Cd4.0 approach - PowerPoint PPT Presentation


Safeguarding Focal Point Training: Person-Centered Approach and Confidentiality

Understanding the principles of a person-centered approach, confidentiality, and consent is crucial in safeguarding training. This training focuses on addressing safety concerns, conducting investigations, and maintaining confidentiality. Ground rules ensure respectful participation and sensitive is

0 views • 24 slides


Progressive Approach to Relational Entity Resolution

In this research paper authored by Yasser Altowim, Dmitri Kalashnikov, and Sharad Mehrotra, a progressive approach to relational entity resolution is presented. The study focuses on balancing cost and quality in entity resolution tasks for relational datasets. The goal is to develop a method that ac

1 views • 20 slides



Spider Feasibility: A Structured Approach to Quality Improvement

Polypharmacy among seniors is a prevalent issue with potentially harmful consequences. The SPIDER approach, focusing on medication appropriateness through evidence-based quality improvement initiatives, aims to address this challenge. Utilizing a structured process informed by data, evidence, and re

1 views • 15 slides


Evolution of Management Theories: Classical Approach and Scientific Management

Explore the evolution of management theories focusing on the Classical Approach and Scientific Management. The Classical Approach emphasizes efficiency and specialization, while Scientific Management introduced systematic methods to increase productivity. Learn about key figures like Frederick Winsl

8 views • 31 slides


Semasiology: The Study of Meaning in Language

Semasiology, a branch of lexicology, focuses on the study of meaning in language through different approaches such as the referent approach and functional approach. The referent approach links the sound form with the concept denoted by the word, while the functional approach emphasizes the relations

2 views • 15 slides


Scotlands Approach to Developing Four Capacities in Education

Scotlands approach focuses on nurturing self-respect, physical, mental, and emotional well-being, secure values and beliefs, enthusiasm for learning, determination for achievement, openness to new ideas, and a range of skills and values to help individuals succeed in various areas and scenarios. The

0 views • 10 slides


Selling Process: Stages and Importance

The selling process is essential in today's competitive market environment, where producers need to persuade consumers to purchase their products. It consists of stages such as prospecting, pre-approach, approach, presentation, handling objections, closing the sale, and follow-up. Prospecting involv

1 views • 99 slides


The Child-Centred Approach in Social Services

Embracing a child-centred approach is essential in providing effective intervention and support in social services. This approach prioritizes the rights, best interests, and voices of children, promoting dignity, cultural respect, and involvement in decision-making. Children's desires for awareness,

2 views • 16 slides


UK Mini Mitral Trial: Minimally Invasive Thoracoscopic Approach vs Conventional Sternotomy for Mitral Valve Repair

The UK Mini Mitral Trial compares the outcomes of minimally invasive thoracoscopic-guided right minithoracotomy versus conventional sternotomy for mitral valve repair. The trial aims to determine if physical function improvement post-surgery at 12 weeks is superior in the minimally invasive approach

1 views • 24 slides


Modigliani and Miller Approach: Refinement of Net Operating Income Approach

The Modigliani and Miller approach refines the net operating income approach by assuming that the cost of debt is always less than the cost of equity. The overall cost of capital remains constant regardless of the debt-equity mix, as the market capitalizes the firm as a whole. This approach suggests

0 views • 5 slides


Strengthening Environmental Statistics in Zambia: Capacity Assessment Results

Presentation of the results from a survey conducted in Zambia to identify environmental statistics in the National Statistical System. The survey focused on key capacity areas applying the CD4.0 approach, including institutional setting, legal framework, funds, infrastructure, data coordination, sta

0 views • 27 slides


Impact of Streamlined HIV Care on Economic Burden among Infected Adults

Streamlined HIV care models aim to reduce the economic burden faced by HIV-infected adults by minimizing healthcare costs and improving access to care. The SEARCH trial in Kenya and Uganda implemented population-based testing and supported linkage to antiretroviral therapy (ART) regardless of CD4 co

2 views • 22 slides


Clinical Trial Comparison of Immediate vs Deferred Antiretroviral Therapy in HIV-Infected Individuals

This study compared immediate initiation of antiretroviral therapy (ART) with deferred treatment in HIV-infected individuals with CD4+ count >500 cells/mm3. Results showed a significant reduction in primary composite endpoint events in the immediate ART group compared to the deferred ART group. Seri

0 views • 4 slides


Comparison of DOR and DRV/r in DRIVE-FORWARD Study

DRIVE-FORWARD Study compared the efficacy of doravirine (DOR) with darunavir/ritonavir (DRV/r) in treatment-naive HIV patients. The study aimed to show non-inferiority of DOR based on virologic response at week 48. Results indicated similar virologic response rates between DOR and DRV/r groups, with

