Allergies and Antiallergic Agents
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Antiallergic agents
Оренбург,2017
The allergy - (from Greek
allos
-other,
ezgon
-action) is the condition of a
hyperreactivity of an organism developing
at repeated influences of particular
substances.
At the heart of the allergy is the
immune response, which
flowing past
with tissue damage. The substances
causing an allergy are called allergens.
At effect of allergens on an organism
allergic reaction is formed. The
development mechanism which can
represent on the following scheme
.
Allergic reaction
proceeds in 3
stages
.
1 stage is called immunologic:
At action of an antigen the system of humoral
immunity is activated, and antibodies which
are localized on mast cells are formed.
Antigenmast cell
humoral immunity
fixing (sheaf)
mast cell
IMMUNOLOGIC STAGE
At repeated hit the 2nd stage develops in an organism: The
antigen interacts with antibodies on a surface of mast cells. It
causes degranulate of mast cells and selection of allergy
mediators from them: Histaminums, bradikinina, leykotriyena.
leukotrieni
histamine
bradykinin
PATOCHEMICAL STAGE
3 stage: As a result of the subsequent action of mediators on
specific receptors in bodies and fabrics develops allergic
reactions which are shown in the form of stretching of vessels,
increase in a transmittivity of their walls, hypostasis of fabrics,
decrease in a AD and a bronchospasm.
receptors
LTr
BRr
HISr
PATHOPHYSIOLOGICAL STAGE
On the nature of manifestation allergic
reactions are subdivided on:
1) Reactions of immediate type (in a few
minutes after repeated contact with
allergen)
It is anaphylactic shock, a Quincke's disease,
an urticaria, an itch, hay fever.
2) Reactions of delayed type (arise in 2-3
days)
Reactions of a casting-off of a transplantant,
a contact dermatitis etc. concern to them
Principles of treatment of allergic
reactions:
1) Immediate termination of
contact with allergen
2) Specification of the nature of
allergen (pollen of plants, hair of
animals, medicinal substances)
3) Purpose of antiallergic tools
Classification of antiallergic medicines.
I. The tools which are slowing
down development of an
immunologic stage.
1) MEDICINES OF
GLUCOCORTICOIDS
- Prednisolonum
- Dexamethazonum
- Triamcinolone
3) M - HOLINOBLOKATOR
A) Not selection M1,M2, M3
- Atropinum
– Methacinum
- Itrop
B) The selection M3 - holinobloktara
- Tiotropy
4) BRONCHIAL SPASMOLYTICS OF
MYOTROPIC ACTION
- Theophyllinum
- Aminophyllinum
5) BLOCKERS OF CALCIUM CHANNELS
- Kromolin of sodium
- nedokromit
- Ketotifenum
II. The tools interfering degranulate of
mast cells and selection of Histaminum,
leykotriyen
1) MEDICINES OF GLUCOCORTICOIDS
- Prednisolonum
- Dexamethazonum
2) Β-ADRENOMIMETIKI
A) not the selection and,
β
-
adrenomimetiki
- adrenaline
B) not selection
β
1
β
2 of an
adrenomimetika
- Isadrinum
C) the selection
β
2-adrenomimetik
- Salbutamolum
– Fenoterolum
III. Tools, the interfering interactions of mediators of allergic reaction
with bodies targets.
1) BLOCKERS OF H1-HISTAMINIC RECEPTORS
- Dimedrol
– Tavegilum
– Suprastinum
- Klaritin
- A
е
rius
-Diazolinum
2) TOOLS WITH ANTILEYKOTRIYENOVY ACTION
A) inhibitors LOG
- Zileuton
B) blockers leykotriyenovykh of receptors
-Zafirlukast
Glucocorticoids
Medicines:
Analogs of natural
hormones
- Hidrocortizonum
Synthetic medicines
- Prednisolonum
- Dexamethazonum
- Triamcinolone
Pharmacodynamics(mechanism of action)
:
The mechanism of antiallergic action is connected with three components
1) Break interaction of macrophages with antigens i.e. blocks an antigen
presentation stage.
2) Brake activity of a phospholipase of A2 which participates in formation of
arachidonic acid of which it is formed leykotriyena subsequently – mediators of
allergic reaction.
