Explore Zilebesiran, an investigational RNA interference therapeutic targeting hepatic AGT synthesis for hypertension. Primary findings from Phase 2 trial KARDIA-1 reveal sustained blood pressure reduction. Addressing the unmet need for innovative antihypertensive treatments.

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Steatotic liver disease, including metabolic dysfunction associated steatohepatitis (MASLD) and metabolic associated alcoholic liver disease (MALD), is a common cause of liver test abnormalities in the United States. Risk factors such as obesity and metabolic syndrome can lead to advanced fibrosis a

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Liver is the largest gland in our body, and an important metabolic organ which carries out many essential biological functions. The liver is a wedge-shaped, reddish-brown in color with two lobes of different size and shape. The approximate weight of a human liver is 1.5 kilograms. It is in the upper

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Explore the latest advancements in infectious disease control through the lens of renowned epidemiologists and researchers. Delve into the impact of the COVID-19 pandemic, the historical prevalence of infectious diseases, and early infection prevention practices. Uncover the evolution of infectious

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The natural history of disease development outlines the progression of a disease in an individual without intervention, from exposure to outcome. Learning objectives include defining prevention terms, understanding disease severity, prevention levels, and intervention measures. Studying disease prog

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Neuro diseases are very bad diseases. Many people are caught by Neuro diseases nowadays. It is related to brain diseases. Many people in India are caught by Neuro Diseases. It happens in Adults as well as children.\nA person of any age can be affected by this. Before this time very bad disease Named

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Acetaminophen poisoning occurs when the body is overwhelmed by high doses of the drug, leading to liver toxicity and potentially fatal consequences. The mechanism of toxicity involves the depletion of glutathione and the formation of a harmful metabolite, N-acetyl-para-benzoquinoneimine (NAPQI). Con

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Epidemiology is the study of disease patterns, factors influencing disease occurrence, and the core functions of surveillance, field investigation, and analytic studies. It involves understanding disease characteristics, natural history, and evaluating the effectiveness of activities to mitigate dis

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Test your knowledge on heart disease with this Heart Health Jeopardy game. Learn about heart disease facts, statistics, risk factors, and common types of heart diseases. Understand the importance of recognizing heart attack symptoms and the significance of factors like high blood pressure, high chol

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Fat Cow Syndrome, also known as Fatty Liver Disease in Cattle, is a condition commonly seen in high-producing cows during the transition period around calving. The disease is characterized by mobilization of excessive body fat to the liver due to negative energy balance, leading to hepatic lipidosis

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Tyzzer's disease is an acute bacterial infection affecting rodents and rabbits, caused by Clostridium piliforme. Discovered in 1917 by Ernest Tyzzer, the disease is characterized by necrotic lesions in the caecal mucosa, liver, and heart. Initially known as Bacillus piliformis, it was later renamed

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Early identification and separation of suspected Marburg virus disease patients play a crucial role in preventing the spread of the disease within healthcare settings. Screening and setting up specific areas for identification and isolation are essential steps to protect healthcare workers, patients

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Bilirubin, a yellow compound in the catabolic pathway, plays a crucial role in health. Estimating serum bilirubin levels is key in diagnosing conditions like jaundice. Elevated levels, above 2 mg/dl, can indicate disease. Jaundice, characterized by skin and eye discoloration, has pre-hepatic, hepati

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Malnutrition is common in chronic liver disease, leading to complications such as ascites and infections. Sarcopenia and weight loss are prevalent regardless of BMI. Critical care patients with liver disease face challenges due to limited physiological reserve, with main causes for ICU admission bei

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Nasopulmonary drug delivery system, utilizing the nasal route for drug administration, offers advantages such as hepatic first-pass metabolism avoidance and rapid drug absorption. This system is beneficial for pharmacologically active compounds with poor stability in gastrointestinal fluids. While i

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This article discusses disease control processes in epidemiology, including reducing disease incidence, duration, and transmission. It covers public policy interventions, elimination, eradication, and extinction of infectious agents. It also highlights preventable causes of disease and different lev

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Phenytoin, a medication with high protein binding and hepatic metabolism, exhibits saturated pharmacokinetics with a narrow therapeutic range of 10-20 µg/mL for total serum concentrations. Adverse effects vary with serum levels: minor CNS depression at >15 µg/mL, nystagmus at >20 µg/mL, and ataxi

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Challenging liver cirrhosis management in elderly patients with refractory ascites has high mortality rates, and transplantation is not always viable. Transjugular intrahepatic portosystemic shunt (TIPS) serves as a non-curative treatment option, aiming to reduce portal hypertension. The procedure i

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Veins play a crucial role in the circulatory system by carrying deoxygenated blood back to the heart. This lecture covers the general principles of veins, the anatomy of major veins like the superior and inferior vena cavae, tributaries, and their roles in different parts of the body. It also discus

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Understanding the natural history, evaluation, and management of benign liver lesions is crucial for diagnosing incidental liver findings. Common benign liver lesions include hepatic hemangioma, focal nodular hyperplasia, hepatic adenoma, and hepatic cyst. Differential diagnosis plays a key role in

