Clinical trial infrastructure - PowerPoint PPT Presentation


OCTIVUS Randomized Clinical Trial: OCT-Guided vs IVUS-Guided PCI

The OCTIVUS Randomized Clinical Trial compared the clinical efficacy and safety of Optical Coherence Tomography (OCT)-guided and Intravascular Ultrasound (IVUS)-guided strategies in patients undergoing PCI for significant CAD. The study aimed to determine if OCT-guided PCI is noninferior to IVUS-gui

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Challenges and Progress in Chilean Infrastructure Development

The challenges of Public-Private Partnerships (PPPs) in Chile within the framework of best practices and international standards are discussed, highlighting the need for long-term infrastructure planning and enhanced governance. The 2017 OECD Infrastructure Governance Review identified deficiencies

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ARREST Trial: Expedited Transfer for Non-ST Elevation OHCA

This prospective, multicentre, randomised clinical trial led by Dr. Tiffany Patterson aims to determine whether direct delivery to a cardiac arrest centre following non-ST elevation out-of-hospital cardiac arrest reduces deaths compared to delivery to the nearest emergency department. Funded by the

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Early Vasopressors in Sepsis Clinical Trial: Improving Patient Outcomes

This UK-wide clinical trial aims to assess the effectiveness of early peripheral norepinephrine infusion in adult patients with septic shock. The study will compare the impact on mortality and other outcomes of targeting a mean arterial pressure (MAP) above 65mmHg within the first 48 hours of admiss

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Overview of UW Clinical Trial Office Budget Review

UW Clinical Trial Office conducts budget reviews to ensure compliance and financial accountability in clinical trials. The office collaborates with various departments to manage billing compliance, financial risks, and institutional policies. The primary focus is on avoiding patient billing errors,

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Infrastructure Development Bank of Zimbabwe (IDBZ) - Financing Zimbabwe's Infrastructure Needs

The presentation by the Infrastructure Development Bank of Zimbabwe (IDBZ) at the CIFOZ Congress 2018 outlines the critical infrastructure sectors, funding requirements, and the funding gap faced by Zimbabwe. IDBZ is mandated to facilitate infrastructure development in key sectors like ICT, housing,

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Empagliflozin Effects on Heart Failure with Reduced Ejection Fraction: EMPEROR-Reduced Trial Overview

Empagliflozin's impact on cardiovascular and renal events in heart failure with reduced ejection fraction was assessed in the EMPEROR-Reduced trial led by Milton Packer, MD, and Faiez Zannad, MD. The trial, enriched for patients with severe left ventricular dysfunction, randomized participants to em

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Simulation Techniques in Clinical Trial Design

Explore the process of simulating clinical trial designs, including traditional and adaptive approaches. Learn how to generate data, conduct analysis, make within-trial decisions, and summarize results using fixed-sample two-arm parallel group trials and group-sequential designs. Dive into methods l

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UK Mini Mitral Trial: Minimally Invasive Thoracoscopic Approach vs Conventional Sternotomy for Mitral Valve Repair

The UK Mini Mitral Trial compares the outcomes of minimally invasive thoracoscopic-guided right minithoracotomy versus conventional sternotomy for mitral valve repair. The trial aims to determine if physical function improvement post-surgery at 12 weeks is superior in the minimally invasive approach

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Understanding Different Types of Hearings in the Court Management System

Explore the various types of hearings available in the Court Management System, such as Motion Calendar, Special Sets, Calendar Call/Trial, Pre-Trial Conference, and Case Management. Learn how to set up new hearings/events and understand the process of generating trial orders and pre-trial conferenc

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STRESS-L Trial: Study on Reversal of Septic Shock with Landiolol

The STRESS-L Trial focuses on reversing septic shock using Landiolol, a beta-blockade treatment. It provides training for non-GCP trained clinicians involved in eligibility review, medical care, and prescribing in the trial. The slides cover key GCP principles, trial agenda, study information, backg

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Understanding Clinical Trials: Types and Designs

Clinical trials are essential research studies that evaluate new tests and treatments to improve human health outcomes. They involve various phases, designs, and purposes, such as treatment trials, prevention trials, and observational studies. Different types of clinical trial designs include experi

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The CLEAR Trial: Investigating Hypertonic Saline and Carbocisteine in Bronchiectasis

