Innovations in Infectious Disease Control: Insights from Experts

Explore the latest advancements in infectious disease control through the lens of renowned epidemiologists and researchers. Delve into the impact of the COVID-19 pandemic, the historical prevalence of infectious diseases, and early infection prevention practices. Uncover the evolution of infectious disease control and the crucial role of innovation in shaping public health strategies. Discover how past infections have influenced human populations and the significance of early interventions in disease management.

• Infectious Diseases
• Public Health
• Innovation
• Epidemiology
• COVID-19

leanna Follow

Uploaded on Apr 02, 2024 | 0 Views

Download Presentation

Please find below an Image/Link to download the presentation.

The content on the website is provided AS IS for your information and personal use only. It may not be sold, licensed, or shared on other websites without obtaining consent from the author. Download presentation by click this link. If you encounter any issues during the download, it is possible that the publisher has removed the file from their server.

Presentation Transcript

1. Innovatie in de Infectieziektebestrijding Al doende leert men Dr Tjalling Leenstra, arts M+G epidemioloog Hoofd LCI Centrum Infectieziektebestrijding 30ste Transmissiedag infectieziekten - 28 maart 2023 1

2. - Is innovatie in IZB iets nieuws? - Wat heeft de COVID-19 pandemie ons gebracht? - Is innovatie een keuze? (potenti le) belangenverstrengeling geen Voor bijeenkomst mogelijk relevante relaties met bedrijven Sponsoring of onderzoeksgeld Honorarium of andere (financi le) vergoeding Aandeelhouder Andere relatie, namelijk geen n.v.t. n.v.t. n.v.t. n.v.t. 2

3. Infectieziekten hebben ons gevormd 3 Karlsson, E., Kwiatkowski, D. & Sabeti, P. Natural selection and infectious disease in human populations. Nat Rev Genet15, 379 393 (2014). https://doi.org/10.1038/nrg3734 Wolfe, N., Dunavan, C. & Diamond, J. Origins of major human infectious diseases. Nature 447, 279 283 (2007). https://doi.org/10.1038/nature05775

4. Infectieziekten hebben ons gevormd Murray, D. R., & Schaller, M. (2010). Historical Prevalence of Infectious Diseases Within 230 Geopolitical Regions: A Tool for Investigating Origins of Culture. Journal of Cross-Cultural Psychology, 41(1), 99 108. https://doi.org/10.1177/0022022109349510 Murray, D. R. (2014). Direct and Indirect Implications of Pathogen Prevalence for Scientific and Technological Innovation. Journal of Cross-Cultural Psychology, 45(6), 971- 985. https://doi.org/10.1177/0022022114532356 4

5. Vroege infectiepreventie (NPI) On the continent of Africa, the practice of intentional dental modification has a long history, with the earliest evidence of dental ablation in Morocco dating from 13,800 to 16,100 BP The Chronology and Significance of Ablation in the Later Stone Age Maghreb Isabelle De Groote, Louise T. Humphrey https://doi.org/10.5744/florida/9780813054834.0 03.0002 5 La Malaria by Auguste Hebert

6. Vroege Rx interventies 6

7. Infectieziektebestrijding https://www.ggd.amsterdam.nl/ggd/organisatie/ggd/ 7

8. Opkomende infecties! Averting wildlife-borne infectious disease epidemics requires a focus on socio-ecological drivers and a redesign of the global food system Author: Giulia I. Wegner,Kris A. Murray,Marco Springmann,Adrian Muller,Susanne H. Sokolow,Karen Saylors,David M. Morens Publication: EClinicalMedicine Publisher: Elsevier Date: May 2022 DOI:https://doi.org/10.1016/j.eclinm.2022.101386 Mishra, J., Mishra, P. & Arora, N.K. Linkages between environmental issues and zoonotic diseases: with reference to COVID-19 pandemic. Environmental Sustainability 4, 455 467 (2021). https://doi.org/10.1007/s42398-021-00165-x 8

9. Lokaal Regionaal Mondiaal Mobility networks determine the spread of epidemics. Credit: Max Planck Institute f r Dynamics and Self-organization Global spread of dengue virus types: mapping the 70 year history Trends in Microbiology, VOLUME 22, ISSUE 3, P138- 146, MARCH 01, 2014 DOI: https://doi.org/10.1016/j.tim.2013.12.011 https://earth.org/data_visualization/pandemic-map-cholera/ 9

10. Opkomende infectieproblematiek!! AMR immuunsuppressie - vaccine evasion 10 Lancet VOLUME 19, ISSUE 7, P759-769, JULY 01, 2019, DOI:https://doi.org/10.1016/S1473-3099(19)30297-X

11. https://amazingerasmusmc.nl/biomedisch/afscheidsrede-prof- johan-mackenbach-op-reis-door-de-geschiedenis-van-ziekten 11

