HER2 activation plays a crucial role in promoting tumor proliferation and survival in NSCLC. Driven by oncogenic downstream signaling pathways, HER2 overexpression and gene amplification lead to the formation of heterodimers and activation of key signaling cascades. Additionally, HER2 mutations are

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This slideshow provides an overview of tumor classification, nomenclature, and key concepts in pathology. It covers the definitions of neoplasm, tumor, and oncology, the classification of tumors into benign and malignant categories, as well as the importance of stroma in tumor behavior. It also expl

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Discover the best spine tumor treatment at Medspine, the leading hospital with top surgeon and specialist in Medavakkam, Perumbakkam, Royapettah, Chennai.

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Explore the comprehensive agenda covering topics like the general structure of the circulatory system, blood circulation in the human body, risk factors for cardiovascular diseases, and physiotherapeutic approaches in cardiac rehabilitation. Gain insights into the anatomy of the heart, arteries, vei

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Learn the importance of bystander CPR in saving lives during sudden cardiac arrest incidents. Understand the steps to perform hands-only CPR, identify compression rates, and the role of the Good Samaritan law. Discover key facts about sudden cardiac arrest and how bystander intervention can signific

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Acoramidis, a next-generation TTR stabilizer, shows promising results in improving cardiac function and promoting regression in Transthyretin Amyloid Cardiomyopathy. The ATTRibute-CM Cardiac Magnetic Resonance Substudy evaluated changes in cardiac structure, function, and amyloid burden after treatm

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Cardiac implantable devices like pacemakers, cardiac loop records, and implantable cardioverter defibrillators require extensive cardiac implant monitoring services to help safeguard the patients' heart health at all times. Let\u2019s get started.\n

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Cardiac output, stroke volume, end-diastolic and end-systolic volumes play vital roles in cardiovascular function. Factors affecting cardiac output include physiological conditions and pathological states like hyperthyroidism and myocardial infarction. Venous return, controlled by mechanisms like Fr

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Study investigates the association between renal and cerebral near-infrared spectroscopy (NIRS) values and low cardiac output syndrome in single ventricle patients post Stage I palliation. Data from infants who underwent surgery between 2010-2019 is analyzed to determine correlations with adverse ou

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Dive into the intricate details of cardiac electrical activity in this lecture led by Physiology Team 436. Explore topics like the cardiac conductive system, action potentials, refractory periods, excitation-contraction coupling, and the effects of autonomic stimulation on heart electrophysiology. D

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Grading and staging are crucial in determining the aggressiveness and extent of malignant tumors. Grading involves assessing the level of malignancy based on cell differentiation and mitotic activity, while staging considers the size of the tumor, lymph node involvement, and presence of metastases.

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Explore the intricate workings of the cardiac cycle, from the mechanical and electrical changes to the phases in both atria and ventricles. Learn about the time duration of a cardiac cycle, the impact of heart rate on systole and diastole, and various pressure, volume, and sound changes occurring du

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The electrocardiogram (ECG) is a result of intricate physiological and technological processes involving transmembrane ionic currents, cardiac activation sequences, and electrode connections. The cardiac conduction system consists of various components like the sinoatrial node, atrioventricular node

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Twofold increase in sudden cardiac arrests on the ACCU prompted the implementation of the Cardiac Watcher Program in Children's Medical Center, Dallas. The program aims to decrease cardiac arrests by improving patient identification and creating a shared mental model among team members. Developed pa

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Normal pregnancy induces significant physiologic changes in the cardiovascular system, which can impact women with pre-existing cardiac diseases. Understanding the New York Heart Association classification scheme is crucial for assessing symptomatology during pregnancy. Rheumatic Heart Disease, part

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This trial aims to compare the efficacy and safety of molecularly-guided therapy or cancer immunotherapy based on genomic profiling with platinum-based chemotherapy in patients with cancer of unknown primary site. The study design includes multiple treatment regimens guided by genomic profiles, with

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WAGR syndrome is a rare genetic condition associated with Wilms Tumor, aniridia, and developmental delays. Wilms Tumor is a form of kidney cancer mostly affecting children and is linked to genetic disorders like WAGR syndrome. The risk of Wilms Tumor is higher in children with WAGR syndrome, with po

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Learn how to perform hands-only CPR effectively in case of cardiac arrest. Understand the importance of quick action, proper compression rate, and the Good Samaritan law. Discover facts about sudden cardiac arrest and why bystander CPR can significantly increase survival rates. Follow a guide on wha

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Near-infrared spectroscopy (NIRS) has been studied in infants after Stage I palliation surgery to assess its association with low cardiac output and adverse outcomes. This retrospective study investigated postoperative cerebral and renal NIRS values in infants with single ventricle physiology. Resul

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Explore the role of Steroids, Cardiac Glycosides, and Triterpenoids in pharmacognosy and phytochemistry, focusing on their general introduction, composition, chemistry, biosources, therapeutic uses, and commercial applications. Learn about the structure and attachment of sugar parts in Cardiac Glyco

