HER2 activation plays a crucial role in promoting tumor proliferation and survival in NSCLC. Driven by oncogenic downstream signaling pathways, HER2 overexpression and gene amplification lead to the formation of heterodimers and activation of key signaling cascades. Additionally, HER2 mutations are

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This slideshow provides an overview of tumor classification, nomenclature, and key concepts in pathology. It covers the definitions of neoplasm, tumor, and oncology, the classification of tumors into benign and malignant categories, as well as the importance of stroma in tumor behavior. It also expl

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Viruses interact with host cells in various ways, encoding genes that manipulate cell functions for their benefit. These interactions can range from benign to lethal outcomes. Factors influencing these interactions include viral factors, cellular responses, and the presence of virulence factors. Dif

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Despite frequently being benign, uterine endometrial polyps can have a serious influence on a woman\u2019s general health and her ability to conceive. These minute tissue developments in the uterine coating can cause a large number of side effects and results. Endometrial polyps, though usually non-

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Neonatal jaundice, a common condition in newborns, results from elevated bilirubin levels. While often benign, high levels can lead to complications like kernicterus. Recognizing risk factors, limitations of clinical assessment, and appropriate evaluation and treatment are crucial in managing neonat

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Discover the best spine tumor treatment at Medspine, the leading hospital with top surgeon and specialist in Medavakkam, Perumbakkam, Royapettah, Chennai.

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brain tumor is an abnormal growth of cells in the brain. Tumors can be either cancerous (malignant) or non-cancerous (benign). Cancerous tumors grow and spread aggressively, potentially invading nearby tissues and spreading to other parts of the body, while non-cancerous tumors are usually less aggr

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Testicular tumors are predominantly malignant, with germ cell tumors being the most common type. This article delves into the classification of testicular tumors, including primary and secondary, benign and malignant, germ cell, and non-germ cell tumors. Clinical findings such as painless enlargemen

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Grading and staging are crucial in determining the aggressiveness and extent of malignant tumors. Grading involves assessing the level of malignancy based on cell differentiation and mitotic activity, while staging considers the size of the tumor, lymph node involvement, and presence of metastases.

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Lipomas are common benign tumors that often present as small, painless, subcutaneous masses. This summary provides insights into the clinical features of lipomas, including their typical characteristics and management recommendations. It emphasizes the importance of reassurance, observation, and app

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Benign breast conditions can manifest in various ways, including pain, palpable masses, and nipple discharge. Familiarity with common inflammatory conditions like mastitis and abscesses, as well as understanding fibrocystic changes and benign tumors such as fibroadenoma, is crucial. Mammographic scr

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This case involves a 2-month-old female with Tetralogy of Fallot, carrying a genetic variation in the 19p13.11 region. The evaluation process includes assessing genes, known dosage sensitivity, gene count, and detailed analysis of the duplication found in the DGV Gold Standard Dataset. The frequency

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This 1-week course delves into the pathophysiology, diagnosis, and treatment of diseases affecting the Hematopoietic System. Topics covered include benign and malignant hematologic disorders, pediatric and adult presentations, blood component therapy, transfusion medicine, and more. Faculty units fr

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Laryngeal tumours can be benign or malignant, with different types such as papilloma, chondroma, paraganglioma, and squamous cell carcinoma. These tumours present with various symptoms and may spread through direct, lymphatic, or hematogenous routes. Risk factors include tobacco smoking, alcohol con

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Hypertension, a common yet serious health issue, is explored in detail in this lecture. The etiology, risk factors, and complications of hypertension are discussed, along with the classification into primary, secondary, benign, and malignant hypertension. The lecture also covers causes of secondary

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Urinary retention can be acute or chronic, resulting in the painful inability to void or fully empty the bladder. In men, common causes include benign prostatic enlargement and post-surgery complications, while women may experience it due to pelvic prolapse or neurological issues. Initial management

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This trial aims to compare the efficacy and safety of molecularly-guided therapy or cancer immunotherapy based on genomic profiling with platinum-based chemotherapy in patients with cancer of unknown primary site. The study design includes multiple treatment regimens guided by genomic profiles, with

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Episcleritis and scleritis are inflammatory conditions affecting the episclera and sclera of the eye, respectively. Episcleritis is benign, self-limiting, and rarely progresses to scleritis, presenting with redness and mild discomfort. Scleritis, on the other hand, is a more serious condition that c

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WAGR syndrome is a rare genetic condition associated with Wilms Tumor, aniridia, and developmental delays. Wilms Tumor is a form of kidney cancer mostly affecting children and is linked to genetic disorders like WAGR syndrome. The risk of Wilms Tumor is higher in children with WAGR syndrome, with po

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Melanoma, a type of skin cancer, can be life-threatening if not diagnosed early. This study presented at the IEEE EMBC conference focuses on using a convolutional neural network for automated detection of melanoma lesions in clinical images. The importance of early detection is highlighted, as exper