The CLEAR Trial is a 2x2 factorial randomized trial evaluating the effectiveness of hypertonic saline and carbocisteine for airway clearance in bronchiectasis over 52 weeks. Led by Professor Stuart Elborn and Professor Judy Bradley from Queen's University Belfast, the trial focuses on clinical and c

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Infrastructure Prioritization Framework and Challenges

The Infrastructure Prioritization Framework (IPF) is a tool designed to support the infrastructure planning process, aiming to address challenges such as infrastructure gaps, limited resources, and technical capacity constraints. The tool integrates social, environmental, and financial criteria to h

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ACST-2 Trial: Stenting vs. Surgery for Carotid Artery Stenosis

ACST-2 is a randomized trial comparing carotid artery stenting (CAS) versus carotid artery surgery (CEA) in asymptomatic patients with severe carotid stenosis. The trial, published in The Lancet in August 2021, involved 3625 patients. While surgery has been shown to reduce stroke rates, modern medic

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Understanding the Criminal Trial Process

The Sixth Amendment guarantees various rights during criminal trials, such as a speedy and public trial, trial by jury, notice of accusations, the right to confront witnesses, and the assistance of counsel. Defendants can opt for a bench trial where the judge decides innocence or guilt. Juries, typi

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Streamlined Clinical Trial Infrastructure with Collaborative Leadership

Adaptable and open clinical trial infrastructure emphasizing collaborative leadership with shared responsibilities for successful trial implementation and data integrity. Encourages respectful ownership by investigators while engaging with NIH and SIREN to develop and fund important trials, includin

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The CLEAR Trial: Investigating Hypertonic Saline and Carbocisteine in Bronchiectasis

The CLEAR Trial is a 2x2 factorial randomized trial examining the effectiveness of hypertonic saline and carbocisteine for airway clearance in bronchiectasis over 52 weeks. Led by Professor Stuart Elborn and Professor Judy Bradley from Queen's University Belfast, the study focuses on exacerbation ma

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NCI-MATCH Trial Interim Analysis Results and Status Update

NCI-MATCH is a groundbreaking clinical trial aiming to match tumor gene alterations with targeted therapies. The interim analysis results revealed impressive patient enrollment and site participation exceeding expectations. Despite challenges with pausing new patient registrations for the analysis,

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Enhancing Human Subjects Research Through NIH Policy Changes

The National Institutes of Health (NIH) is implementing reforms and initiatives to improve the stewardship of research involving human subjects, particularly in the context of clinical trials. These changes include new forms for data collection, training in Good Clinical Practice, use of a single In

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Essential Elements of Clinical Trial Protocols

Understanding the key components of a clinical trial research protocol is essential for conducting successful studies. This includes identifying session objectives, discussing trial protocol contents, exploring observational study elements, and learning about reporting guidelines. Study objectives f

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Family Law Trial Skills Workshop: Evidence Collection and Trial Techniques

Enhance your trial skills in family law with a focus on evidence collection, trial strategies, and client examination. Learn best practices for preserving evidence, drafting persuasive statements, and navigating trials confidently. This workshop covers important aspects of evidence collection, such

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Enhancing Clinical Trial Milestone Predictions with nQuery Predict

Explore the innovative tool nQuery Predict for accurate clinical trial milestone predictions, demonstrated in a webinar hosted by industry experts. Learn about key milestones, adaptive design considerations, enrollment predictions, and the significance of statistical approaches in optimizing trial d

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Civil Rights Litigation Steps Overview

Exploring the detailed process of civil rights litigation, covering steps from fact gathering to trial preparation and post-trial activities. The visual presentation showcases key elements such as client retention, complaint filing, discovery phases, trial preparation, and post-trial procedures like

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Civil Jury Trial Simulation: Winter v. TBD, Inc.

Simulation competition where students portray attorneys and witnesses in a civil jury trial based on the case of professional writer Riley Winter suing an online magazine for wrongful termination due to age discrimination. Judges preside over the trial, score performances, and provide feedback, focu

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Analyzing Clinical Trial Results for Rare Diseases: Challenges, Highlights & Missing Data

This analysis delves into the challenges, strengths, weaknesses, and missing data in a clinical trial study focusing on rare diseases. It critiques aspects such as recruitment, study design, surrogate markers, and statistical analysis, offering valuable insights for interpreting clinical trial resul

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Participating in a Mock Criminal Jury Trial Competition

In this competition, students simulate a criminal jury trial where they take on roles as attorneys and witnesses in a fictitious jurisdiction called Midlands. This year's case involves State v. Sinclair, focusing on the murder trial of Skyler Sinclair, a suspect in the death of an undercover officer

