Insights into Complex Medical Dermatology: Pearls Lecture by Dr. Joseph L. Jorizzo

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Dr. Joseph L. Jorizzo, a renowned dermatologist, provides valuable insights on complex medical dermatology, emphasizing the importance of clinicopathologic diagnosis, patient education, and therapeutic principles. He highlights the need for a comprehensive approach in managing dermatologic and systemic complaints, offering guidance on therapy selection, disease extent assessment, and etiology evaluation.


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  1. Pearls Lecture Medical Dermatologic Society 2022 Joseph L. Jorizzo, MD Professor, Founder & Former Chair Department of Dermatology Atrium Health Wake Forest Baptist Winston-Salem, NC, USA Clinical Professor Department of Dermatology Weill Cornell Medical Center/New York Presbyterian Hospital New York, NY, USA Nathan L. Bowers, MD, PhD Chief Resident Department of Dermatology

  2. Complex Medical Dermatology General Principles What I am told on the first visit is patient education on the second visit is an excuse Quote from anonymous patient

  3. Complex Medical Dermatology Dermatologic & Systemic Complaints Possibilities 1. Clinicopathologic diagnosis unifies dermatologic and internal complaints. (eg. Sarcoidosis) 2. Clinicopathologic diagnosis reveals a reactive dermatosis. (eg. Cutaneous vasculitis) 3. No direct relationship. (eg. Scabies/fibromyalgia)

  4. Complex Medical Dermatology The patient wants to skip to their own research therapy Step 1 Clinicopathologic Diagnosis caution regarding therapy effect and site selection Step 2 Assess extent of disease regarding internal manifestations Step 3 Assess for etiology Step 4 Therapeutic ladder

  5. Complex Medical Dermatology General Therapy Principles 1. Match duration of therapy to duration of illness and explain rebound 2. Discuss what is perfect for the first scheduled follow ups and long term approach and outlook 3. Discuss resistant local disease 4. Package insert is a legal document If you were my family member and document discussion

  6. Complex Medical Dermatology Therapy Juggling Multiple Colleagues 1. Clear responsibility for each medication and disease aspect only one person drives each aspect 2. Cell phone for colleague 3. Pre Clear systemic medications with doctors for serious illnesses 4. Offer two options at baseline if they exist eg. Rheum vs Derm for Dermatomyositis 5. Avoid dueling egos

  7. Disease Pearls Oral Lichen Planus NO EROSIONS 1. Gingival Care 2. Manage Candida 3. Dilute Peroxide/repopulate probiotic 4. 1mg tacrolimus capsule swish and spit 5. Topical/intralesion cortico-steroid for erosions 6. Oral Methotrexate or Mycophenolate (Bx proven disease) 7. Repeat Biopsy for >CC exclusion as indicated

  8. Cutaneous Small Vessel Vasculitis 1. Insist on clinicopathologic confirmation 2. Labs and colleague assessment for internal disease with each flare 3. Etiology tests once at baseline unless significant change 4. Therapeutic ladder a) Palpable purpura only (eg.colchicine/dapsone) b) Erosions but no internal involvement (eg. Methotrexate,slow taper of corticosteroids) c) Systemic Disease (often colleagues)

  9. Pyoderma Gangrenosum 1. Confirm diagnosis clincopathologically to exclude differential but early lesions are neutrophilic 2. Internal manifestations of disease itself 3. Etiology is key to management 4. Manage inflammatory component 5. Manage wound (Gulliver s sign) Gentain violet/Vaseline/gauze/compression underlying disease Idiopathic

  10. Pemphigus Vulgaris After confirmation of diagnosis at baseline 1. Choice of Rituxin at baseline vs Rituxin when needed 2. Aim for perfect control 3. Complete remission off therapy should be a goal 4. Rebound should be anticipated 5. Aphthae/Burning mouth late in course

  11. Thank you!

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