Hyperemesis Gravidarum: Causes, Symptoms, and Treatment

HYPEREMESIS GRAVIDARUM
I
n
t
r
o
d
u
c
t
i
o
n
.
Excessive vomiting during pregnancy. It starts
from 6
th
 to 8
th
 week.
E
p
i
d
e
m
i
o
l
o
g
y
Studies showed that approximately 27 to 30
percent of women experience only nausea, while
vomiting may be seen in 28% to 52% percent of
all pregnancies.
P
a
t
h
o
p
h
y
s
i
o
l
o
g
y
Theories suggest a great role played by levels
of  hCG and Estrogen .
R
i
s
k
 
f
a
c
t
o
r
s
Family history
Multiple pregnancy
Polyhydramnios
Prime gravidity
Previous history of hyperemesis gravidarum
Molar pregnancy
Diets rich in fat contents
Obesity
Young age at pregnancy
C
l
i
n
i
c
a
l
 
f
e
a
t
u
r
e
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Excessive Nausea and vomiting
Features of Dehydration
Weight loss
I
n
v
e
s
t
i
g
a
t
i
o
n
s
Full blood count
Renal function test
Urinalysis
Liver function tests
Obstetric ultrasound
T
r
e
a
t
m
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n
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Put the patient Nil per oral for 24 to 48 hours
Urethral catheterization for urine output
monitoring
Vitamin B1 (IV)100mg 24hourly mix in
intravenous rehydration solution AND
Metoclopramide (IM) 5–10 mg 8hourly till
vomiting stops OR
Promethazine (IM) 12.5 mg 12hourly a day
C
o
m
p
l
i
c
a
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Vitamin B1 deficiency
Dehydration
Malnutrition
Wernicke encephalopathy
Esophageal rupture
Pneumothorax.
Electrolyte imbalances
Fetal Complications
P
r
e
v
e
n
t
i
o
n
Proper screening during ANC
Avoiding fatty food staffs
Early diagnosis and treatment
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Hyperemesis gravidarum is a severe form of nausea and vomiting during pregnancy, affecting around 27% to 52% of women. The condition typically starts between the 6th to 8th week of pregnancy and is linked to hormonal changes. Risk factors include family history, obesity, and young age at pregnancy. Clinical features include excessive nausea, dehydration, and weight loss. Diagnosis involves blood tests and ultrasound. Treatment includes IV fluids, antiemetics, and monitoring for complications like dehydration and malnutrition. Prevention strategies include early screening and avoiding fatty foods.


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  1. HYPEREMESIS GRAVIDARUM

  2. Introduction. Introduction. Excessive vomiting during pregnancy. It starts from 6thto 8thweek.

  3. Epidemiology Epidemiology Studies showed that approximately 27 to 30 percent of women experience only nausea, while vomiting may be seen in 28% to 52% percent of all pregnancies.

  4. Pathophysiology Pathophysiology Theories suggest a great role played by levels of hCG and Estrogen .

  5. Risk factors Risk factors Family history Multiple pregnancy Polyhydramnios Prime gravidity Previous history of hyperemesis gravidarum Molar pregnancy Diets rich in fat contents Obesity Young age at pregnancy

  6. Clinical features Clinical features Excessive Nausea and vomiting Features of Dehydration Weight loss

  7. Investigations Investigations Full blood count Renal function test Urinalysis Liver function tests Obstetric ultrasound

  8. Treatment Treatment Put the patient Nil per oral for 24 to 48 hours Urethral catheterization for urine output monitoring Vitamin B1 (IV)100mg 24hourly mix in intravenous rehydration solution AND Metoclopramide (IM) 5 10 mg 8hourly till vomiting stops OR Promethazine (IM) 12.5 mg 12hourly a day

  9. Complications Complications Vitamin B1 deficiency Dehydration Malnutrition Wernicke encephalopathy Esophageal rupture Pneumothorax. Electrolyte imbalances Fetal Complications

  10. Prevention Prevention Proper screening during ANC Avoiding fatty food staffs Early diagnosis and treatment

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