Covaris Distributor Training Event 2019 Highlights

Welcome to the Covaris Distributor Training event held on June 18, 2019, featuring presentations, discussions, and networking opportunities. Get insights into the marketing team, schedule details, logistic arrangements, and AFA technology showcased during the event. Connect with key personnel and discover the innovative patented technology discussed at the training session.

• Training
• Covaris
• Distributor
• Event
• Technology

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1. Distributor Training 18 June 2019 Bill Campbell

2. Welcome Welcome to 2019 Covaris Distributor Training Sales and Marketing (Archer Hotel, Covaris) Field Service (Covaris) You are a large part of our success Thank you for your attendance and support! Wednesday afternoon Presentations, brainstorm, feedback, discussion Proprietary 2

3. Introductions Proprietary 3

4. Logistics Breakfast at Archer Hotel every day starting at 7 AM Lunch at Archer Hotel every day starting at 12 PM Dinner Tuesday 6 PM at Bancroft (15 3Rd Ave, across from Archer) Wednesday 6 PM at Redstone American Grill (20 3rd Ave, across from Archer) Transportation (Covaris car pool, Taxi, Uber,) Tuesday 12:45 PM - Plan to leave for Covaris by car pool, taxi, Uber by 12:45 for 1 PM arrival Tuesday 5:15 PM - Plan to leave for Archer Hotel by car pool, taxi, Uber Some repetition different angles Ask questions during presentations, lunch, breaks, etc. Have fun! Proprietary 4

5. Marketing Team Bill Campbell VP of Marketing Field Service Customer Service wcampbell@covaris.com, x2282 Laura Clark Events Manager Events (Planning to Execution) Social Media, Leads lclark@covaris.com, x2290 Roman Rodriguez Director of Marketing Technical Marketing Product Management rrodriguez@covaris.com, x2206 Steve Stefanak Creative Design Manager Collateral, Web, Slides Distributor Portal (News, Events, Collateral) sstefanak@covaris.com, x2223 Bruce Zhang Senior BD Manager, APAC Instruments, Consumables, Reagents Training and customer visits bzhang@covaris.com Patrice Bilesimo Technical Marketing Manager Product value propositions and development pbilesimo@covaris.com Brittany Melanson Marketing Manager Email, Web, Social, Collateral Communications bmelanson@covaris.com, x2298 Quyen Nguyen Associate Product Manager (starts July 8th) Product launch and lifecycle qnguyen@covaris.com Proprietary 5

6. Schedule Proprietary 6

7. Schedule Proprietary 7

8. Schedule Proprietary 8

9. AFA Technology Patented technology (>75 patents) No one has the same process We are only competing with ourselves (enzymes cannot condition, normalize, clean the sample) Expertise in mechanical engineering, acoustic physics, biophysics, molecular biology Adaptive Focused Acoustics Adaptive Made for the sample, not for welding or polishing jewelry Low power, high power, index, pulse, scan, etc. Large format, microTUBE, AFA-TUBE TPX, 5 uL, 384 well, etc. Sample vessel, sample type, solvent type Focused Least amount of energy to reach 1 mPa threshold for cavitation Not a sonicator Isothermal, scalable Acoustics Technology drives our company What applications to focus on with the technology High-throughput, clinical samples disruption dissociation dissolution dissolution Proprietary 9

10. APAC Growth Shifting into higher throughput systems ME220 LE220-plus, LE220R-plus, LE220Rsc 2020 R230, ML230 Consumables driving growth Marketing not a one-way street! What we have, where to find it, customize for you Reach out to us more often! Proprietary 10

11. Key Products Released in Last 12 Months truXTRAC FFPE Magnetic Bead Family tNA kit DNA Plus Kit RNA Plus kit total NA Plus kit total NA Plus 384 kit truPOP Cell Lysis Buffer LE220Rsc R230 2020 for most distributors including APAC 8 AFA-TUBE TPX strip 96 AFA-TUBE TPX plate biological / chemical objects sample preparation ? variable processes analysis & bioinformatics Proprietary 11

12. New Applications Enabled HTP, Clinical DNA Shearing FFPE extraction DNA, RNA, protein, chromatin Cell lysis Bacteria Yeast Human blood HMW DNA Proteomics High-throughput ChIP Automation Testimonials Shawn Levy, HudsonAlpha high DV200, low QNS Sean Glenn, OmniSeq low QNS Devin Rhodenizer, ARUP fully automated LE220R-plus Publications Kresse et al detection of gene fusions Robbe et al equivalent to fresh frozen Twist FFPE protocol sequence what was unsequencable Proprietary 12

13. Planned New Product Releases ML230 Distribution - 2020 New electronics (R230), 8 samples processed simultaneously DNA Shearing microTUBE-50 AFA-TUBE TPX microTUBE-130 Lysis AFA-TUBE TPX FFPE microTUBE-130 (one bead) ChIP microTUBE-130 Mostly 8-strip; could be 4-strip for larger volumes Proprietary 13

14. New Developments ME220 - Illumina is recommending the Covaris ME220 with microTUBE-50 upfront of the TSO500 panel AFA-TUBE TPX DNA shearing at low volumes 5 to 50 uL currently on LE220-plus (R230) Cell lysis (bacteria, yeast, blood) Drives the R230, LE220Rsc (scan a plate) Automation LE220R-plus robotic integration LE220Rsc robotic integration R230 liquid handler; more than DNA shearing Proprietary 14

15. 3 Key Takeaways The acoustic circuit is driven by Covaris technology Instruments, consumables, reagents Quality is most important DV200 FRQ (Functional RNA Quantitation) Proteomics all proteins Microbiome all species Cell lysis HMW, sheared, metabolites, many microorganisms Covaris is more than DNA fragmentation The Science of Sample Prep Conditioning and normalization Standardize the primary solvent layer Applications Chromatin shearing, FFPE extraction, cell lysis, compound dissolution, bead mixing, much more You tell us! Proprietary 15

16. Questions? Proprietary 16