Explore Zilebesiran, an investigational RNA interference therapeutic targeting hepatic AGT synthesis for hypertension. Primary findings from Phase 2 trial KARDIA-1 reveal sustained blood pressure reduction. Addressing the unmet need for innovative antihypertensive treatments.

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A computer system is a programmable digital electronics device that processes data as per program instructions to provide meaningful output. It comprises hardware and software components, with hardware being the physical parts and software essential for driving the hardware. Computer organization fo

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Develop flows showing interaction between SMO modules in the context of open-source architecture using OSC, ONAP, and other code. The objective is to align open-source work with O-RAN trends, improve synergy, reduce duplication, and provide feedback to O-RAN discussions. Related work includes Decoup

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Liver is the largest gland in our body, and an important metabolic organ which carries out many essential biological functions. The liver is a wedge-shaped, reddish-brown in color with two lobes of different size and shape. The approximate weight of a human liver is 1.5 kilograms. It is in the upper

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Acetaminophen poisoning occurs when the body is overwhelmed by high doses of the drug, leading to liver toxicity and potentially fatal consequences. The mechanism of toxicity involves the depletion of glutathione and the formation of a harmful metabolite, N-acetyl-para-benzoquinoneimine (NAPQI). Con

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In the electronic meeting of 3GPP TSG-RAN-WG4, discussions were held on the RF architecture and waveform assumptions for NR V2X intra-band operation in band n79. Various options and recommendations were presented regarding RF architecture, antenna architecture, and waveform definitions for efficient

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Fat Cow Syndrome, also known as Fatty Liver Disease in Cattle, is a condition commonly seen in high-producing cows during the transition period around calving. The disease is characterized by mobilization of excessive body fat to the liver due to negative energy balance, leading to hepatic lipidosis

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Computer architecture and organization are fundamental aspects of computing systems. Computer architecture focuses on the functional design and implementation of various computer parts, while computer organization deals with how operational attributes come together to realize the architectural speci

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Anti-patterns in software architecture are commonly occurring solutions to problems that lead to negative consequences. These arise due to insufficient knowledge or experience, misuse of design patterns, and lack of attention to evolving project architecture. Examples include Jumble, Stovepipe, Spag

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Bilirubin, a yellow compound in the catabolic pathway, plays a crucial role in health. Estimating serum bilirubin levels is key in diagnosing conditions like jaundice. Elevated levels, above 2 mg/dl, can indicate disease. Jaundice, characterized by skin and eye discoloration, has pre-hepatic, hepati

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Malnutrition is common in chronic liver disease, leading to complications such as ascites and infections. Sarcopenia and weight loss are prevalent regardless of BMI. Critical care patients with liver disease face challenges due to limited physiological reserve, with main causes for ICU admission bei

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Nasopulmonary drug delivery system, utilizing the nasal route for drug administration, offers advantages such as hepatic first-pass metabolism avoidance and rapid drug absorption. This system is beneficial for pharmacologically active compounds with poor stability in gastrointestinal fluids. While i

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PowerPC is a RISC instruction set architecture developed by IBM in collaboration with Apple and Motorola in the early 1990s. It is based on IBM's POWER architecture, offering both 32-bit and 64-bit processors popular in embedded systems. The architecture emphasizes a reduced set of pipelined instruc

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Client-server architecture is a computing model where a central server hosts and manages resources and services for client computers over a network. There are different types of clients and servers, each with unique characteristics and roles. This architecture offers various advantages and disadvant

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Phenytoin, a medication with high protein binding and hepatic metabolism, exhibits saturated pharmacokinetics with a narrow therapeutic range of 10-20 µg/mL for total serum concentrations. Adverse effects vary with serum levels: minor CNS depression at >15 µg/mL, nystagmus at >20 µg/mL, and ataxi

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Challenging liver cirrhosis management in elderly patients with refractory ascites has high mortality rates, and transplantation is not always viable. Transjugular intrahepatic portosystemic shunt (TIPS) serves as a non-curative treatment option, aiming to reduce portal hypertension. The procedure i

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Veins play a crucial role in the circulatory system by carrying deoxygenated blood back to the heart. This lecture covers the general principles of veins, the anatomy of major veins like the superior and inferior vena cavae, tributaries, and their roles in different parts of the body. It also discus

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In an ideal scenario, the digital architecture for children would encompass systems such as Enterprise Architecture, Functional Architecture, and Solution Architecture to support UNICEF's high-impact interventions. It would involve integrated platforms for Health Information Exchange, Supply Chain M

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In the Network Architecture Group led by Namseok Ko, significant progress has been made in defining the IMT-2020 architecture. The work has involved gap analysis, draft recommendations, and setting framework and requirements. Phase 1 focused on identifying 19 architectural gaps, such as demands for

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Understanding the natural history, evaluation, and management of benign liver lesions is crucial for diagnosing incidental liver findings. Common benign liver lesions include hepatic hemangioma, focal nodular hyperplasia, hepatic adenoma, and hepatic cyst. Differential diagnosis plays a key role in

