Zongertinib (BI.1810631) Phase I Study in Advanced Solid Tumors with HER2 Aberrations focusing on NSCLC. The trial involves dose escalation and expansion, testing different doses in cohorts with varied HER2 mutations. Primary endpoints include MTD, OR, and DLTs.

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This collection features various experiments in chemistry involving titration and solutions. It includes procedures such as standardizing hydrochloric acid using sodium carbonate, titrating hydrochloric acid with sodium hydroxide to produce sodium chloride, determining the concentration of ethanoic

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The OCTIVUS Randomized Clinical Trial compared the clinical efficacy and safety of Optical Coherence Tomography (OCT)-guided and Intravascular Ultrasound (IVUS)-guided strategies in patients undergoing PCI for significant CAD. The study aimed to determine if OCT-guided PCI is noninferior to IVUS-gui

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Explore the interconnected realms of Experimental Economics and Behavioral Economics through the insightful lectures of John Hey, an Emeritus Professor at the University of York. Discover the methodology of testing economic theories for validity and the practical applications of experimental economi

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The research conducted by Prof. Jishu Shi and his team at Kansas State University delves into the safety and efficacy testing of experimental African Swine Fever (ASF) vaccines using pigs as the model. Various vaccines, including DNA vaccines and live attenuated viruses, were tested against differen

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This educational slide module delves into fundamental statistics for analyzing clinical endpoints in diabetes research. It covers the choice of statistical methods, the distinction between statistical and clinical significance, and the importance of different endpoints in evaluating clinical benefit

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In patients with acute myocardial infarction (AMI) and multivessel coronary artery disease, this study aims to compare fractional flow reserve (FFR)-guided PCI with angiography-guided PCI for non-infarct-related artery lesions. The hypothesis is that selective PCI guided by FFR is superior to routin

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Nonexperimental and quasi-experimental studies resemble experiments but lack random assignment, making them valuable for group comparisons without establishing causation. This type of research design looks at differences between groups that already exist, focusing on group differences rather than ca

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In computer graphics, the Digital Differential Analyzer (DDA) Algorithm is utilized as the basic line drawing algorithm. This method involves interpolation of variables between two endpoints to rasterize lines, triangles, and polygons efficiently. The algorithm requires inputting coordinates of two

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Observation and experiments are two crucial methods in research. An observational study involves observing and measuring variables without influencing responses, while an experiment deliberately applies treatments to measure responses. Confounding variables can affect the results, and factors like e

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This content delves into the basics of experimental research, focusing on different types of experimental designs and control issues. It covers between-group and within-group designs, discussing advantages and disadvantages, as well as methods for controlling for nonequivalence. The importance of ra

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Probability is the measure of the likelihood of an event happening, with experimental and theoretical probability being key concepts. Experimental probability involves determining probabilities through experience or experiments, while theoretical probability can be calculated without prior experienc

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This study by CTTI explores barriers and solutions for adopting digitally derived endpoints in clinical trials. Through in-depth interviews with industry sponsors, the research identifies gaps, barriers, and recommendations for using DHT-derived novel endpoints as key endpoints in pivotal clinical t

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The presentation discusses various endpoints in aortic valve development and Transcatheter Aortic Valve Replacement (TAVR) trials, including comparisons, study stages, and newer devices. It covers different trial populations, primary and secondary endpoints, and the evaluation of non-inferiority. Su

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In the SOLVE-TAVI trial, patients undergoing transcatheter aortic valve implantation were randomized to receive either self-expandable or balloon-expandable valves under general or local anesthesia. The study aims to compare the effectiveness and safety of different valve types and anesthesia approa

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Explore a quiz review covering topics related to scientific method, graphing, and experimental design. Understand key concepts such as hypothesis, scientific law, theory, variables, and experimental control through detailed questions and images. Test your knowledge on laboratory safety, inferences,

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Delve into the world of quantitative research in nursing, exploring different research designs and the concept of causality. Learn about experimental, quasi-experimental, and non-experimental designs, as well as the characteristics of experimental design like manipulation, control, and randomization

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Explore the various quasi-experimental designs, control groups, pretests, and outcome patterns in research methodologies. Understand the implications of different outcome patterns on causal interpretation and validity threats in experimental studies.

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This presentation discusses the exploration of endpoints in pivotal clinical trials to treat Alcohol Use Disorder (AUD), focusing on Primary Alcohol Drinking Endpoints like PSNHDD. Evidence supporting PSNHDD as a primary endpoint includes clinical benefit data from alcohol clinical trials and epidem

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Explore the concepts of pain, distress, and humane endpoints in animals through a training program aimed at researchers developing protocols for the welfare of laboratory animals. The program includes pre- and post-assessments to gauge knowledge and learning outcomes, covers scenarios illustrating c

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Explore key concepts in experimental design in biology through clicker questions focusing on hypotheses, variables, control groups, and experimental groups. Learn how scientists test hypotheses and analyze results to draw valid conclusions in biological studies.

