This study presents findings from the PROSPECTOR clinical trial on the prevalence of the KIT D816V mutation in the peripheral blood of patients with systemic mast cell activation. The study involves multiple centers globally and sheds light on the significance of this mutation in systemic mastocytos

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Systemic mycoses are fungal infections caused by dimorphic fungi such as Histoplasma capsulatum, Blastomyces dermatitidis, and Cryptococcus neoformans. Histoplasmosis is transmitted through inhalation of spores from soil or bat-infested caves, presenting with tuberculate macroconidia and microconidi

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Explore the cutaneous manifestations of systemic diseases, particularly focusing on endocrine disorders like diabetes mellitus. Learn about the dermatologic signs associated with conditions such as hypothyroidism, hyperthyroidism, Addison's disease, and Cushing syndrome. Discover specific manifestat

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This study explores medication adherence among individuals with Multiple Sclerosis (MS), presenting insights from observation to intervention stages. It delves into the background of MS, adherence, Disease-Modifying Therapies (DMTs), and the challenges faced. The team identifies reasons for non-adhe

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Explore the role of language in everyday life, the principles of Systemic Functional Linguistics, and the application of discourse analysis in translation. Delve into the Hallidayan model of language and discourse, examining genre, register, sociocultural environment, and more.

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Explore the complexities of racism, systemic issues, and white fragility in community engagement and research collaborations. Delve into the importance of acknowledging white privilege and understanding systemic racism, focusing on the need for white individuals to actively participate in conversati

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Explore diverse perspectives on racism and racial disparities through personal narratives and societal observations. Engage in conversations about identity, cultural heritage, and confronting biases. Witness the impact of historical patterns and systemic injustices on individuals and communities, wi

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Local anesthetics are crucial in anesthesia for their ability to prevent nerve depolarization, but systemic toxicity can lead to serious complications. Last Causes, signs, and max dosage discussion along with the importance of recognizing early signs like lightheadedness, tinnitus, and late symptoms

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Explore the world of fungi and fungal infections in this foundation block of microbiology. Learn about medically important yeasts, mold fungi, major fungal diseases, antifungal agents, and infection acquisition methods. Dive into hypersensitivity reactions, mycotoxicoses, and various types of fungal

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The 2020 Disparity Study, presented by Mr. Kevin Williams and Ms. Betsy Sava from BBC, delves into the investigation of systemic discrimination in business practices. The study combines statistical evidence with anecdotal research to highlight disparities and barriers faced by minority-owned busines

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Systemic sclerosis (SScl) is an autoimmune disorder affecting connective tissue, leading to fibrosis in the skin, internal organs, and vasculature. It is characterized by Raynaud's phenomenon, digital ischemia, sclerodactyly, and cardiac, lung, gut, and renal involvement. Peak onset is in the fourth

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Explore the cellular processes, symptoms, disease progression, and treatment options associated with Multiple Sclerosis (MS). Discover how MS, an autoimmune disease, affects the nervous system leading to a range of symptoms. Learn about the clinical progression of MS and how the immune system causes

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Gain insight into the systemic inequalities faced by immigrant communities in Greater Manchester, including definitions of refugees and asylum seekers, a snapshot of refugee and migrant communities in Manchester, the Iranian diaspora in the UK, global migrant statistics, and common health issues fac

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Human Immunodeficiency Virus (HIV) is a retrovirus causing Acquired Immunodeficiency Syndrome (AIDS). HIV leads to immune system destruction, making individuals vulnerable to opportunistic infections and tumors. Common sexually transmitted diseases like syphilis, chlamydia, and gonorrhea are discuss

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Explore the various stages of wound infections on a continuum from contamination to systemic infection. Learn how to identify and manage each stage, from presence of microbes to invasion of surrounding tissues. Discover the subtle signs of local and spreading infections, and the serious implications

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Systemic Anti-Cancer Therapy (SACT) involves chemotherapy and targeted agents for cancer treatment. Risks include errors with non-accredited staff, incomplete prescriptions, incorrect dosing, and patient education deficiencies. Safe practice principles emphasize specialist care, established protocol

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Assessing the decade of financial regulation reveals improvements in bank capitalization and systemic risk management. However, challenges remain with sovereign debt levels, low interest rates, and political support for further reforms. The discussion also looks ahead to potential future crises orig

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Assessment is integral to everyday learning, not just formal education. It involves questioning and making judgments, whether in tasting soup or raising a child. This presentation delves into the meaning of quality education, assessment, and their role in curriculum, educational reforms, and sustain

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Educational Psychologists (EPs) play a vital role in supporting children and young people, families, and schools by addressing concerns that impact learning and mental health. They work collaboratively with Mental Health Support Teams (MHSTs) to provide systemic interventions and contribute to the o

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Exploring the challenges white people face in discussing racism, "White Fragility" by Robin DiAngelo sheds light on the systemic issues shaping our lives. It emphasizes the need for white individuals to confront their role in upholding racism, strive for racial humility, and work towards interruptin

