Cholestatic liver disease affects Alkaline Phosphatase (ALP) and bilirubin levels, indicating bile duct damage. GGT and 5'-Nucleotidase help differentiate hepatobiliary vs. bone origin of ALP elevation. ALP is produced by bile duct epithelium and can be normal in acute biliary obstruction. GGT and N

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Hyperparathyroidism is characterized by overactive parathyroid glands leading to excessive secretion of parathyroid hormone and elevated blood calcium levels. This condition can cause symptoms like excessive urination, abdominal pain, weakness, and more. Primary hyperparathyroidism is often due to n

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Pituitary disorders, often caused by tumors, can disrupt hormone production leading to various symptoms like weight gain, vision problems, and hormonal imbalances. The pituitary gland plays a crucial role in regulating bodily functions through hormone secretion. Factors such as tumor growth, head in

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Common gastrointestinal conditions such as peptic ulcers can be effectively treated through approaches like eradicating H. pylori infection, reducing gastric acid secretion, and using mucosal protecting agents. Helicobacter pylori eradication is crucial for healing ulcers and preventing recurrence,

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Liver complications in cystic fibrosis (CF) have gained importance due to CFTR modulators impacting liver health. This presentation by Dr. Zachary M. Sellers delves into new definitions for CF liver disease, CFF recommendations for screening, management, and treatment of hepatobiliary issues in CF.

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Disorders of the lacrimal system can lead to chronic symptoms affecting the eyes, causing discomfort and vision problems. Common abnormalities include dry eye, which can result from tear flow and evaporation issues. Aqueous-deficient dry eye, often associated with Sjögren's syndrome, is characteriz

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The lecture covers the fundamentals of urinary elimination focusing on the kidneys' location, structure, function, and the role of nephrons. It discusses the transport of urine through the ureters to the bladder, highlighting the bladder's muscle layers and the urethra's role in expelling urine. Stu

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This lecture delves into the essential aspects of renal function tests, exploring the functional units of the kidney, the role of nephrons in maintaining homeostasis, and the intricate processes of filtration, reabsorption, and secretion within the renal tubules. Key topics include the hormonal and

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Pancreas is a vital organ in the abdomen with dual exocrine and endocrine functions. As an exocrine organ, it secretes digestive enzymes and bicarbonates into the duodenum for food breakdown. In its endocrine role, the pancreas regulates blood sugar levels by secreting insulin, glucagon, somatostati

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Major lipids like cholesterol and triglycerides play essential roles in the body, but their excess can lead to hyperlipidemia and related conditions. This overview covers the biosynthesis of cholesterol, triglycerides, and the transport of lipids in the bloodstream, discussing the importance of lipo

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Dive into the intricate workings of the digestive system with this comprehensive collection of essential vocabulary. Explore key terms such as absorb, acid, anus, bacteria, bile, and more to enhance your knowledge and understanding. Engage in hands-on activities and visual aids to reinforce learning

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This presentation covers drugs for hyperlipidemia, including bile acid sequestrants, cholesterol absorption inhibitors, statins, fibrates, and relevant drug interactions. It details the actions, adverse effects, contraindications, and notable considerations for each drug class. The included multiple

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Glandular specialized epithelium forms a class of epithelial tissues with specific functions and structures, composed of cuboidal, columnar, and ciliated columnar epithelial cells. These tissues contain gland cells that are secretary in nature, with zymogen granules in the cytoplasm. Glands are spec

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Cholestasis is characterized by reduced bile flow and elevated direct bilirubin. It is critical to differentiate it from neonatal jaundice. In conditions like biliary atresia and 1-antitrypsin deficiency, early diagnosis and intervention are crucial to prevent liver failure. Clinical manifestations

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In this informative content, the histological structures of the liver and spleen are explored in detail. Key components such as hepatocytes, sinusoids, bile canaliculi, and the spaces of Disse in the liver, and the white pulp and red pulp in the spleen are highlighted. The classic liver lobule, cent

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The process begins with chewing skittles in the mouth, where salivary amylase breaks down sugar. The bolus then travels down the esophagus via peristalsis into the stomach, further broken down by gastric juice. The pancreas releases enzymes like amylase and lipase to digest sugars and fats. Bile pro

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The small intestine's motility and secretion processes involve various types of contractions and movements, such as segmentation contractions, peristalsis, and the migrating motor complex. These processes play a crucial role in mixing chyme, aiding in digestion, and facilitating absorption of nutrie

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This content delves into the intricate workings of the stomach, focusing on its motor functions, anatomical and physiological divisions, gastric reservoir, storage and mixing functions, and relaxation reflexes. It emphasizes the key roles of the stomach in storing and preparing food for digestion, a

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Professor Shraddha Singh's lecture series delves into the significance of lipids, the types of lipids, and the role of bile in digestion. Learn about saturated vs. unsaturated fatty acids, common fatty acids found in lipids, lipid structures, and properties. Explore the diverse types of fats we cons

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Neonatal vomiting can be a concern when presenting with bile-stained or blood-stained vomit, projectile vomiting, or associated with weight loss and failure to grow. Various non-surgical and surgical conditions like Pyloric Stenosis can lead to vomiting in neonates. Common causes include Mid-gut vol