12. Infectieziektecrisis in Nederland 1992 poliomyelitis outbreak 2001 anthrax/bio-terrorisme threat (anthrax-letters) 2009 Pandemic Influenza 1994 plague epidemic in India 2010 Q fever 2003 Influenza /fowl plague AI/H7N7 1995 Ebola outbreak in Za re 2011 Mumps 1995 diphteria (Dordrecht) 2011 E Coli O104 (Germany) 2003 SARS 1996 rabies (Alkmaar) 2013 MERS CoV 2004 Lymphogranuloma venereum (LGV) 1996 B. pertussis epidemic 2013 Mazelen 2004 rubella outbreak 1997 cluster meningococcal C disease (Putten) 2014-15 Ebola West-Africa 2005 Clostridium difficile associated diarrhea 2015-16 Zika 1997 Influenza A/H5N1 in Hong Kong 2017-18 MenW 2005 v-CJD 2018 Influenza 1999 Legionnaire s disease (Bovenkarspel) 2006 MRSA in pig farms 2020-2? SARS-Cov-2 / COVID-19 2006 deaths due to seasonal flu vaccination 1999 measles outbreak 2022 Monkeypox 2000 meningococcal W135 disease: import cases after Hadj 2007 outbreak of Q fever 2008 outbreak of Q fever 2001 cluster meningococcal C disease West Brabant 2008 Marburg hemorrhagic fever 12

13. COVID-19 bloeitijd voor innovatie technologische doorbraken culturele aanpassing 13

14. COVID-19 bloei van innovatie Technologisch Medisch Vaccins Ag sneltest Diagnostiek Whole Genome Sequencing ICT Dashboarding Online comms (Teams, Zoom etc.) Cultureel Kennis van infectieziekten R0 BCO Quarantaine Naleving maatregelen Infodemic medRxiv Nepnieuws / complotten 14

15. COVID-19 innovatie in IZB PH interventies Grootschalig testen Ag zelftesten + zelfisolatie Fijnmazig vaccineren BCO CoronaCare CoronaMelder app Risico-gestuurd BCO Samenwerking Multidisciplinaire/-sectorale overleggen Regionaal Epidemiologisch Consulenten Vroeg Rx cortico s + zuurstof thuis Surveillance Dagelijkse updates /dashboards Nieuwe bronnen riool, infectieradar, NICE/LCPS Whole Genome Sequencing Sociaal-wetenschappelijk onderzoek Moeilijk bereikbare groepen Corona GedragsUnit 15

16. Not all that glitters is gold CoronaMelder vs. app 2 CoronaCheck + DCC GGD Contact vs. CoronaCare Ritsema F et al Factors Associated With Using the COVID-19 Mobile Contact-Tracing App Among Individuals Diagnosed With SARS- CoV-2 in Amsterdam, the Netherlands: Observational Study JMIR Mhealth Uhealth 2022;10(8):e31099 DOI: 10.2196/31099 16

17. Is innovatie een keuze? IZB future proof Preparedness Krappe arbeidsmarkt Balans werk-priv Technologische ontwikkelingen Bied kansen! Solutions looking for a problem? 17

18. Preparedness PHEPC: Verbeterde Pandemische Paraatheid in 7 domeinen LCI PvA raakt aan alle domeinen, oa: 1 - 7 BCO, (lucht) havens (risico) communicatie stakeholderanalyse Generiek Draaiboek (evaluatie! En borging verbeteringen) Op basis van evaluaties (PDCA) In samenwerking met IZB professionals! EPI: versterking Surveillance landschap IDS: versterking Laboratorium landschap ZOOver (Z&O): zoonose alle domeinen, en regionaal netwerk (ism RAC/REC) 1 - 7 RIVM: LFI en IV (informatievoorziening, systemen uitwisseling data) GGD: Versterking Infectieziektebestrijding en pandemische paraatheid https://ecdc.europa.eu/sites/portal/files/documents/Technical-Doc-HEPSA-tool.pdf Belfroid et al, BMC Public Health 2020

19. Bovenregionale ondersteuning Krachten bundelen Duurzaam versterken bovenregionale samenwerking IZB NL RIVM CIb en LFI 25 GGD en LFI liaison Bovenregionaal 7 (5) RAC/REC Functioneel samenwerkingsverband Vormgeven m t GGD professionals en VIP programma Samenwerken met LFI in ontwikkeling Resultaat oa verhogen van -uniformiteit & kwaliteit -efficiency -carriereperspectief NB geen bezuiniging

20. Artificile Intelligentie als oplossing AI assisted decision making Patroonherkenning AI assisted scientific understanding Computational microscope Source of inspiration Agent of understanding AI assisted discovery?? Zal AI de IZB professional vervangen? ? Krenn, M., Pollice, R., Guo, S.Y. et al. On scientific understanding with artificial intelligence. Nat Rev Phys 4, 761 769 (2022). https://doi.org/10.1038/s42254-022-00518-3 20

21. Artificile Intelligentie op voorwaarde Biased AI Onderrepresentatie in brongegevens Normen & waarden ontwikkelaar Sens./spec. algoritme Acceptabele sens./spec. Efficiency vs. Equity In silico vs. real world Transparantie Ethische validatie Zeggenschap bij ontwikkeling 21

22. Ik wens iedereen een inspirerende dag!!! 22