Recycl
ing
AG
macrophage
Predece
ssor
BL
Active
BL
BL
PL
PL
JgM+AG
JgM+AG
Indication for use:
1.
А
nafilaktichesky shock
2. Asthmatic status
3. Quincke's edema
4. Eczema
5. Psoriasis
Side effects:
1. Itsenko's syndrome -
Cushing
2. Steroid ulcers
3. Steroid diabetes mellitus
4. Arterial hypertension
β
- adrenomimetiki
Not the
selection and, β-
adrenomimetik
- adrenaline
Pharmacodynamics
(
mechanism of action
);:
1) Stimulates
β
2 adrenoreceptors of bronchial
tubes and causes broncholitic effect
2) Stimulates
β
1 adrenoreytseptor of heart and causes cardiotonic effect
3) excites a1 adrenoreceptors of vessels and causes a vasoconstriction that leads to
increase in a AD
Indication for use
1) Anaphylactic shock
2) Attacks of bronchial
asthma
Side effects
1) Tachycardia
2) Arterial
hypertension
3) Cardiac arrhythmia
Not selection b1 b 2 of
an adrenomimetika
- Isadrinum
Pharmacodynamics
(
mechanism of action
)
: 1) Stimulates b2
adrenoreceptors of bronchial tubes and causes broncholitic
effect
2) Stimulates b1 adrenoreceptors of heart and causes
cardiotonic effect
Indication for use
1) Bronchospasms
2) AV-blockade
Side effects
1) Tachycardia
2) Cardiac arrhythmia
3) Arterial
hypertension
The selection b2-
adrenomimetik
- Salbutamolum
– Fenoterolum
Pharmacodynamics
(
mechanism of action
)
: Selectively
adrenoreceptors of bronchial tubes stimulate only B2 and cause
a bronchospasm. Medicines stimulate B2 adrenoreceptors of
bronchial tubes and activate adenylatecyclase, fortify TsAMF
that leads to decrease in level of calcium. The input of calcium
is limited. Calcium channels are closed and concentration of
calcium decreases. there is a decrease in a tone of bronchial
tubes and the broncholitic effect is observed
At the same time stimulate b2 adernoretseptor of mast cells
where also activate adenylatecyclase and at the same time the
TsAMF level increases, the calcium input via calcium channels
as a result of it mnizhatsya degranulate and release of
Histaminum is slowed down that also results in bronkholitichsky
effect
Indication for use:
1) Attacks of bronchial
asthma
2) Prophylaxis of attacks of
asthma
Side effects
:
In case of an
overdose bronchial
obstructive effect is
possible
.
Dispensing mode:
Appoint in the form of
aerosols two breaths at an
attack no more than 6 times
a day
Not selection M1,M2, M3 -
Holinoblokator
- Atropinum
– Methacinum
- Itrop
Pharmacodynamics
(
mechanism
of action
)
: Block M3
holinoretseptor and cause
broncholitic effect. Block M-2
holinoretseptor and cause
cardiotonic effect. Block m-1
holinoretseptor and cause a
mydriasis and paralysis of
accommodation.