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This content delves into the secretory functions of the alimentary tract, focusing on the secretion of saliva and the role of mastication. It covers the anatomy of salivary glands, composition of saliva, control of secretion by the nervous system, and the functions of saliva in lubrication, protecti

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Choledocholithiasis, the presence of stones in the common bile duct, is a common condition found in a percentage of patients with gallstones. The stones can be primary or secondary, causing a range of clinical manifestations from silent obstruction to cholangitis or gallstone pancreatitis. Diagnosis

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Peritonitis is inflammation of the peritoneum, often caused by bacterial infections or other factors like bile leaks or ruptured ectopic pregnancies. Recognizing the signs, such as sudden abdominal pain and tenderness, is crucial for early diagnosis and treatment. Effective management involves treat

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This article highlights the digestion and metabolism of fat in both ruminant and non-ruminant species. It explains the differences in lipid digestion in the stomach and small intestine of animals, focusing on the role of lipase, bile, and colipase in the breakdown of triglycerides. The process of mi

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Elizabethans believed in the connection between health, temperament, and the four humours - yellow bile, black bile, phlegm, and blood - each associated with specific personality traits. They also linked star signs to body parts and embraced the divine order of the chain of being, respecting the hie

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This informative content delves into the anatomy and function of the gallbladder, discussing its role in storing and concentrating bile. It explains the composition of bile, the process of emulsifying fats, and the consequences of bile flow obstruction. Various disorders affecting the biliary system

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The gastrointestinal tract (GIT) is responsible for digestion, absorption, and secretion through various glands along the alimentary canal. Secretions are stimulated by factors like direct contact, nervous system activation, and hormonal regulation. Hormones released in response to food presence hel

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This content delves into the concept of renal clearance, exploring its relation to lipophilicity and mechanisms such as glomerular filtration, tubular secretion, and reabsorption. The processes occurring at the nephron level and the vascularization scheme are detailed, along with a breakdown of phys

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The stomach plays crucial roles in food storage, chyme preparation, water absorption, and slow emptying into the small intestine. Its motor functions include maintaining a reservoir, mixing food, and facilitating relaxation reflexes for optimal digestion. Anatomically and physiologically, the stomac

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This content provides a detailed exploration of medical terminology related to the gastrointestinal system. It covers definitions, word roots, combining vowels, suffixes, and prefixes commonly used in this medical field. The material includes information on anatomical terms such as anus, appendix, c

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In this informative presentation by Assistant Professor Dr. Emre Hamurtekin, the focus is on gastrointestinal secretions including salivary, gastric, pancreatic, biliary, and intestinal fluids. Structural considerations such as the surface area for absorption, sphincters, villi, and crypts are discu

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The liver is a crucial organ with dual functions and a complex anatomical structure. It consists of hepatic lobes and lobules, where hepatocytes play a vital role in various functions. The liver receives blood supply from both the hepatic artery and portal vein, allowing for essential processes such

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Hepatobiliary and pancreatic disorders can lead to conditions like jaundice, caused by an accumulation of bilirubin. Jaundice can be classified as prehepatic, intrahepatic, or posthepatic depending on the underlying causes such as liver damage, hepatitis, cirrhosis, or bile duct obstructions. Liver

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Multi-society State-of-the-Art Consensus Conference focused on strategies to prevent bile duct injuries during cholecystectomy. Work Group Five, led by Rajesh Aggarwal and Carol-Anne Moulton, explored the effectiveness of coaching surgeons in mitigating risks. Recommendation A suggests continued sur

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Bilirubin, a key pigment in bile, is derived from heme breakdown and plays a crucial role in the liver's detoxification process. This article explores the metabolism of bilirubin, its relationship with heme and globin, as well as its excretion steps involving enzymatic reactions and conjugation in h

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Bile, produced in the liver, helps in fat digestion and is composed of various substances. Bile acids are essential for digestion and are categorized as primary and secondary bile acids. The gallbladder stores and releases bile, aiding in fat digestion. Gallstones are solid materials that form in th

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Hormone secretion is tightly regulated to prevent overproduction or underproduction. It involves various factors such as nervous system signals, chemical changes in the blood, and feedback mechanisms. Hormones play a vital role in maintaining homeostasis by acting on target cells and eliciting speci

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The pituitary gland, located at the base of the brain, comprises two main portions - the anterior lobe (adenohypophysis) and the neurohypophysis. The anterior lobe consists of various cell types that secrete hormones like GH, prolactin, TSH, ACTH, FSH, and LH. GH, also known as STH, plays a crucial

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Bile acid sequestrants such as colestipol and cholestyramine act by binding bile acids, promoting hepatic conversion of cholesterol, and increasing LDL-receptor activity to clear LDL-cholesterol. They may interfere with fat-soluble vitamin absorption and have common side effects like constipation an

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The gallbladder and bile duct anatomy includes details on shape, length, capacity, blood supply, lymphatics, physiology, bile production, functions, investigations, congenital abnormalities, types of obstructions, clinical features, differential diagnosis, and treatment options including surgery and

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