Biphasic Decay of Infectious SARS-CoV-2 Population

This study analyzes the biphasic decay of infectious SARS-CoV-2 populations on different surfaces. The data shows variations in the decay rates of the virus on materials such as glass, banknotes, stainless steel, plastic, and mask layers. The findings reveal differing half-lives and decay patterns, providing insights into the persistence of the virus on various surfaces.

• Infectious disease
• SARS-CoV-2
• Decay rates
• Surface transmission
• Virus persistence

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Uploaded on Dec 14, 2024 | 0 Views

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1. Appendix: Biphasic decay of infectious SARS-CoV-2 population A) Glass 1.0E+07 1.0E+06 1.0E+05 TCID50/ml 1.0E+04 1.0E+03 1.0E+02 1.0E+01 1.0E+00 0 10 20 30 40 50 60 Time (h) Short half-life Long half-life 1.0E+07 1.0E+06 1.0E+06 1.0E+05 1.0E+05 1.0E+04 y = 807557e-0.572x R = 0.8603 TCID50/ml TCID50/ml 1.0E+04 1.0E+03 1.0E+03 1.0E+02 y = 217113e-0.143x R = 0.9333 1.0E+02 1.0E+01 1.0E+01 1.0E+00 1.0E+00 0 1 2 3 4 0 10 20 30 40 50 60 Time (h) Time (h) Half-life of free infectious SARS-CoV-2: 0 - 3 hr, T1/2 = 1.2 hr 3 hr - 2d, T1/2= 4.8 hr

2. B) Banknote 1.0E+07 1.0E+06 1.0E+05 TCID50/ml 1.0E+04 1.0E+03 1.0E+02 1.0E+01 1.0E+00 0 10 20 30 40 50 60 Time (h) Short half-life Long half-life 1.0E+05 1.0E+07 1.0E+06 1.0E+04 1.0E+05 TCID50/ml TCID50/ml 1.0E+03 1.0E+04 y = 1E+06e-0.783x R = 0.9914 y = 22422e-0.088x R = 0.9981 1.0E+03 1.0E+02 1.0E+02 1.0E+01 1.0E+01 1.0E+00 1.0E+00 0 2 4 6 8 0 10 20 30 40 50 60 Time (h) Time (h) 0 - 6 hr, T1/2 = 0.9 hr 6 hr - 2d, T1/2= 7.9 hr Half-life of free infectious SARS-CoV-2:

3. C) Stainless steel 1.0E+06 1.0E+05 1.0E+04 TCID50/ml 1.0E+03 1.0E+02 1.0E+01 1.0E+00 0 20 40 60 80 100 120 Time (h) Short half-life Long half-life 1.0E+06 1.0E+06 1.0E+05 1.0E+05 y = 636214e-2.616x R = 1 1.0E+04 1.0E+04 TCID50/ml TCID50/ml y = 196964e-0.047x R = 0.8982 1.0E+03 1.0E+03 1.0E+02 1.0E+02 1.0E+01 1.0E+01 1.0E+00 1.0E+00 0 0.2 0.4 0.6 0 20 40 60 80 100 120 Time (h) Time (h) Half-life of free infectious SARS-CoV-2: 0 -30 min, T1/2 = 30 min - 4d, T1/2= 0.3 hr 14.7 hr

4. D) Plastic 1.0E+06 1.0E+05 1.0E+04 TCID50/ml 1.0E+03 1.0E+02 1.0E+01 1.0E+00 0 20 40 60 80 100 120 Time (h) Short half-life Long half-life 1.0E+06 1.0E+05 1.0E+05 1.0E+04 y = 765950e-0.445x R = 0.938 1.0E+04 TCID50/ml TCID50/ml 1.0E+03 1.0E+03 1.0E+02 1.0E+02 y = 38438e-0.061x R = 0.9827 1.0E+01 1.0E+01 1.0E+00 1.0E+00 0 2 4 6 8 0 20 40 60 80 100 120 Time (h) Time (h) Half-life of free infectious SARS-CoV-2: 0 - 6 hr, T1/2 = 1.6 hr 6 hr - 4 d, T1/2= 11.4 hr

5. E) Mask, inner layer 5000000 4500000 4000000 3500000 TCID50/ml 3000000 2500000 2000000 1500000 1000000 500000 0 0 20 40 60 80 100 120 Time (h) Long half-life Short half-life 1.0E+07 1.0E+06 1.0E+06 1.0E+05 1.0E+05 y = 1E+06e-0.697x R = 0.886 1.0E+04 TCID50/ml TCID50/ml 1.0E+04 1.0E+03 1.0E+03 1.0E+02 1.0E+02 y = 137578e-0.07x R = 0.9776 1.0E+01 1.0E+01 1.0E+00 1.0E+00 0 50 100 150 0 1 2 3 4 Time (h) Time (h) 0-3hr, T1/2 = 1.0hr 6hr-4d, T1/2= Half-life of free infectious SARS-CoV-2: 9.9hr

6. F) Mask, outer layer 1.0E+06 1.0E+05 1.0E+04 TCID50/ml 1.0E+03 1.0E+02 1.0E+01 1.0E+00 0 20 40 60 80 100 120 140 160 180 Time (h) Long half-life Short half-life 1.0E+06 1.0E+06 1.0E+05 1.0E+05 y = 123363e-0.029x R = 0.9531 y = 667911e-0.499x R = 0.9666 1.0E+04 1.0E+04 TCID50/ml TCID50/ml 1.0E+03 1.0E+03 1.0E+02 1.0E+02 1.0E+01 1.0E+01 1.0E+00 1.0E+00 0 1 2 3 4 0 50 100 150 200 Time (h) Time (h) Half-life of free infectious SARS-CoV-2: 0 - 3 hr, T1/2 = 1.4 hr 3 hr - 7 d, T1/2= 23.9 hr