PrEP Use and STIs Association Study Among YMSM/TGW in Chicago

A longitudinal cohort study by Ethan Morgan, Ph.D., examined the link between Pre-Exposure Prophylaxis (PrEP) use and rectal Sexually Transmitted Infections (STIs) among young men who have sex with men and transgender women in Chicago. The study found no significant relationship between PrEP use and the risk of rectal STIs, despite PrEP users showing an increased likelihood of engaging in condomless anal sex. The research involved multilevel regression models and mediation analyses but did not support a direct association between PrEP use and rectal STIs.

• PrEP
• STIs
• YMSM
• TGW
• Chicago

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Uploaded on Dec 07, 2024 | 0 Views

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1. PrEP Use and STIs are not Associated Longitudinally in a Cohort Study of YMSM/TGW in Chicago Ethan Morgan, PhD Institute for Sexual and Gender Minority Health and Wellbeing Northwestern University

2. No Disclosures to Declare 1

3. Methods Goal: To understand whether pre-exposure prophylaxis (PrEP) users are at increased risk for rectal sexually transmitted infections (STIs). Sample: Ongoing longitudinal cohort study of young men who have sex with men and transgender women (YMSM/TGW) in Chicago, aged 16-29 (N~1100, n=744) Analyses: Longitudinal multilevel lagged regression models Mediation models considering the potential pathway: PrEP use Condomless Anal Sex (CAS) Rectal STIs 2

4. Proportion of participants testing positive for any rectal STI 25 20 15 Percent 10 5 0 Visit 1 to Visit 3 Visit 3 to Visit 5 Visit 5 to Visit 7 Pre-PrEP Uptake No PrEP Post-PrEP Uptake No PrEP 3

5. Results Sample: PrEP use: 32.9%, RCT-NG: 16.8%, RCT-CT: 23.0% Longitudinal lagged models: No significant relationship between PrEP use and risk of rectal STI Similar results with varying PrEP use patterns Mediation models: PrEP use prospectively predicted increase likelihood of CAS, but CAS did not predict rectal STIs 4

6. Acknowledgements NIH/NIDA U01DA036939 F32DA046313 Co-Authors Dr. Brian Mustanski Dr. Michael Newcomb Dr. Richard D Aquila Dr. Christina Dyar 5