Indication for use
:
1) Attacks of bronchial
asthma
2) Basic therapy of
bronchial asthma
The selection M3 - holinobloktar
-
Tiotropy
Pharmacodynamics
(
mechanism of action
)
: Medicine blocks
m3-holinoretseptory the gladkomyshechnykh of cells of
bronchial tubes, activity of a guanilattsiklaza is braked,
the Ts-GMF level decreases. In a rezuldtata of it the
calcium input is blocked, its level decreases and develops
broncholitic effect
Blocks m-holinoretseptory in mast cells. The
guanilattsiklaza is braked, the Ts-GMF level decreases,
calcium channels, a calcium input are blocked
Emission of Histaminum is as a result slowed down and
that also promotes broncholitic effect
Indication for use:
1) Prophylaxis of
attacks of bronchial
asthma
Side effects:
1) tachycardia
2) heartaches
3) Increase in an
ophthalmotonus
4) Dryness in a mouth
Bronchial spasmolytics of myotropic
action
- Theophyllinum
- Aminophyllinum
Release forms:
Tablets and solutions for
injections
Pharmacodynamics
(
mechanism of
action
)
. Medicines have direct
miorelaksiruyushchy action on
unstriated muscles of bronchial tubes
and cause broncholitic effect
In High doses of relatives to toxic
blocks FDE that also promotes
accumulation of Ts-AMF and decrease
in level of calcium. What sometimes
strengthens action of b2-
adrenomimetik
Indication for us
е:
1) attack of bronchial
asthma
2) Prophylaxis of
attacks of asthma
Side effects:
1) Hypotensive
reaction
Blockers of calcium channels
-Cromolyn sodium
- Nedocromil
- Ketotifen
Pharmacodynamics
(
mechanism of
action
)
: Block calcium channels
and reduce calcium ions in the
gladkomyshechnykh cells of
bronchial tubes, causes
broncholitic effect
Indications to application
:
-
Basic therapy of bronchial asthma
Tools, the interfering interactions of
mediators of allergic reaction with bodies
targets
Blockers of H1-histaminic receptors
- Dimedrol
– Tavegilum
– Suprastinum
-
Diazolinum
-
Klaritin
- Erius
Pharmacodynamics
(
mechanism
of action
)
: Medicines block H-1
histaminic receptors in
internals and interfere with
action of Histaminum on them.
Thus eliminate symptoms of
allergic reaction.
Indication for use:
1) Urticaria
2) Allergic rhinitises
3) Allergic conjunctivitis
4) Polinoza
5) Itch
Side effects
:
1) Depressing of a CNS shown: sleepiness,
reduction in the rate of motive reaction
2) Atropinopodobny action: dryness in a
mouth, tachycardia, a mydriasis
3) Ganglioblokiruyushchy action - hypotonic
reaction
4) The irritant action which is shown a
dyspepsia
5) Mestnoanesteziruyushchy action at
medicine reception inside.
Medicines with antileykotriyenovy
action
A) inhibitors of LOG
-zileuton
Pharmacodynamics
(
mechanism
of action
)
: Blocks a
lipoxygenase and slows down
synthesis of leykotriyen which
are mediators of allergic
reaction. As a result symptoms
of an allergy are suppressed.
B) leukotriene
receptor blockers
- Zafirlukast
Pharmacodynamics
(
me
chanism of action
)
:
Blocks leykotriyenovy
receptors in bodies
targets and suppresses
allergic reaction.
Indication for use:
-
Basic therapy of
bronchial asthma
Allergies are hyperreactivity conditions caused by particular substances called allergens. The immune response plays a key role in allergic reactions, which occur in three stages: immunologic, pathochemical, and pathophysiological. These reactions can manifest immediately or with a delayed onset. Antiallergic agents aim to alleviate symptoms and manage allergic reactions.
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Presentation Transcript
Antiallergic agents ,2017
The allergy - (from Greek allos-other, ezgon-action) is the condition of a hyperreactivity of an organism developing at repeated influences of particular substances.
At the heart of the allergy is the immune response, which flowing past with tissue damage. The substances causing an allergy are called allergens. At effect of allergens on an organism allergic reaction is formed. The development mechanism which can represent on the following scheme.
Allergic reaction proceeds in 3 stages.
