Sglt2 inhibitors - PowerPoint PPT Presentation

Consultant Nephrologist Paraskevi Liaveri discusses the association between SGLT-2 inhibitors and acute kidney injury (AKI). Pharmacovigilance reports highlight a higher risk of AKI with these drugs, especially when combined with RAAS blockers, diuretics, or NSAIDs. Studies suggest potential mechani

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Human heart development begins in the 3rd week of gestation with the formation of heart tubes that eventually differentiate into various cardiac structures. The heart undergoes folding and septation processes during development, leading to the formation of crucial septa. Molecular regulation, involv

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Major lipids like cholesterol and triglycerides play essential roles in the body, but their excess can lead to hyperlipidemia and related conditions. This overview covers the biosynthesis of cholesterol, triglycerides, and the transport of lipids in the bloodstream, discussing the importance of lipo

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The AMPK system plays a crucial role in regulating energy homeostasis by sensing the cellular AMP:ATP ratio and responding to metabolic stresses that affect ATP production or consumption. AMPK is activated by factors such as hypoxia, glucose deprivation, and metabolic inhibitors, as well as by compo

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COX enzymes, including COX1, COX2, and COX3, play a crucial role in synthesizing prostanoids like prostaglandins in the body, affecting pain and inflammation. By inhibiting these enzymes, relief from pain and inflammation can be achieved. However, non-selective COX inhibitors may lead to various sid

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This presentation covers drugs for hyperlipidemia, including bile acid sequestrants, cholesterol absorption inhibitors, statins, fibrates, and relevant drug interactions. It details the actions, adverse effects, contraindications, and notable considerations for each drug class. The included multiple

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Enzyme activity is influenced by various factors such as enzyme concentration, temperature, pH, substrate concentration, inhibitors, activators, and physical agents. The rate of enzyme-catalyzed reactions is directly proportional to enzyme concentration, and temperature plays a significant role with

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Define oxidation, reduction, oxidizing agent, reducing agent, standard electrode potential, Nernst equation, and corrosion in the context of chemical engineering. Discuss different forms of corrosion, including uniform corrosion, galvanic corrosion, pitting corrosion, and stress corrosion. Explore m

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Explore the classification of antihypertensive agents used in treating hypertension, including beta blockers, centrally acting agents, ganglionic blockers, ACE inhibitors, vasodilators, and more. Learn about the Renin-Angiotensin System, ACE inhibitors, and specific drugs like Captopril and Benazepr

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Pet Food Ingredients Market By Pet (Dog, Cat, Fish, and Others), By Ingredients (Specialty Proteins, Amino Acids, Mold Inhibitors, Gut Health Ingredients, Phosphates, Vitamins, Acidifiers, Carotenoids, Enzymes, Mycotoxin Detoxifiers, Flavors & Sweete

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Cognitive enhancers play a crucial role in managing Alzheimer's Disease, with Cholinesterase inhibitors (AChEI) like Donepezil, Galantamine, and Rivastigmine recommended for mild to moderate AD, and Memantine for moderate to severe cases. These medications act through different mechanisms, with AChE

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Explore the factors influencing enzyme activity, such as substrate and enzyme concentration, temperature, pH, and inhibitors. Learn how to simulate enzyme kinetics using equipment like popping beads and stopwatches. Analyze results to understand the impact of substrate concentration on reaction rate

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The development of antimicrobial drugs has significantly improved therapeutics by controlling infections and preventing complications. These drugs target invading microorganisms using selective toxicity, sparing host cells. Antimicrobial drugs are classified based on site, mechanism of action, and c

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Enzyme inhibition plays a crucial role in pharmacology and biochemistry by regulating enzymatic reactions. Inhibitors can be reversible or irreversible, affecting enzyme activity differently. Competitive, uncompetitive, and noncompetitive inhibition types are explained along with examples like diiso

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Nitric oxide (NO), a vital molecule formed from arginine, plays diverse roles in the body including vasodilation, neurotransmission, platelet regulation, and immune response. Its formation involves a complex enzyme called nitrogen oxide synthase. Various inhibitors and clinical implications, such as

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The DAPA-HF trial investigated the use of dapagliflozin, an SGLT2 inhibitor, in patients with heart failure and reduced ejection fraction, regardless of diabetes status. Funded by AstraZeneca, the study enrolled 4,744 patients from 20 countries, showing promising results in reducing cardiovascular d

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In this experiment, the effect of inhibitors on enzymatic reactions, specifically acid phosphatase, is explored. Different types of inhibition (competitive, noncompetitive, uncompetitive) are examined, along with reversible and irreversible inhibitors. The study aims to determine the type of inhibit

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The British Association of Dermatologists conducted a national clinical audit program in 2015 to evaluate atopic eczema in children based on NICE guidelines. The audit included contributions from BAD and BSPD members, as well as private providers. It involved 128 submissions from 98 centers, with 12

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Antibiotic prescribing in patients on protein pump inhibitors (PPIs) is associated with an increased risk of Clostridium difficile infection. A review was conducted on high-risk antibiotic prescriptions, revealing instances where patients were prescribed against guidelines, leading to potential comp

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Antipsychotics and antidepressants play crucial roles in treating psychological and affective disorders in veterinary medicine. Antidepressants are vital in managing abnormal mood and behavior linked to depression, while antipsychotics help address various nervous disorders. The classification of an

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Highlighting the current guideline recommendations for treating patients with Heart Failure with Reduced Ejection Fraction (HFrEF), this educational slide module emphasizes the importance of implementing the recommended therapies effectively. It covers the foundational treatments recommended by vari

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Dormancy in plants, involving seeds and buds, is a state where growth is temporarily halted due to internal or external factors. Factors like immature embryos, impermeable seed coats, and growth inhibitors contribute to seed dormancy. The presence of inhibitors like abscisic acid and the influence o

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Discover how PDE-5 inhibitors go beyond treating erectile dysfunction, with approved and emerging compounds, alternative dose regimens, concentration sites, and potential targets like cardiovascular diseases and the central nervous system.