0 views • 10 slides


Cutaneous Manifestations of HIV and AIDS

Human Immunodeficiency Virus (HIV) is a lentivirus that infects CD4 T lymphocytes, leading to Acquired Immunodeficiency Syndrome (AIDS). Cutaneous manifestations of HIV/AIDS vary depending on the stage of infection and CD4 T cell counts. Early signs include exanthem, oral hairy leukoplakia, candidia

0 views • 17 slides


Role of REG3 and I-FABP in HIV-Related Gut Permeability and Inflammation

This presentation highlights the significance of Regenerating Islet-Derived Protein-3 (REG3) and Intestinal Fatty Acid Binding Protein (I-FABP) in microbial translocation, inflammation, and reservoir size in individuals living with HIV. REG3 and I-FABP serve as markers of gut epithelial damage and p

0 views • 7 slides


Comparison of NNRTI vs. NNRTI and RPV/FTC/TDF vs. EFV/FTC/TDF in STAR Study

STAR Study compared the efficacy and safety of RPV/FTC/TDF and EFV/FTC/TDF in treatment-naive HIV patients. The study included 394 participants in each group, assessing HIV RNA suppression rates, CD4 count improvements, treatment responses, and resistance analyses up to 48 weeks. Results showed RPV/

0 views • 15 slides


Immune Cell Analysis Supplementary Figures

This collection of supplementary figures provides detailed flow cytometry data on immune cell populations, including CD4+ T cells, CD8+ T cells, tumor-associated macrophages, and more. The figures also include information on immune checkpoint molecules like PD-L1 and TIGIT. Each figure presents spec

0 views • 4 slides


Comparison of INSTI vs. EFV in STARTMRK GS-US-236-0102

In the STARTMRK study, Raltegravir (RAL) was compared to Efavirenz (EFV) in combination with TDF/FTC for the treatment of HIV. The study aimed to demonstrate non-inferiority of RAL compared to EFV in achieving HIV RNA levels below 50 c/mL. Baseline characteristics and patient disposition were assess

0 views • 12 slides


Comparison of NNRTI vs NNRTI and DRIVE-AHEAD Study: DOR/3TC/TDF vs EFV/FTC/TDF

The comparison study explores NNRTI regimens alongside the DRIVE-AHEAD trial, focusing on DOR/3TC/TDF vs EFV-FTC/TDF. DRIVE-AHEAD assesses the efficacy and safety of DOR in ARV-naïve HIV patients, aiming for non-inferiority based on virologic response, with DOR exhibiting potential neuropsychiatric

0 views • 11 slides


Monitoring Delays in Adopting WHO HIV Treatment Guidelines in LMICs

Scientific evidence supports immediate ART in preventing illness and deaths. WHO guidelines, revised in 2015 to recommend treating all PLHIV regardless of CD4 count, have seen delays in adoption at the national level in low- and middle-income countries (LMICs). This study quantifies delays in adopti

0 views • 14 slides


Innovative Approach to Conflict Resolution in Homelessness Crisis

Cleveland Mediation Center (CMC) employs a Diversion Conflict Resolution Approach to address homelessness crisis as effectively as conflicts. By applying the Empowerment Theory of Conflict, they empower individuals in crisis to regain control over their situations and lives. Through a strength-based

0 views • 11 slides


Basic HIV Course for Health Professionals Session 1: Introduction to HIV

This session introduces basic epidemiological concepts, differentiates between HIV and AIDS, explains the HIV life cycle, and discusses how HIV is transmitted. Definitions of key terms like prevalence, incidence, mortality rate, and morbidity are provided. The session also highlights the differences

0 views • 30 slides


Role of V3 Region in HIV Entry to CD4 T-Cells

The V3 region of gp120 plays a crucial role in HIV entry to CD4 T-cells by determining the coreceptor usage. Studies focus on the structural aspects of V3, its conservation, coreceptor binding, and antibody accessibility. The HIV envelope structure, including trimeric spikes with gp120 and gp41 glyc

0 views • 24 slides


HIV/AIDS Treatment Literacy: A Comprehensive Guide

This educational module covers various aspects of HIV/AIDS treatment literacy, including disease progression, CD4 cells, antiretroviral therapy, opportunistic infections, and clinical monitoring. It explains the latent and advanced stages of HIV, the importance of maintaining a good immune system, a

0 views • 22 slides


HIV and AIDS: The Progression in Adult Natural History

HIV infection progresses in stages from acute infection with flu-like symptoms to a latency period of no symptoms, then advancing to AIDS where the immune system is significantly weakened, leading to opportunistic infections and HIV-related cancers. The virus targets CD4 cells, impacting the immune

