A Rare Case of Ascites in a 22-Year-Old Female: Clinical Presentation and Investigations

 
A RARE CASE OF ASCITES
Dr. Siva Krishna
DEPARTMENT OF MEDICINE
 
CHIEF COMPLAINTS
 
22 yr/Female, Resident of Lonavala, came with chief
complaints of:
Abdominal distension and Pain in abdomen since 3 days
No h/o loose stool, vomiting, fever
No h/o blood in stools
No h/o breathlessness
 
 
Past history
 
No H/O HTN/DM
No H/O TB/Asthma
No H/O Thyroid/Epilepsy
No H/O similar complaints in past
No H/O Jaundice
H/O Normal delivery 6 months back
No H/O OC Pills usage.
 
 
 
Family history
 
Not significant
No similar history in the
family members
 
Personal history
Sleep normal
Appetite decreased
Bladder normal
Bowel normal
Mixed diet
No any addictions
 
 
On examination
Afebrile
Pulse: 92/min
BP:     110/70mmhg
RR:     18/min
 
General examination
 
No Pallor
No Icterus
No Edema
No Cyanosis, Clubbing, Lymphadenopathy.
No signs of Liver cell failure
 
Systemic examination
 
PA  
:  Soft and distended, mild hepatomegaly
             Shifting dullness present
             No fluid thrill
CVS
 : Normal
RS 
   : Normal vesicular breath sounds
CNS 
: Conscious oriented to time place and person
 
Ascitic fluid suggestive of 
transudative nature
SAAG: 1.61
 
Radiological investigations
 
USG Abdomen & Pelvis:
Liver 16cms enlarged, with
   normal echogenicity.
Portal veins-normal
Pseudo gall bladder wall
thickening
Spleen, Pancreas, Kidney: Normal
 
Free fluid noted in pouch of
Douglas, pelvis, perihepatic
and perisplenic region.
Right sided minimal pleural
effusion.
 
CXR: 
Normal
 
Color Doppler of Portal System
 
Liver
 18cms, relative atrophy of left lobe of liver with
enlargement of caudate lobe of liver.
Hepatic veins- 
Right hepatic vein appears thrombosed / thick
                              hyper echoic.
                              Middle hepatic vein appears patent.
                              Left hepatic vein- thrombosed.
 
IVC – normal, no thrombosis
Portal vein – 7mm with reversal of flow
Collaterals- intrahepatic venovenous collaterals seen with
no flow s/o thrombosis.
Conclusion: Budd-Chiari Syndrome 
with portal
hypertension.
 
CECT A/P
 
A
 
B
 
CECT A/P
 
c
 
D
 
On Upper GI endoscopy
 
Mild portal hypertensive gastropathy
Nodular pangastritis
 
Pro thrombotic profile 
was 
NORMAL
 
Diagnosis
 
Budd-chiari syndrome 
– most probable 
post partum 
etiology.
 
Treatment
 
Inj. Enoxaparin 0.6cc BD for 5 days &
overlapped with
Tab. Acenocoumaral 2mg OD on day 3 of
enoxaparin
Tab. Furosemide/Spironolactone 20/50mg BD
Tab. Propranolol 40mg OD
 
 
Follow up after one month
 
Patient had symptomatically improved.
Patient was continued on anticoagulation medication
and INR was maintained between 2-3.
On USG: No evidence of ascites.
 
DISCUSSION
 
BUDD-CHIARI SYNDROME is a very rare condition affecting
one in a million.
Presents with classical 
triad
 of Abdominal pain, Ascites, liver
enlargement.
Etiology
 : Idiopathic in approximately 1/3
rd
 of patients,
Thrombotic diathesis, pregnancy, post partum, OCP, Chronic
infection, Chronic inflammatory diseases, hematological
disorders like Polycythemia rubra vera, Paroxysmal nocturnal
hemoglobinuria, antiphospholipid antibody syndrome.
 
Clinical variants
 of Budd-chiari syndrome:
 
Acute and sub acute 
form
 
: Characterized by rapid
development of abdominal pain, ascites, hepatomegaly,
jaundice and renal failure
Chronic 
form: Progressive ascites, 50% pt have renal
impairment, Jaundice is absent.
Fulminant
 form: Hepatic failure present, ascites, tender
hepatomegaly, jaundice, and renal failure.
 
References
 
1.
Rajani R, Melin T, Björnsson E, Broomé U, Sangfelt P, Danielsson A, Gustavsson A,
Grip O, Svensson H, Lööf L, Wallerstedt S, Almer SH (Feb 2009). "Budd–Chiari
syndrome in Sweden: epidemiology, clinical characteristics and survival - an 18-
year experience". Liver International. 29 (2): 253–9. doi:10.1111/j.1478-
3231.2008.01838.x. PMID 18694401.
2.
 "Etiology, management, and outcome of the Budd–Chiari syndrome".
3.
 "Hepatic vein thrombosis (Budd–Chiari syndrome)".
4.
 "The Budd–Chiari syndrome: a review".
5.
 "Budd–Chiari syndrome: long-term survival and factors affecting mortality".
6.
 "Budd–Chiari Syndrome: clinical patterns and therapy".
7.
 "Budd–Chiari syndrome: etiology, diagnosis and management".
8.
 "Case records of the Massachusetts General Hospital. Weekly
clinicopathological exercises. Case 51-1987. Progressive abdominal distention in
a 51-year-old woman with polycythemia vera"
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A 22-year-old female presented with abdominal distension and pain. Her medical history, family history, and personal habits were reviewed. Examination revealed mild hepatomegaly and shifting dullness. Lab investigations showed normal values with no signs of infection. Ascitic fluid analysis indicated a transudative nature. Radiological investigations also supported the diagnosis. Overall, the case highlights a complex presentation of ascites in a young female.


