Novel Isotope Production Using the TR19 Cyclotron
This research project focuses on establishing routine production of theragnostics using the TR19 cyclotron, developing solid targetry for radiometals, and performing FLUKA analysis to inform targetry. The approach involves establishing a solid target system, developing methods for producing Radium targets, and providing Ac-225 regularly. Accomplishments include developing a solid targetry system, installing targetry cooling system, and implementing electrodeposition system. Research output includes support for post-docs and visiting professors/students, presentations at various conferences, and manuscripts submitted/accepted. No disclosures provided. Nuclear data in progress.
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Novel Isotope Production Using the TR19 Cyclotron Name of Researchers: Cathy S. Cutler (PI), Dohyun Kim, Jasmine Hatcher-Lamarre PD: PD 19-001 Total Approved Funding: $745,824 Funding Expended from Prior Years: $497,365 FY21 Expense as of 4/30/21: $48,116
Project Goals Establish routine production of theragnostics on the TR19 cyclotron. Develop solid targetry for radiometals Develop solid target holder and cooling system Perform FLUKA analysis to inform targetry Evaluate separations Funding will provide feasibility data to apply for external funding from NIH, DOD, DOE, research foundations and private corporations.
Approach Taken Establish solid target system Solid target holder and cooling system Performed FLUKA analysis to determine Ra-226 targetry and, best angles, coverings and beam energies Developed methods for producing Radium targets Produced Ba targets that were fully characterized and irradiated at the Tandem to inform Ra targetry Working with Rad Con and ESH to develop Ra target facility and handling procedures Modifying Mobius for Rn cryo-trapping Provides Ac-225 free of Ac-227 on a regular basis
Accomplishments to Date Developed solid targetry system that has undergone engineering analysis Installed targetry cooling system required for solid target irradiations Performed FLUKA analysis to determine Ra-226 targetry and, best angles, coverings and beam energies Developed and implemented electrodeposition system for solid targetry Produced Ba targets that were fully characterized and irradiated at the Tandem to inform Ra targetry Working with Rad Con and ESH to develop Ra target facility and handling procedures Modifying Mobius for Rn cryo-trapping Transportation containers defined 4
Research Output Post Docs supported Jasmine Hatcher-Lamarre and Rick Darienzo Visiting Professors and Students: Lynn Francesconi, Najah Curtis, Isabella Pasha Presentations: TAT meeting in Ontario, Plenary at 9ICI, Alpha emitters talk at the SNMMI, 2 talks at the IAEA, 5 Invited Manuscripts: 1 accepted in NMB third most downloaded manuscript, 2nd submitted Disclosures: None Provided Nuclear Data In progress
Goals for the Remainder of the Project Setup facility to handle Ra-226 Obtain Ra-226 to prepare mg size targets for feasibility irradiations Setup radon monitoring and mobius trapping system Perform mg target feasibility runs Setup method to fabricate larger targets Setup robotic arm for target transfer
Return on Investment (ROI) Future Potential Funding Sources: The isotope program has already committed and is sending base funding to support the cyclotron. They are very interested in establishing routine production of Ac-225 from Ra-226 irradiations. There is significant interest in Ac-225 free from Ac-227. If we were producing now they could sell all we could make. This will result in additional hires to support the cyclotron operations and two to three hires for routine processing and target recycling starting at once a month and going up to twice a month. Further interested in producing additional items such as Y-86, Cd- 109, Se-72, Re-186/189. Anticipated Return-On-Investment ($/timeframe): Currently receiving 350/yr in base funding. Production lines would result in 1-2 million per year to support staff in these new processes and could go up to 4 million/yr. Describe Relationship to BNL and NPP s Strategic Objectives: Cultivating and exploring these isotope production capabilities will advance the performance of continued discovery within the Collider Accelerator department as well as address the needs for the Department of Energy Nuclear Physics program office. These new capabilities will facilitate the development of theragnostics to meet the NSAC-I recommendation in the 2015 report. 7
