's case involves State v. Sinclair, focusing on the murder trial of Skyler Sinclair, a suspect in the death of an undercover officer

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AIRWAYS-3 is a multi-centre, open-label, randomized trial evaluating the clinical and cost effectiveness of a supraglottic airway (SGA) versus tracheal intubation during in-hospital cardiac arrest (IHCA). The trial aims to determine the functional status and health-related quality of life outcomes o

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A study on the trends in self-reported sleep-related problems among U.S. adults, particularly those with Chronic Kidney Disease (CKD). The findings indicate a higher prevalence of sleep disorders, trouble sleeping, and nocturia in adults with CKD compared to those without CKD. The data suggests that

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The CLEAR Trial is a 2x2 factorial randomized trial led by Professor Stuart Elborn and Professor Judy Bradley to assess the effectiveness of hypertonic saline and carbocisteine for airway clearance in bronchiectasis patients over 52 weeks. The trial involves various study sites and potential new sit

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Understanding the role and benefits of partnering with a Clinical Trial Unit (CTU) is essential for potential Chief Investigators. A CTU handles various aspects of trial coordination, from developing trial materials to overseeing regulatory permissions and data management. UK Clinical Trials Units (

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The trial of O.J. Simpson for the brutal murders of Nicole Brown Simpson and Ron Goldman captivated the nation, with overwhelming evidence implicating Simpson. Despite the compelling case against him, Simpson's defense team, led by Johnnie Cochran, raised doubts about the integrity of the evidence a

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Simulation of a criminal jury trial where students act as attorneys and witnesses in a fictitious jurisdiction called Midlands. This year's case involves the attempted murder of Kerry Bell-Leon, with witness selection varying in each round. Judges play crucial roles in presiding over the trial, scor

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