The Lymphatic System and Immune Response
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Lymphatic tissue consists predominantly of
lymphocytes. These and a variable number of
plasma cells, macrophages, and other cells
occur among a framework of reticular cells
and fibers. In H&E preparations lymphatic
tissue appears purple because of the
presence of numerous small lymphocytes,
each with a basophilic nucleus and little
cytoplasm.
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• Lymphocytes
T cells
B cells
• Plasma cells
• Bone marrow
• Thymus
• Lymph Node
• Mucosa-associated lymphoid tissue (MALT)
• Spleen
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The bone marrow and thymus are considered
as primary immune/lymphoid components of
the functioning immune and lymphatic
systems.
because they contain the stem cells that will
develop into T cells, B cells and natural killer
cells
Diffuse lymphatic tissue is characterized by a moderate concentration of
scattered Iymphocytes. A round, oval, or irregularly circumscribed
aggregation of mostly small, densely packed lymphocytes is called a
lymphatic nodule. A nodule may contain a central pale area, the germinal
center. Because the majority of cells of the germinal center are larger
lymphocytes with more cytoplasm and lightly staining nuclei, this region
appears pale in contrast to the dense corona (marginal zone, peripheral
zone) of small lymphocytes. Diffuse lymphatic tissue and lymphatic nodules
are components of most lymphatic organs. They also appear in the
connective tissue of the digestive, respiratory, urinary, and reproductive
organs, among other locations.
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Aggregations of lymphatic nodules
form Peyer's patches in the lamina
propria and submucosa of the
small intestine, particularly the
ileum.
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Tonsils are collections of lymphatic nodules
and diffuse lymphatic tissue. They occur in
the connective tissue below the epithelium
in specific regions of the tongue, pharynx,
and larynx.
Follicular tonsils are characterized by deep
invaginations of the surface epithelium
called crypts. A crypt together with its
associated lymphatic tissue is a tonsillar
follicle.
Collectively, several follicles form the tonsil.
Examples of tonsils with crypts include the
following: lingual tonsils of the horse, pig,
and cow; paraepiglottic tonsils of the pig,
sheep, and goat; palatine tonsils of the
horse, pig, and ruminant.
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Tonsils without crypts have a
smooth, somewhat folded, or
bulging surface, but lack deep
invaginations of the epithelium.
Examples of these are the tubal
tonsils or ruminants, the
paraepiglottic tonsil of the cat, and
the palatine tonsils of carnivores.
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A lymph node is organized into a cortex and medulla.
The cortex consists of lymphatic nodules surrounded by diffuse
lymphatic tissue. Extensions of the latter tissue into the medulla are
called medullary cords.
Lymphocytes, other leukocytes, macrophages, and plasma cells can be
found in the medullary cord.
A capsule of connective tissue, with some smooth muscle and elastic
fibers, covers the lymph node. Parts of the capsule extend inward as
trabeculae.
Afferent lymphatic vessels penetrate the capsule to join the
subcapsular sinus. Cortical sinuses connect the subcapsular sinus to
medullary sinuses. The latter lead to efferent lymphatic vessels at the
hilus. The various sinuses are less cellular than the parenchyma and
appear pale by comparison. They are lined by a discontinuous
endothelium and are spanned by a network of cytoplasmic processes
of reticular cells. They contain some free cells such as lymphocytes
and macrophages.
Blood vessels enter and leave the node
mostly from the region of the hilus.
Unique blood vessels called
postcapillary venules are found in the
deep cortex. They are lined by elongated
cells that appear cuboidal when cut in
cross section.
Lymphocytes migrate between these
cells.
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lymph node of the pig, for example, is
characteristically atypical with the
location of the cortical and medullary
tissue, as well as the flow of lymph,
being reversed
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Hemal nodes occur along
blood vessels of ruminants.
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Located posterior to the sternum in the anterior part
of the mediastinum, the thymus is a bi-lobed nodular
organ that is very large in the yong, reaching
maximum size at puberty then becoming smaller in a
process called involution. Immature T lymphocytes
move from the bone marrow into the thymus where
they become immunocompetent T cells. These T
cells then leave the thymus, go into the circulation
and eventually find their way to lymph nodes,
mucosa-associated lymphoid tissue or the spleen.
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MALT is really connective tissue located beneath mucous
membranes in which the lymphocyte is the predominant cell
type. Examples occur in the respiratory, gastrointestinal, urinary
and reproductive tracts. The exact extent of these aggregations
of lymphocytes is not easily discernible because they have no
distinct capsule like that of lymph nodes.
However, they are like lymph nodes in that they often have a
pale-staining germinal center containing actively dividing
lymphocytes like the germinal centers in lymph nodes.
