Understanding Key Clinical Approaches and Commonly Missed Aspects in Medical Diagnoses

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Explore essential clinical approaches in diagnosing acute and chronic problems, along with strategies for effective studying and preparing for uncommon scenarios. Discover commonly missed aspects in familiar approaches and less familiar presentations in various medical conditions.


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  1. Station 5 Wang Zhemin

  2. General 3 min History + 3 min Examination + 2 min Counseling + 2 min Discussion Acute Problem: Contextualised differentials Chronic Problem: Diagnose, evaluate features, complications, associations Concerns: Explicitly elicit Counseling: Diagnosis/Differentials, Disposition, Treatment (symptoms, underlying), Follow Up/Discharge Advice

  3. How to Study/Think? Approaches (top down): Breadth (types and content), patterns, thinking of paces diagnoses (guide inspection) Conditions (bottom up): Know enough (don t need too much) about your PACES favourites Concept of opening doors and moving up floors

  4. Knowing What is Common Grave s (7): Neck swelling, fever, periodic paralysis, agranulocytosis Acromegaly (7) Psoriasis (5): Joint Pain Systemic Sclerosis (5): SOB Ank Spond (4): Back Pain Gout (4): Joint pain Others: Retinitis pigmentosa, MEN, NF, SLE, HHT, RA, Sjogren s Tendon Xanthoma, DM, Hypothyroidism, TIA/hemiplegic migraine, CMT, Osteogensis imperfecta, ITP

  5. Preparing for the Uncommon Approaches Commonly missed aspects of familiar approaches Unfamiliar approaches Conditions PACES Favourites Knowing how these can present in a station 5 scenario

  6. Commonly missed things in familiar approaches Headache: Hypertension, hyperviscosity, GCA Chest Pain: Odynophagia Hypertension: OSA, drugs, vasculitis Lower Limb Swelling: Thyroid disease, drugs (CCB) Abdominal Pain: Medical causes (hereditary angioedema, familial mediterranean fever) Diarrhea: VIPoma, carcinoid

  7. Less familiar approaches Tremors, chorea Visual problems Amnesia Parasthesia Hand pain Weight gain Sweating Itch Flushing Eye swelling Rash: Raynaud s, erythema nodosum, pyoderma gangrenosum

  8. PACES Favourites Rheum + Endocrine conditions most common Neuro conditions possible Wilson s, PBC, Polyglandular Autoimmune Syndrome, MEN Syndrome, Amyloidosis, Retinitis Pigmentosa, HHT, NF, Tuberous Sclerosis, Sturge Weber, Acute Intermittent Porphyria, Osteogenesis Imperfecta, VHL, Peutz Jeghers, Carcinoid, Hereditary Angioedema

  9. Patterns Headache Headache + Hypertension: Pheochromocytoma, Hypertension causing HA, CCB use, Raised ICP with Cushing s reflex, Pituitary tumours with 2 endocrinopathy (acromegaly, cushing s) Headache + BOV: GCA, glaucoma, BIH, SOL with visual tract compromise (pituitary tumour, cerebral SOL) Thunderclap Headache: SAH, cerebral venous sinus thrombosis, cervical artery dissection, reversible cerebral vasoconstriction syndromes Headache with raised ICP features: SOL (rmb pituitary tumour), BIH, thrombosis/hemorrhage Abdominal Pain Intermittent: Biliary colic, renal colic, constipation colic, gut claudication, acute intermittent porphyria, hereditry angioedema Dark urine: Ureteric colic, biliary obstruction, acute intermittent porphyria

  10. Examples Easy: Inflammatory back pain secondary to psoriatic arthropathy Hx of back pain inflammatory in nature evaluate for autoimmune, infective, neoplastic causes Hx yielding of rash suggestive of psoriasis Consider other cx of psoriasis e.g. ILD, nail changes Intermediate: LL swelling from nephrotic syndrome from amyloidosis in patient with RA History of LL swelling sugestive of hypoalbuminemia Cause of hypoalbuminemia suggestive of nephrotic syndrome History of RA suggestive of possible amyloidosis; Ddx might include NSAID induced nephrotic syndrome

  11. Examples Difficult: Polyuria secondary to diabetis insipidus from hypercalcemia due to hyperparathyoidism in MEN syndrome Polyuria history Features of hypercalcemia established Evaluate for cause of hypercalcemia malignancy, myeloma, TB, sarcoid, PTH Explore laterally to pick up other MEN symptoms or fam/personal hx

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