Address Prediction and Recovery in EECS 470 Lecture Winter 2024
Explore the concepts of address prediction, recovery, and interrupt recovery in EECS 470 lecture featuring slides developed by prominent professors. Topics include branch predictors, limitations of Tomasulo's Algorithm, various prediction schemes, branch history tables, and more. Dive into bimodal,
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Genomic Inference of Human Population Size Changes Over Time
Explore the genomic inference of a severe human bottleneck during the Early to Middle Pleistocene transition, tracing the evolution of hominins over the last 4 million years, and studying essential events in the emergence of humans in the last one million years. Discover well-known human population
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Latest Developments in Genomic Medicine and NHS Genomic Strategy
The genomic medicine field is advancing rapidly, with a focus on enhancing healthcare services through genomic testing for prediction, prevention, diagnosis, and precision medicine. The NHS is actively integrating genomics into its healthcare system, aiming for equitable access to genomic testing. I
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Understanding H.264/AVC: Key Concepts and Features
Exploring the fundamentals of MPEG-4 Part 10, also known as H.264/AVC, this overview delves into the codec flow, macroblocks, slices, profiles, reference picture management, inter prediction techniques, motion vector compensation, and intra prediction methods used in this advanced video compression
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Advancements in Air Pollution Prediction Models for Urban Centers
Efficient air pollution monitoring and prediction models are essential due to the increasing urbanization trend. This research aims to develop novel attention-based long-short term memory models for accurate air pollution prediction. By leveraging machine learning and deep learning approaches, the s
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Precision Oncology Research using Deep Learning Models
Lujia Chen, a Postdoc Associate at the University of Pittsburgh, focuses on developing deep learning models for precision oncology. By utilizing machine learning, especially deep learning models, Chen aims to identify cancer signaling pathways, predict drug sensitivities, and personalize cancer trea
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Gene Prediction: Similarity-Based Approaches in Bioinformatics
Gene prediction in bioinformatics involves predicting gene locations in a genome using different approaches like statistical methods and similarity-based approaches. The similarity-based approach uses known genes as a template to predict unknown genes in newly sequenced DNA fragments. This method in
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Understanding State of Charge Prediction in Lithium-ion Batteries
Explore the significance of State of Charge (SOC) prediction in lithium-ion batteries, focusing on battery degradation models, voltage characteristics, accurate SOC estimation, SOC prediction methodologies, and testing equipment like Digatron Lithium Cell Tester. The content delves into SOC manageme
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Lab 2: DNA Extraction Techniques for Arthropods and Wolbachia
In this lab activity, students will learn how to isolate genomic DNA from arthropods and Wolbachia bacteria. The goal is to transition from fieldwork to molecular biology, utilizing DNA as a diagnostic tool. The activity involves extracting total genomic DNA from identified species and includes pre-
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KFRE: Validated Risk Prediction Tool for Kidney Replacement Therapy
KFRE, a validated risk prediction tool, aids in predicting the need for kidney replacement therapy in adults with chronic kidney disease. Developed in Canada in 2011, KFRE has undergone validation in over 30 countries, showing superior clinical accuracy in KRT prediction. Caution is advised when usi
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Genomic Evaluation of a 2-Month-Old Female with Tetralogy of Fallot
This case involves a 2-month-old female with Tetralogy of Fallot, carrying a genetic variation in the 19p13.11 region. The evaluation process includes assessing genes, known dosage sensitivity, gene count, and detailed analysis of the duplication found in the DGV Gold Standard Dataset. The frequency
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Understanding Challenges and Gaps in Genetic and Genomic Testing for Breast Cancer Risk
The report highlights current challenges and identified gaps in genetic and genomic testing for breast cancer risk assessment. The workgroup aims to catalog existing materials, address terminology confusion, and improve public and clinician education. Challenges include complex terminology, uncertai
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Molecularly-Guided Therapy vs Platinum Chemotherapy in CUP Patients
This trial aims to compare the efficacy and safety of molecularly-guided therapy or cancer immunotherapy based on genomic profiling with platinum-based chemotherapy in patients with cancer of unknown primary site. The study design includes multiple treatment regimens guided by genomic profiles, with
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Real-time Experimental Lightning Flash Prediction Report
