Overview of Chelating Agents in Pharmacology
Chelating agents
Chelating agents
Pharmacology SDL project
Group no. 10
Section B10
Index
Index
1.
Definition
Definition
2.
Dimercaprol
Dimercaprol
3.
Succimer
Succimer
4.
Edeta
Edeta
5.
Calcium disodium edetate
Calcium disodium edetate
6.
Pencillamine
Pencillamine
7.
Desferrioxamine of
Desferrioxamine of
Chelating agents
Chelating agents
Definition
Definition
•
They are organic compounds which bind with
They are organic compounds which bind with
heavy metal ions to form firmly bound complexes
heavy metal ions to form firmly bound complexes
which are non-toxic and easily excreted in urine
which are non-toxic and easily excreted in urine
Dimercaprol
Dimercaprol
(bal)
(bal)
•
It is effective in treatment of
It is effective in treatment of
acute
acute
poisoning
poisoning
of metal
of metal
•
E.g.
E.g.
arsenic, mercury, antimony
arsenic, mercury, antimony
as
as
affinity of BAL to metal ions is greater
affinity of BAL to metal ions is greater
than that metal to tissue enzymes.
than that metal to tissue enzymes.
Succimer
Succimer
(di-mercapto succinic acid)
(di-mercapto succinic acid)
dmsa
dmsa
•
Used for the treatment of high blood
Used for the treatment of high blood
lead
lead
concentrations, and
concentrations, and
mercury
mercury
poisoning .
poisoning .
•
Mechanism
Mechanism
: It binds with high specificity ions
: It binds with high specificity ions
of lead in the blood to form a water-soluble
of lead in the blood to form a water-soluble
complex excreted by kidneys.
complex excreted by kidneys.
Edta
Edta
(Ethylene diamine tetracyclic acid)
(Ethylene diamine tetracyclic acid)
•
it is effective in treatment of poisoning with
it is effective in treatment of poisoning with
Ca++.
Ca++.
•
Mechanism
Mechanism
: once injected to the blood
: once injected to the blood
stream, it circulates in blood, binding to
stream, it circulates in blood, binding to
Ca++ and collecting all the metal into a
Ca++ and collecting all the metal into a
compound that’s filtered through the kidney
compound that’s filtered through the kidney
and released in the urine.
and released in the urine.
Calcium disodium edetate
Calcium disodium edetate
•
It is a salt of edetate with
It is a salt of edetate with
two sodium
two sodium
and
and
one calcium
one calcium
atom
atom
•
Mechanism:
Mechanism:
It is used by
It is used by
IV
IV
infusion to
infusion to
chelate
chelate
lead
lead
in lead poisoning because
in lead poisoning because
lead has a great affinity for EDETA,
lead has a great affinity for EDETA,
than calcium and thus replaces calcium
than calcium and thus replaces calcium
in this complex
in this complex
Penicillamine
Penicillamine
•
It is effective chelator of
It is effective chelator of
copper
copper
. It is mainly used in
. It is mainly used in
hepato -lenticular degeneration
hepato -lenticular degeneration
"Wilson's disease"
"Wilson's disease"
it is
it is
may also be used for
may also be used for
mercury
mercury
,
,
cobalt
cobalt
, lead to poisoning
, lead to poisoning
as well as
as well as
rheumatoid arthritis
rheumatoid arthritis
.
.
Desferrioxamine of Chelating agents
Desferrioxamine of Chelating agents
•
Selectively chelates iron in ferric state so,
Selectively chelates iron in ferric state so,
used in acute
used in acute
iron
iron
poisoning.
poisoning.
Chelating activity of some drugs:
Chelating activity of some drugs:
•
Tetracycline
Tetracycline
•
Salicylates
Salicylates
Chelating agents are organic compounds that bind with heavy metal ions to form non-toxic complexes excreted in urine. Dimercaprol, Succimer, Edeta, Calcium disodium edetate, Penicillamine, and Desferrioxamine are key examples used in treating metal poisoning by forming stable complexes with metals for elimination.
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Presentation Transcript
Chelating agents Pharmacology SDL project Group no. 10 Section B10
Index 1. Definition 2. Dimercaprol 3. Succimer 4. Edeta 5. Calcium disodium edetate 6. Pencillamine 7. Desferrioxamine of Chelating agents
Definition They are organic compounds which bind with heavy metal ions to form firmly bound complexes which are non-toxic and easily excreted in urine
Dimercaprol (bal) It is effective in treatment of acute poisoning of metal E.g. arsenic, mercury, antimony as affinity of BAL to metal ions is greater than that metal to tissue enzymes.
Succimer (di-mercapto succinic acid) dmsa Used for the treatment of high blood lead concentrations, and mercury poisoning . Mechanism: It binds with high specificity ions of lead in the blood to form a water-soluble complex excreted by kidneys.
Edta (Ethylene diamine tetracyclic acid) it is effective in treatment of poisoning with Ca++. Mechanism: once injected to the blood stream, it circulates in blood, binding to Ca++ and collecting all the metal into a compound that s filtered through the kidney and released in the urine.
Calcium disodium edetate It is a salt of edetate with two sodium and one calcium atom Mechanism: It is used by IV infusion to chelate lead in lead poisoning because lead has a great affinity for EDETA, than calcium and thus replaces calcium in this complex
Penicillamine It is effective chelator of copper. It is mainly used in hepato -lenticular degeneration "Wilson's disease" it is may also be used for mercury, cobalt, lead to poisoning as well as rheumatoid arthritis.
Desferrioxamine of Chelating agents Selectively chelates iron in ferric state so, used in acute iron poisoning.
Chelating activity of some drugs: can chelate Tetracycline ??++,??++,??++ can chelate Salicylates ??++,Fe++
