Understanding Liver Function Tests in Cholestatic Injury
Cholestatic liver disease affects Alkaline Phosphatase (ALP) and bilirubin levels, indicating bile duct damage. GGT and 5'-Nucleotidase help differentiate hepatobiliary vs. bone origin of ALP elevation. ALP is produced by bile duct epithelium and can be normal in acute biliary obstruction. GGT and N
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Understanding Steatotic Liver Disease: Importance, Epidemiology, and Pathology
Steatotic liver disease, including metabolic dysfunction associated steatohepatitis (MASLD) and metabolic associated alcoholic liver disease (MALD), is a common cause of liver test abnormalities in the United States. Risk factors such as obesity and metabolic syndrome can lead to advanced fibrosis a
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Liver Transplant in India for treatment
Liver is the largest gland in our body, and an important metabolic organ which carries out many essential biological functions. The liver is a wedge-shaped, reddish-brown in color with two lobes of different size and shape. The approximate weight of a human liver is 1.5 kilograms. It is in the upper
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Understanding Liver Complications in Cystic Fibrosis: Latest Insights for 2024
Liver complications in cystic fibrosis (CF) have gained importance due to CFTR modulators impacting liver health. This presentation by Dr. Zachary M. Sellers delves into new definitions for CF liver disease, CFF recommendations for screening, management, and treatment of hepatobiliary issues in CF.
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Best Liver transplant hospitals in India
Best Liver Transplant Hospitals in India\nThe liver is a vital organ that performs important functions in the human body, including detoxification, metabolism, and the production of essential proteins. However, certain conditions such as liver failure, cirrhosis, or liver cancer may necessitate a li
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Bone Marrow Transplant Cost in India
The supple, fatty tissue found inside your bones is called bone marrow. The cells that make blood and platelets are found in bone marrow, which also produces billions of new blood cells daily.\nA bone marrow transplant (BMT) includes using healthy blood-forming stem cells to replace the patients' di
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Nutrition and Obesity in Pre/Post-Transplant Care by Kim Flack MS, RD, CNSC, LDN
This educational material highlights the crucial role of nutrition in the pre/post-transplant phases, focusing on the evaluation, challenges, and strategies for optimizing nutrition before and after liver transplantation. It addresses the limitations of BMI in assessing nutritional status, the preva
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Histological Structure of Liver and Spleen: Key Features and Functions
In this informative content, the histological structures of the liver and spleen are explored in detail. Key components such as hepatocytes, sinusoids, bile canaliculi, and the spaces of Disse in the liver, and the white pulp and red pulp in the spleen are highlighted. The classic liver lobule, cent
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Liver Transplantation Report 2021/22 Statistics & Research Findings
The Annual Report on Liver Transplantation 2021/22 presents detailed statistics and clinical research findings from the NHS Blood and Transplant BLTG Transplant Meeting in September 2022. The report covers an overview, transplant list, donor and organ supply, transplant activity, and outcomes. It hi
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Expedited Organ Placement Concept Paper - Addressing Critical Transplant System Issues
This concept paper outlines a proposal to address key challenges in the current organ transplant system, such as lack of transparency and consistency in organ placement. The focus is on developing an expedited placement system with specific triggers and qualifications to improve access to organs for
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Liver Services at Imperial College Healthcare NHS Trust
The liver services at Imperial College Healthcare NHS Trust, led by Dr. Ameet Dhar, provide a comprehensive range of services for patients with liver conditions. With over 2000 new patients seen annually, services include inpatient care, specialist clinics, outreach programs, and referral pathways.