0 views • 29 slides


Safety and Pharmacodynamic Activity of Vesatolimod (GS-9620) in HIV-Infected Individuals

Vesatolimod (GS-9620) has shown to be safe and pharmacodynamically active in individuals infected with HIV. Studies demonstrate its potential to eliminate and activate infected CD4 T cells, recruit immune cells like NK cells and macrophages, and work in combination with broadly neutralizing antibodi

0 views • 21 slides


Association of Maternal Viral Load and CD4 Count with Perinatal HIV-1 Transmission Risk

Increased maternal viral load (MVL) and decreased CD4 cell counts have been linked to higher risks of perinatal and postnatal HIV-1 transmission during breastfeeding. The PROMISE Postpartum Component study examines the association between these factors and transmission risk, providing insights into

0 views • 15 slides


Prospective Cohort Study on Acute HIV Infection in Bangkok

The study focuses on initiating combination antiretroviral therapy for all HIV-infected individuals to preserve the CD4+ T cell population, restrict viral reservoir seeding, and minimize viral evolution. Rapid suppression of HIV viraemia in patients could lead to potential candidates for future cure

0 views • 12 slides


Guidelines for Virologic and Immunologic Monitoring in HIV Care

These guidelines aim to assist clinicians in utilizing HIV viral load testing and CD4 count monitoring effectively in HIV care. They provide recommendations on the appropriate timing of tests to assess ART responses, address adherence barriers, and manage resistance assays. Regular monitoring is cru

0 views • 12 slides


Personalized Celebrity Video Search: Cross-space Mining Approach

This study presents a novel approach for personalized celebrity video search based on cross-space mining, aiming to match user interests with celebrity popularity. By learning the interest space of users and the popularity space of celebrities, the framework correlates the two spaces to enhance sear

0 views • 23 slides


Impact Evaluation of UN-Habitat's Housing Approach 2008-2019

The Impact Evaluation of UN-Habitat's Housing Approach assessed the impact of UN-Habitat's efforts in providing adequate, affordable housing, and reducing urban poverty between 2008-2019. The evaluation included regional and country reports, focusing on the effects and impacts of UN-Habitat's Housin

0 views • 14 slides


Immunizations for Adults with HIV: Recommendations and Considerations

This information provides guidelines on immunizations for adults with HIV, including considerations and contraindications. It emphasizes the importance of following vaccination recommendations from reputable health organizations for individuals with different CD4 counts. Additionally, it highlights

0 views • 19 slides


Caterpillar Cat 239D COMPACT TRACK LOADER (Prefix CD4) Service Repair Manual Instant Download

Caterpillar Cat 239D COMPACT TRACK LOADER (Prefix CD4) Service Repair Manual Instant Download

0 views • 24 slides


INFODERMATOLOGY

Delve into the molecular basis of aging through the study of cell-to-cell transcriptional variability, differential gene expression, and transcriptomic changes in CD4+ T cells. Explore how age impacts transcriptional dynamics and gene activation, shedding light on cellular aging mechanisms.

0 views • 8 slides


transcriptional variability

This study delves into the molecular basis of aging, focusing on how aging impacts transcriptional dynamics using single-cell RNA sequencing in CD4+ T cells of mice. The research explores divergence in transcriptome between mouse species, differentially expressed genes, and the activation-induced tr

1 views • 15 slides


Comparison of INSTI vs PI

Study WAVES compares the efficacy of EVG/C/FTC/TDF versus ATV/r/FTC/TDF in women with ARV-naïve HIV. The study assesses virologic success, CD4 cell count changes, and response rates at week 48. Baseline characteristics and patient disposition, as well as HIV RNA levels, CD4 cell counts, and treatme

0 views • 9 slides


Impact of Raltegravir Intensification on IRIS in REALITY Trial

The REALITY trial investigated the impact of Raltegravir intensification on immune reconstitution inflammatory syndrome (IRIS) in individuals starting antiretroviral therapy with low CD4 counts in sub-Saharan Africa. Results showed faster viral load declines with RAL-intensified therapy, but no redu

0 views • 22 slides


Constructing Inverse Probability Weights for Dynamic Interventions

Lauren Cain, Principal Statistician at Takeda Pharmaceuticals, presents a case study on determining the optimal CD4 cell count to initiate antiretroviral therapy. The presentation covers clinical guidelines, treatment strategies, examples of dynamic interventions, and more. Attendees will engage in

0 views • 79 slides


Constructing Inverse Probability Weights for Dynamic Interventions

Principal Statistician Lauren Cain explores the optimal frequency for monitoring CD4 cell count and HIV RNA in individuals on treatment. Examples of dynamic monitoring strategies and classifications are discussed, shedding light on the implications for healthcare guidelines.

0 views • 64 slides