TLR1 - Toll-like Receptor-1 in Immunology Research at University of São Paulo

Alan Frazão da Silva from the Department of Immunology at the University of São Paulo's Institute of Biomedical Sciences is conducting research on TLR1, a Toll-like receptor involved in immune responses against gram-negative bacteria and autoimmune diseases like Type 1 Diabetes and Graves' disease. This research focuses on the expression, signaling pathways, and disease associations of TLR1 with insights into genetic factors influencing disease susceptibility and progression.

• Immunology Research
• TLR1
• Toll-like Receptor
• University of São Paulo
• Autoimmune Diseases

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1. Universidade de So Paulo Instituto de Ci ncia Biom dicas Departamento de Imunologia Alan Fraz o da Silva TLR1 Toll-like receptor - 1

2. TLR1 Toll-like receptor - 1 Expressed at the plasma membrane TLR2 is a co-receptor and forms a heterodimer with TLR1 PAMPs Lipoproteins and triacylated lipopeptides of gram negative bacteria and Mycoplasma Kawai and Akira; 2010 DAMPs -defensin-3 Moresco et al.; 2011 Funderburg et al.; 2007

3. TLR1 Toll-like receptor - 1 Kawai and Akira; 2010; Moresco et al.; 2011. Signalling pathway PAMP binding INFLAMMATION Recruitment - MyD88 aptamer-like protein - Myeloid differentiation factor 88 Release of inflammatory citokines TNF- IL-1 IL-6 Clivage and activation Activation of inflammatory proteins genes

4. TLR1 Toll-like receptor - 1 Diseases associated Type 1 Diabetes mellitus .SNPs: rs4833095 and rs5743612 seems to be related to the etiology of the disease in a chinese Han population Grave s disease .SNPs: rs5743565 presents a protective effect in cantonese women (China) with GD, because it promotes a decrease of autoimmunity response. Yingchi Zhang et al.; 2021.

5. Universidade de So Paulo Instituto de Ci ncia Biom dicas Departamento de Imunologia Alan Fraz o da Silva TLR1 Toll-like receptor - 1