Iron metabolism & Hemoglobin catabolism
This content delves into the intricate processes of iron metabolism and hemoglobin catabolism as elucidated by Dr. Sunita Mittal. Explore the fascinating mechanisms underlying these vital biological processes, shedding light on their significance in maintaining proper physiological functions. Gain insights into the interplay between iron regulation and the breakdown of hemoglobin, essential for understanding various health conditions and developing effective treatments.
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Presentation Transcript
Iron metabolism & Hemoglobin catabolism By Dr Sunita Mittal
Learning Objectives Iron metabolism Hemoglobin catabolism (Fate of old RBCs) Prehepatic Jaundice
(Fe+2 +2) Metabolism ) Metabolism Iron Iron (Fe Iron is essential for formation of Heme part of Hemoglobin and other heme containing substances
(Fe+2 +2) Metabolism ) Metabolism Iron Iron (Fe Normal serum iron level (50-170 g/dL) Total Iron Binding Capacityof blood (TIBC) Nr : 240 450 g/dL Serum ferritin=Normal value 25 -75 ng/mL
Iron (Fe Iron (Fe+2 +2) Metabolism Distribution ) Metabolism Distribution The total body iron content is = 4 5 gm Distribution in body-
Iron Regulation in body happens at the level of absorption-HOW
HEPCIDIN is the key regulator of iron in our body by regulating its absorption and release Hypoxia
Hemoglobin Catabolism (destruction of old RBCs) Red cell destruction usually occurs after an average life span of 120 days The cells are removed extravascularly by macrophages specially in the spleen but also in bone marrow and liver.
Hemoglobin Catabolism - Jaundice Jaundice is also called icterus. It is yellow discoloration of the skin, subcutaneous tissue and bulbar sclera, due to an increase of bile pigments in the blood Normal levels vary slightly from lab to lab; they range from about 0.2 1.2 mg/dL. According to causes of Jaundice- Pre-hepatic Jaundice Hepatic Jaundice Obstructive Jaundice
Self Self Assesment Assesment 1. Normal serum iron level is-------------------------------------------------------- 2. Total Iron Binding Capacity of blood (TIBC) Nr value-------------------- 3. Serum ferritin=Normal value ------------------------------------------------ 4. Low levels of ferritin are indicative of ---------------------------------------------------- 5. Normal Iron distribution to Hb is ------------(g), to Myoglobin -----------(g)and to Ferritin---------(g) 6. Avg daily intake - about ----------------- mg and the amount of iron absorbed is normally about --------------% or --------------------- mg. 7. Avg daily loss is about ---------------------------mg through ---------------------------------------- 8. Excess iron combines with--------------------------forming tissue ferritin in macrophages in -----------------------mainly and ----------------------.
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