NADH Fate in Cellular Metabolism
Glycolysis
The Fate of NADH
NADH in Recycling in the Cytoplasm
•
Aerobic Pathway
•
Aspartate/Malate Shuttle
•
Glycerol 3-phosphate-DHAP Shuttle
•
Anaerobic Pathway
•
Lactate and the Cori Cycle
•
Ethanol production (in yeast)
Malate – Aspartate Shuttle System
Aspartate Aminotransferase
Malate
Dehydrogenase
Figure modified from:
Son, H.F. and Kim, J-J. (2016) PLoS One 10.1371
M
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IM Space
Matrix
Glutamate
Aspartate
-ketoglutarate
Oxaloacetate
Aspartate Aminotransferase
-ketoglutarate
Malate
Malate
Aspartate
Glutamate
Oxaloacetate
Aspartate Aminotransferase
Malate
Dehydrogenase
Malate
Dehydrogenase
NADH
NAD
+
NADH
NAD
+
Glycerol-3 Phosphate – DHAP Shuttle
Figure from
Boghog2
Summary of Aerobic Pathway of
NADH Oxidation
•
Malate – Aspartate Shuttle Preserves the NADH
•
NADH worth ~3 ATP in this process
•
Glycerol 3 Phosphate – DHAP Shuttle converts NADH to
FADH for entry into the Electron Transport Chain.
•
NADH worth ~1.8 ATP in this process
Anaerobic Metabolism in Animals
Pyruvate
Lactate
Lactate
Dehydrogenase
NADH/H+
NAD+
Figure modified from
Zlir’a
Formation of
lactate allows
recycling of NADH
to NAD+ in the
cytoplasm
Figure from
Boundless Biology, LumenCandella
The Cori Cycle
Figure modified from
Servier Medical Art
We now return to the glycolytic process to explore the fate of NADH that is produced during this metabolic pathway.
Explore the intricate pathways involved in the fate of NADH in cellular metabolism, including aerobic and anaerobic processes such as the Malate Aspartate Shuttle, Glycerol-3Phosphate DHAP Shuttle, and the Cori Cycle. Learn how NADH is recycled and its significance in energy production.
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Presentation Transcript
Glycolysis The Fate of NADH
NADH in Recycling in the Cytoplasm Aerobic Pathway Aspartate/Malate Shuttle Glycerol 3-phosphate-DHAP Shuttle Anaerobic Pathway Lactate and the Cori Cycle Ethanol production (in yeast)
Malate Aspartate Shuttle System Malate Dehydrogenase Aspartate Aminotransferase Figure modified from: Son, H.F. and Kim, J-J. (2016) PLoS One 10.1371
Malate Malate Aspartate Shuttle System Aspartate Shuttle System Aspartate Aminotransferase Oxaloacetate Malate Glutamate Dehydrogenase Malate -ketoglutarate NADH Aspartate NAD+ IM Space Matrix Malate Aspartate Glutamate -ketoglutarate Malate Dehydrogenase NAD+ Oxaloacetate Aspartate Aminotransferase NADH
Glycerol-3 Phosphate DHAP Shuttle Figure from Boghog2
Summary of Aerobic Pathway of NADH Oxidation Malate Aspartate Shuttle Preserves the NADH NADH worth ~3 ATP in this process Glycerol 3 Phosphate DHAP Shuttle converts NADH to FADH for entry into the Electron Transport Chain. NADH worth ~1.8 ATP in this process
Anaerobic Metabolism in Animals NADH/H+ NAD+ Lactate Dehydrogenase Pyruvate Lactate Figure modified from Zlir a
Formation of lactate allows recycling of NADH to NAD+ in the cytoplasm Figure from Boundless Biology, LumenCandella
The Cori Cycle To Bloodstream Glucose Glucose Pyruvate To Muscle NADH NAD+ 2 ATP Pyruvate NADH NAD+ To Liver Lactate To Bloodstream Figure modified from Servier Medical Art