This Real-time Experimental Lightning Flash Prediction Report presents a detailed analysis of lightning flash forecasts based on initial conditions. Prepared by a team at the Indian Institute of Tropical Meteorology, Ministry of Earth Sciences, India, the report includes data on accumulated total li
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Patient Choice for Whole Genome Sequencing in NHS: Education & Training Slide Deck
Developed by Genomics Education Programme, these slides focus on the patient choice consent model for whole genome sequencing in NHS Genomic Medicine Service. The model aims to ensure informed choices for genomic testing, including participation in the National Genomic Research Library. It covers se
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Privacy-Preserving Prediction and Learning in Machine Learning Research
Explore the concepts of privacy-preserving prediction and learning in machine learning research, including differential privacy, trade-offs, prediction APIs, membership inference attacks, label aggregation, classification via aggregation, and prediction stability. The content delves into the challen
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Evaluating Genomic Science: Insight into Genome Canada's Mission and Impact
This conversation with Dr. Samantha Evans, Director of Evaluation at Genome Canada, delves into the importance of program evaluation in genomic science. Genome Canada aims to connect ideas, invest in science and technology, and maximize impacts across sectors. The evaluation process involves collect
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Wetland Prediction Model Assessment in GIS Pilot Study for Kinston Bypass
Wetland Prediction Model Assessment was conducted in a GIS pilot study for the Kinston Bypass project in Lenoir County. The goal was to streamline project delivery through GIS resources. The study focused on Corridor 36, assessing various wetland types over a vast area using statistical and spatial
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Clipper: A Low Latency Online Prediction Serving System
Machine learning often requires real-time, accurate, and robust predictions under heavy query loads. However, many existing frameworks are more focused on model training than deployment. Clipper is an online prediction system with a modular architecture that addresses concerns such as latency, throu
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Precision Oncology and Genomic Changes in Cancer Treatment
Explore the intricate details of cancer treatment through precision oncology, focusing on cell of origin, genomic changes, tumor microenvironment, host factors, and response to various treatments such as chemotherapy, biological therapy, and immune therapy. The natural history and histology-guided c
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Theoretical Justification of Popular Link Prediction Heuristics
This content discusses the theoretical justification of popular link prediction heuristics such as predicting connections between nodes based on common neighbors, shortest paths, and weights assigned to low-degree common neighbors. It also explores link prediction generative models and previous empi
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Using Decision Trees for Program-Based Static Branch Prediction
This presentation discusses the use of decision trees to enhance program-based static branch prediction, focusing on improving the Ball and Larus heuristics. It covers the importance of static branch prediction, motivation behind the research, goals of the study, and background on Ball and Larus heu
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Understanding Ridge Regression in Genomic Selection
Explore the concept of ridge regression in genomic selection, involving the development of genomic selection methods, pioneers in implementation, fixed and random effects, and the over-fitting phenomenon. Learn how ridge regression addresses issues of over-fitting by introducing regularization param
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Decoding the Hidden Regulatory Codes Shaping Protein Evolution
The study explores the intricate relationship between genetic and regulatory codes that shape protein evolution. Discusses how duons, genomic footprints, and transcription factors densely populate and constrain protein-coding exons. Highlights how regulatory elements influence codon choice independe
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Understanding Causality in News Event Prediction
Learning about the significance of predictions in news events and the process of causality mining for accurate forecasting. The research delves into problem definition, solution representation, algorithms, and evaluation in event prediction. Emphasis is placed on events, time representation, predict
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Insights into Gene Regulation through Genomic Data Analysis
Explore the intricate world of gene regulation and genomic data analysis through a comprehensive study presented at a faculty workshop in 2014. Delve into the evolution and classification of biology, the impact of genome sequencing on digitizing biology, and the potential of genetic information vari
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Genomics Facilitator's Toolkit Summary & Sample Requirements
This toolkit provides essential resources for healthcare professionals involved in genomics services, covering topics such as genomic medicine, whole genome sequencing, clinical genetic testing methods, interpretation of DNA variants, and more. It also details the specific sample requirements for di