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Understanding Abnormal Liver Function Tests: Insights from Dr. Heather Lewis, Consultant Hepatologist
Abnormal liver function tests can be a perplexing issue with various underlying causes. Dr. Heather Lewis, a renowned Consultant Hepatologist at Imperial College Healthcare NHS Trust, sheds light on the significance of liver function tests, liver enzymes, and blood markers in diagnosing liver condit
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Evaluation and Management of Incidental Liver Lesions
Understanding the natural history, evaluation, and management of benign liver lesions is crucial for diagnosing incidental liver findings. Common benign liver lesions include hepatic hemangioma, focal nodular hyperplasia, hepatic adenoma, and hepatic cyst. Differential diagnosis plays a key role in
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Insights into Liver Anatomy, Function, and Imaging Studies
Delve into a comprehensive overview of the liver's anatomy, including ligaments, blood supply, and structure in the hilum. Explore the vital functions performed by the liver, such as maintaining body temperature, synthesizing clotting factors, and drug metabolism. Discover liver function tests and t
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Canadian Cardiac Transplant Network Status Review 2021
The Canadian Cardiac Transplant Network Status Review 2021 provides a detailed overview of cardiac transplant programs across various provinces in Canada from 2016 to 2021. The report includes data on the number of cases, hospitals involved, and referral centers, showcasing the trends in cardiac tra
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Evolution of Liver Biopsy in Children: ESPGHAN Position Paper
Liver biopsy plays a crucial role in diagnosing, staging, and prognostic evaluation of liver diseases in children. Indications for liver biopsy include diagnostic, prognostic, and monitoring purposes. Specific scenarios like neonatal cholestasis and progressive familial intrahepatic cholestasis requ
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Understanding Liver Detoxification and Harmony in Traditional Chinese Medicine
The liver plays a crucial role in detoxification and maintaining harmony in the body according to Traditional Chinese Medicine (TCM). Issues like liver disharmony can lead to various symptoms and health conditions. TCM emphasizes the importance of supporting liver function for overall well-being by
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NGM282 in NASH: Phase 2 Study on Liver Fat Reduction and Histology Changes
A phase 2 study on NGM282 in NASH patients showed a significant decrease in liver fat content, meeting the primary endpoint. Exploratory findings also indicated potential improvements in liver histology. The treatment involved NGM282 at 3 mg QD, with additional rosuvastatin if needed. Promising resu
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Understanding Abnormal Liver Function Tests: Acute vs. Chronic Approach
Comprehensive discussion on assessing patients with abnormal liver test results, focusing on distinguishing between acute and chronic liver conditions. Covers diagnostic workup, patient cases, and differential diagnosis, emphasizing the importance of patient history, physical examination, and key di
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Organ Offer Management at Keck USC Transplant Institute
Keck USC Transplant Institute is a multi-organ transplant center with a dedicated team managing organ offers. The team structure includes RN-Transplant Coordinators, Call Team Managers, and Donor Allocation Specialists. They handle a range of tasks from reviewing offers with physicians/surgeons to p
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Anaesthetic Management of 11-Year-Old Female with End-Stage Renal Disease (ESRD) for Renal Transplant and Ileal Conduit
An 11-year-old female child with end-stage renal disease (ESRD) and multiple surgical histories was evaluated for renal transplant and ileal conduit surgery. The patient presented with hypertension, chronic kidney disease, neurogenic bladder, and urinary incontinence. Preoperative assessments reveal
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National Liver Review Board: Solving Inconsistencies in Transplant Approvals
The National Liver Review Board, led by Dr. Ryutaro Hirose at the University of California, San Francisco, aims to address inconsistencies in liver transplant applications and approvals across UNOS regions. The board focuses on eliminating disparities in acceptance rates, refining approval practices
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CYNOBIL Liver Capsules – Boost Liver Health & Detox | LYF Healthcare
CYNOBIL liver capsules offer comprehensive liver support with a natural blend of silymarin, artichoke extract, and NAC. Improve liver function, detox, and digestion with CYNOBIL by LYF Healthcare.\n
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Analysis of Kidney Transplant Trends in End-Stage Renal Disease Patients (1996-2013)
This report delves into the trends surrounding kidney transplants in end-stage renal disease (ESRD) patients from 1996 to 2013. It looks at the percentage of dialysis patients wait-listed, unadjusted kidney transplant rates, number of patients wait-listed for kidney transplants, transplant counts, p
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Proposal for Expedited Placement of Livers in OPO Committee
This proposal aims to address the lack of policies regarding expedited placement of livers, leading to inconsistencies in access for transplant candidates. The solutions include creating a system for expediting liver offers, focusing on in-OR turndowns, and implementing opt-in criteria for transplan