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Exploring the use of mTOR inhibitors in liver transplantation for hepatocellular carcinoma (HCC), this content presents recent study results and experiences from the Korean population. It discusses the preventive potential of mTOR inhibitors in HCC recurrence based on previous studies and the need f

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This educational slide module provides an overview of the guideline recommendations for SGLT2 inhibitors in the treatment of heart failure, including HFrEF, HFmrEF, and HFpEF. It covers recommendations from AHA, ACC, HFSA, ESC, CCS, and CHFS guidelines, highlighting the role of SGLT2 inhibitors as a

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In this detailed overview, we explore antifungal inhibitors and drugs, including their mechanisms of action, impact on eukaryotes and prokaryotes, common agents affecting fungal sterols and cell walls, as well as synthetic antifungals. From polyenes like nystatin to azoles such as voriconazole, this

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Organisms carefully control enzyme production and activation as per varying needs and conditions within cells. Enzyme activity is influenced by factors such as pH, temperature, regulatory molecules, cofactors, compartmentalization, covalent modification, and feedback inhibition. Enzymes can be regul

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This study compares the efficacy and safety of different protease inhibitors (PIs) including ATV, ATV/r, LPV/r, FPV/r, DRV/r, and SQV/r in HIV treatment. The ARTEMIS study specifically focuses on comparing DRV/r and LPV/r in combination with TDF/FTC in ARV-naive patients. Results show non-inferiorit

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Explore the selection and sequence of therapy for ER-positive, HER2-negative metastatic breast cancer, along with novel agents and strategies under evaluation. Learn about cases of postmenopausal women with metastatic breast cancer, CDK4/6 inhibitors, and the impact of targeted therapies on patient

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PCSK9 inhibitors are a novel class of medications that help lower LDL cholesterol levels, reducing the risk of cardiovascular events. This article covers their mechanism of action, patient groups benefiting from them, efficacy in LDL-C lowering, and safety considerations. Learn how PCSK9 inhibitors

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Coagulation screening involves tests like Prothrombin Time (PT) and Thrombin Time, which assess different pathways in blood clotting. PT measures factors like VII, V, X, prothrombin, and fibrinogen to evaluate coagulation integrity. Understanding the interpretation of PT results is crucial in identi

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Potent P2Y12 inhibitors like ticagrelor have shown significant reduction in ischaemic events compared to clopidogrel in acute myocardial infarction patients. Despite the strong antiplatelet efficacy, there is a higher bleeding risk associated with potent P2Y12 inhibitors, prompting the exploration o

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In this comprehensive presentation, Dr. Gza T. Terzhalmy discusses Gastroesophageal Reflux Disease (GERD) and Peptic Ulcer Disease (PUD). Explore the mechanisms of action of proton pump inhibitors, risk assessment factors, symptoms of GERD and PUD, treatment strategies, and more. Gain insights into

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This content delves into the use of antibiotics beyond beta-lactam antibiotics in biotechnology, focusing on cell wall inhibitors like Vancomycin, Cycloserine, and Bacitracin, along with anti-tuberculosis agents such as Isoniazid and Ethambutol. It explains their mechanisms of action, sources, and a

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Adverse effects of immune checkpoint inhibitors, focusing on a case study of immune-mediated colitis in a 61-year-old woman undergoing combination ICI therapy. Covers investigations, management strategies, and clinical lessons for handling immune-related adverse events.

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This study aims to evaluate the impact of GLP-1 receptor agonists, DPP-4 inhibitors, and SGLT-2 inhibitors on COPD exacerbations in patients with COPD and type 2 diabetes. The research methodology, inclusion and exclusion criteria, exposure definition, and follow-up endpoints are detailed, providing

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In the field of HIV treatment, switching to integrase strand transfer inhibitors (INSTI) and non-nucleoside reverse transcriptase inhibitors (NNRTI) has been studied extensively. The SWORD Study examined the switch to dolutegravir (DTG) plus rilpivirine (RPV) while the LATTE-2 Study focused on the s

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These Phase III trials evaluate the efficacy of Obinutuzumab in combination with other agents for different types of lymphoma, showing promising results in terms of progression-free survival (PFS) and overall survival (OS). The studies compare Obinutuzumab with Bendamustine, Rituximab, and CHOP regi

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Highlights from the EHA2023 Hybrid Congress discussing the latest updates on BTK inhibitors for Mantle Cell Lymphoma (MCL) presented by Amin SULAIMAN. The phase II IMCL-2015 GELTAMO trial's 5-year update on first-line Ibrutinib with Rituximab for indolent MCL is detailed, along with baseline charact

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This content by Hala Aqeel Shams delves into the topic of Protein Synthesis Inhibitors. It covers various aspects of inhibiting protein synthesis and its implications in the field of clinical pharmacology. The author's detailed exploration provides valuable insights for those studying or working in

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