Zongertinib Trial in HER2 Aberrant Tumors
Zongertinib (BI.1810631) Phase I Study in Advanced Solid Tumors with HER2 Aberrations focusing on NSCLC. The trial involves dose escalation and expansion, testing different doses in cohorts with varied HER2 mutations. Primary endpoints include MTD, OR, and DLTs.
2 views • 14 slides
Titration Colour Changes
This collection features various experiments in chemistry involving titration and solutions. It includes procedures such as standardizing hydrochloric acid using sodium carbonate, titrating hydrochloric acid with sodium hydroxide to produce sodium chloride, determining the concentration of ethanoic
0 views • 10 slides
OCTIVUS Randomized Clinical Trial: OCT-Guided vs IVUS-Guided PCI
The OCTIVUS Randomized Clinical Trial compared the clinical efficacy and safety of Optical Coherence Tomography (OCT)-guided and Intravascular Ultrasound (IVUS)-guided strategies in patients undergoing PCI for significant CAD. The study aimed to determine if OCT-guided PCI is noninferior to IVUS-gui
8 views • 27 slides
ARREST Trial: Expedited Transfer for Non-ST Elevation OHCA
This prospective, multicentre, randomised clinical trial led by Dr. Tiffany Patterson aims to determine whether direct delivery to a cardiac arrest centre following non-ST elevation out-of-hospital cardiac arrest reduces deaths compared to delivery to the nearest emergency department. Funded by the
0 views • 17 slides
Comprehensive Bug Hunting Toolkit for Cybersecurity Enthusiasts
Explore a detailed guide on bug hunting tools, techniques, and resources by expert bug hunter Orwa Atyat from Jordan. Learn valuable tips on finding high/critical bugs, conducting basic recon, subdomain enumerations, collecting URLs/endpoints, and searching for backup files. Enhance your cybersecuri
2 views • 14 slides
Efficacy and Safety of Ferric Carboxymaltose for Heart Failure with Iron Deficiency
Iron deficiency is prevalent in heart failure patients with reduced ejection fraction and is linked to poor outcomes. The HEART-FID trial investigates the impact of intravenous ferric carboxymaltose (FCM) on all-cause mortality, heart failure hospitalizations, and exercise capacity in chronic HFrEF
1 views • 17 slides
SISTER Study: Improving Stroke Treatment Response with TS23
SISTER Study led by Eva Mistry aims to identify a safe and effective dose of TS23 for treating ischemic stroke patients with core-penumbra mismatch. The Phase-2 trial involves 300 adults and spans 54 months, with primary endpoints focusing on treatment efficacy and safety. The study is randomized, p
0 views • 22 slides
Extracorporeal Life Support for Acute Myocardial Infarction Complicated by Cardiogenic Shock
This study explores the use of extracorporeal life support (ECLS) in patients with acute myocardial infarction complicated by cardiogenic shock. The researchers investigate the impact of ECLS on mortality and various secondary endpoints such as renal failure, recurrent infarction, and need for revas
0 views • 20 slides
Optimal First Line Therapy for Metastatic Melanoma: Nivolumab and Relatlimab
Discussing the efficacy and safety of Nivolumab and Relatlimab as a superior first-line therapy option for newly diagnosed metastatic melanoma patients, with comparisons to other treatments based on key endpoints and tolerability data presented at ASCO Annual Meeting.
