Exploring the PROTEOCURE COST Action: Targeting Proteolysis for Proteome Remodeling

CA20113-

sound

proteome

for

sound

body:

targeting

proteolysis

for

proteome

remodeling

The

‘P

ROTEO

URE

’

COST

Action

COST

provides

networking

opportunities

for

researchers

and

innovators

in

order

to

strengthen

Europe’s

capacity

to

address

scientific,

technological

and

societal

challenges

ALL

FIELDS

OF

S&T

(mono-

or

interdisciplinary,

new

and

emerging

fields)

ALL

PARTNERS

(academia,

public

organisa-

tion,

industry,

NGO,

International

Organi-

sations)

BOTTOM-

UP

APPROACH

ALL

CAREER

STAGES

(young

and

experienced

resear-

chers)

ALL

COUNTRIES

•

COST

Full

Members

•

Cooperating

Member

and

+1

Partner

Member

•

Near

Neighbour

Countries

•

Global

cooperation

European

Cooperation

in

Science

Technology

Benefits

of

participating

in

COST

Action

Scientific

Networking

Career

opportunities

Financial

support

COST

Action

PROTEO

CURE

TARGETING

PROTEOLYSIS

FOR

PROTEOME

REMODELING

ACTION

CHAIR

ACTION

VICE-

CHAIR

GH

Scientific

Representative

Rosa

Farràs,

ES

Labs

members

European

countries

https://proteocure.eu/

Olivier

Coux,

FR

olivier.coux@cnrs.fr

Institut

de

Genetique

Moleculaire

de

Montpellier,

France

farras@cipf.es

Centro

de

Investigación

Príncipe

Felipe

Valencia,

Spain

Duration:

Nov

–

Oct

PROJECT MANAGER

Laetitia Poidevin, ES

proteocuregrantholder@cipf.es

Centro

de

Investigación

Príncipe

Felipe

Valencia,

Spain

PROTEO

CURE

 Core Group :

scientific activities coordination

PROTEO

CURE

 Core Group :

dissemination & networking activities

Carmen Rivas

PROTEO

CURE

 Core Group :

Working group leaders

The

PROTEO

CURE

COST

Action

RAISON

D’ÊTRE

OF

THE

ACTION

To

foster

European

research

aiming

at

reshaping

the

proteome

for

therapeutic

needs

by

targeting

or

highjacking

the

proteolytic

machinery

•

Generate knowledge

•

Train people

•

Foster collaborations (European grants)

•

Identify targets of therapeutic / biotechnological interest

•

Develop novel drugs to cure / manipulate

Decreasing

the

energy

barriers

Basic

science

Clinics

Industry

rivate

sector

WG1

Pathologies

pathways

WG2

Screening

Identification

and

targeting

of

active

molecules

WG

ACI

Network

WG

Directed

proteolysis

WG1

goal:

to

constitue

‘task

forces’

per

pathology

or

biological

pathway,

gathering

labs

working

on

the

same

pathology

to

share

knowledge,

techniques,

models,

etc.

WG2

goal:

to

facilitate

foster

identification

and

transational

maturation

of

molecules

active

on

relevant

and

validated

proteostasis

targets.

WG3

goal:

to

promote

directed

proteolysis

approaches

in

Europe

by

favouring

the

development

of

bridges

between

biologists

and

chemists.

WG4

goal:

to

promote

integration

of

ACI

(Academic,

Clinician,

Industrial)

sectors

in

order

to

create

fertile

environment

for

rapid

translation

of

discoveries

and

ideas

into

innovativa

therapies..

Working

groups

Working

groups

WG1

WG4

WG3

WG

Pathol.1

Pathway

Pathway

Pathway

Pathol.2

Pathway

Pathway

Pathway

Pathol.3

Pathway

Pathway

Pathway

Pathol.