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Portal vein imaging is crucial for evaluating conditions affecting the abdominal part of the gastrointestinal tract. Techniques such as spleno-portography and CT triphasic contrast imaging are used to visualize the portal vein and diagnose anomalies like portal-systemic collaterals and porto-systemi

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The large intestine plays a crucial role in digestion. This comprehensive overview covers the different parts of the large intestine, characteristic features of the colon, anatomy details, peritoneal covering, relations with surrounding structures, arterial and nerve supply, and important flexures l

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A detailed description of a compound tubulo-acinar gland with serous-secreting nature is provided, highlighting its cellular composition, arrangement of ducts, and connective tissue organization. The glandular structure, including adenomeres, centroacinar cells, and myoepithelial cells, is discussed

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Recognize major complications of liver cirrhosis including hepatic failure, portal hypertension, ascites, hepatorenal syndrome, and esophageal varices. Learn about the pathogenetic mechanisms, clinical features, and pathological findings associated with these complications.

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Learn about the major complications of liver cirrhosis, including portal hypertension, hepatic failure, ascites, spontaneous bacterial peritonitis, and more. Explore the pathogenetic mechanisms, clinical features, and pathological findings associated with these complications, and understand the impa

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Exercise therapy plays a crucial role in managing nonalcoholic fatty liver disease (NAFLD) by improving hepatic aminotransferases and reducing steatosis. Lifestyle modifications, including increased physical activity, are essential in the treatment of NAFLD. This includes aerobic exercise, resistanc

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This case study delves into a challenging scenario where a hepatologist grapples with a patient presenting HLH associated with liver injury in the context of sarcoidosis. Despite inconclusive initial investigations, further work-up reveals indications of secondary HLH/MAS. The management involves a

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Proposed establishment of a Working Group by the CESG to develop a Service-Oriented Architecture (SOA) framework for space mission operations within the CCSDS. The focus includes identifying services, use cases, architecture definitions, and business cases to enhance CCSDS-wide interoperability and

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Y86 Instruction Set Architecture is a simplified pseudo-language based on x86 (IA-32) architecture. It involves implementing the Fetch-Decode-Execute cycle, where instructions are fetched from memory, decoded, and executed. The Y86 ISA offers a simpler set of instructions and formats compared to x86

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The liver is a crucial organ with dual functions and a complex anatomical structure. It consists of hepatic lobes and lobules, where hepatocytes play a vital role in various functions. The liver receives blood supply from both the hepatic artery and portal vein, allowing for essential processes such

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This paper explores how Service-Oriented Architectures (SOA) can be integrated with the HL7 Clinical Document Architecture to facilitate the sharing of Summary Care Records between healthcare information systems. It highlights the benefits of a federated architecture based on SOA and coding standard

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Delve into the world of modern architecture trends, focusing on Expressionist architecture in Europe during the early 20th century and the influential Bauhaus movement in Germany. Expressionist architecture emphasized emotional effects through distorted forms inspired by nature, while the Bauhaus sc

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This content showcases various aspects of 5G system architecture, including system handover, non-roaming architecture, service-based architecture, and user plane functionality. It delves into the control plane functions, user plane functions, and core network endpoints of the 5G network. The images

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Client/Server Computing architecture separates clients and servers over a network, allowing for file sharing, resource allocation, and service requests. Clients initiate services from servers, with transparent server locations and message-passing transactions. Systems with C/S architecture include f

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HHS is an acute infectious disease in chickens characterized by high morbidity and mortality, excess pericardial fluid, and multifocal hepatic necrosis. It mainly affects broilers and broiler parents, with clinical signs such as sudden mortality, lethargy, and ruffled feathers. Post-mortem lesions i

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Delve into the concepts of memory hierarchy, cache optimizations, RISC architecture, and other architecture styles in embedded computer architecture. Learn about Accumulator and Stack architectures, their characteristics, advantages, and example code implementations. Explore the differences between

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Covering topics like Instruction-Set Architecture (ISA), 5-stage pipeline, and Pipelined instructions, this course delves into the intricacies of advanced computer architecture, with a focus on achieving high performance by optimizing data flow to execution units. The course provides insights into t

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This presentation delves into the software architecture design and implementation of a Document Filter System (DFS) aimed at efficiently finding relevant information. It discusses the architecture's effectiveness in supporting diverse applications, multilingual document searching, complex query func

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This content describes the MOIMS Protocol Viewpoint inputs to the SEA Reference Architecture updates by Roger Thompson from ESA SAWG. It includes details about the graphical conventions, data store elements, organizational domains, network layers, communications protocols, and space communications c

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Serum bilirubin levels are crucial in diagnosing conditions like jaundice, with total, direct, and indirect bilirubin playing key roles. Excess bilirubin in the blood can lead to jaundice, characterized by yellow discoloration of the skin and eyes. Different types of jaundice, including pre-hepatic,

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