0 views • 8 slides
Overview of Cohort Studies in Epidemiology
Cohort studies are a type of observational study where a group of healthy subjects is followed over time to investigate relationships between exposures and outcomes. They provide valuable insights into disease development and risk factors, offering advantages like assessing multiple exposures and en
0 views • 21 slides
Digital Health Technology-Derived Clinical Outcome Assessments in Regulatory Decision-Making
This session discusses the landscape of DHT-derived novel endpoints in clinical research, focusing on considerations for regulatory decision-making. It explains the use of digital health technology in clinical outcome assessments and highlights the potential benefits of digitally collected COAs, suc
0 views • 42 slides
Empagliflozin Effects on Heart Failure with Reduced Ejection Fraction: EMPEROR-Reduced Trial Overview
Empagliflozin's impact on cardiovascular and renal events in heart failure with reduced ejection fraction was assessed in the EMPEROR-Reduced trial led by Milton Packer, MD, and Faiez Zannad, MD. The trial, enriched for patients with severe left ventricular dysfunction, randomized participants to em
1 views • 22 slides
Understanding Statistical Methods for Clinical Endpoints in Diabetes Research
This educational slide module delves into fundamental statistics for analyzing clinical endpoints in diabetes research. It covers the choice of statistical methods, the distinction between statistical and clinical significance, and the importance of different endpoints in evaluating clinical benefit
1 views • 37 slides
Comparison of FFR-guided PCI vs Angiography-guided PCI in AMI with Multivessel Disease: FRAME-AMI Trial
In patients with acute myocardial infarction (AMI) and multivessel coronary artery disease, this study aims to compare fractional flow reserve (FFR)-guided PCI with angiography-guided PCI for non-infarct-related artery lesions. The hypothesis is that selective PCI guided by FFR is superior to routin
2 views • 23 slides
Understanding the Fundamental Theorem of Calculus
The Fundamental Theorem of Calculus states that if a function is continuous on an interval and has an antiderivative on that interval, then the integral of the function over the interval is equal to the difference of the antiderivative evaluated at the endpoints. This concept is further explored thr
0 views • 14 slides
Back Titration in Analytical Chemistry
Back titration is a technique used in analytical chemistry to determine the concentration of an analyte by reacting it with an excess of another reagent first, followed by titration of the excess reactant. This method is especially useful in cases where direct titration endpoints are difficult to di
2 views • 14 slides
Digital Differential Analyzer (DDA) Algorithm in Computer Graphics
In computer graphics, the Digital Differential Analyzer (DDA) Algorithm is utilized as the basic line drawing algorithm. This method involves interpolation of variables between two endpoints to rasterize lines, triangles, and polygons efficiently. The algorithm requires inputting coordinates of two
0 views • 9 slides
Molecularly-Guided Therapy vs Platinum Chemotherapy in CUP Patients
This trial aims to compare the efficacy and safety of molecularly-guided therapy or cancer immunotherapy based on genomic profiling with platinum-based chemotherapy in patients with cancer of unknown primary site. The study design includes multiple treatment regimens guided by genomic profiles, with
4 views • 9 slides
Enhancing User Productivity with Outlook Actionable Messages
Explore how to develop and deploy Outlook Actionable Messages to optimize user productivity. Join Julie Turner, a seasoned professional developer, in learning about connectors, message creation, API endpoints, security, and more, to create targeted and interactive messages within Outlook. Get a hand
0 views • 18 slides
Benefits and Structure of VoIP for Business
VoIP offers various benefits for businesses, including cost savings, increased productivity, and feature-rich communication. It allows seamless voice networks, mobility, and integration of data applications with phones. The traditional phone system is likely to be replaced by VoIP. The VoIP structur
0 views • 42 slides
Understanding Biomarkers in Therapeutic Innovation
European Patients Academy on Therapeutic Innovation explains how biomarkers are measurable indicators providing insights into health conditions. Biomarkers like glucose levels in diabetes management and MRI imaging for Multiple Sclerosis play crucial roles. The Academy aims to enhance the medicine d
0 views • 24 slides
Understanding Network Programming in Python
Learn about IP addresses, ports, network sockets, and socket functions in network programming using Python. Explore the concepts of communication endpoints, socket creation, and essential functions for network communication.
0 views • 34 slides
Geometry Formulas and Examples for Midpoint and Distance Calculations
Explore the midpoint and distance formulas in geometry with detailed explanations and examples. Learn how to find midpoints, endpoints, and distances between points on a coordinate plane. Enhance your understanding of segment bisectors and midpoint calculations through practical illustrations.