The larger aggregations contain B and T cell zones and antigen
processing cells; the smaller, more scattered MALT components
such as those in the intestines and respiratory tract are mostly T
lymphocytes. Some B cells and plasma cells are also present
.
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:
• in the wall of the pharynx - tonsils (palatine,
lingual, pharyngeal)
• in the wall of the small intestine - aggregate
lymphoid nodules
• in the wall of the colon-aggregate lymphoid
nodules
• in the walls of the appendix
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• in the wall of the vagina
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The spleen has a capsule that is rich in smooth
muscle and elastic fibers. In horses and cows two or
three layers of muscle are oriented perpendicular to
each other, while in carnivores, pigs, sheep, and
goats the muscle fibers are interwoven.
The capsule is thickest in the horse and cow and
thinnest in carnivores. Trabeculae project into the
interior of the spleen from the capsule. They tend to
be especially large in cows and sheep.
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The parenchyma of the spleen is divisible into the white and red
pulp. Dense accumulations of lymphocytes, arranged around
central arteries, form the periarterial lymphatic sheaths (PALS).
These, along with lymphatic nodules, comprise the white pulp.
White pulp appears purple in H&E preparations because of the
high concentration of numerous small lymphocytes.
Red pulp, because of the large numbers of erythrocytes it contains
in its reticular meshwork and blood vessels, is stained red in H&E
preparatIons.
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The bursa of Fabricius is a sac like dorsal diverticulum of the
proctodeum that is unique to birds. It is characterized by tall,
thick mucosal folds (plicae) filled with numerous polyhedral
follicles. Each follicle, composed of lymphatic tissue, is divided
into a cortex and medulla. A layer of undifferentiated epithelial
cells occupies the periphery of the medulla, which is separated
from the cortex by a capillary layer. The bursa is lined by a
pseudostratified columnar epitheliwn, except at the apex of each
follicle, which is covered by an epithelial tuft of simple columnar
cells
.
The lymphatic system, a vital component of the immune system, consists of lymphocytes, plasma cells, and other cells within a framework of reticular cells and fibers. It includes lymphoid organs like the bone marrow, thymus, lymph nodes, and spleen. Diffuse lymphatic tissue and lymphatic nodules are crucial in immune response, while structures like Peyer's patches and tonsils play specific roles in mucosal immunity. Understanding these components is essential for comprehending the body's defense mechanisms.
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Presentation Transcript
Histology Immune System: Lymphatic System
Immune System Lymphatic tissue consists predominantly of lymphocytes. These and a variable number of plasma cells, macrophages, and other cells occur among a framework of reticular cells and fibers. In H&E preparations lymphatic tissue appears purple presence of numerous small lymphocytes, each with a basophilic nucleus and little cytoplasm. because of the
The components are: Lymphocytes T cells B cells Plasma cells Bone marrow Thymus Lymph Node Mucosa-associated lymphoid tissue (MALT) Spleen
NOTE: The bone marrow and thymus are considered as primary immune/lymphoid components of the functioning immune systems. because they contain the stem cells that will develop into T cells, B cells and natural killer cells and lymphatic
Diffuse lymphatic tissue is characterized by a moderate concentration of scattered Iymphocytes. A round, aggregation of mostly small, densely packed lymphocytes is called a lymphatic nodule. A nodule may contain a central pale area, the germinal center. Because the majority of cells of the germinal center are larger lymphocytes with more cytoplasm and lightly staining nuclei, this region appears pale in contrast to the dense corona (marginal zone, peripheral zone) of small lymphocytes. Diffuse lymphatic tissue and lymphatic nodules are components of most lymphatic organs. They also appear in the connective tissue of the digestive, respiratory, urinary, and reproductive organs, among other locations. oval, or irregularly circumscribed
Peyer's patches Aggregations of lymphatic nodules form Peyer's patches in the lamina propria and submucosa of the small intestine, ileum. particularly the
Tonsils with crypt Tonsils are collections of lymphatic nodules and diffuse lymphatic tissue. They occur in the connective tissue below the epithelium in specific regions of the tongue, pharynx, and larynx. Follicular tonsils are characterized by deep invaginations of the surface epithelium called crypts. A crypt together with its associated lymphatic tissue is a tonsillar follicle. Collectively, several follicles form the tonsil. Examples of tonsils with crypts include the following: lingual tonsils of the horse, pig, and cow; paraepiglottic tonsils of the pig, sheep, and goat; palatine tonsils of the horse, pig, and ruminant.