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Completed compilation and evaluation of experimental Pn and half-lives for nuclei in the Z=2-28 region, led by Balraj Singh at McMaster University. The work involved preparing lists of neutron-rich nuclides, identifying potential emitters, analyzing available experimental data for 1n, 2n, 3n, and 4n

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European research focuses on advanced modeling of C/C, C/SiC, and SiC/SiC composites for aerospace and nuclear applications, with an emphasis on correlating simulations with experimental validation. Laboratories are progressing towards a multiscale approach, integrating micro/nanomechanical characte

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Centuries of normative debate on paternalism have resulted in its ubiquity in various aspects of society, from consumer protection to safety regulations. However, there is a scarcity of empirical studies on the motivations behind paternalistic interventions. This experimental investigation delves in

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This project discusses the API endpoints and data structures from the PaNOSC Workshop, focusing on reviewing use cases, required search results/data, actors involved, and the design of endpoints reflecting proposal/experiment processes. It covers detailed discussions on data models, instrument setup

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Experimental studies involve the investigator assigning exposures and following subjects to observe disease development. Different types of experimental studies exist, such as preventive and therapeutic types, each with its limitations, including ethical concerns and challenges in recruiting subject

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This article discusses an algorithm proposed by L.R. Rabiner and M.R. Sambur in 1975 for determining endpoints in isolated utterances. The algorithm focuses on detecting word boundaries in speech through the recognition of silence, which can lead to reduced processing load and increased convenience,

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IGEL Universal Management Suite (UMS) is a comprehensive system that empowers IT professionals with easy control over all endpoints. Included features like centralized installation, configuration, and update management make UMS a versatile tool for managing IGEL Zero Clients and third-party endpoint

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This review covers topics such as experimental classification, the comparison of non-experimental and experimental research, software features like JMP and SPSS, outlier handling in data analysis, and levels of measurement in statistical analysis.

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Vietnam School on Neutrino is an annual event started in 2017 to promote experimental neutrino physics in Vietnam. Led by Prof. Jean Tran Thanh Van, the school focuses on lectures, software and hardware training, group works, and excursions. With a mix of students from various countries, the aim is

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Slider-crank mechanism analysis involves understanding the transformation of input motion into desired output motion. This mechanism consists of a crank, coupler, slider, and ground link, converting circular motion into linear motion. Experimental procedures involve setting crank angles and recordin

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This study and simulation focus on the experimental setup, measurement techniques, and results of a down-flow bubble column. It explores novel features such as inverted bubbly flow, micro-bubble generation, and gas injection. Detailed analysis includes axial and radial variations of volumetric gas h

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Eugene J. Sullivan, MD, explains the importance of establishing efficacy in clinical trials based on substantial evidence from well-controlled trials. The discussion includes primary endpoints for Phase 3 trials, legal and regulatory requirements, and the significance of clinically meaningful effect

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These guidelines outline the identification of scientific endpoints, humane intervention points, and cumulative endpoints in animal research. They emphasize the need for protocols approved by animal care committees, consideration of welfare-appropriate endpoints, and adaptation of endpoints during t

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Explore the foundations of experimental and quasi-experimental designs, delving into causal relationships, counterfactual reasoning, and the importance of validating statistical and internal conclusions. Learn about causes, effects, and the complexity of determining causation in research. Discover R

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This content delves into the study of probability, covering topics such as representing probabilities of simple and compound events, calculating relative frequencies, multi-step chance experiments, theoretical and experimental probabilities. It explains concepts like chance experiments, sample space

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Epidemiological studies and experimental studies play vital roles in understanding cause-and-effect relationships in research. Experimental studies involve manipulating independent variables and measuring dependent variables, with categories such as true experimental, quasi-experimental, and pre-exp

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Exploring nuclear physics research through Califa simulations and experimental observations with a focus on PID gating, clustering algorithms, beam settings, and Ca isotopes chain gating. The study involves simulating events on CH2 targets, analyzing clustering effects, and observing opening angles

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Proposed campaign in FY25 by the LBS Lab to measure specific deliverables, compare results with experimental and theory PIs, collaborate with others, and assess technical issues such as target fabrication feasibility. The campaign involves motivation, relevant milestones, previous/simulated results,

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This content explores the importance of reviewing research protocols to minimize pain and distress in animal experiments. It covers defining pain, distress, experimental and humane endpoints, evaluating management strategies, and ensuring ethical practices. It also includes a quick exercise to asses

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