Precision Oncology and Genomic Changes in Cancer Treatment

Explore the intricate details of cancer treatment through precision oncology, focusing on cell of origin, genomic changes, tumor microenvironment, host factors, and response to various treatments such as chemotherapy, biological therapy, and immune therapy. The natural history and histology-guided clinical trials play crucial roles in understanding and treating cancer effectively.

• Precision Oncology
• Genomic Changes
• Cancer Treatment
• Cell of Origin
• Tumor Microenvironment

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1. Morphology, Anatomy Natural History, Response to Treatment

2. Gene expression, Proteomics, etc Morphology, Anatomy Natural History, Response to Treatment

3. Cell of Origin Genomic Changes Shat et al, Nature 2012 Gene expression, Proteomics, etc Morphology, Anatomy Natural History, Response to Treatment

4. Cell of Origin Genomic Changes Tumor Microenvironment Fibroblasts Macrophages Lymphocytes Endothelial cells Shat et al, Nature 2012 Gene expression, Proteomics, etc Morphology, Anatomy Natural History, Response to Treatment

5. Cell of Origin Genomic Changes Tumor Microenvironment Host Factors Fibroblasts Macrophages Lymphocytes Endothelial cells Shat et al, Nature 2012 Gene expression, Proteomics, etc Morphology, Anatomy Natural History, Response to Treatment

6. Precision Oncology Cell of Origin Genomic Changes Tumor Microenvironment Host Factors Fibroblasts Macrophages Lymphocytes Endothelial cells Shat et al, Nature 2012 Gene expression, Proteomics, etc Morphology, Anatomy Natural History, Response to Treatment Chemotherapy (DNA repair/checkpoint/cell death) Biological therapy (growth signaling pathways) Immune Therapy (tumor/host factors)

7. Precision Oncology Cell of Origin Genomic Changes Tumor Microenvironment Host Factors Fibroblasts Macrophages Lymphocytes Endothelial cells Shat et al, Nature 2012 Gene expression, Proteomics, etc Morphology, Anatomy Histology guided clincial trials Natural History, Response to Treatment Chemotherapy (DNA repair/checkpoint/cell death) Biological therapy (growth signaling pathways) Immune Therapy (tumor/host factors)

8. Precision Oncology Cell of Origin Genomic Changes Tumor Microenvironment Host Factors Fibroblasts Macrophages Lymphocytes Endothelial cells Shat et al, Nature 2012 Gene expression, Proteomics, etc Morphology, Anatomy BIG DATA?? Histology guided clincial trials Genomically informed Clinical trials Natural History, Response to Treatment Chemotherapy (DNA repair/checkpoint/cell death) Biological therapy (growth signaling pathways) Immune Therapy (tumor/host factors)

9. Precision Oncology Cell of Origin Genomic Changes Tumor Microenvironment Host Factors Fibroblasts Macrophages Lymphocytes Endothelial cells Shat et al, Nature 2012 Gene expression, Proteomics, etc Morphology, Anatomy BIG DATA?? Histology guided clincial trials Genomically informed Clinical trials Natural History, Response to Treatment Chemotherapy (DNA repair/checkpoint/cell death) Biological therapy (growth signaling pathways) Immune Therapy (tumor/host factors) Shridar Ganesan, MD, Phd Assoc. Dir. Transl. Science Chief, Sec. Molecular Oncology Rutgers -CINJ