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Proposal to Delay HCC Exception Score Assignment in Liver and Intestine Committee
The proposal aims to postpone the assignment of HCC exception scores to achieve balance in dropout and transplant rates between HCC and non-HCC liver transplant candidates. By adjusting the score calculation schedule and considering supporting evidence, the goal is to promote equalization in the tra
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Principles and Management of Acute Liver Disorders by Consultant Hepatologist
This presentation discusses the principles, causes, presentations, management, and prognosis of acute liver disorders, with a focus on insult to the normal liver leading to liver injury, inflammation, and necrosis. It covers causes such as drugs, viruses, ischemia, autoimmune conditions, Budd-Chiari
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Understanding Acute Liver Disorders: Causes, Presentations, and Management
Acute liver disorders can have various causes such as drugs, viruses, ischemia, autoimmune conditions, and more. The presentations of acute liver disease can include abnormal liver tests, jaundice, liver impairment, and even liver failure. Management involves removing and treating the underlying cau
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Understanding Drug-Induced Liver Injury (DILI) and Its Implications
Drug-Induced Liver Injury (DILI) is a serious concern that can lead to fatal liver damage, affecting drug development and potentially causing market withdrawal. This article explores the importance of DILI awareness, the critical functions of the liver, common causes of liver failure, and the backgr
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Managing Abnormal Liver Function Tests in Primary Care: Summary Guideline
Guideline drafted by Dr. Sally Hull and Dr. Lucy Carter focuses on identifying patients at risk of chronic liver disease, increasing testing for treatable liver conditions, and auditing prevalence of major liver diseases. The importance of diagnosing Non-Alcoholic Fatty Liver Disease (NAFLD) and str
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Liver Disease Burden in Tower Hamlets
Dr. Somen Banerjee, Director of Public Health in London Borough Tower Hamlets, highlights the concerning liver disease mortality rates in the area, with high incidence of cirrhosis, cancer, and hepatitis B and C. The data reveals a significant burden of liver diseases such as Non-Alcoholic Fatty Liv
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Understanding Liver Function Tests and Their Significance
The liver carries out essential metabolic, excretory, protective, synthetic, and storage functions in the body. Liver function tests play a crucial role in screening for liver dysfunction, recognizing patterns of liver disease, assessing patient prognosis, monitoring disease progression, and evaluat
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Efficacy of Ombitasvir-Paritaprevir-Ritonavir and Dasabuvir with Ribavirin in Liver Transplant Recipients with Recurrent HCV GT1
The CORAL-I trial evaluated the safety and efficacy of the 3D regimen (ombitasvir-paritaprevir-ritonavir + dasabuvir) combined with ribavirin for 24 weeks in liver transplant recipients with recurrent HCV genotype 1. The study included treatment-naive individuals after transplantation, with specific
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Understanding Drug-Induced Liver Injury (DILI)
Drug-induced liver injury (DILI) can present as cholestasis, hepatocyte necrosis, steatosis, vascular damage, and hepatic fibrosis. Various drugs like antibiotics, NSAIDs, recreational drugs, and herbal remedies can cause liver damage. Recognizing DILI is crucial in patients with liver dysfunction o
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Overview of Common Surgical Liver Diseases and Portal Hypertension
The liver plays a crucial role in metabolism, coagulation, and immune function. Surgical diseases of the liver, such as liver cysts and cavernous haemangiomas, can impact its normal functions. Imaging modalities like ultrasound (US), CT scans, and MRI are essential for diagnosing and staging liver t
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Guidance for Patients with COVID-19 and Liver Disease Overview
This guidance provides detailed information on COVID-19 and liver disease, covering topics such as COVID-19 overview, liver test abnormalities, co-morbidities, viral hepatitis B and C, metabolic dysfunction, autoimmune hepatitis, clinical care aspects, complications management, screening for HCC, an
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Elevated Resting Heart Rate in Heart Transplant Recipients: A Prognostic Indicator?
Elevated resting heart rate is being investigated as a potential adverse prognostic indicator in heart transplant recipients. This study aims to determine if sustained tachycardia increases the risk of all-cause mortality and cardiac allograft vasculopathy in these patients through a retrospective a
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Replication Kinetics in Post-Transplant CMV Infections
This study explores the variation in replication kinetics of Cytomegalovirus (CMV) during post-transplant infections. The aim is to assess the doubling time of CMV and evaluate the rationale behind weekly screening intervals in transplant recipients. Methods include analyzing CMV PCR samples and rev
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Liver Transplant in India
The Liver is one of the five Vital Organs in the human body. The Liver performs many important functions for the proper functioning of the Human Body. Any changes or abnormalities in liver tissues can affect the quality of life and may need medical t
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