Viral Infections of the Respiratory System Lecture Summary & Quiz

This lecture covers viral infections of the respiratory system, focusing on Avian flu, Influenza Virus, Respiratory Syncytial Virus, Human metapneumovirus, Parainfluenza viruses, Measles, and Mumps virus. It includes information on the structure, symptoms, lab diagnosis, treatment, and prevention of these viruses. Helpful videos for further understanding are also provided.

• Viral Infections
• Respiratory System
• Lecture Summary
• Avian Flu
• Influenza

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1. Lecture : viruses 1+2 SUMMARY + QUIZ + helpful videos " . "

2. V1 Viral Infections of the Respiratory System Avian flu: Avian influenza type A virus (H5N1) Influenza Virus (A, B, C) Family orthomyxoviridae orthomyxoviridae Structure Enveloped virus with 2 projecting glycoprotein spikes (H & N) Routine testing = direct detection of virus from sputum, nasopharyngeal swab, aspirate (NPA), or respiratory secretion by direct immunofluorescent essay (IFA) Genome 8 segmented - polarity ssRNA I.P. 1 4 days Symptoms Fever, malaise, headache, cough, chills, sore throat, and generalized pain Range from typical flu to severe respiratory disease. Diarrhea, abdominal pain, nose bleed. Transmission is always through inhalation of infectious aerosol droplets. Lab diagnosis Routine testing PCR, detection of viral RNA in throat swap Treatment Amantadine (A only) Rimantadine, Oseltamivir, or Zanamivir (A & B) Oseltamivir Zanamivir (should be started within 48 hrs) Prevention 1. Flu shot vaccine 2. Nasal spray flue vaccine

3. V1 Viral Infections of the Respiratory System Respiratory Syncytial Virus & Human metapneumovirus Viral Parainfluenza Measeles Mumps virus Family Paramyxoviridae Paramyxoviridae Paramyxoviridae Paramyxoviridae Structure Enveloped virus Enveloped virus Enveloped virus Enveloped virus covered with two glycoprotein spikes (H & N) Genome polarity ssRNA polarity ssRNA polarity ssRNA polarity ssRNA I.P. 7 14 days 18 21 days Symptoms Fever, harsh cough, difficult inspiration. (Croup, bronchiolitis, pneumonia) Bronchiolitis (<6months) Pneumonia Fever, cough, conjunctivitis, runny nose, koplik s spot, rash Moderate fever, malaise, pain on chewing or swallowing, particularly acidic liquids. Sudden onset of fever and painful swelling of parotid gland Lab diagnosis Routine testing Tissue culture PCR Routine testing Cell culture (with CPE) PCR Serology by detection of IgM Ab using ELISA in case of SSPE detection of measles antibodies in CSF or detection of viral NA using PCR. Serology by detection of IgM Ab using ELISA, cell culture and isolation of the virus from saliva or detection of viral NA using PCR Treatment No specific treatment (only supportive treatment) Ribavirin (for infants) No specific treatment No specific treatment Prevention No vaccine available No vaccine available (passive immunization immunoglobulin given for infected premature infants) MMR Vaccine MMR Vaccine

4. V1 Videos Influenza: https://www.youtube.com/watch?v=U17Rbx1AmN4 Measles: https://www.youtube.com/watch?v=YBceTQ97FnM Mumps: https://www.youtube.com/watch?v=s3ACcn8IWFc

9. SAQ:An 8 year old child is presented with fever, malaise and cough he visits an E.R doctor in the hospital , the doctor suspects a viral infection he later diagnosed him with influenza. Based on this info answer the following 1- if the influenza was type B what is the treatment? ANS: Rimatidine , Oseltamivir , Zanamivir 2- what are the currently circulating strains of influenza? ANS: H1N1 , H3N2 3- what is the most common complication that could arise in children duo to influenza? ANS: Reyes syndrome Direct questions: 1- What is the treatment for Respiratory syntical virus and human metapneumoviruse in infants? ANS: Ribavirin 2- What is the virus that is presented with Kopliks spot? ANS: Measels 3- What is the most common cause of common cold? ANS: Rhinovirus 4- what virus has ocnogenic (cancer) properties? ANS: Epstien Barr Virus (EBV) 5- What are the viruses that can be detected using serology detection of IgM antibodies using ELISA? ANS : Measels , Mumps , EBV ZOOM to see the answers ;)

10. MCQs: 1.Which one of the following is considered as first cause of common cold? a. Rhinovirus b. Coronavirus c. Adenovirus 2.Which one of the following is structurally non-enveloped? a. Parainfluenza b. Coronavirus c. Rhinovirus 3.Which one of the following is the only virus with dsDNA? a. Adenovirus b. Influenza c. Respiratory Syncitial 4.Avian flu do not usually infect humans. a. T b. F 4- a 3- a 2- c 1- a Thanks 434team

11. GOOD LUCK! -See you next block ^^ The Editing File We are waiting for your feedback @microbio436 436microbiologyteam@gmail.com