1 stage is called immunologic: At action of an antigen the system of humoral immunity is activated, and antibodies which are localized on mast cells are formed. Antigenmast cell humoral immunity fixing (sheaf) mast cell IMMUNOLOGIC STAGE
At repeated hit the 2nd stage develops in an organism: The antigen interacts with antibodies on a surface of mast cells. It causes degranulate of mast cells and selection of allergy mediators from them: Histaminums, bradikinina, leykotriyena. leukotrieni PATOCHEMICAL STAGE bradykinin histamine
3 stage: As a result of the subsequent action of mediators on specific receptors in bodies and fabrics develops allergic reactions which are shown in the form of stretching of vessels, increase in a transmittivity of their walls, hypostasis of fabrics, decrease in a AD and a bronchospasm. receptors LTr BRr HISr PATHOPHYSIOLOGICAL STAGE
On the nature of manifestation allergic reactions are subdivided on: 1) Reactions of immediate type (in a few minutes after repeated contact with allergen) It is anaphylactic shock, a Quincke's disease, an urticaria, an itch, hay fever. 2) Reactions of delayed type (arise in 2-3 days) Reactions of a casting-off of a transplantant, a contact dermatitis etc. concern to them
Principles of treatment of allergic reactions: 1) Immediate termination of contact with allergen 2) Specification of the nature of allergen (pollen of plants, hair of animals, medicinal substances) 3) Purpose of antiallergic tools
Classification of antiallergic medicines. I. The tools which are slowing down development of an immunologic stage. 1) MEDICINES OF GLUCOCORTICOIDS - Prednisolonum - Dexamethazonum - Triamcinolone
II. The tools interfering degranulate of mast cells and selection of Histaminum, leykotriyen 3) M - HOLINOBLOKATOR A) Not selection M1,M2, M3 - Atropinum Methacinum - Itrop B) The selection M3 - holinobloktara - Tiotropy 4) BRONCHIAL SPASMOLYTICS OF MYOTROPIC ACTION - Theophyllinum - Aminophyllinum 5) BLOCKERS OF CALCIUM CHANNELS - Kromolin of sodium - nedokromit - Ketotifenum 1) MEDICINES OF GLUCOCORTICOIDS - Prednisolonum - Dexamethazonum 2) -ADRENOMIMETIKI A) not the selection and, - adrenomimetiki - adrenaline B) not selection 1 2 of an adrenomimetika - Isadrinum C) the selection 2-adrenomimetik - Salbutamolum Fenoterolum
III. Tools, the interfering interactions of mediators of allergic reaction with bodies targets. 1) BLOCKERS OF H1-HISTAMINIC RECEPTORS - Dimedrol Tavegilum Suprastinum - Klaritin - A rius -Diazolinum 2) TOOLS WITH ANTILEYKOTRIYENOVY ACTION A) inhibitors LOG - Zileuton B) blockers leykotriyenovykh of receptors -Zafirlukast
Glucocorticoids Medicines: Analogs of natural hormones - Hidrocortizonum Synthetic medicines - Prednisolonum - Dexamethazonum - Triamcinolone
Pharmacodynamics(mechanism of action): The mechanism of antiallergic action is connected with three components 1) Break interaction of macrophages with antigens i.e. blocks an antigen presentation stage. 2) Brake activity of a phospholipase of A2 which participates in formation of arachidonic acid of which it is formed leykotriyena subsequently mediators of allergic reaction. Recycl ing AG Active BL PL JgM+AG Predece ssor BL macrophage BL PL JgM+AG
Indication for use: 1. nafilaktichesky shock 2. Asthmatic status 3. Quincke's edema 4. Eczema 5. Psoriasis
Side effects: 1. Itsenko's syndrome - Cushing 2. Steroid ulcers 3. Steroid diabetes mellitus 4. Arterial hypertension
- adrenomimetiki Not the selection and, - adrenomimetik - adrenaline
Pharmacodynamics(mechanism of action);: 1) Stimulates 2 adrenoreceptors of bronchial tubes and causes broncholitic effect 2) Stimulates 1 adrenoreytseptor of heart and causes cardiotonic effect 3) excites a1 adrenoreceptors of vessels and causes a vasoconstriction that leads to increase in a AD
Indication for use 1) Anaphylactic shock 2) Attacks of bronchial asthma
Side effects 1) Tachycardia 2) Arterial hypertension 3) Cardiac arrhythmia
Not selection b1 b 2 of an adrenomimetika - Isadrinum
Pharmacodynamics(mechanism of action): 1) Stimulates b2 adrenoreceptors of bronchial tubes and causes broncholitic effect 2) Stimulates b1 adrenoreceptors of heart and causes cardiotonic effect
Indication for use 1) Bronchospasms 2) AV-blockade
Side effects 1) Tachycardia 2) Cardiac arrhythmia 3) Arterial hypertension
The selection b2- adrenomimetik - Salbutamolum Fenoterolum
Pharmacodynamics(mechanism of action): Selectively adrenoreceptors of bronchial tubes stimulate only B2 and cause a bronchospasm. Medicines stimulate B2 adrenoreceptors of bronchial tubes and activate adenylatecyclase, fortify TsAMF that leads to decrease in level of calcium. The input of calcium is limited. Calcium channels are closed and concentration of calcium decreases. there is a decrease in a tone of bronchial tubes and the broncholitic effect is observed At the same time stimulate b2 adernoretseptor of mast cells where also activate adenylatecyclase and at the same time the TsAMF level increases, the calcium input via calcium channels as a result of it mnizhatsya degranulate and release of Histaminum is slowed down that also results in bronkholitichsky effect
Indication for use: 1) Attacks of bronchial asthma 2) Prophylaxis of attacks of asthma
Side effects:In case of an overdose bronchial obstructive effect is possible.Dispensing mode: Appoint in the form of aerosols two breaths at an attack no more than 6 times a day
Not selection M1,M2, M3 - Holinoblokator - Atropinum Methacinum - Itrop
Pharmacodynamics(mechanism of action): Block M3 holinoretseptor and cause broncholitic effect. Block M-2 holinoretseptor and cause cardiotonic effect. Block m-1 holinoretseptor and cause a mydriasis and paralysis of accommodation.