Pathway

Pathway

Pathway

Meetings

•

ProteoCure

meetings

or

co-

organized

meetings

•

In

person

or

virtual

STSMs

(Short

term

scientific

missions)

•

Exchanges

between

labs

Training

schools

Dissemination:

Dissemination

conference

grants,

newsletters,

mailing

lists,

webinars…

ITC

conference

grants:

support

for

Young

Researchers

and

Innovators

from

participating

Inclusiveness

Target

Countries/Near

Neighbour

Countries

to

establish

strong

network

and

increase

their

visibility

in

the

research

community.

See

proteocure.eu

for

details

Collaborative

activities

tools

Collaborative

activities

tools

Also,

•

Webinars

•

Mailing lists

•

Detailed information of members on website,

including research interest, emails etc.

•

Job offers

•

Forum

See

proteocure.eu

for details

Members

Austria

Belgium

Croatia

Cyprus

Czech

Republic

Denmark

Estonia

Finland

France

Germany

Greece

Iceland

Ireland

Italy

Lithuania

Luxembourg

The

Republic

of

Moldova

The

Netherlands

Norway

Poland

Portugal

Romania

Serbia

Slovenia

Spain

Sweden

Switzerland

Turkey

United

Kingdom

Israel

Participating

Teams

PROTEOCURE

Membership

COST

Members

non-

ITCs

(Inclusiveness

Target

Countries)

COST

Members

ITCs

COST

Cooperating

Member

•

ORE

is

the

EC’s

Open

Access

publishing

platform

for

scientific

articles

for

Horizon

Europe.

•

As

from

September

2022,

COST

Actions

can

submit

directly

to

this

publishing

venue,

free

of

charge.

•

ORE

is

reliable

peer-

reviewed

publishing

service

of

high

scientific

quality,

with

swift

publication

times.

•

Submitted

publications

must

be

original,

not

be

submitted

anywhere

else

for

publication,

and

stem

from

COST

Actions.

ORE

accepts

articles

in

all

fields

of

science.

•

Please

note

that

this

is

complementary

to

the

existing

Open

Access

expenses

covered

by

the

COST

rules.

For

more

info

visit

the

ORE

website:

https://open-

research-

europe.ec.europa.eu/

Open

Research

Europe

www.proteocure.eu

@ProteoCure

www.youtube.com/@proteocure9354

Join

us!

THANK

you!

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The PROTEOCURE COST Action focuses on targeting proteolysis for proteome remodeling, aiming to enhance Europe's scientific and technological capacity through collaboration across various fields and career stages. Participating in this initiative offers financial support, scientific networking, and career opportunities. The project spans from November 2021 to October 2025, with a core group overseeing scientific activities, dissemination, and networking efforts. With members from 30 European countries, PROTEOCURE aims to drive global cooperation and scientific advancement.

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CA20113- A sound proteome for a sound body: targeting proteolysis for proteome remodeling The PROTEOCURE COST Action

European Cooperation in Science & Technology COST provides networking opportunities for researchers and innovators in order to strengthen Europe s capacity to address scientific, technological and societal challenges ALL FIELDS OF S&T (mono- or interdisciplinary, new and emerging fields) ALL CAREER STAGES (young and experienced resear- chers) ALL PARTNERS (academia, public organisa- tion, industry, NGO, International Organi- sations) ALL COUNTRIES 41 COST Full Members + 1 Cooperating Member and +1 Partner Member 14 Near Neighbour Countries Global cooperation BOTTOM-UP APPROACH

Benefits of participating in a COST Action Financial support Scientific Networking Career opportunities

COST Action PROTEOCURE TARGETING PROTEOLYSIS FOR PROTEOME REMODELING Duration: Nov 2021 Oct 2025 PROJECT MANAGER ACTION CHAIR ACTION VICE-CHAIR GH Scientific Representative Laetitia Poidevin, ES Olivier Coux, FR Rosa Farr s, ES 318 Labs members 30 European countries https://proteocure.eu/ olivier.coux@cnrs.fr Institut de Genetique Moleculaire de Montpellier, France rfarras@cipf.es Centro de Investigaci n Pr ncipe Felipe Valencia, Spain proteocuregrantholder@cipf.es Centro de Investigaci n Pr ncipe Felipe Valencia, Spain