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Systemic steroids, potent immunosuppressive and anti-inflammatory agents, play a crucial role in dermatological therapy. This article discusses the pharmacology, mechanism of action, cellular effects, and clinical applications of glucocorticoids. It covers topics such as cortisol synthesis, glucocor

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This presentation by Dr. Ruchi Dua, Associate Professor at Aiims Rishikesh, delves into the complications of tuberculosis including local and systemic effects, as well as various presentations of extrapulmonary TB. Topics covered include common complications like respiratory failure, pleural effusio

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The U.S. Poverty Domestic Housing Policy Forum held on March 17, 2022, shed light on the deep-rooted oppression and discrimination impacting housing policies. The forum emphasized the importance of combating racism, classism, and other oppressions to effectively address poverty. It highlighted the d

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Empowerment through systemic change grants is a focus of the Society of St. Vincent de Paul National Council. The initiative aims to shift conditions perpetuating poverty, with an emphasis on long-term impact, engagement, sustainability, replicability, innovation, collaboration, and being data-drive

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This presentation explores how various factors in both inside and outside environments can influence the development and progression of Multiple Sclerosis (MS). Topics covered include the gut microbiome, Epstein-Barr virus, obesity, tobacco use, vitamin D levels, exposure to organic solvents, and sh

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This content delves into the crucial role of litigation in combatting systemic discrimination, particularly in the context of under-representation of women in male-dominated work environments. It emphasizes the need for multiple strategies, including legal action, to address discriminatory barriers

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This content explores various systemic diseases and their oral manifestations relevant to dentistry. It covers associations between heart disease and periodontal disease, effects of chronic corticosteroid use on the pulmonary system, endocrine disorders like diabetes and thyroid issues, autoimmune d

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Development of a comprehensive guidebook for supported living services aimed at individuals with I/DD, their families, providers, and community stakeholders. The initiative focuses on identifying and addressing systemic barriers hindering the utilization of supported living services, with goals to p

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Portal vein imaging is crucial for evaluating conditions affecting the abdominal part of the gastrointestinal tract. Techniques such as spleno-portography and CT triphasic contrast imaging are used to visualize the portal vein and diagnose anomalies like portal-systemic collaterals and porto-systemi

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Systemic diseases, disorders, and conditions can affect the periodontium by impairing the host's barrier function and immunity, leading to periodontal destruction. Endocrine disorders like diabetes mellitus and hormonal changes, as well as female sex hormones during puberty, menstruation, pregnancy,

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The relationship between oral health and systemic diseases is significant, with manifestations within the oral cavity providing clues to underlying systemic issues. Disease processes involve aspects like etiology, pathogenesis, morphologic changes, and clinical significance. Organisms and toxins spr

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A study presented at the Consortium of Multiple Sclerosis Centers showed that ublituximab significantly improved fatigue in patients with multiple sclerosis. The research highlighted the impact of MS-related fatigue on patients' quality of life and daily activities. ULTIMATE I and II trials compared

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This study discusses systemic climate risk in the financial sector by examining the effects of climate risks on financial institutions. It aims to design a market-based framework to assess the vulnerability of financial institutions to climate risks and analyze potential contagion effects. The frame

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This lecture series discusses the various skin manifestations of connective tissue diseases, focusing on Lupus Erythematosus and other related conditions. It covers different types of Lupus, its effects on the body systems, treatment options, and psychosocial impacts. Additionally, the presentation

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Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons, leading to muscle weakness and various symptoms. This case study focuses on Judy, a 52-year-old woman diagnosed with ALS, detailing her symptoms, progression, exercise routine, assistive device us

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A 42-year-old African American male with a history of Multiple Sclerosis presented with a fever of unknown origin, challenging the medical team to identify the underlying cause despite multiple investigations, treatments, and consultations. His complex medical history, including prior UTI treatment

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Recent clinical trials for systemic sclerosis (SSc) show progress in utilizing broad immunosuppression for SSc skin and lung conditions. New treatments such as Nintedanib, Lenabasum, and Lanifibranor offer hope for improved outcomes. Research focuses on defining pathogenesis and exploring targeted t

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Explore the systemic change approach to combating unjust structures that oppress individuals living in poverty. Delve into understanding systems as interconnected wholes and the significance of systemic thinking in driving transformation. Uncover the complexities of social systems and the need to ac

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Juvenile Idiopathic Arthritis (JIA) is arthritis of unknown origin that starts before the 16th birthday and lasts at least 6 weeks. It was previously known as juvenile rheumatoid arthritis (JRA). The diagnosis of JIA requires meeting specific criteria, and it can be classified into various subtypes

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This study by I. Trapina aims to investigate the prevalence and functionality of SNPs in proteasome genes to assess their potential as molecular markers for multiple sclerosis in the Latvian population. Multiple sclerosis is an autoimmune disease affecting the central nervous system, and the role of

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