Innovative Drug Delivery Systems for Gastric Conditions
Explore unique non-effervescent drug delivery systems for managing gastric conditions, including colloidal gel barriers, microporous membrane systems, alginate beads, and hollow microspheres. Learn how these systems work to enhance drug absorption and efficacy in the stomach. Images and detailed descriptions provided.
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Presentation Transcript
(Part-2) Non-effervescent system 1. Colloidal gel barrier systems Such system contains drug with gel forming hydrocolloids meant to remain buoyant on stomach contents. These systems incorporate a high level of one or more gel forming highly swellable cellulose type hydrocolloids. E.g.Type equation here. HPMC, HEC. On coming in contact with gastric fluids forms a viscous core. Incorporates H20 and entraps air. Density of system falls below 1gm/cm3. Then it starts floating.
2. Microporous membrane system Based on the encapsulation of drug reservoir inside a microporous compartment. The peripheral walls of the drug reservoir compartment are completely sealed to prevent any direct contact of the gastric mucosal surface with the undissolved drug. In stomach the floatation chamber containing entrapped air causes the delivery system over the gastric contents. Gastric fluid enters through the aperture, dissolves the drug and carries the dissolved drug for absorption.
3. Alginate beads Spherical beads of approximately 2.5mm diameter can be prepared by dropping a sodium alginate solution to aqueType equation here.ous solution of calcium chloride, causing precipitation of alginate. ?????? ???????? + ??????? ? ?????? ??????? ???????? + ???? The beads are then separated and frozen in liquid nitrogen, and freeze dried at -400C for 24 hours, leading to the formation of porous system. Maintain a floating force of over 12 hours.
4. Hollow microspheres Microballoons/hollow microspheres loaded with drugs are prepared by simple solvent evaporation method. Commonly used polymers to develop these systems are polycarbonate, cellulose acetate, calcium alginate, Eudragit S, agar and pectin etc. These systems have capacity to float on acidic dissolution media containing surfactant for about 12 hours invitro.
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