Managing Diabetes Condition with Ginger Supplements Study

The study explores the use of ginger supplements in managing diabetes, highlighting the significant impact of the disease on cost and quality of life. It includes details on the controlled crossover study conducted with participants taking ginger root powder capsules, the measurements of oxidative biomarkers and lipid profile, and the statistical analysis performed. The research emphasizes the need for effective management strategies for diabetes given its prevalence and lack of cure.

• Diabetes
• Ginger Supplements
• Management
• Clinical Study
• Blood Glucose

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Uploaded on Sep 10, 2024 | 0 Views

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1. Managing Diabetes condition with Ginger Supplements Herbert Jelinek1,4, Wei Xu2, Patrick Ball2, Tony Sahama3and Andrew Stranieri4 1 School of Community Health, Charles Sturt University (CSU), NSW, 2 Discipline of Pharmacy, School of Biomedical Science, CSU, Wagga Wagga, NSW 3 School of Electrical Engineering & Computer Science, QUT, Brisbane 4 Centre for Informatics and Applied Optimisation, School of Science, Information Technology & Engineering, University of Ballarat, Melbourne, Vic

2. Background (what is it?) Diabetes is a silent killer Impact is significant (Cost and Quality of Life) Financial cost of type-2 diabetes is around $11billion Around 300 Australians develop diabetes per day Around 2 million Australians have diabetes: 50% type-2 ~ 50% type-2 are undiagnosed ? (Diabetes Australia 2008) There is no cure for type-1 and type-2 diabetes The disease must be managed with lifestyle regular blood glucose testing Mediation when required through clinical intervention Clinical management of patient with chronic diseases management processes and protocols alternative approaches(e.g., elevation of antioxidants .,) Clinical validation and scientific experiments .., 10/09/2024 Jelinek et al 2012 ICHM2012 2

3. Materials & Methods (How did we approach the problem?) A controlled crossover study A randomised control trail (30 volunteers: 18 males + 12 females) Participants (type -2 , 14 participants 10 males + 4 females) The control group of 16 participants Randomisation (Group A and B of each comprise 15 participants) The treatment: Ginger root powder capsule (1000mg) daily for 4 weeks Before the treatments: Reference blood samples was taken Oxidative biomarkers and Lipid profile were measured (GSM, MDA, LDL, HDL) Group A: gets the treatments while Group B: Vitamin B1 100mg tablet daily (placebo) After 4 weeks second blood sample was taken oxidative biomarkers and lipid profile were measured and compared with initial readings groups cross over then repeated with Group A after 4 weeks the third blood sample was taken Statistical Analysis (Hypothesis Testing) Two-sample t-test (P<0.05; CI=95%) and more ..? May be Factorial Experiments? Repeat the experiments Clinical validation and scientific experiments .., 10/09/2024 Jelinek et al 2012 ICHM2012 3

4. What we achieved so far? a) Non-diabetic group had lower BMI waist circumference higher total cholesterol, LDL, HDL b) Type-2 diabetic group (after Ginger treatment) GSH value decreased significantly (P<0.034) No difference for MDA & Methaemoglobin With Vitamin B1 treatment, there is no differences were found for GSH, MDA and Methaemoglobin in either group 10/09/2024 Jelinek et al 2012 ICHM2012 4

5. How close are we? 80 70 60 Data.Trend[, 4] 50 40 30 20 10 20 30 40 50 60 70 80 90 10/09/2024 Jelinek et al 2012 ICHM2012 5 Data.Trend[, 5]

6. How close are we? 80 70 60 Data.Trend1[, 5] 50 40 30 20 10 200 400 600 800 1000 1200 1400 Data.Trend1[, 2] 10/09/2024 Jelinek et al 2012 ICHM2012 6

7. How close are we? 1000 s(Data.Trend1[, 5],2.55) 500 0 -500 10 20 30 40 50 60 70 80 Data.Trend1[, 5] Jelinek et al 2012 ICHM2012 10/09/2024 7

8. What we can say about it? Direct measurements Self-managing type-2 candidates more accurate and faster diagnosis reduction of early clinical time intervals Reduction in BMI cholesterol- LDL, HDL In-direct measurements Reduction in GSH in the type-2 group Ginger may have an antioxidant effect Likelihoodof reducing the diabetic .?? 10/09/2024 Jelinek et al 2012 ICHM2012 8