Comprehensive Analysis of Gene Expression and Regulatory Potential Through eCLIP Profiles

Explore a thorough examination of gene expression and regulatory potential using eCLIP profiles, shRNA, RNA-Seq, secondary structure conservation, and prioritized genes. Uncover insights on users' variants, regulator scores, nucleotide scores, RBP rank lists, mutation burden, and more. Dive deep into baseline scores, reweighted scores, and prioritized variants across multiple data contexts.

• Gene Expression
• Regulatory Potential
• eCLIP Profiles
• RNA-Seq
• Mutation Burden

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Uploaded on Sep 07, 2024 | 3 Views

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2. Pre-built context User-Specific Inputs SNP Data Expression Profiles Mutation Profiles Base Pair Features 112 RBP Profiles Regulatory Potential Differential Expression Base Pair DAF% RBP DAF% Co-binding Recurrence Motif Regulator Score Element Score Nucleotide Score RAD Score Mandatary process Optional process Baseline Tissue

3. XX eCLIP profiles XX shRNA RNA-Seq XX RNA Bind- n-Seq Secondary Structure Conservation Pre-built data context Regulator Score Element Score Nucleotide Score Score Engine 1 Baseline Score Gene Rank List Users Variants Score Engine 2 Expression Profiles Mutation Burden RBP rank list Prioritized Genes

4. XX eCLIP profiles XX shRNA RNA-Seq XX RNA Bind- n-Seq Secondary Structure Conservation Regulator Score Element Score Nucleotide Score Pre-built data context Expression Profiles Gene Rank List Prioritized Genes Mutation Burden Score Engine 1 Baseline Score Users Variants RBP rank list Score Engine 2

5. XX eCLIP profiles XX shRNA RNA-Seq XX RNA Bind- n-Seq Secondary Structure Conservation Expression Profiles Prioritized Genes Users Variants Regulator Score Element Score Nucleotide Score RBP rank list Gene Rank List Mutation Burden Pre-built data context User Specific data context Baseline Score Score Engine 1 Reweighted Score Score Engine 2 Prioritized Variants

6. XX eCLIP profiles XX shRNA RNA-Seq XX RNA Bind- n-Seq Secondary Structure Conservation Regulator Score Element Score Basepair Score Pre-built data context Prioritized Genes Pre-built data context Baseline Score Score Engine 1 Expression Profiles Users Variants Mutation Burden RBP rank list Gene Rank List Score Engine 1 Reweighted Score Prioritized Variants

7. XXX Bind-n- Seq Secondary Structure XXX Bind-n- Seq XXX shRNA RNA-seq XXX eCLIP XXX shRNA RNA-seq Expression Profiles Prioritized Genes Users Variants Regulator Score Element Score Nucleotide Score RBP rank list Gene Rank List Mutation Burden Pre-built data context User Specific data context Baseline Score Score Engine 1 Xxx eCLIP Xxx KD Xxx Bind-n-Seq Reweighted Score Score Engine 2 Prioritized Variants

8. 1092 Patients RNA Structure Conservation 1092 Patients RNA Structure Conservation Xxx eCLIP Xxx KD Xxx Bind-n-Seq Expression Profiles Prioritized Genes Users Variants Regulator Score Element Score Nucleotide Score RBP rank list Gene Rank List Mutation Burden Pre-built data context User Specific data context Baseline Score Score Engine 1 Reweighted Score Score Engine 2 Prioritized Variants

9. SNP data Rare Variant enrichment RBP Score XXX eCLIP Define binding hotspots XXX shRNA RNA-Seq Gene-RBP association Element Score Pre-built data context Score Engine 1 Baseline Score XXX Bind-n-Seq Motif breaking Basepair Score Secondary Structure Gerp Score Score Engine 2 Prioritized Genes Expression Profiles Users Variants

10. SNP data RBP Score XXX eCLIP XXX shRNA RNA-Seq Element Score Pre-built data context XXX Bind-n-Seq Secondary Structure Basepair Score Gerp Score Baseline Score