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Parathyroid carcinoma (PC) is a rare malignancy often challenging to differentiate from benign thyroid nodules. This case study highlights a 50-year-old male patient whose nonfunctioning sporadic PC was initially misidentified as a follicular thyroid nodule. Despite preoperative evaluations, includi

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Explore the general features of lymphoproliferative disorders, including benign causes like infectious mononucleosis and the classification of malignant LPDs. Delve into chronic lymphoid leukemia, along with common LPDs such as Burkitt lymphoma, Follicular lymphoma, multiple myeloma, and Hodgkin lym

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Cancer is a disease characterized by the uncontrollable growth and spread of abnormal cells in the body. These cells form tumors that can be either cancerous (malignant) or non-cancerous (benign). Cancer can develop in various parts of the body and is often caused by genetic changes that affect cell

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Positron Emission Tomography (PET) is a medical imaging technique focusing on metabolic differences in the body. By using positron-emitting radioisotopes, PET can detect how molecules are taken up by healthy and cancerous cells, aiding in accurate tumor localization with lower doses. The evolution o

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Disney's role in diplomacy, particularly in South America, reveals a complex interplay between cultural dominance, commercial interests, and government policies. The Good Neighbors Office aimed to counter German propaganda through positive American portrayal, but overlooked cultural differences and

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This comprehensive guide covers the diagnosis and management of parotid tumors, including anatomy, differential diagnosis, and management strategies. It discusses the approach to evaluating patients with neck lumps, differential diagnoses to consider, and the management techniques for both benign an

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Research collaboration aimed to enhance locoregional tumor control and reduce distant failure by combining charged particles irradiation and anticancer drug Epothilone B in cultured human tumor cells from Milano and Roma. The study explores the impact on clonogenic survival, growth curves, and deter

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Understanding the natural history, evaluation, and management of benign liver lesions is crucial for diagnosing incidental liver findings. Common benign liver lesions include hepatic hemangioma, focal nodular hyperplasia, hepatic adenoma, and hepatic cyst. Differential diagnosis plays a key role in

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The Gamma Knife Stereotactic Radiosurgery is a precise and effective treatment method where highly focused radiation beams are used to target tumors and abnormalities in the brain. It does not remove the tumor directly but affects DNA, cell growth, and blood vessels. The procedure involves three mai

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NCI-MATCH is a groundbreaking clinical trial aiming to match tumor gene alterations with targeted therapies. The interim analysis results revealed impressive patient enrollment and site participation exceeding expectations. Despite challenges with pausing new patient registrations for the analysis,

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This study by Shyamala Maherswaran, Ph.D., and team focuses on characterizing mutations in EGFR in circulating tumor cells using SARMS assay and CTC-chip. The research investigates the effectiveness of these non-invasive methods in analyzing tumors and explores the role of the T790M mutation in resp

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This collection of supplementary figures provides detailed flow cytometry data on immune cell populations, including CD4+ T cells, CD8+ T cells, tumor-associated macrophages, and more. The figures also include information on immune checkpoint molecules like PD-L1 and TIGIT. Each figure presents spec

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Vestibular schwannoma, also known as acoustic neuroma, is a common tumor in the cerebellopontine angle. It can be sporadic or associated with neurofibromatosis type 2. Patients typically present with hearing loss and tinnitus, which may be gradual or sudden. Grading systems like Koos, Ojemann, and J

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Neoplasia encompasses abnormal tissue growth that can be benign or malignant. This article explores neoplastic terms, tumor classifications, cancer staging, and genetic factors in cancer development. Gain insights into the characteristics of benign tumors, the biology of cancer including carcinogene

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Neoplasia, or new growth, is characterized by uncoordinated growth exceeding that of normal tissues, persistent growth independent of stimuli, loss of responsiveness to growth controls, and local expansion regardless of host environment. Tumors are classified into benign and malignant categories in

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Canine mammary neoplasms, including benign adenomas and malignant carcinomas, are common in intact female dogs. This article discusses the clinical signs, diagnosis methods like FNAC and biopsy, WHO clinical staging system, and the importance of palpating regional lymph nodes for prognosis assessmen

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Understanding the classification of tumors is crucial in the field of pathology. This detailed overview covers the definitions of neoplasia and tumors, the differentiation between benign and malignant tumors, nomenclature, and characteristics of various tumor types. It discusses the behaviors of ben

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Pathologist Saeed Samie discusses feelings of safety and satisfaction when reporting thyroid FNA results, emphasizing certainty in malignant lesions over benign ones. Reduction of unnecessary surgical interventions and the importance of uniform categorization for clinical decision-making and guideli

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Opportunities and strategies to engage trainees in benign hematology education, focusing on the importance of early exposure, clinical experiences, and fostering engagement with benign hematologists. Discusses challenges in the field and the benefits of double boarding in hematology and oncology.

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Fibroadenomas are common benign breast tumors, with unknown pathogenesis but linked to hormonal factors. They typically present as painless, movable masses and are often diagnosed through ultrasound or mammogram. Management involves monitoring or surgical excision based on size, growth rate, patient

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