Indication for use: 1) Attacks of bronchial asthma 2) Basic therapy of bronchial asthma
The selection M3 - holinobloktar - Tiotropy
Pharmacodynamics(mechanism of action): Medicine blocks m3-holinoretseptory the gladkomyshechnykh of cells of bronchial tubes, activity of a guanilattsiklaza is braked, the Ts-GMF level decreases. In a rezuldtata of it the calcium input is blocked, its level decreases and develops broncholitic effect Blocks m-holinoretseptory in mast cells. The guanilattsiklaza is braked, the Ts-GMF level decreases, calcium channels, a calcium input are blocked Emission of Histaminum is as a result slowed down and that also promotes broncholitic effect
Indication for use: 1) Prophylaxis of attacks of bronchial asthma
Side effects: 1) tachycardia 2) heartaches 3) Increase in an ophthalmotonus 4) Dryness in a mouth
Bronchial spasmolytics of myotropic action - Theophyllinum - Aminophyllinum Release forms: Tablets and solutions for injections
Pharmacodynamics (mechanism of action). Medicines have direct miorelaksiruyushchy action on unstriated muscles of bronchial tubes and cause broncholitic effect In High doses of relatives to toxic blocks FDE that also promotes accumulation of Ts-AMF and decrease in level of calcium. What sometimes strengthens action of b2- adrenomimetik
Indication for us: 1) attack of bronchial asthma 2) Prophylaxis of attacks of asthma
Side effects: 1) Hypotensive reaction
Blockers of calcium channels -Cromolyn sodium - Nedocromil - Ketotifen
Pharmacodynamics(mechanism of action): Block calcium channels and reduce calcium ions in the gladkomyshechnykh cells of bronchial tubes, causes broncholitic effect Indications to application: -Basic therapy of bronchial asthma
Tools, the interfering interactions of mediators of allergic reaction with bodies targets Blockers of H1-histaminic receptors - Dimedrol Tavegilum Suprastinum - Diazolinum -Klaritin - Erius
Pharmacodynamics(mechanism of action): Medicines block H-1 histaminic receptors in internals and interfere with action of Histaminum on them. Thus eliminate symptoms of allergic reaction.
Indication for use: 1) Urticaria 2) Allergic rhinitises 3) Allergic conjunctivitis 4) Polinoza 5) Itch
Side effects: 1) Depressing of a CNS shown: sleepiness, reduction in the rate of motive reaction 2) Atropinopodobny action: dryness in a mouth, tachycardia, a mydriasis 3) Ganglioblokiruyushchy action - hypotonic reaction 4) The irritant action which is shown a dyspepsia 5) Mestnoanesteziruyushchy action at medicine reception inside.
Medicines with antileykotriyenovy action A) inhibitors of LOG -zileuton
Pharmacodynamics(mechanism of action): Blocks a lipoxygenase and slows down synthesis of leykotriyen which are mediators of allergic reaction. As a result symptoms of an allergy are suppressed.