0 views • 12 slides
Evaluation of Risk Stratification Schemes for Ischaemic Stroke and Bleeding in Atrial Fibrillation Patients
A study conducted in Sweden on 182,678 patients with atrial fibrillation aimed to investigate risk factors for stroke and bleeding. The research assessed the application of CHA2DS2-VASc and HAS-BLED schemes for stroke and bleeding risk evaluations. Data from the Swedish Atrial Fibrillation cohort st
0 views • 20 slides
Efficient Line Segment Intersection Algorithm
This content discusses the Line Segment Intersection problem and presents an efficient algorithm using the line sweep technique. The algorithm utilizes ordered sets implemented as balanced search trees to efficiently determine if any two line segments intersect in the plane. By sorting endpoints and
0 views • 10 slides
Understanding Rolle's Mean Value Theorem in Calculus
Rolle's Mean Value Theorem states that if a function is continuous in a closed interval, differentiable in the open interval, and the function values at the endpoints of the interval are equal, then there exists at least one point where the derivative of the function is zero. This theorem is verifie
0 views • 11 slides
Enhancing Enterprise Security and Efficiency with IBM Endpoint Manager - BigFix
Discover the benefits of using IBM Endpoint Manager - BigFix, such as reducing operational overhead, managing patches efficiently, enhancing security, ensuring audit compliance, and centrally managing IT configurations. With features like quick patch deployment, machine inventory, customization opti
0 views • 18 slides
Switch to LPV/r + RAL Study: Efficacy and Safety Findings
This study, named KITE, focused on switching to LPV/r and RAL treatment in HIV patients without virologic failure. The trial included 40 participants continuing triple therapy, with primary endpoints being HIV RNA levels and event-free treatment failure. Results showed high virological response rate
0 views • 6 slides
Simplified Serverless Stack Platform Deployment with SST
Streamline your serverless application deployment process with Serverless Stack Platform (SST). Easily configure, reference, and deploy AWS resources across different stacks. Take advantage of simplified authentication, high availability, scalability, and cost-effectiveness. Combine the best feature
0 views • 14 slides
Challenges and Recommendations for DHT-derived Endpoints in Clinical Trials
This study by CTTI explores barriers and solutions for adopting digitally derived endpoints in clinical trials. Through in-depth interviews with industry sponsors, the research identifies gaps, barriers, and recommendations for using DHT-derived novel endpoints as key endpoints in pivotal clinical t
0 views • 16 slides
Managing Your Globus Deployment at Oak Ridge National Lab
This deployment guide provides detailed steps on enabling your storage system using Globus Connect Server, creating endpoints, accessing servers, setting up Globus ID, and testing file transfers. The tutorial includes slides, useful links, and passwords for admin access, making the process straightf
0 views • 53 slides
Advances in Aortic Valve Development and TAVR Trials
The presentation discusses various endpoints in aortic valve development and Transcatheter Aortic Valve Replacement (TAVR) trials, including comparisons, study stages, and newer devices. It covers different trial populations, primary and secondary endpoints, and the evaluation of non-inferiority. Su
0 views • 18 slides
Comparison of Valve Types and Anesthesia Strategies in Transcatheter Aortic Valve Implantation
In the SOLVE-TAVI trial, patients undergoing transcatheter aortic valve implantation were randomized to receive either self-expandable or balloon-expandable valves under general or local anesthesia. The study aims to compare the effectiveness and safety of different valve types and anesthesia approa
0 views • 27 slides
Geometric Shapes and Concepts Overview
Illustrations showcasing various geometric shapes and concepts including quadrilaterals with specific attributes, triangles with different angle measurements, endpoints and segments, and intersecting lines. Explore the visual representations to enhance your understanding of basic geometry.
0 views • 23 slides
ADNI Private Partner Scientific Board (PPSB) Update 2015
The ADNI Private Partner Scientific Board (PPSB) Update for 2015 highlights key leadership, partner organizations, deliverables, and accomplishments in advancing drug development. Susan De Santi as Chairperson, along with industry leaders, plays a crucial role in advising and collaborating with ADNI
0 views • 23 slides
Three-Year Outcomes of Left Atrial Appendage Closure vs. Oral Anticoagulation in Atrial Fibrillation
The PRAGUE-17 study compares the three-year outcomes of left atrial appendage closure (LAAC) versus direct oral anticoagulation in patients with atrial fibrillation. LAAC was found to be non-inferior to NOACs for the primary composite endpoint, with similar incidence rates for secondary endpoints. T
0 views • 21 slides
Enhancing Retrospective Assessment: AWERBs' Role and Process
AWERBs play a crucial role in the retrospective assessment of projects involving severe procedures by evaluating objectives, harm to animals, and 3Rs implementation. Project license holders provide essential information to AWERBs for assessment, leading to the submission of outcomes for official ins
0 views • 7 slides
Understanding the Importance of Validity, Reliability, and Reproducibility in Clinical Measurements
Clinical practice involves measuring quantities to aid in diagnosis, predict patient outcomes, and serve as study endpoints. Errors in measurements can lead to inaccurate results and affect clinical decisions. Trueness and precision, accuracy, bias, and method comparison are essential concepts in as
0 views • 25 slides
Exploration of Endpoints in Clinical Trials for Alcohol Use Disorder
This presentation discusses the exploration of endpoints in pivotal clinical trials to treat Alcohol Use Disorder (AUD), focusing on Primary Alcohol Drinking Endpoints like PSNHDD. Evidence supporting PSNHDD as a primary endpoint includes clinical benefit data from alcohol clinical trials and epidem
0 views • 54 slides