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  1. A RARE CASE OF ASCITES Dr. Siva Krishna DEPARTMENT OF MEDICINE

  2. CHIEF COMPLAINTS 22 yr/Female, Resident of Lonavala, came with chief complaints of: Abdominal distension and Pain in abdomen since 3 days No h/o loose stool, vomiting, fever No h/o blood in stools No h/o breathlessness

  3. Family history Past history No H/O HTN/DM Not significant No similar history in the No H/O TB/Asthma family members No H/O Thyroid/Epilepsy No H/O similar complaints in past No H/O Jaundice H/O Normal delivery 6 months back No H/O OC Pills usage.

  4. Personal history Sleep normal Appetite decreased Bladder normal Bowel normal Mixed diet No any addictions

  5. On examination Afebrile Pulse: 92/min BP: 110/70mmhg RR: 18/min

  6. General examination No Pallor No Icterus No Edema No Cyanosis, Clubbing, Lymphadenopathy. No signs of Liver cell failure

  7. Systemic examination PA : Soft and distended, mild hepatomegaly Shifting dullness present No fluid thrill CVS : Normal RS : Normal vesicular breath sounds CNS : Conscious oriented to time place and person

  8. Lab investigations Hb TLC DLC Platelet Count Hematocrit Blood urea/ Creatinine Total Bilirubin/Direct Bilirubin SGPT/SGOT Na+/ K+ Total Protein Albumin/Globulin Pt-Inr/aPtt Amylase/Lipase HIV/HbsAg/HCV 11.8 gm% 7800 N:46 L:37 E:05 M:12 2.10 lakh 35.3 25/0.7 0.59/0.28 28/24 134/3.7 5.34 3.01/2.31 1.0/39.8 58/30 Negative

  9. Ascitic fluid Physical Appearance Clear, pale yellow. No clots, coagulum or cobweb R/M Total Proteins/ Albumin Sugars ADA LDH Amylase/ Lipase Zero cells 2.5/1.4 128 3.8 65 28/64 Ascitic fluid suggestive of transudative nature SAAG: 1.61

  10. Radiological investigations CXR: Normal USG Abdomen & Pelvis: Free fluid noted in pouch of Liver 16cms enlarged, with Douglas, pelvis, perihepatic normal echogenicity. and perisplenic region. Portal veins-normal Right sided minimal pleural Pseudo gall bladder wall effusion. thickening Spleen, Pancreas, Kidney: Normal

  11. Color Doppler of Portal System Liver 18cms, relative atrophy of left lobe of liver with enlargement of caudate lobe of liver. Hepatic veins- Right hepatic vein appears thrombosed / thick hyper echoic. Middle hepatic vein appears patent. Left hepatic vein- thrombosed.

  12. IVC normal, no thrombosis Portal vein 7mm with reversal of flow Collaterals- intrahepatic venovenous collaterals seen with no flow s/o thrombosis. Conclusion: Budd-Chiari Syndrome with portal hypertension.

  13. CECT A/P A B

  14. CECT A/P c D

  15. On Upper GI endoscopy Mild portal hypertensive gastropathy Nodular pangastritis Pro thrombotic profile was NORMAL Diagnosis Budd-chiari syndrome most probable post partum etiology.

  16. Treatment Inj. Enoxaparin 0.6cc BD for 5 days & overlapped with Tab. Acenocoumaral 2mg OD on day 3 of enoxaparin Tab. Furosemide/Spironolactone 20/50mg BD Tab. Propranolol 40mg OD

  17. Follow up after one month Patient had symptomatically improved. Patient was continued on anticoagulation medication and INR was maintained between 2-3. On USG: No evidence of ascites.

  18. DISCUSSION BUDD-CHIARI SYNDROME is a very rare condition affecting one in a million. Presents with classical triad of Abdominal pain, Ascites, liver enlargement. Etiology : Idiopathic in approximately 1/3rd of patients, Thrombotic diathesis, pregnancy, post partum, OCP, Chronic infection, Chronic inflammatory diseases, hematological disorders like Polycythemia rubra vera, Paroxysmal nocturnal hemoglobinuria, antiphospholipid antibody syndrome.

  19. Clinical variants of Budd-chiari syndrome: Acute and sub acute form: Characterized by rapid development of abdominal pain, ascites, hepatomegaly, jaundice and renal failure Chronic form: Progressive ascites, 50% pt have renal impairment, Jaundice is absent. Fulminant form: Hepatic failure present, ascites, tender hepatomegaly, jaundice, and renal failure.

  20. References 1. Rajani R, Melin T, Bj rnsson E, Broom U, Sangfelt P, Danielsson A, Gustavsson A, Grip O, Svensson H, L f L, Wallerstedt S, Almer SH (Feb 2009). "Budd Chiari syndrome in Sweden: epidemiology, clinical characteristics and survival - an 18- year experience". Liver International. 29 (2): 253 9. doi:10.1111/j.1478- 3231.2008.01838.x. PMID 18694401. 2. "Etiology, management, and outcome of the Budd Chiari syndrome". 3. "Hepatic vein thrombosis (Budd Chiari syndrome)". 4. "The Budd Chiari syndrome: a review". 5. "Budd Chiari syndrome: long-term survival and factors affecting mortality". 6. "Budd Chiari Syndrome: clinical patterns and therapy". 7. "Budd Chiari syndrome: etiology, diagnosis and management". 8. "Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 51-1987. Progressive abdominal distention in a 51-year-old woman with polycythemia vera"

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