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Cardiac failure is a condition where the heart is unable to meet tissue metabolic needs despite normal or increased venous return. Causes include decreased contractility, coronary blood flow, damaged valves, and more. Normal resting cardiac output is 5 Lt/mts, with adaptive mechanisms like the Frank

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Positron Emission Tomography (PET) is a medical imaging technique focusing on metabolic differences in the body. By using positron-emitting radioisotopes, PET can detect how molecules are taken up by healthy and cancerous cells, aiding in accurate tumor localization with lower doses. The evolution o

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This guide provides detailed instructions and images on how to measure various parameters in cardiac MR imaging, including left ventricle measurements in diastole and systole, LA measurements, aorta measurements, and EF calculations using CVI42 software. It also includes steps for phase calculations

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Research collaboration aimed to enhance locoregional tumor control and reduce distant failure by combining charged particles irradiation and anticancer drug Epothilone B in cultured human tumor cells from Milano and Roma. The study explores the impact on clonogenic survival, growth curves, and deter

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Cardiovascular disease remains a significant contributor to maternal mortality in the UK, with maternal deaths from cardiac issues outnumbering those from other direct causes, except thrombosis. The prevalence of cardiovascular risk factors in pregnant women, combined with a lack of consideration fo

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The Canadian Cardiac Transplant Network Status Review 2021 provides a detailed overview of cardiac transplant programs across various provinces in Canada from 2016 to 2021. The report includes data on the number of cases, hospitals involved, and referral centers, showcasing the trends in cardiac tra

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The Gamma Knife Stereotactic Radiosurgery is a precise and effective treatment method where highly focused radiation beams are used to target tumors and abnormalities in the brain. It does not remove the tumor directly but affects DNA, cell growth, and blood vessels. The procedure involves three mai

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This presentation emphasizes the importance of dispatcher-assisted bystander CPR in identifying pulseless, non-breathing patients to improve cardiac arrest survival rates. Highlighting the need for community involvement, it showcases the impact of prompt response and effective CPR on increasing surv

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Sudden cardiac arrest is a critical condition where the heart suddenly stops beating, leading to a lack of blood flow to vital organs. Learn about the definition, statistics, importance of early CPR, and treatments for sudden cardiac arrest to increase survival rates. Bystander participation in perf

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Learn about interventions to improve survival and neurological recovery post-cardiac arrest. Discover key aspects of successful post-arrest care and eligibility for interventions reducing brain injury. Includes priorities, clinical cases, prehospital care, stabilization, and identification of treata

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Thrombolytics are suggested for cardiac arrest from presumed PE despite lack of RCTs focusing on this subset. Studies on undifferentiated cardiac arrest did not show a survival benefit. Trials using tissue plasminogen activator in PEA arrest showed no significant difference in outcomes, while a stud

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This project aims to increase cardiac arrest survival rates by training dispatchers to assist bystanders in providing CPR to patients who are pulseless and not breathing. By bringing dispatcher-assisted CPR to Milwaukee County, the goal is to enhance bystander CPR rates and ultimately improve cardia

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This review focuses on the quality of care provided to adult patients aged 16 years and older who were admitted to the hospital after experiencing an out-of-hospital cardiac arrest. Key messages highlight the importance of strategies for rapid and high-quality resuscitation, documentation of advance

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Cardiopulmonary resuscitation (CPR) is crucial in cases of cardiac arrest, a leading cause of death globally. Immediate recognition of symptoms such as unresponsiveness and abnormal breathing, early activation of emergency services, and prompt initiation of CPR can significantly improve survival rat

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A 35-year-old male autodriver presented with dyspnea, chest pain, and a history of alcohol addiction. Past procedures included PTCA with stent in the LAD. Diagnostic tests revealed severe cardiac issues leading to CABG surgery with a twist involving pericardial adhesiolysis and cardiopulmonary bypas

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Initial clinical evaluation of a child with possible cardiac abnormalities includes history taking and physical examination. History should cover symptoms related to pulmonary and systemic venous congestion, cyanosis, cyanotic spells, palpitations, chest pain, and more. The general physical examinat

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Delve into the intricacies of cardiac auscultation with a focus on heart sounds and murmurs. Learn about stethoscope placement, heart sound differentiation, physiological splitting, cardiac murmur classification, and hemodynamic changes in various heart conditions. Explore essential learning outcome

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Explore the complex processes underlying cardiac action potential, from ionic equilibrium to resting membrane potential and excitability in cardiac cells. Learn about the critical thresholds, equilibrium potentials, and gradients that regulate the electrical activity of the heart. Discover the intri

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Vestibular schwannoma, also known as acoustic neuroma, is a common tumor in the cerebellopontine angle. It can be sporadic or associated with neurofibromatosis type 2. Patients typically present with hearing loss and tinnitus, which may be gradual or sudden. Grading systems like Koos, Ojemann, and J

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A 3-year-old girl presented with persistent fever, leading to the discovery of a cardiac mass diagnosed as histiocytic neoplasia through imaging and biopsy. Primary cardiac tumors are rare in children, with benign tumors being more common. Histiocytic sarcomas are malignant neoplasms with characteri

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