Tonsils without crypts Tonsils without crypts have a smooth, somewhat bulging surface, but lack deep invaginations of the epithelium. Examples of these are the tubal tonsils or ruminants, paraepiglottic tonsil of the cat, and the palatine tonsils of carnivores. folded, or the
lymph node A lymph node is organized into a cortex and medulla. The cortex consists of lymphatic nodules surrounded by diffuse lymphatic tissue. Extensions of the latter tissue into the medulla are called medullary cords. Lymphocytes, other leukocytes, macrophages, and plasma cells can be found in the medullary cord. A capsule of connective tissue, with some smooth muscle and elastic fibers, covers the lymph node. Parts of the capsule extend inward as trabeculae. Afferent lymphatic vessels penetrate subcapsular sinus. Cortical sinuses connect the subcapsular sinus to medullary sinuses. The latter lead to efferent lymphatic vessels at the hilus. The various sinuses are less cellular than the parenchyma and appear pale by comparison. They are lined by a discontinuous endothelium and are spanned by a network of cytoplasmic processes of reticular cells. They contain some free cells such as lymphocytes and macrophages. the capsule to join the
Blood vessels enter and leave the node mostly from the region of the hilus. Unique blood postcapillary venules are found in the deep cortex. They are lined by elongated cells that appear cuboidal when cut in cross section. Lymphocytes migrate cells. The amount or cortical and medullary tissue can vary from that of the "typical" lymph node. The lymph node of the pig, for example, is characteristically atypical location of the cortical and medullary tissue, as well as the flow of lymph, being reversed vessels called between these arrangement of with the
Hemal nodes occur Hemal blood vessels of ruminants. They are characterized blood-filled sinuses cellular cords. tissue and muscle form the capsule and trabeculae (which are sparse). Hemal nodes lack lymphatic vessels. Hemolymph nodes, in contrast to hemal possess lymphatic Their sinuses receive a mixture of blood and lymph. nodes along by between Connective some smooth nodes, vessels.
Thymus Located posterior to the sternum in the anterior part of the mediastinum, the thymus is a bi-lobed nodular organ that is very large in the yong, reaching maximum size at puberty then becoming smaller in a process called involution. Immature T lymphocytes move from the bone marrow into the thymus where they become immunocompetent T cells. These T cells then leave the thymus, go into the circulation and eventually find their way to lymph nodes, mucosa-associated lymphoid tissue or the spleen.
Mucosa-associated lymphoid tissue (MALT) MALT is really connective tissue located beneath mucous membranes in which the lymphocyte is the predominant cell type. Examples occur in the respiratory, gastrointestinal, urinary and reproductive tracts. The exact extent of these aggregations of lymphocytes is not easily discernible because they have no distinct capsule like that of lymph nodes. However, they are like lymph nodes in that they often have a pale-staining germinal center lymphocytes like the germinal centers in lymph nodes. The larger aggregations contain B and T cell zones and antigen processing cells; the smaller, more scattered MALT components such as those in the intestines and respiratory tract are mostly T lymphocytes. Some B cells and plasma cells are also present. containing actively dividing
Distribution of MALT In the digestive system: in the wall of the pharynx - tonsils (palatine, lingual, pharyngeal) in the wall of the small intestine - aggregate lymphoid nodules in the wall of the colon-aggregate lymphoid nodules in the walls of the appendix In the reproductive system: in the wall of the vagina
Spleen The spleen has a capsule that is rich in smooth muscle and elastic fibers. In horses and cows two or three layers of muscle are oriented perpendicular to each other, while in carnivores, pigs, sheep, and goats the muscle fibers are interwoven. The capsule is thickest in the horse and cow and thinnest in carnivores. Trabeculae project into the interior of the spleen from the capsule. They tend to be especially large in cows and sheep.
Spleen The parenchyma of the spleen is divisible into the white and red pulp. Dense accumulations of lymphocytes, arranged around central arteries, form the periarterial lymphatic sheaths (PALS). These, along with lymphatic nodules, comprise the white pulp. White pulp appears purple in H&E preparations because of the high concentration of numerous small lymphocytes. Red pulp, because of the large numbers of erythrocytes it contains in its reticular meshwork and blood vessels, is stained red in H&E preparatIons.
Lymphatic tissues in bird Lymph nodes do not occur in the chicken . However, diffuse lymphatic tissue and lymphatic nodules are widespread. The bursa of Fabricius is a sac like dorsal diverticulum of the proctodeum that is unique to birds. It is characterized by tall, thick mucosal folds (plicae) filled with numerous polyhedral follicles. Each follicle, composed of lymphatic tissue, is divided into a cortex and medulla. A layer of undifferentiated epithelial cells occupies the periphery of the medulla, which is separated from the cortex by a capillary layer. The bursa is lined by a pseudostratified columnar epitheliwn, except at the apex of each follicle, which is covered by an epithelial tuft of simple columnar cells.