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Network Coordinate-based Web Service Positioning Framework for Response Time Prediction
This paper presents the WSP framework, a network coordinate-based approach for predicting response times in web services. It explores the motivation behind web service composition, quality-of-service evaluation, and the challenges of QoS prediction. The WSP framework enables the selection of web ser
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Genomic Selection in Dairy Cattle: Advantages, Disadvantages, and Impact
Genomic selection in dairy cattle focuses on specialized breeds like Holstein, Jersey, Brown Swiss, and Ayrshire. It brings reliable breeding values at a young age, higher success rates in obtaining top bulls, and lower costs for test proofs, leading to a shorter generation interval. While it offers
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Genomic Prediction of Feed Intake in U.S. Holsteins
This study discusses the inclusion of feed intake data from U.S. Holsteins in genomic prediction, focusing on residual feed intake (RFI) as a new trait. The research involves data from research herds and genotypes of cows, with genetic evaluation models and genomic evaluation for predicting feed int
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Genomic Imputation Pipeline Overview
This document outlines a genomic imputation pipeline for multiple GWAS studies using reference panels such as 1000 Genomes Phase I data. It covers steps like data matching, phasing, and imputation using tools like Beagle and Minimac. The expected output includes imputed dosages and quality measures.
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Evaluation of Genomic Deletion in a 4-Month-Old Male with Bilateral Microphthalmia
Clinical assessment was conducted on a 4-month-old male with bilateral microphthalmia due to a genomic deletion in the 13q12.11 region. The deletion encompasses part of a protein-coding gene and has been associated with various birth defects and developmental delays in previous cases. Detailed evalu
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Introduction to BED Files: An Overview of Browser Extensible Data Format
BED (Browser Extensible Data) files are commonly used for annotating genomic sequences by specifying ranges on chromosomes. They consist of required fields like chromosome name, start and end positions, and optional fields for additional information such as name, score, strand, and color representat
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Amendments to WIPPS Manual for Climate Prediction at INFCOM-3, April 2024
The document discusses amendments to the Manual on WIPPS for climate prediction, including new recommendations for weather, climate, water, and environmental prediction activities. It introduces concepts such as Global Climate Reanalysis and the coordination of multi-model ensembles for sub-seasonal
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Genomic Recursions in Genomic BLUP for Animal Breeding
Explore the application of genomic recursions in single-step genomic best linear unbiased predictor (BLUP) for genetic evaluations in animal breeding. Understand the significance of using genomic data to improve genetic selection, increase accuracy, shorten generation intervals, and enhance genetic
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Mainstreaming Genomic Medicine: 100,000 Genomes Project Update
The Mainstreaming Genomic Medicine post provides insights into the background and progress of the 100,000 Genomes Project, including details on genetic vs. genomic testing, the setup of NHS Genomic Medicine Centres, types of cancer included, and samples taken. It covers the project's inception, key
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Genetic Analysis of 17p13.3 Deletion in a 10-Year-Old Female
This genetic case study involves a 10-year-old female with a de novo 17p13.3 deletion, presenting with mild intellectual disability and growth delay. The deletion overlaps with the Miller-Dieker syndrome critical region, impacting genes associated with lissencephaly and cognitive impairment. Through
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Understanding Mainstreaming in Genomic Testing for Lynch Syndrome
Mainstreaming in healthcare involves shifting genomic testing from Clinical Genetics to various specialties, such as cancer MDTs. This process impacts consent for genetic testing and result communication. NDRS data analyzes the time to diagnosis, while training and resources focus on why mainstreami
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Concept Development and Implementation of Ridge Regression in Genomic Selection
This presentation delves into the concept development and implementation of ridge regression in genomic selection, emphasizing the importance of avoiding overfitting by regulating parameters and distinguishing between fixed and random effects. The pioneers of ridge regression and Bayesian methods ar
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Analysis and Comparison of Wave Equation Prediction for Propagating Waves
Initial analysis and comparison of the wave equation and asymptotic prediction of a receiver experiment at depth for one-way propagating waves. The study examines the amplitude and information derived from a wave equation migration algorithm and its asymptotic form. The focus is on the prediction of
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