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AIRWAYS-3 Trial: Advanced Airway Management in In-Hospital Cardiac Arrest

AIRWAYS-3 is a multi-centre, open-label, randomized trial evaluating the clinical and cost effectiveness of a supraglottic airway (SGA) versus tracheal intubation during in-hospital cardiac arrest (IHCA). The trial aims to determine the functional status and health-related quality of life outcomes o

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Introduction to Terraform for Infrastructure Automation

Terraform is a powerful tool used for building, changing, and versioning infrastructure efficiently and safely. It operates based on Infrastructure as Code principles, allowing for versioning of infrastructure configurations like any other code. With features like Execution Plans, Resource Graph, an

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Perception and Awareness of Clinical Research in Trial Participants and the Public of Andhra Pradesh

This study focuses on understanding the perception and awareness of clinical research among trial participants and the general public in Andhra Pradesh. It highlights the importance of creating awareness about clinical research, previous study results, public attitudes towards clinical trials, and e

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The CLEAR Trial: Investigating Hypertonic Saline and Carbocisteine for Bronchiectasis

The CLEAR Trial is a 2x2 factorial randomized trial led by Professor Stuart Elborn and Professor Judy Bradley to assess the effectiveness of hypertonic saline and carbocisteine for airway clearance in bronchiectasis patients over 52 weeks. The trial involves various study sites and potential new sit

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Key Aspects of Partnering with a Clinical Trial Unit for Successful Trials

Understanding the role and benefits of partnering with a Clinical Trial Unit (CTU) is essential for potential Chief Investigators. A CTU handles various aspects of trial coordination, from developing trial materials to overseeing regulatory permissions and data management. UK Clinical Trials Units (

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The O.J. Simpson Murder Trial

The trial of O.J. Simpson for the brutal murders of Nicole Brown Simpson and Ron Goldman captivated the nation, with overwhelming evidence implicating Simpson. Despite the compelling case against him, Simpson's defense team, led by Johnnie Cochran, raised doubts about the integrity of the evidence a

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Preparation and Roles for the Trial of King Louis XVI

Participants are preparing for the trial of King Louis XVI by researching charges, roles, and responsibilities. The trial process includes reading indictments, opening statements, questioning phases, and final statements. Each role, including Louis, Marie, Robespierre, Marat, and a woman from the 3r

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AMTA Criminal Jury Trial Competition Overview

Simulation of a criminal jury trial where students act as attorneys and witnesses in a fictitious jurisdiction called Midlands. This year's case involves the attempted murder of Kerry Bell-Leon, with witness selection varying in each round. Judges play crucial roles in presiding over the trial, scor

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The CLEAR Trial: Investigating Hypertonic Saline and Carbocisteine for Bronchiectasis Patients

The CLEAR Trial, led by Professor Stuart Elborn and Professor Judy Bradley, aims to assess the clinical and cost-effectiveness of hypertonic saline and carbocisteine for airway clearance in bronchiectasis patients over 52 weeks. The trial involves a 2x2 factorial design and various study sites acros

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Improving First Nation Infrastructure and Housing through Fiscal Management Act Model

The presentation at the AFN National Housing and Infrastructure Forum in October 2017 highlighted the challenges faced by First Nation communities in developing sustainable infrastructure. The current system is inefficient, prompting the exploration of alternatives like the First Nations Fiscal Mana

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The CLEAR Trial: Investigating Hypertonic Saline and Carbocisteine for Bronchiectasis Treatment

The CLEAR Trial is a 2x2 factorial randomized trial assessing the clinical and cost-effectiveness of hypertonic saline and carbocisteine for airway clearance in bronchiectasis patients over 52 weeks. Led by Professor Stuart Elborn and Professor Judy Bradley, the trial involves randomization, sealed

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Digital Infrastructure in India: Creating Pathways for Economic Growth

Digital infrastructure in India plays a crucial role in driving economic growth and development. The focus on creating a national digital grid and catalyzing investments in digital infrastructure is essential for the country's digital transformation. Improving digital infrastructure can unlock signi

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Understanding State and Local Public Infrastructure Finance

Exploring the significance of state and local public infrastructure finance, this lecture discusses the need for investment in long-lived public assets like roads, bridges, water systems, and energy production. It highlights the urgency to address the deteriorating infrastructure in the US and the i

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