Gene duplication - PowerPoint PPT Presentation

Explore various physical and chemical methods used for gene transfer, including electroporation, particle bombardment, microinjection, ultrasound, and bacterial transformation. Learn how DNA enters the nucleus and the role of retroviruses in gene transfer efficiency. Understand the process of RNA co

0 views • 17 slides

This article provides insights into the status, regulatory considerations, and delivery methods of gene therapy and genome editing technologies. It discusses approved gene therapies in the US, human genome editing in clinical applications, and the regulatory authority of the FDA over gene therapy. T

3 views • 27 slides

Gene expression is a crucial process that leads to the production of functional gene products like RNA and proteins. This article explores the regulation of gene expression in both prokaryotes and eukaryotes, covering the importance of regulating gene expression, types of regulation elements, specif

7 views • 22 slides

Bioinformatics involves analyzing biological sequences through sequence alignment to uncover functional, structural, and evolutionary insights. This process helps in tasks like annotation of sequences, modeling protein structures, and analyzing gene expression experiments. Basic steps include compar

0 views • 6 slides

Gene set enrichment tests help identify functional gene sets enriched in hit lists compared to background sets. Various biases (technical, biological, statistical) can lead to incorrect conclusions in data analysis, emphasizing the importance of recognizing and addressing them. Technical biases like

0 views • 29 slides

Delve into the world of genetics and genomics through the lens of integrative biology, investigating the differences between cell types, the rationale for gene expression profiling, and the analysis of differential gene expression in various diseases. Uncover the significance of gene ontology, co-ex

0 views • 22 slides

Gene prediction in bioinformatics involves predicting gene locations in a genome using different approaches like statistical methods and similarity-based approaches. The similarity-based approach uses known genes as a template to predict unknown genes in newly sequenced DNA fragments. This method in

3 views • 40 slides

The process of cloning and expressing the human insulin gene has revolutionized the production of insulin for treating diabetes. By using genetically engineered bacteria, the human insulin gene is inserted, expressed, and purified to create insulin for therapeutic use. This innovation has overcome c

3 views • 20 slides

This content provides information on the Summer Institutes of Statistical Genetics module, focusing on gene expression profiling. It includes details on the schedule, experimental design, RNA sequencing workflow, modes of bulk RNA sequencing, and RNASeq software. The content discusses crucial steps

0 views • 11 slides

Gene mutations play a significant role in molecular biology, leading to alterations in DNA sequences that can impact offspring. These mutations can arise spontaneously or be induced by various factors, such as mutagens. Understanding gene mutations is crucial for comprehending the genetic basis of c

2 views • 27 slides

Gene drive technology is a cutting-edge approach aimed at combating malaria by spreading genetically modified genes in mosquito populations. This technology has the potential to protect endangered species and conserve nature. However, successful implementation requires complex collaborations, risk a

2 views • 16 slides

This presentation delves into the intricate concepts of gene duplication, DNA mutation, and read mapping in the context of molecular evolution. It explains the various types of mutations, the significance of gene duplication in generating new genetic material, and the process of read mapping to alig

0 views • 19 slides

Gene therapy involves introducing DNA into a patient to treat genetic diseases by correcting disease-causing mutations. There are two types of gene therapy: somatic gene therapy and germline gene therapy, each with different implications. Techniques such as gene augmentation therapy and gene inhibit

2 views • 15 slides

This comprehensive content delves into the intricate mechanisms of gene regulation and control of gene expression. It covers topics such as transcriptional regulation, bacterial genes classification, and the role of regulatory proteins. Explore how genes are regulated at transcription, translation,

0 views • 17 slides

Explore the dynamic world of gene expression with the Chunky and Chips Gene Expression Group at the University of Notre Dame. Dive into topics like transcription, translation, and cellular events influencing gene expression. Delve into real-world scenarios and gain insights into the cellular level b

0 views • 20 slides

In this case study, a 2-year-old male presenting with developmental delay and seizures was evaluated for a CNV at the 12p13.1p12.3 region. The CNV was found to overlap with the GRIN2B gene, a known haploinsufficient gene associated with developmental disorders. Despite potential additional scoring c

0 views • 17 slides

Epistasis is a phenomenon where the phenotypic expression of one gene is influenced by interactions with another gene. This concept, first introduced in 1909, plays a crucial role in genetics, affecting various traits and evolutionary processes. The difference between dominance and epistasis lies in

1 views • 41 slides

Every vocational or occupational training program in a community college district must be reviewed biennially as per California Ed Code 78016. The review ensures programs meet labor market demand, avoid unnecessary duplication, and demonstrate student success. A completed example highlights meeting

0 views • 12 slides

Maternal inheritance of a 3q26.32 duplication in a 6-year-old male with autism was assessed using the GAIN scoring metric. The duplication involves the TBL1XR1 gene and was found to fully overlap with a known haploinsufficient gene. The genomic content evaluation indicates the presence of one protei

0 views • 14 slides

The Gene Wiki Jamboree FaceBase Spring Meeting in 2010 aimed to create collaboratively-written and community-reviewed review articles for every gene in the human genome and every concept relevant to FaceBase. It highlighted the value of such articles, providing quick summaries and compilations of re