PROTEOCURECore Group : scientific activities coordination Grant award coordinator Rosa Barrio STSM coordinators Meetings coordinators Training schools coordinators Georgia Chachami Alfred Vertegaal Christine Blattner Makis Skoulakis Klaudia Brix Elah Pick

PROTEOCURECore Group : dissemination & networking activities Dissemination activities Science communication coordinator Eric Chevet Manuel Rodriguez Michael Glickman Target groups committee Stakeholderscommittee Networking committee Nico Dantuma Mohamad Abbas Carmen Rivas Ayala Shiber Germana Meroni Aleksandra Divac Rankov

PROTEOCURECore Group : Working group leaders Working group 1 Working group 2 Carmela Giglione Gilles Lalmanach Rune Matthiesen Matthias Stein Working group 3 Working group 4 Carles Galdeano Catherine Lindon Michael Clague Esther Slammer

ThePROTEOCURE COST Action RAISON D TRE OF THE ACTION To foster European research aiming at reshaping the proteome for therapeutic highjacking the proteolytic machinery needs by targeting or Generate knowledge Train people Foster collaborations (European grants) Identify targets of therapeutic / biotechnological interest Develop novel drugs to cure / manipulate

Decreasing the energy barriers Basic science Clinics Industry/ Private sector

Working groups WG2 goal: to facilitate / foster identification and transational maturation of molecules active on relevant and validated proteostasis targets. WG1 goal: to constitue taskforces per pathology or biological pathway, gathering labs working on the same pathology to share knowledge, techniques, models, etc. WG2 Screening / Identification and targeting of active molecules WG1 Pathologies / pathways WG3 Directed proteolysis WG4 ACI Network WG4 goal: to promote integration of ACI (Academic, Clinician, Industrial) sectors in order to create a fertile environment for rapid translation of discoveries and ideas into innovativa therapies.. WG3 goal: to promote directed proteolysis approaches in Europe by favouring the development of bridges between biologists and chemists.

Working groups Pathol.1 Pathway x Pathway y Pathway z Pathol. X Pathol.2 Pathway a Pathway b Pathway z WG1 Pathway 1 Pathway 2 Pathway 3 Pathol.3 Pathway e Pathway f Pathway g

Collaborative activities & tools Meetings ProteoCure meetings or co-organized meetings In person or virtual STSMs (Short term scientific missions) Exchanges between labs Training schools Dissemination: Dissemination conference grants, newsletters, mailing lists, webinars ITC conference grants: support for Young Researchers and Innovators from participating Inclusiveness Target Countries/Near Neighbour Countries to establish a strong network and increase their visibility in the research community. See proteocure.eu for details

Collaborativeactivities&tools Also, Webinars Mailing lists Detailed information of members on website, including research interest, emails etc. Job offers Forum See proteocure.eufor details

PROTEOCURE Membership 30 Members Luxembourg The Republic of Moldova The Netherlands Norway Poland Portugal Romania Serbia Slovenia Spain Sweden Switzerland Turkey Austria Belgium Croatia Cyprus Czech Republic Denmark Estonia Finland France Germany Greece Iceland Ireland Italy United Kingdom Israel Lithuania 318 Participating Teams COST Members non-ITCs (Inclusiveness Target Countries) COST Members ITCs COST Cooperating Member

Open Research Europe ORE is the EC s Open Access publishing platform for scientific articles for Horizon Europe. As from 30 September 2022, COST Actions can submit directly to this publishing venue, free of charge. ORE is a reliable peer-reviewed publishing service of high scientific quality, with swift publication times. Submitted publications must be original, not be submitted anywhere else for publication, and stem from COST Actions. ORE accepts articles in all fields of science. Please note that this is complementary to the existing Open Access expenses covered by the COST rules. For more info visit the ORE website: https://open-research-europe.ec.europa.eu/