Sequence Alignment in Genetics
Sequence
Alignment
What is Sequence Alignment?
•
Quite simply, the comparison of two or
more
DNA or protein sequences to each
other.
•
The purpose of alignment is to highlight
similarity between the sequences.
Why Do We Use Alignment?
Fundamental assumption of
sequence alignment:
•
Sequences that are similar share a common ancestral
sequence.
•
Due to common ancestry, similar sequences have
similar functionality.
•
Sequences that share a common ancestor are said to
be
homologous.
Alignment can be easy or difficult
GCGGCCCA TCAGGTAGTT GGTGG
GCGGCCCA TCAGGTAGTT GGTGG
GCGTTCCA TCAGCTGGTT GGTGG
Easy
GCGTCCCA TCAGCTAGTT GGTGG
GCGGCGCA TTAGCTAGTT GGTGA
******** ********** *****
TTGACATG CCGGGG---A AACCG
TTGACATG CCGGTG--GT AAGCC
TTGACATG -CTAGG---A ACGCG
Difficult due to insertions or deletions(indels)
TTGACATG -CTAGGGAAC ACGCG
TTGACATC -CTCTG---A ACGCG
******** ?????????? *****
Types of Alignment
1. Global Alignment
2. Local Alignment
Sequence alignment is the comparison of DNA or protein sequences to highlight similarities, often indicating a common ancestral sequence. This process is essential in determining homology and functional similarities between sequences. Types of alignment include global and local alignment, with challenges like insertions and deletions affecting difficulty levels.
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Presentation Transcript
Sequence Alignment
What is Sequence Alignment? Quite simply, the comparison of two or more DNA or protein sequences to each other. The purpose of alignment is to highlight similarity between the sequences.
Why Do We Use Alignment? Fundamental assumption of sequence alignment: Sequences that are similar share a common ancestral sequence. Due to common ancestry, similar sequences have similar functionality. Sequences that share a common ancestor are said to be homologous.
Alignment can be easy or difficult GCGGCCCA TCAGGTAGTT GGTGG GCGGCCCA TCAGGTAGTT GGTGG GCGTTCCA TCAGCTGGTT GGTGG Easy GCGTCCCA TCAGCTAGTT GGTGG GCGGCGCA TTAGCTAGTT GGTGA ******** ********** ***** TTGACATG CCGGGG---A AACCG TTGACATG CCGGTG--GT AAGCC TTGACATG -CTAGG---A ACGCG Difficult due to insertions or deletions(indels) TTGACATG -CTAGGGAAC ACGCG TTGACATC -CTCTG---A ACGCG ******** ?????????? *****
Types of Alignment 1. Global Alignment 2. Local Alignment