0 views • 13 slides

This supplementary data includes raw data from agarose gel electrophoresis showing gene expression levels for human SOX17, FOXA2, AFP, ALB, and ACTB in various cellular samples. The gel images depict the expected sizes of amplicons for each gene in different conditions and time points of cell cultur

0 views • 5 slides

In this project, the focus is on identifying splice sites relevant to the inhibitory dopamine receptor gene (D2). The problem involves finding splicing elements within a specific range of known splice sites in the gene. The data provided includes the D2 gene entry in FASTA format, a database of spli

1 views • 13 slides

Reverse genetic approaches involve mutating a target gene to observe its phenotypic effects, providing insights into the gene's normal function. Techniques like gene knockout, knockdown, and homologous recombination are used to manipulate genes and study genetic pathways, leading to discoveries in v

0 views • 6 slides

The lecture covers the essential aspects of hypothesis testing in gene expression profiling, emphasizing experimental design, confounding factors, normalization of samples, linear modeling, gene-level contrasts, t-tests, ANOVA, and significance assessment techniques. Practical insights are shared on

0 views • 9 slides

Complementary nitrogenous bases in DNA, pyrimidines (thymine, cytosine) and purines (adenine, guanine), store biological information through antiparallel strands. DNA, with non-coding regions, undergoes replication and transcription to RNA for protein synthesis. Nucleic acids, DNA, and RNA are cruci

0 views • 7 slides

This study explores the effects of silencing the APP gene and activating the CaMKII pathway on synaptic plasticity in Alzheimer's disease. The experiment aims to maintain the secretion of neurotransmitters by presynaptic neurons when the APP gene is knocked out, potentially offering insights into no

0 views • 11 slides

Smad7 knockout leads to increased Collagen 1 gene levels in kidney cells, potentially contributing to renal fibrosis. Lack of Smad7 protein may result in overproduction of Collagen 1. This protein is found in the extracellular matrix and plays a crucial role in kidney fibrosis pathways, such as TGF-

0 views • 12 slides

Exploring the fundamentals of genetics engineering, this lecture covers topics such as DNA structure, gene expression, gene function, genome, mutation, recombination, and genetic modification. Understand the significance of DNA, genes, and the processes involved in gene expression. Dive into the wor

0 views • 20 slides

Expression vectors are designed to facilitate gene expression by carrying essential elements such as promoters, terminators, and fusion tags. They allow precise control over gene regulation for transcription and translation in host cells, enabling efficient protein production. Different promoters li

0 views • 15 slides

This case study involves a 4-year-old male with developmental delay and a duplication in the 2p21 region. The genetic analysis indicates no parental testing has been done, and the duplication has been reported as LP/VUS (Likely Pathogenic / Variant of Uncertain Significance). Predicted genes and int

0 views • 16 slides

In this project, the Cstps-1 gene from Citrus sinensis is being cloned to produce the enzyme Citrus Valencene Synthase (CVS) responsible for generating the fragrant valencene compound. The process involves DNA isolation from a Valencia orange, gene amplification, vector transformation, and testing f

0 views • 8 slides

Multiple enhancers play a crucial role in regulating gene expression in a cell, with approximately 3-5 enhancers associated per human gene. These enhancers are essential for tissue-specific expressions and are active within the same cell line. The use of multiple enhancers can impact gene expression

0 views • 30 slides

Workshop outcomes and discussions from the MDA-NINDS Workshop on Best Practices for Gene Therapy Programs, highlighting key challenges, possible solutions, and the impact on translational funding programs. The workshop format included orienting talks and panels focusing on scientific premise, regula

0 views • 17 slides

A novel approach to treat, cure, or prevent disease by changing a person's gene expression through gene therapies which aims at modifying the genetic makeup of individuals. This innovative field involves deliberate gene modification to restore normal cell functioning and tissue repair. Explore the s

0 views • 9 slides

This update reveals the ongoing efforts of the Hearing Loss Gene Curation Working Group (HL CDWG) in curating gene-disease relationships, variant classifications, and expert reviews within the field of hearing loss. The group's goals, working group members, gene curation strategy, and clinical valid

0 views • 25 slides

A crucial role in web development, with a domain-specific language widely used by developers worldwide. This study explores the significance of refactoring duplication in CSS, outlining types of duplication and presenting empirical results. Despite CSS's importance for styling web documents, challen

0 views • 28 slides

DNA contains promoters where RNA polymerase binds to initiate gene transcription. Explore the regulation of gene expression from skin cells to neurons. Learn about the Gal4/UAS system in manipulating gene expression and assessing phenotypes in various organisms.

0 views • 10 slides

This update provides details on the goals and members of the Hearing Loss Clinical Domain Working Group (CDWG). The group aims to facilitate gene and variant curation for hearing loss, utilizing expert reviews and collaborating with resources globally. Key activities include gene curation, variant c

1 views • 25 slides

Dive into evidence-based improvement of gene predictions in chimpanzees, focusing on ab initio predictions and utilizing various computational and cognitive skills to annotate mammalian genomes. Explore basic gene structures, motif information, and strategies to refine gene models for accurate annot

0 views • 28 slides

ClinGen RASopathies involve complex diseases associated with the RAS/MAPK pathway, affecting various systems and presenting congenital anomalies. The working group focuses on gene and variant curation, aiming to resolve discrepancies in pathogenicity classification and define gene-disease relationsh

0 views • 31 slides