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Portal vein imaging is crucial for evaluating conditions affecting the abdominal part of the gastrointestinal tract. Techniques such as spleno-portography and CT triphasic contrast imaging are used to visualize the portal vein and diagnose anomalies like portal-systemic collaterals and porto-systemi

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Patients with coronary artery disease should be screened for peripheral vascular disease as it is a frequent integrator of global cardiovascular risk. The association of atherosclerosis in various arterial diseases highlights the importance of identifying multisite artery disease. The prevalence and

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The Human Disease Symptom Network (HSDN) is constructed using a large-scale medical bibliographic records database to form a network of human diseases based on symptom similarities. By integrating disease-gene associations and protein-protein interaction data, correlations between symptom similarity

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The large intestine plays a crucial role in digestion. This comprehensive overview covers the different parts of the large intestine, characteristic features of the colon, anatomy details, peritoneal covering, relations with surrounding structures, arterial and nerve supply, and important flexures l

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A detailed description of a compound tubulo-acinar gland with serous-secreting nature is provided, highlighting its cellular composition, arrangement of ducts, and connective tissue organization. The glandular structure, including adenomeres, centroacinar cells, and myoepithelial cells, is discussed

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Recognize major complications of liver cirrhosis including hepatic failure, portal hypertension, ascites, hepatorenal syndrome, and esophageal varices. Learn about the pathogenetic mechanisms, clinical features, and pathological findings associated with these complications.

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Learn about the major complications of liver cirrhosis, including portal hypertension, hepatic failure, ascites, spontaneous bacterial peritonitis, and more. Explore the pathogenetic mechanisms, clinical features, and pathological findings associated with these complications, and understand the impa

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Exercise therapy plays a crucial role in managing nonalcoholic fatty liver disease (NAFLD) by improving hepatic aminotransferases and reducing steatosis. Lifestyle modifications, including increased physical activity, are essential in the treatment of NAFLD. This includes aerobic exercise, resistanc

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This case study delves into a challenging scenario where a hepatologist grapples with a patient presenting HLH associated with liver injury in the context of sarcoidosis. Despite inconclusive initial investigations, further work-up reveals indications of secondary HLH/MAS. The management involves a

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Columnaris disease, also known as Saddleback disease, is a common bacterial infection in fish that is often brought about by poor handling and high stress levels. This disease manifests as tail and fin rot, leading to rapid fish mortality. The causative organism, Cytophaga (formerly Flexibacter), is

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The equine stomach is relatively small compared to the horse's body size, with distinct regions such as the cardia, fundus, body, and pyloric region. It is located on the left side of the abdomen, under the ribs. The stomach's blood supply includes branches from the aorta, splenic artery, and hepati

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View detailed radiology imaging of the esophagus and stomach conducted by Dr. A. Alhawas, showcasing various anatomical structures such as the splenic artery, abdominal aorta, common hepatic artery, and more. Explore pathologically changed layers in pyloric stenosis, arterial blood supply to the pyl

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The liver is a crucial organ with dual functions and a complex anatomical structure. It consists of hepatic lobes and lobules, where hepatocytes play a vital role in various functions. The liver receives blood supply from both the hepatic artery and portal vein, allowing for essential processes such

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Explore the latest findings from the Alzheimer's Disease Genetics Symposium 2019 on disease mechanisms, drug targets, and genetic pathways. Dive into the progress made by the Alzheimer's Disease Genetics Consortium over the past decade. Transition to a Genome-Wide Association Study uncovering suscep

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Dr. Somen Banerjee, Director of Public Health in London Borough Tower Hamlets, highlights the concerning liver disease mortality rates in the area, with high incidence of cirrhosis, cancer, and hepatitis B and C. The data reveals a significant burden of liver diseases such as Non-Alcoholic Fatty Liv

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Acute liver failure is a severe condition characterized by rapid liver dysfunction within 6 months of symptom onset, leading to encephalopathy, coagulopathy, and jaundice. This condition can be classified as hyperacute, acute, subacute, fulminant, or sub-fulminant based on the duration from jaundice

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Drug-induced liver injury (DILI) can present as cholestasis, hepatocyte necrosis, steatosis, vascular damage, and hepatic fibrosis. Various drugs like antibiotics, NSAIDs, recreational drugs, and herbal remedies can cause liver damage. Recognizing DILI is crucial in patients with liver dysfunction o

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Inflammatory Bowel Disease (IBD) encompasses Crohn's disease (CD) and ulcerative colitis (UC), chronic conditions with immunologic basis. This article delves into the epidemiology, pathophysiology, and differences between CD and UC, highlighting clinical features, pathology, and complications like a

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HHS is an acute infectious disease in chickens characterized by high morbidity and mortality, excess pericardial fluid, and multifocal hepatic necrosis. It mainly affects broilers and broiler parents, with clinical signs such as sudden mortality, lethargy, and ruffled feathers. Post-mortem lesions i

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Explore the nutrition implications and management strategies for CF-related liver disease, gastrointestinal complications, and CF-related diabetes in patients. Learn about the proposed mechanisms, prevalence rates, and consequences of hepatic complications in cystic fibrosis. Gain insights into neon

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