Pathophysiology of Acute Appendicitis

Necrosis, perforation, and arterial compromise in acute appendicitis lead to lumen obstruction, increased luminal pressure, bacterial growth, and venous obstruction. Symptoms typically include periumbilical or epigastric pain due to visceral pain caused by lumen obstruction.

• Appendicitis
• Pathophysiology
• Acute
• Necrosis
• Obstruction

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Uploaded on Oct 02, 2024 | 0 Views

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1. Acute appendicitis

2. PATHOPHYSIOLOGY Necrosis, Perforation Arterial compromised Lumen obstruction Luminal pressure Bacterial growth, Venous obstruction Fecalith, lymphoid follicles

3. History Periumbilical or epigastric pain Lumen obstruction Visceral pain Anorexia (90%), nausea & vomiting (70%), diarrhea (10%) Right lower quadrant pain Transmural inflammation Parietal pain Peritoneal irritation, pain on movement, fever, tachycardia Diffused tenderness Ruptured appendicitis with peritonitis

4. Physical examination McBurney s point tenderness Rovsing s sign RLQ pain resulting from palpation in the left lower quadrant

5. Lab & Radiologic exam Lab CBC U/A Electrolytes, BUN, creatinine Pregnancy test Radiologic exam X-ray: rarely helpful Ultrasound: operator dependent CT scan: most common, sensitivity 94%, specificity 95% MRI: for pregnant patient

6. Alvarado Score for Acute Appendicitis (MANTRELS) Abdominal pain that Migrates to the right iliac fossa (2pts) Anorexia (loss of appetite) or ketones in the urine Nausea or vomiting Total score <5 5 or 6 7 or 8 9 or 10 Tenderness in the right iliac fossa Unlikely Possible Likely Highly likely Rebound tenderness Fever of 37.3 C or more (Elevated temperature) Leukocytosis, (>10000 WBC/mL) (2pts) Neutrophilia, or Shift of neutrophils to the left

7. Treatment Antibiotics therapy Broad-spectrum gram-negative and anaerobic coverage Appendectomy Open appendectomy Conventional procedure Laparoscopic appendectomy Reduce pain, hospital stay Quicker return to work Lower risk of wound infection Benefit in obese and woman